Lista de obras -

AP-1 binding transcriptionally regulates human neutral ceramidase

artículo científico publicado en 2011

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

artículo científico publicado en 2016

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

scientific article published on 08 April 2019

Altered sphingolipid metabolism in patients with metastatic pancreatic cancer

artículo científico publicado en 2013

Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy

artículo científico publicado en 2011

C(6)-Ceramide-Coated Catheters Promote Re-Endothelialization of Stretch-Injured Arteries

artículo científico publicado en 2008

C6-ceramide nanoliposomes target the Warburg effect in chronic lymphocytic leukemia

artículo científico publicado en 2013

Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer cells

artículo científico publicado en 2008

Ceramide 1-phosphate mediates endothelial cell invasion via the annexin a2-p11 heterotetrameric protein complex

artículo científico publicado en 2013

Ceramide 1-phosphate regulates cell migration and invasion of human pancreatic cancer cells

artículo científico publicado en 2015

Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia

scientific article published on 19 November 2019

Ceramide modulates HERG potassium channel gating by translocation into lipid rafts

artículo científico publicado en 2010

Ceramide nanoliposomes as a MLKL-dependent, necroptosis-inducing, chemotherapeutic reagent in ovarian cancer

artículo científico publicado en 2017

Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains

scientific journal article

Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia

artículo científico publicado en 2016

Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells

artículo científico publicado en 2019

Circulating sphingolipid biomarkers in models of type 1 diabetes

artículo científico publicado en 2010

Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer ⬇️

artículo científico publicado el 1 de octubre de 2011

Conductance-Based Biophysical Distinction and Microfluidic Enrichment of Nanovesicles Derived from Pancreatic Tumor Cells of Varying Invasiveness

artículo científico publicado en 2019

Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy

artículo científico publicado en 2006

Diabetes diminishes phosphatidic acid in the retina: a putative mediator for reduced mTOR signaling and increased neuronal cell death

artículo científico publicado en 2012

Dysregulation of sphingolipid metabolism in cancer ⬇️

artículo científico publicado el 15 de enero de 2011

Effective encapsulation and biological activity of phosphorylated chemotherapeutics in calcium phosphosilicate nanoparticles for the treatment of pancreatic cancer

artículo científico publicado en 2017

Ether-linked diglycerides inhibit vascular smooth muscle cell growth via decreased MAPK and PI3K/Akt signaling

artículo científico publicado en 2008

Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH

scientific article published on 16 May 2020

Exogenous ceramide-1-phosphate reduces lipopolysaccharide (LPS)-mediated cytokine expression

artículo científico publicado en 2011

Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome-Induced Cell Death in Head and Neck Squamous Cell Carcinoma

artículo científico publicado en 2020

Inhibition of NADPH oxidase by glucosylceramide confers chemoresistance ⬇️

artículo científico publicado el 1 de diciembre de 2010

Inhibition of corneal inflammation by liposomal delivery of short-chain, C-6 ceramide

artículo científico publicado en 2008

Insulin signaling in retinal neurons is regulated within cholesterol-enriched membrane microdomains.

artículo científico publicado en 2011

Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo

artículo científico publicado en 2017

Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells

artículo científico publicado en 2015

Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia--Impact on enzyme activity and response to cytotoxics

artículo científico publicado en 2015

Nanoliposomal minocycline for ocular drug delivery

artículo científico publicado en 2012

Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice

artículo científico publicado en 2018

Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains

artículo científico publicado en 2011

Novel off-target effect of tamoxifen--inhibition of acid ceramidase activity in cancer cells

artículo científico publicado en 2013

Optimized expression and purification of myristoylated human neuronal calcium sensor 1 in E. coli.

artículo científico publicado en 2008

Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway

artículo científico publicado en 2010

PhotoImmunoNanoTherapy reveals an anticancer role for sphingosine kinase 2 and dihydrosphingosine-1-phosphate

scientific article published on 14 February 2013

Preclinical development of a C6-ceramide NanoLiposome, a novel sphingolipid therapeutic

artículo científico

Propagation of Undifferentiated Human Embryonic Stem Cells with Nano-Liposomal Ceramide

artículo científico publicado en 2009

SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models

artículo científico publicado en 2017

STAT3 mediates C6-ceramide-induced cell death in chronic lymphocytic leukemia

Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia

scientific article published on 01 September 2019

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

artículo científico publicado en 2016

Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition

artículo científico publicado en 2009

Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia

artículo científico publicado en 2015

Targeting glucosylceramide synthase synergizes with C6-ceramide nanoliposomes to induce apoptosis in natural killer cell leukemia

artículo científico publicado en 2012

Targeting sphingosine kinase-1 to inhibit melanoma.

