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-------A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS--

artículo científico publicado en 2021

A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.

artículo científico publicado en 2011

A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia ⬇️

artículo científico publicado el 26 de junio de 2012

A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p.

artículo científico publicado en 2006

A local circadian clock calls time on lung inflammation.

artículo científico publicado en 2014

A method for the in vivo measurement of zebrafish tissue neutrophil lifespan ⬇️

artículo científico publicado el 16 de julio de 2012

A role for caspase-1 in serum withdrawal-induced apoptosis of endothelial cells

artículo científico publicado en 2003

A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension

artículo científico publicado en 2019

A transgenic zebrafish model of neutrophilic inflammation

artículo científico publicado en 2006

A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism

artículo científico publicado en 2014

Acceleration of human neutrophil apoptosis by TRAIL.

artículo científico publicado en 2003

Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model

artículo científico publicado en 2011

Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor

Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor

artículo científico publicado en 2005

Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes

artículo científico publicado en 2005

Alveolar Macrophage Apoptosis Contributes to Pneumococcal Clearance in a Resolving Model of Pulmonary Infection ⬇️

artículo científico publicado el 15 de noviembre de 2003

Alveolar Macrophage Apoptosis-associated Bacterial Killing Helps Prevent Murine Pneumonia

artículo científico publicado en 2019

CTLA-4 polymorphisms in allergy and asthma and the TH1/ TH2 paradigm

artículo científico publicado en 2004

Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury

artículo científico publicado en 2002

Contrasting roles for reactive oxygen species and nitric oxide in the innate response to pulmonary infection with Streptococcus pneumoniae

artículo científico publicado en 2006

Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.

artículo científico publicado en 2006

Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia

artículo científico publicado en 2006

Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.

artículo científico publicado en 2012

Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis

artículo científico publicado en 2017

Development of a Consensus Statement for the Definition, Diagnosis, and Treatment of Acute Exacerbations of Idiopathic Pulmonary Fibrosis Using the Delphi Technique.

artículo científico publicado en 2015

Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD.

artículo científico publicado en 2016

Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease.

artículo científico publicado en 2010

Drift-Diffusion Analysis of Neutrophil Migration during Inflammation Resolution in a Zebrafish Model.

artículo científico publicado en 2012

Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance

artículo científico publicado en 2005

Effect of Co-trimoxazole (Trimethoprim-Sulfamethoxazole) vs Placebo on Death, Lung Transplant, or Hospital Admission in Patients With Moderate and Severe Idiopathic Pulmonary Fibrosis: The EME-TIPAC Randomized Clinical Trial

artículo científico publicado en 2020

Effective caspase inhibition blocks neutrophil apoptosis and reveals Mcl-1 as both a regulator and a target of neutrophil caspase activation

artículo científico publicado en 2011

Endotoxin tolerance induces selective alterations in neutrophil function.

artículo científico publicado en 2005

Erratum: A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p

article

Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract

artículo científico publicado en 2005

Facilitation of IL-22 production from innate lymphoid cells by prostaglandin E2 prevents experimental lung neutrophilic inflammation

artículo científico publicado en 2018

Gelsolin in idiopathic pulmonary fibrosis: a new target supports a central role for epithelial injury in disease pathogenesis

artículo científico publicado en 2009

Genetic factors in idiopathic pulmonary fibrosis: transforming growth factor-beta implicated at last

artículo científico publicado en 2003

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.

artículo científico publicado en 2017

Granulocyte apoptosis in the pathogenesis and resolution of lung disease

artículo científico publicado en 2006

Hypoxia selectively inhibits respiratory burst activity and killing of Staphylococcus aureus in human neutrophils.

artículo científico publicado en 2010

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

artículo científico publicado en 2022

Hypoxia, the HIF pathway and neutrophilic inflammatory responses.

artículo científico

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

artículo científico publicado en 2013

Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function

scientific article published on 21 April 2009

IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo

scientific article published on 01 July 2019

Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen

artículo científico publicado en 2016

Identifying and hurdling obstacles to translational research

artículo científico publicado en 2007

Idiopathic pulmonary fibrosis

scientific article published on 22 June 2011

Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages

artículo científico publicado en 2017

Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa.

artículo científico publicado en 2007

Implications of apoptotic cell death of resident and recruited cells in COPD

artículo científico publicado en 2008

Incapacitating the immune system in cystic fibrosis

artículo científico publicado en 2007

Induction of neutrophil apoptosis by the Pseudomonas aeruginosa exotoxin pyocyanin: a potential mechanism of persistent infection

artículo científico publicado en 2002

Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor.

artículo científico publicado en 2007

Interleukin 18 receptor 1 gene polymorphisms are associated with asthma

article

Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages

artículo científico publicado en 2011

Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis

artículo científico publicado en 2012

Modeling inflammation in the zebrafish: how a fish can help us understand lung disease

artículo científico publicado en 2007

Monocytes Regulate the Mechanism of T-cell Death by Inducing Fas-Mediated Apoptosis during Bacterial Infection ⬇️

artículo científico publicado el 19 de julio de 2012

Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression

artículo científico publicado en 2016

NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival

artículo científico publicado en 2017

Neutrophil apoptosis in infectious disease

artículo científico publicado en 2007

Neutrophil energetics and oxygen sensing

artículo científico publicado en 2014

Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis

artículo científico publicado en 2020

Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis

artículo científico publicado en 2006

Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection.

artículo científico publicado en 2004

Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease is Enhanced by Nrf2 Agonists.

artículo científico publicado en 2018

PGE production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo

scientific article published on 05 September 2018

Pathological networking: a new approach to understanding COPD.

artículo científico publicado en 2007

Pathways regulating lipopolysaccharide-induced neutrophil survival revealed by lentiviral transduction of primary human neutrophils.

artículo científico publicado en 2008

Phenotipic analysis of neutrophil population from GBM patients

artículo científico publicado en 2018

Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish

artículo científico publicado en 2010

Pneumococcal pneumonia: mechanisms of infection and resolution.

artículo científico

Pneumolysin activates macrophage lysosomal membrane permeabilization and executes apoptosis by distinct mechanisms without membrane pore formation

artículo científico publicado en 2014

Potentiation of TLR4 signalling by plasmin activity

artículo científico publicado en 2006

Practical and conceptual models of chronic obstructive pulmonary disease.

artículo científico publicado en 2007

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

artículo científico publicado en 2011

Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae

artículo científico publicado en 2011

Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo.

artículo científico publicado en 2017

Pyocyanin production by Pseudomonas aeruginosa induces neutrophil apoptosis and impairs neutrophil-mediated host defenses in vivo

artículo científico publicado en 2005

Quantitative linkage genome scan for atopy in a large collection of Caucasian families

artículo científico publicado en 2006

RESPIRE: The National Institute for Health Research's (NIHR) Global Respiratory Health Unit

article

Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia

artículo científico publicado en 2008

Reducing the toll of inflammatory lung disease.

artículo científico publicado en 2007

Regulation of human neutrophil chemokine receptor expression and function by activation of Toll-like receptors 2 and 4.

artículo científico publicado en 2005

Regulation of neutrophil senescence by microRNAs

artículo científico publicado en 2011

Regulation of phagocyte lifespan in the lung during bacterial infection.

artículo científico publicado en 2006

Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines

artículo científico publicado en 2012

Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span.

artículo científico publicado en 2003

Semaphorin 3F signaling actively retains neutrophils at sites of inflammation

scientific article published on 19 March 2020

Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution.

artículo científico publicado en 2014

Sir,

article

Staphylococcus aureus induces eosinophil cell death mediated by α-hemolysin

artículo científico publicado en 2012

Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin

artículo científico publicado en 2008

TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation

artículo científico publicado en 2011

Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease.

artículo científico publicado en 2006

The Anti-Apoptotic Effect of Respiratory Syncytial Virus on Human Peripheral Blood Neutrophils is Mediated by a Monocyte Derived Soluble Factor

artículo científico publicado en 2011

The Efficacy and Mechanism Evaluation of Treating Idiopathic Pulmonary fibrosis with the Addition of Co-trimoxazole (EME-TIPAC): study protocol for a randomised controlled trial.

artículo científico publicado en 2018

The HIF/VHL pathway: from oxygen sensing to innate immunity

artículo científico publicado en 2007

The expression and roles of Toll-like receptors in the biology of the human neutrophil.

artículo científico publicado en 2005

The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages

artículo científico publicado en 2010

The regulation of pulmonary inflammation by the hypoxia-inducible factor-hydroxylase oxygen-sensing pathway.

artículo científico

The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis

artículo científico publicado en 2005

The role of interleukin-1beta in direct and toll-like receptor 4-mediated neutrophil activation and survival

artículo científico publicado en 2004

The role of neutrophils in cancer

article

Three novel Bid proteins generated by alternative splicing of the human Bid gene

artículo científico publicado en 2003

Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cells

artículo científico publicado en 2004

Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses

artículo científico publicado en 2002

Toll-like receptors and chronic lung disease.

artículo científico publicado en 2005

Toll-like receptors in health and disease: complex questions remain.

artículo científico publicado en 2003

Zebrafish as a model for the study of neutrophil biology

artículo científico

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