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(+)-2-(1-Hydroxyl-4-oxocyclohexyl) ethyl caffeate suppresses solar UV-induced skin carcinogenesis by targeting PI3K, ERK1/2, and p38.

artículo científico publicado en 2014

(-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78.

artículo científico publicado en 2006

(-)-Epigallocatechin gallate regulates CD3-mediated T cell receptor signaling in leukemia through the inhibition of ZAP-70 kinase

artículo científico publicado en 2008

(-)-Epigallocatechin-3-gallate inhibition of Epstein-Barr virus spontaneous lytic infection involves ERK1/2 and PI3-K/Akt signaling in EBV-positive cells

artículo científico publicado en 2012

(3-Chloroacetyl)-indole, a novel allosteric AKT inhibitor, suppresses colon cancer growth in vitro and in vivo.

artículo científico publicado en 2011

2-Arachidonoylglycerol stimulates activator protein-1-dependent transcriptional activity and enhances epidermal growth factor-induced cell transformation in JB6 P+ cells

artículo científico publicado en 2005

20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol suppresses UV-Induced MMP-1 expression through AMPK-mediated mTOR inhibition as a downstream of the PKA-LKB1 pathway

artículo científico publicado en 2014

20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginseng, inhibits colon cancer growth by targeting TRPC channel-mediated calcium influx.

artículo científico publicado en 2013

244-MPT overcomes gefitinib resistance in non-small cell lung cancer cells

artículo científico publicado en 2015

3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2

scientific article published on 01 February 2019

3,6,2',4',5'-Pentahydroxyflavone, an orally bioavailable multiple protein kinase inhibitor, overcomes gefitinib resistance in non-small cell lung cancer

artículo científico publicado en 2014

5-deoxykaempferol plays a potential therapeutic role by targeting multiple signaling pathways in skin cancer

artículo científico publicado en 2010

6,7,4'-Trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2 ⬇️

artículo científico publicado el 21 de enero de 2011

6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1.

artículo científico publicado en 2013

7,3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase

artículo científico publicado en 2010

7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4.

artículo científico publicado en 2011

A Novel Cinnamon-Related Natural Product with Pim-1 Inhibitory Activity Inhibits Leukemia and Skin Cancer

artículo científico publicado en 2015

A Small Molecule Inhibitor of the β-Catenin-TCF4 Interaction Suppresses Colorectal Cancer Growth In Vitro and In Vivo.

artículo científico publicado en 2017

A chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases.

artículo científico publicado en 2013

A combination of paclitaxel and siRNA-mediated silencing of Stathmin inhibits growth and promotes apoptosis of nasopharyngeal carcinoma cells

artículo científico publicado en 2013

A derivative of chrysin suppresses two-stage skin carcinogenesis by inhibiting mitogen- and stress-activated kinase 1.

artículo científico publicado en 2013

A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer

artículo científico publicado en 2016

A new functional IDH2 genetic variant is associated with the risk of lung cancer

artículo científico publicado en 2016

A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development

artículo científico publicado en 2004

A regulatory mechanism for RSK2 NH(2)-terminal kinase activity

artículo científico publicado en 2009

A selective small-molecule inhibitor of c-Jun N-terminal kinase 1

artículo científico publicado en 2009

ADA-07 Suppresses Solar Ultraviolet-Induced Skin Carcinogenesis by Directly Inhibiting TOPK.

artículo científico publicado en 2017

AID expression increased by TNF-α is associated with class switch recombination of Igα gene in cancers

artículo científico publicado en 2015

AKT as a Therapeutic Target for Cancer

scientific article published on 26 February 2019

ANTs and cancer: Emerging pathogenesis, mechanisms, and perspectives

scientific article published on 10 December 2020

APIO-EE-9 is a novel Aurora A and B antagonist that suppresses esophageal cancer growth in a PDX mouse model

artículo científico publicado en 2017

ARC is a critical protector against inflammatory bowel disease (IBD) and IBD-associated colorectal tumorigenesis

scientific article published on 19 August 2020

Activation of the Ig Iα1 promoter by the transcription factor Ets-1 triggers Ig Iα1-Cα1 germline transcription in epithelial cancer cells

artículo científico publicado en 2013

Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin

artículo científico publicado en 2015

Addressing the challenges of applying precision oncology.

artículo científico publicado en 2017

Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2

artículo científico publicado en 2012

Analysis of hydrophobic and hydrophilic moments of short penetrating peptides for enhancing mitochondrial localization: prediction and validation

scientific article published on 27 March 2019

Analysis of the role of p38 MAP kinase in epidermal growth factor-induced JB6 Cl41 cell transformation by cDNA array ⬇️

artículo científico publicado el 18 de enero de 2012

Anticancer activity of 3-demethylubiquinone Q2. In vivo experiments and probable mechanism of action

artículo científico publicado en 2008

Apoptosis induction by arsenic: mechanisms of action and possible clinical applications for treating therapy-resistant cancers

artículo científico publicado en 2000

Arsenite inhibits p53 phosphorylation, DNA binding activity, and p53 target gene p21 expression in mouse epidermal JB6 cells

artículo científico publicado en 2006

Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1.

artículo científico publicado en 2003

Aspirin Prevents Colorectal Cancer by Normalizing EGFR Expression

artículo científico publicado en 2015

Ataxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3.

artículo científico publicado en 2003

Aurora B kinase as a novel molecular target for inhibition the growth of osteosarcoma

scientific article published on 01 March 2019

Autophagy and cellular senescence mediated by Sox2 suppress malignancy of cancer cells

artículo científico publicado en 2013

Bakuchiol suppresses proliferation of skin cancer cells by directly targeting Hck, Blk, and p38 MAP kinase

artículo científico publicado en 2016

Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells

artículo científico publicado en 2007

Breaking the NF-κB and STAT3 Alliance Inhibits Inflammation and Pancreatic Tumorigenesis ⬇️

artículo científico publicado el 26 de octubre de 2010

Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib-resistant lung cancer growth

artículo científico publicado en 2014

CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction

scientific article published on 25 June 2019

CInQ-03, a novel allosteric MEK inhibitor, suppresses cancer growth in vitro and in vivo

artículo científico publicado en 2013

COOH-terminal Src kinase-mediated c-Jun phosphorylation promotes c-Jun degradation and inhibits cell transformation.

artículo científico publicado en 2006

CRISPR/Cas9 - An evolving biological tool kit for cancer biology and oncology

article published in 2019

Caffeic acid directly targets ERK1/2 to attenuate solar UV-induced skin carcinogenesis.

artículo científico publicado en 2014

Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression

artículo científico publicado en 2008

Caffeine inhibits cell proliferation by G0/G1 phase arrest in JB6 cells

artículo científico publicado en 2004

Cancer prevention and control: alarming challenges in China ⬇️

artículo científico publicado en 2016

Cancer prevention by food factors through targeting signal transduction pathways

artículo científico publicado en 2004

Cancer prevention research - then and now

artículo científico publicado en 2009

Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2

Ceftriaxone, an FDA-approved cephalosporin antibiotic, suppresses lung cancer growth by targeting Aurora B ⬇️

artículo científico publicado el 7 de septiembre de 2012

Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3.

artículo científico publicado en 2006

Cell growth inhibition by 3-deoxysappanchalcone is mediated by directly targeting the TOPK signaling pathway in colon cancer

scientific article published on 31 December 2018

Chemopreventive Effects of Licorice and Its Components

artículo científico publicado en 2015

Circulating Prostaglandin Biosynthesis in Colorectal Cancer and Potential Clinical Significance

artículo científico publicado en 2015

Circulating Tumor Cells: Moving Biological Insights into Detection.

artículo científico publicado en 2017

Cocarcinogenic effect of capsaicin involves activation of EGFR signaling but not TRPV1.

artículo científico publicado en 2010

Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase

artículo científico publicado en 2008

Coffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPK ⬇️

artículo científico publicado el 11 de febrero de 2011

Computational and Biochemical Discovery of RSK2 as a Novel Target for Epigallocatechin Gallate (EGCG)

artículo científico publicado en 2015

Concordant effects of aromatase inhibitors on gene expression in ER+ Rat and human mammary cancers and modulation of the proteins coded by these genes

artículo científico publicado en 2013

Correction: Structural Diversity of the Active N-Terminal Kinase Domain of p90 Ribosomal S6 Kinase 2.

artículo científico publicado en 2009

Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity

artículo científico publicado en 2007

Curcumin suppresses proliferation of colon cancer cells by targeting CDK2.

scientific article published on 18 February 2014

Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation

artículo científico publicado en 2008

Cyclin-dependent kinase-3-mediated c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformation.

artículo científico publicado en 2009

DAPK1 mediates the G1 phase arrest in human nasopharyngeal carcinoma cells induced by grifolin, a potential antitumor natural product ⬇️

artículo científico publicado el 6 de septiembre de 2011

DNMT1 mediates metabolic reprogramming induced by Epstein-Barr virus latent membrane protein 1 and reversed by grifolin in nasopharyngeal carcinoma

artículo científico publicado en 2018

Dactylone inhibits epidermal growth factor-induced transformation and phenotype expression of human cancer cells and induces G1-S arrest and apoptosis.

artículo científico publicado en 2007

Daily or weekly dosing with EGFR inhibitors, gefitinib and lapatinib, and AKt inhibitor MK2206 in mammary cancer models

artículo científico publicado en 2018

Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate.

artículo científico publicado en 2002

Delphinidin attenuates neoplastic transformation in JB6 Cl41 mouse epidermal cells by blocking Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling

artículo científico publicado en 2008

Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MAPKK4 and PI-3 kinase

artículo científico publicado en 2009

Dialogue between ERKs and JNKs: friendly or antagonistic?

artículo científico publicado en 2003

Differential gene expression profiles of Jnk1- and Jnk2-deficient murine fibroblast cells.

artículo científico publicado en 2002

Direct inhibition of insulin-like growth factor-I receptor kinase activity by (-)-epigallocatechin-3-gallate regulates cell transformation

scientific article published on 01 March 2007

Direct targeting of MEK1/2 and RSK2 by silybin induces cell-cycle arrest and inhibits melanoma cell growth.

artículo científico publicado en 2013

Discovery of Novel Checkpoint Kinase 1 Inhibitors by Virtual Screening Based on Multiple Crystal Structures ⬇️

artículo científico publicado el 12 de octubre de 2011

Discovery of the novel mTOR inhibitor and its antitumor activities in vitro and in vivo

artículo científico publicado en 2013

Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance

scientific article published on 20 May 2020

EBV encoded miR-BHRF1-1 potentiates viral lytic replication by downregulating host p53 in nasopharyngeal carcinoma ⬇️

artículo científico publicado el 17 de noviembre de 2011

EBV(LMP1)-induced metabolic reprogramming inhibits necroptosis through the hypermethylation of the promoter

EBV-Encoded LMP1 Upregulates Igκ 3′Enhancer Activity and Igκ Expression in Nasopharyngeal Cancer Cells by Activating the Ets-1 through ERKs Signaling ⬇️

artículo científico publicado el 1 de enero de 2012

EBV-LMP1 suppresses the DNA damage response through DNA-PK/AMPK signaling to promote radioresistance in nasopharyngeal carcinoma

artículo científico publicado en 2016

EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma

artículo científico publicado en 2015

ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4.

artículo científico publicado en 2012

ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal

scientific article published on 13 April 2014

Effect of intermittent dosing regimens of erlotinib on methylnitrosourea-induced mammary carcinogenesis

artículo científico publicado en 2013

Effects of MAP kinase inhibitors on epidermal growth factor-induced neoplastic transformation of human keratinocytes

artículo científico publicado en 2006

Effects of gefitinib (Iressa) on mammary cancers: preventive studies with varied dosages, combinations with vorozole or targretin, and biomarker changes.

artículo científico publicado en 2008

Efficacy of the EGFr inhibitor Iressa on development of chemically-induced urinary bladder cancers: Dose dependency and modulation of biomarkers ⬇️

artículo científico publicado el 1 de marzo de 2011

Embryonic stem‐cell‐preconditioned microenvironment induces loss of cancer cell properties in human melanoma cells ⬇️

artículo científico publicado el 16 de agosto de 2011

Epigallocatechin 3-gallate and green tea catechins: United they work, divided they fail

artículo científico publicado en 2009

Epigallocatechin gallate suppresses lung cancer cell growth through Ras-GTPase-activating protein SH3 domain-binding protein 1.

artículo científico publicado en 2010

Epigallocatechin-gallate Suppresses Tumorigenesis by Directly Targeting Pin1

artículo científico publicado en 2011

Epstein-Barr virus oncoprotein LMP1 mediates survivin upregulation by p53 contributing to G1/S cell cycle progression in nasopharyngeal carcinoma ⬇️

artículo científico publicado el 17 de enero de 2012

Equol, a metabolite of the soybean isoflavone daidzein, inhibits neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 pathway

artículo científico publicado en 2007

Eriodictyol inhibits RSK2-ATF1 signaling and suppresses EGF-induced neoplastic cell transformation ⬇️

artículo científico publicado el 22 de noviembre de 2010

Erratum

Esculetin suppresses proliferation of human colon cancer cells by directly targeting β-catenin

artículo científico publicado en 2013

Ethyl gallate as a novel ERK1/2 inhibitor suppresses patient-derived esophageal tumor growth

scientific article published on 21 December 2018

Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling

artículo científico publicado en 2014

Evaluation of cancer-preventive activity and structure-activity relationships of 3-demethylubiquinone Q2, isolated from the ascidian Aplidium glabrum, and its synthetic analogs ⬇️

artículo científico publicado en 2006

Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer

artículo científico publicado en 2010

Fluvastatin Inhibits HMG-CoA Reductase and Prevents Non-Small Cell Lung Carcinogenesis

scientific article published on 25 September 2019

Four Is Better Than 1-Strength in Numbers!

artículo científico publicado en 2016

Fyn is a novel target of (-)-epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation

artículo científico publicado en 2008

GSK3β-mediated expression of CUG-translated WT1 is critical for tumor progression

artículo científico publicado en 2020

Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17

artículo científico publicado en 2015

Glycolytic genes in cancer cells are more than glucose metabolic regulators

artículo científico publicado en 2014

Gossypetin is a novel MKK3 and MKK6 inhibitor that suppresses esophageal cancer growth in vitro and in vivo

artículo científico publicado en 2018

Gossypin inhibits gastric cancer growth by direct targeting of AURKA and RSK2

artículo científico publicado en 2018

Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis

artículo científico publicado en 2015

HI-511 overcomes melanoma drug resistance via targeting AURKB and BRAF V600E

scientific article published on 01 August 2020

Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity.

artículo científico publicado en 2015

Herbacetin suppresses cutaneous squamous cell carcinoma and melanoma cell growth by targeting AKT and ODC.

artículo científico publicado en 2017

Heterogeneity of aberrant immunoglobulin expression in cancer cells ⬇️

artículo científico publicado el 22 de agosto de 2011

Hirsutenone in Alnus extract inhibits akt activity and suppresses prostate cancer cell proliferation

artículo científico publicado en 2014

Histone XH2AX is required for Xenopus anterior neural development: critical role of threonine 16 phosphorylation.

artículo científico publicado en 2010

IDH2 is a novel diagnostic and prognostic serum biomarker for non-small-cell lung cancer

artículo científico publicado en 2018

Identification of an Aurora kinase inhibitor specific for the Aurora B isoform.

artículo científico publicado en 2012

Identification of mammalian target of rapamycin as a direct target of fenretinide both in vitro and in vivo

artículo científico publicado en 2012

Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer

artículo científico publicado en 2016

In vitro Anticancer Activities of Some Triterpene Glycosides from Holothurians of Cucumariidae, Stichopodidae, Psolidae, Holothuriidae and Synaptidae families

artículo científico publicado en 2016

Inducible covalent posttranslational modification of histone H3.

artículo científico publicado en 2005

Induction and Prevention of Gastric Cancer with Combined Helicobacter Pylori and Capsaicin Administration and DFMO Treatment, Respectively

scientific article published on 28 March 2020

Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways.

artículo científico publicado en 2003

Inhibiting breast cancer by targeting the thromboxane A2 pathway.

artículo científico publicado en 2017

Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin

artículo científico publicado en 2016

Inhibition of LTA4H by bestatin in human and mouse colorectal cancer

artículo científico publicado en 2019

Inhibitory effects of caffeine analogues on neoplastic transformation: structure-activity relationship

artículo científico publicado en 2008

Involvement of ERKs and mitogen- and stress-activated protein kinase in UVC-induced phosphorylation of ATF2 in JB6 cells

artículo científico publicado en 2004

Involvement of ERKs, RSK2 and PKR in UVA-induced signal transduction toward phosphorylation of eIF2alpha (Ser(51)).

artículo científico publicado en 2007

Involvement of the paxillin pathway in JB6 Cl41 cell transformation

artículo científico publicado en 2006

Isoangustone A, a novel licorice compound, inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma

scientific article published on 08 October 2013

Isoliquiritigenin induces apoptosis and inhibits xenograft tumor growth of human lung cancer cells by targeting both wild type and L858R/T790M mutant EGFR.

artículo científico publicado en 2014

Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K.

artículo científico publicado en 2011

JNK1 and 2 play a negative role in reprogramming to pluripotent stem cells by suppressing Klf4 activity

artículo científico publicado en 2013

Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity

artículo científico publicado en 2010

Kaempferol targets RSK2 and MSK1 to suppress UV radiation-induced skin cancer

artículo científico publicado en 2014

Knock-down of the TIM/TIPIN complex promotes apoptosis in melanoma cells

scientific article published on 19 May 2020

Knockdown of Pyruvate Kinase M Inhibits Cell Growth and Migration by Reducing NF-kB Activity in Triple-Negative Breast Cancer Cells

scientific article published on 01 September 2019

LTA4H regulates cell cycle and skin carcinogenesis.

artículo científico publicado en 2017

Lack of chemopreventive efficacy of metformin in rodent models of urinary bladder, head and neck, and colon/intestine cancer

artículo científico publicado en 2017

Lack of effect of metformin on mammary carcinogenesis in nondiabetic rat and mouse models

artículo científico publicado en 2015

Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells

scientific article published on 21 June 2019

Lapatinib, a Preventive/Therapeutic Agent against Mammary Cancer, Suppresses RTK-Mediated Signaling through Multiple Signaling Pathways ⬇️

artículo científico publicado el 26 de julio de 2011

Licochalcone A, a natural inhibitor of c-Jun N-terminal kinase 1.

artículo científico publicado en 2013

Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization

artículo científico publicado en 2018

Luteolin inhibits protein kinase C(epsilon) and c-Src activities and UVB-induced skin cancer

artículo científico publicado en 2010

Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells.

artículo científico publicado en 2006

MLK3 is a direct target of biochanin A, which plays a role in solar UV-induced COX-2 expression in human keratinocytes

artículo científico publicado en 2013

MST1 promotes apoptosis through phosphorylation of histone H2AX

artículo científico publicado en 2010

Marine alkaloid polycarpine and its synthetic derivative dimethylpolycarpine induce apoptosis in JB6 cells through p53- and caspase 3-dependent pathways.

artículo científico publicado en 2004

Mitochondrial network structure homeostasis and cell death

artículo científico publicado en 2018

Mitogen- and stress-activated kinase 1-mediated histone H3 phosphorylation is crucial for cell transformation

artículo científico publicado en 2008

Mitogen-activated protein kinase activation in UV-induced signal transduction

artículo científico publicado en 2003

Molecular and cellular targets

artículo científico publicado en 2006

Molecular mechanisms of green tea polyphenols with protective effects against skin photoaging

artículo científico

Molecular targets of phytochemicals for cancer prevention ⬇️

artículo científico publicado el 10 de febrero de 2011

Myricetin inhibits UVB-induced angiogenesis by regulating PI-3 kinase in vivo

artículo científico publicado en 2009

Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1.

artículo científico publicado en 2007

Myricetin suppresses UVB-induced skin cancer by targeting Fyn.

artículo científico publicado en 2008

Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf.

artículo científico publicado en 2010

NS-398 and piroxicam suppress UVB-induced activator protein 1 activity by mechanisms independent of cyclooxygenase-2.

artículo científico publicado en 2002

Naproxen induces cell-cycle arrest and apoptosis in human urinary bladder cancer cell lines and chemically induced cancers by targeting PI3K.

artículo científico publicado en 2013

Naringenin targets ERK2 and suppresses UVB-induced photoaging

artículo científico publicado en 2016

Natural alkaloid and polyphenol compounds targeting lipid metabolism: Treatment implications in metabolic diseases

scientific article published on 11 January 2020

Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFα and ROS production

artículo científico publicado en 2015

Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production

artículo científico publicado en 2016

Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases

artículo científico publicado en 2012

Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth

artículo científico publicado en 2012

Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation

artículo científico publicado en 2007

P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation

artículo científico publicado en 2011

PGC1α/CEBPB/CPT1A axis promotes radiation resistance of nasopharyngeal carcinoma through activating fatty acid oxidation.

artículo científico publicado en 2019

PKCι is a target of 7,8,4'-trihydroxyisoflavone for the suppression of UVB-induced MMP-1 expression.

artículo científico publicado en 2017

PPMP, a novel tubulin-depolymerizing agent against esophageal cancer in patient-derived tumor xenografts

artículo científico publicado en 2016

Pharmacological TLR4 antagonism using topical resatorvid blocks solar UV-induced skin tumorigenesis in SKH-1 mice

artículo científico publicado en 2018

Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation

artículo científico publicado en 2002

Phosphorylation of H2AX at Ser139 and a new phosphorylation site Ser16 by RSK2 decreases H2AX ubiquitination and inhibits cell transformation

artículo científico publicado en 2011

Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha

artículo científico publicado en 2005

Phosphorylation of Sox2 Cooperates in Reprogramming to Pluripotent Stem Cells ⬇️

artículo científico publicado el 1 de diciembre de 2010

Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines

artículo científico publicado en 2011

Phosphorylation of caspase-8 (Thr-263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability.

artículo científico publicado en 2010

Phosphorylation of histone H2B serine 32 is linked to cell transformation.

artículo científico publicado en 2011

Phosphorylation of histone H3 at serine 10 is indispensable for neoplastic cell transformation

artículo científico publicado en 2005

Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells

artículo científico publicado en 2003

Polycomb (PcG) proteins, BMI1 and SUZ12, regulate arsenic-induced cell transformation ⬇️

artículo científico publicado el 28 de julio de 2012

Post-translational modification of p53 in tumorigenesis

artículo científico publicado en 2004

Posttranslational regulation of PGC-1α and its implication in cancer metabolism

scientific article published on 26 March 2019

Precision medicine: the foundation of future cancer therapeutics

artículo científico publicado en 2017

Precision oncology- the future of personalized cancer medicine?

artículo científico publicado en 2017

Prediction of molecular targets of cancer preventing flavonoid compounds using computational methods

artículo científico publicado en 2012

Prevention of chemically induced urinary bladder cancers by naproxen: protocols to reduce gastric toxicity in humans do not alter preventive efficacy

artículo científico publicado en 2015

Preventive effects of NSAIDs, NO-NSAIDs, and NSAIDs plus difluoromethylornithine in a chemically induced urinary bladder cancer model

artículo científico publicado en 2013

Proceedings--targeting carcinogenesis: transduction, transcription, translation

artículo científico publicado en 2006

Promotion of cell proliferation and inhibition of ADCC by cancerous immunoglobulin expressed in cancer cell lines

artículo científico publicado en 2011

Protein activation mapping of human sun-protected epidermis after an acute dose of erythemic solar simulated light

artículo científico publicado en 2017

Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia

scientific article published on 07 November 2019

Purpurogallin is a novel mitogen-activated protein kinase kinase 1/2 inhibitor that suppresses esophageal squamous cell carcinoma growth in vitro and in vivo

artículo científico publicado en 2019

Quercetin-3-methyl ether suppresses proliferation of mouse epidermal JB6 P+ cells by targeting ERKs.

artículo científico publicado en 2011

Quercetin‐3‐methyl ether inhibits lapatinib‐sensitive and ‐resistant breast cancer cell growth by inducing G2/M arrest and apoptosis ⬇️

artículo científico publicado el 15 de noviembre de 2011

RCC2 Promotes Esophageal Cancer Growth by Regulating Activity and Expression of the Sox2 Transcription Factor

scientific article published on 14 August 2020

RSK2 as a key regulator in human skin cancer

artículo científico publicado en 2012

RSK2 is required for TRAF6 phosphorylation-mediated colon inflammation

artículo científico publicado en 2018

RSK2 mediates NF-{kappa}B activity through the phosphorylation of IkappaBalpha in the TNF-R1 pathway.

artículo científico publicado en 2010

RSK2 mediates muscle cell differentiation through regulation of NFAT3.

artículo científico publicado en 2007

RSK2 phosphorylates T-bet to attenuate colon cancer metastasis and growth

artículo científico publicado en 2017

Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine

artículo científico publicado en 2008

Recent advances in precision oncology research

scientific article published on 16 April 2018

Regulation of microRNAs by epigenetics and their interplay involved in cancer

artículo científico publicado en 2013

Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase

artículo científico publicado en 2004

Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity ⬇️

artículo científico publicado el 12 de julio de 2012

Requirement of ATM in UVA-induced signaling and apoptosis.

artículo científico publicado en 2001

Resatorvid-based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV-induced NF-κB and AP-1 Signaling in Keratinocytes and Mouse Skin

artículo científico publicado en 2016

Resveratrol directly targets COX-2 to inhibit carcinogenesis.

artículo científico publicado en 2008

Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A₄hydrolase

artículo científico publicado en 2010

Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation ⬇️

artículo científico publicado en 2007

Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells

artículo científico publicado en 2010

Scutellarin Suppresses Patient-Derived Xenograft Tumor Growth by Directly Targeting AKT in Esophageal Squamous Cell Carcinoma

scientific article published on 25 September 2019

Select dietary phytochemicals function as inhibitors of COX-1 but not COX-2

artículo científico publicado en 2013

Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4 Protein Stability in Mouse Embryonic Stem Cells

artículo científico publicado en 2017

Signal Transduction and Molecular Targets of Selected Flavonoids ⬇️

artículo científico publicado el 15 de abril de 2013

Signal transduction molecules as targets for cancer prevention

artículo científico publicado en 2009

Signal transduction pathways in cancer development and as targets for cancer prevention