artículo científico publicado en 2012

The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines

artículo científico publicado en 2015

Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia

artículo científico publicado en 2011

Therapeutic strategies for diabetes and complications: a role for sphingolipids?

artículo científico publicado en 2010

Toll-like receptors at the ocular surface

artículo científico publicado en 2008

Transcriptional regulation of the human neutral ceramidase gene

artículo científico publicado en 2011

Tumor-promoting effects of pancreatic cancer cell exosomes on THP-1-derived macrophages

artículo científico publicado en 2018

Use of high performance liquid chromatography-electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels

artículo científico publicado en 2009

Lista de obras de

AP-1 binding transcriptionally regulates human neutral ceramidase

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Altered sphingolipid metabolism in patients with metastatic pancreatic cancer

Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy

C(6)-Ceramide-Coated Catheters Promote Re-Endothelialization of Stretch-Injured Arteries

C6-ceramide nanoliposomes target the Warburg effect in chronic lymphocytic leukemia

Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer cells

Ceramide 1-phosphate mediates endothelial cell invasion via the annexin a2-p11 heterotetrameric protein complex

Ceramide 1-phosphate regulates cell migration and invasion of human pancreatic cancer cells

Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia

Ceramide modulates HERG potassium channel gating by translocation into lipid rafts

Ceramide nanoliposomes as a MLKL-dependent, necroptosis-inducing, chemotherapeutic reagent in ovarian cancer

Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains

Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia

Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells

Circulating sphingolipid biomarkers in models of type 1 diabetes

Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer ⬇️

Conductance-Based Biophysical Distinction and Microfluidic Enrichment of Nanovesicles Derived from Pancreatic Tumor Cells of Varying Invasiveness

Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy

Diabetes diminishes phosphatidic acid in the retina: a putative mediator for reduced mTOR signaling and increased neuronal cell death

Dysregulation of sphingolipid metabolism in cancer ⬇️

Effective encapsulation and biological activity of phosphorylated chemotherapeutics in calcium phosphosilicate nanoparticles for the treatment of pancreatic cancer

Ether-linked diglycerides inhibit vascular smooth muscle cell growth via decreased MAPK and PI3K/Akt signaling

Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH

Exogenous ceramide-1-phosphate reduces lipopolysaccharide (LPS)-mediated cytokine expression

Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome-Induced Cell Death in Head and Neck Squamous Cell Carcinoma

Inhibition of NADPH oxidase by glucosylceramide confers chemoresistance ⬇️

Inhibition of corneal inflammation by liposomal delivery of short-chain, C-6 ceramide

Insulin signaling in retinal neurons is regulated within cholesterol-enriched membrane microdomains.

Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo

Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells

Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia--Impact on enzyme activity and response to cytotoxics

Nanoliposomal minocycline for ocular drug delivery

Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice

Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains

Novel off-target effect of tamoxifen--inhibition of acid ceramidase activity in cancer cells

Optimized expression and purification of myristoylated human neuronal calcium sensor 1 in E. coli.

Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway

PhotoImmunoNanoTherapy reveals an anticancer role for sphingosine kinase 2 and dihydrosphingosine-1-phosphate

Preclinical development of a C6-ceramide NanoLiposome, a novel sphingolipid therapeutic

Propagation of Undifferentiated Human Embryonic Stem Cells with Nano-Liposomal Ceramide

SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models

STAT3 mediates C6-ceramide-induced cell death in chronic lymphocytic leukemia

Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition

Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia

Targeting glucosylceramide synthase synergizes with C6-ceramide nanoliposomes to induce apoptosis in natural killer cell leukemia

Targeting sphingosine kinase-1 to inhibit melanoma.

The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines

Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia

Therapeutic strategies for diabetes and complications: a role for sphingolipids?

Toll-like receptors at the ocular surface

Transcriptional regulation of the human neutral ceramidase gene

Tumor-promoting effects of pancreatic cancer cell exosomes on THP-1-derived macrophages

Use of high performance liquid chromatography-electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels