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Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT

artículo científico publicado el 19 de julio de 2011

Atomic description of the immune complex involved in heparin-induced thrombocytopenia

artículo científico publicado en 2015

Bad (or good) things come in small packages.

artículo científico publicado en 2013

CXCL12-CXCL4 heterodimerization prevents CXCL12-driven breast cancer cell migration

artículo científico publicado en 2019

Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin.

artículo científico publicado en 2013

Distinct specificity and single-molecule kinetics characterize the interaction of pathogenic and non-pathogenic antibodies against platelet factor 4-heparin complexes with platelet factor 4.

artículo científico publicado en 2013

Dynamic antibody-binding properties in the pathogenesis of HIT.

artículo científico publicado en 2012

Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia

artículo científico publicado en 2018

Efficacy of IVIG affinity-purified anti-double-stranded DNA anti-idiotypic antibodies in the treatment of an experimental murine model of systemic lupus erythematosus

scientific article published on 01 November 2002

Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia

artículo científico publicado en 2017

Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis

scientific article published on 01 March 2020

Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly

artículo científico publicado en 2007

Induction of biologically active antineutrophil cytoplasmic antibodies by immunization with human apoptotic polymorphonuclear leukocytes

artículo científico publicado en 2002

Molecular and cellular pathogenesis of heparin-induced thrombocytopenia (HIT)

artículo científico publicado en 2018

Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia

artículo científico publicado el 19 de agosto de 2010

PF4/heparin complexes are T cell-dependent antigens

artículo científico publicado en 2005

Platelet Factor 4 Inhibits and Enhances HIV-1 Infection in a Concentration-Dependent Manner by Modulating Viral Attachment

artículo científico publicado en 2016

Platelet factor 4-containing immune complexes induce platelet activation followed by calpain-dependent platelet death

scientific article published on 24 June 2019

Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia

artículo científico publicado en 2015

Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia

artículo científico publicado en 2016

Role of monocytes and endothelial cells in heparin-induced thrombocytopenia

artículo científico publicado en 2016

Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications

artículo científico publicado en 2005

T2 magnetic resonance: a diagnostic platform for studying integrated hemostasis in whole blood--proof of concept.

artículo científico publicado en 2014

The antigenic complex in HIT binds to B-cells via complement and complement receptor 2 (CD21).

artículo científico publicado en 2016

The role of surface PF4: glycosaminoglycan complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT).

artículo científico publicado en 2006

Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia

artículo científico publicado en 2004