artículo científico publicado en 2005

Small molecule inhibitors of mesotrypsin from a structure-based docking screen

artículo científico publicado en 2017

Src is a novel potential off-target of RXR agonists, 9-cis-UAB30 and Targretin, in human breast cancer cells

artículo científico publicado en 2014

Structural Diversity of the Active N-Terminal Kinase Domain of p90 Ribosomal S6 Kinase 2

artículo científico publicado en 2009

Structural and functional analysis of the natural JNK1 inhibitor quercetagetin

artículo científico publicado en 2013

Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2

artículo científico publicado en 2008

Structural basis for multifunctional roles of human Ints3 C-terminal domain

scientific article published on 23 November 2020

Sunlight UV-induced skin cancer relies upon activation of the p38α signaling pathway

artículo científico publicado en 2013

T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway

scientific journal article

T-LAK cell-originated protein kinase (TOPK) phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity

artículo científico publicado en 2010

T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation

artículo científico publicado en 2007

TRAF1 Is Critical for DMBA/Solar UVR-Induced Skin Carcinogenesis

artículo científico publicado en 2017

TRAF1 Is Critical for Regulating the BRAF/MEK/ERK Pathway in Non-Small Cell Lung Carcinogenesis

artículo científico publicado en 2018

TRAF4 is a critical molecule for Akt activation in lung cancer.

artículo científico publicado en 2013

TRPV1-antagonist AMG9810 promotes mouse skin tumorigenesis through EGFR/Akt signaling ⬇️

artículo científico publicado el 23 de febrero de 2011

Targeted therapy of the AKT kinase inhibits esophageal squamous cell carcinoma growth in vitro and in vivo

scientific article published on 03 April 2019

Targeting AKT with oridonin inhibits growth of esophageal squamous cell carcinoma in vitro and patient derived xenografts in vivo.

artículo científico publicado en 2018

Targeting CPT1A-mediated fatty acid oxidation sensitizes nasopharyngeal carcinoma to radiation therapy.

artículo científico publicado en 2018

Targeting Epstein-Barr virus oncoprotein LMP1-mediated high oxidative stress suppresses EBV lytic reactivation and sensitizes tumors to radiation therapy

artículo científico publicado en 2020

Targeting PRPK Function Blocks Colon Cancer Metastasis

artículo científico publicado en 2018

Targeting PRPK and TOPK for skin cancer prevention and therapy

scientific article published on 14 June 2018

Targeting ornithine decarboxylase (ODC) inhibits esophageal squamous cell carcinoma progression

artículo científico publicado en 2017

Targeting the COX1/2-Driven thromboxane A2 pathway suppresses Barrett's esophagus and esophageal adenocarcinoma development

scientific article published on 07 November 2019

Taxifolin Suppresses UV-Induced Skin Carcinogenesis by Targeting EGFR and PI3K ⬇️

artículo científico publicado el 17 de julio de 2012

The Ashitaba (Angelica keiskei) Chalcones 4-hydroxyderricin and Xanthoangelol Suppress Melanomagenesis By Targeting BRAF and PI3K

artículo científico publicado en 2018

The CUG-translated WT1, not AUG-WT1, is an oncogene

artículo científico publicado en 2017

The Crystal Structure of the Active Form of the C-Terminal Kinase Domain of Mitogen- and Stress-Activated Protein Kinase 1

artículo científico publicado en 2010

The Hormel Institute International Cancer Research Conference—2017 meeting report.

artículo científico publicado en 2018

The P110 subunit of PI3-K is a therapeutic target of acacetin in skin cancer

artículo científico publicado en 2013

The PGC-1/ERR network and its role in precision oncology

The Prolyl Isomerase Pin1 Is a Novel Target of 6,7,4'-Trihydroxyisoflavone for Suppressing Esophageal Cancer Growth

artículo científico publicado en 2017

The Role of Deubiquitinases in Oncovirus and Host Interactions

artículo científico publicado en 2019

The Role of Heterodimeric AP-1 Protein Comprised of JunD and c-Fos Proteins in Hematopoiesis ⬇️

artículo científico publicado el 20 de julio de 2012

The Role of PGC1α in Cancer Metabolism and its Therapeutic Implications

artículo científico publicado en 2016

The T-LAK Cell-originated Protein Kinase Signal Pathway Promotes Colorectal Cancer Metastasis

artículo científico publicado en 2017

The Two Faces of Capsaicin ⬇️

artículo científico publicado el 12 de abril de 2011

The anticancer effects of actinoporin RTX-A from the sea anemone Heteractis crispa (=Radianthus macrodactylus)

artículo científico publicado en 2009

The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development

artículo científico publicado en 2008

The daidzein metabolite, 6,7,4'-Trihydroxyisoflavone, is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1.

artículo científico publicado en 2014

The enigmatic effects of caffeine in cell cycle and cancer

artículo científico publicado en 2006

The epithelial-mesenchymal transition (EMT) is regulated by oncoviruses in cancer

artículo científico publicado en 2016

The functional contrariety of JNK

artículo científico publicado en 2007

The ginsenoside 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol induces autophagy and apoptosis in human melanoma via AMPK/JNK phosphorylation

artículo científico publicado en 2014

The intermediate filament protein vimentin is a new target for epigallocatechin gallate

artículo científico publicado en 2005

The p53 protein is a novel substrate of ribosomal S6 kinase 2 and a critical intermediary for ribosomal S6 kinase 2 and histone H3 interaction.

artículo científico publicado en 2005

The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects

artículo científico publicado en 2002

The resveratrol analogue 3,5,3',4',5'-pentahydroxy-trans-stilbene inhibits cell transformation via MEK

artículo científico publicado en 2008

The retinoic acid derivative, ABPN, inhibits pancreatic cancer through induction of Nrdp1

artículo científico publicado en 2015

The role of histone H3 phosphorylation (Ser10 and Ser28) in cell growth and cell transformation

artículo científico publicado en 2006

The role of necroptosis, an alternative form of cell death, in cancer therapy ⬇️

artículo científico publicado el 1 de julio de 2013

The role of oxidative stress in EBV lytic reactivation, radioresistance and the potential preventive and therapeutic implications.

artículo científico publicado en 2017

The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols.

artículo científico publicado en 2004

The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity

artículo científico publicado en 2005

Theaflavin-3, 3'-digallate induces epidermal growth factor receptor downregulation.

artículo científico publicado en 2006

Therapies based on targeting Epstein-Barr virus lytic replication for EBV-associated malignancies.

artículo científico publicado en 2018

Toxic phytochemicals and their potential risks for human cancer

artículo científico publicado en 2015

Tpl2 is a key mediator of arsenite-induced signal transduction

artículo científico publicado en 2009

Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis.

artículo científico publicado en 2009

Treatment implications of natural compounds targeting lipid metabolism in nonalcoholic fatty liver disease, obesity and cancer

artículo científico publicado en 2019

Trichothecin inhibits invasion and metastasis of colon carcinoma associating with SCD-1-mediated metabolite alteration

artículo científico publicado en 2019

Tumor necrosis factor receptor-associated factor family protein 2 is a key mediator of the epidermal growth factor-induced ribosomal S6 kinase 2/cAMP-responsive element-binding protein/Fos protein signaling pathway

artículo científico publicado en 2012

Tumor suppressor p16 inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction

artículo científico publicado en 2013

Tumor suppressor p16(INK4a) inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction.

artículo científico publicado en 2013

Tyrosylprotein sulfotransferase-1 and tyrosine sulfation of chemokine receptor 4 are induced by Epstein-Barr virus encoded latent membrane protein 1 and associated with the metastatic potential of human nasopharyngeal carcinoma

artículo científico publicado en 2013

USP8 is a novel target for overcoming gefitinib resistance in lung cancer

scientific article published on 07 June 2013

Update on Cancer Prevention Research in the United States and China: The 2009 China—U.S. Forum on Frontiers of Cancer Research ⬇️

artículo científico publicado el 1 de diciembre de 2010

Veratramine modulates AP-1-dependent gene transcription by directly binding to programmable DNA.

artículo científico publicado en 2017

Wild-type IDH2 contributes to Epstein-Barr virus-dependent metabolic alterations and tumorigenesis

artículo científico publicado en 2020

Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer

scientific article published on 16 July 2018

[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase

artículo científico publicado en 2009

[6]-shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2.

artículo científico publicado en 2013

[Corrigendum] Daily or weekly dosing with EGFR inhibitors, gefitinib and lapatinib, and AKT inhibitor MK2206 in mammary cancer models

scientific article published on 17 October 2018

c-Jun N-terminal kinase 1 phosphorylates Myt1 to prevent UVA-induced skin cancer.

artículo científico publicado en 2009

miR-504 mediated down-regulation of nuclear respiratory factor 1 leads to radio-resistance in nasopharyngeal carcinoma

artículo científico publicado en 2015

p38 Mitogen-activated protein kinase regulation of JB6 Cl41 cell transformation promoted by epidermal growth factor

artículo científico publicado en 2003

p38α MAPK is required for arsenic-induced cell transformation

artículo científico publicado en 2016

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