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8-Azapurines as new inhibitors of cyclin-dependent kinases

artículo científico publicado en 2005

A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway

artículo científico publicado en 2013

A Cyclic Pentamethinium Salt Induces Cancer Cell Cytotoxicity through Mitochondrial Disintegration and Metabolic Collapse

scientific article published on 28 August 2019

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

artículo científico publicado en 2018

A Multiprotein Binding Interface in an Intrinsically Disordered Region of the Tumor Suppressor Protein Interferon Regulatory Factor-1

artículo científico publicado el 18 de enero de 2011

A global analysis of the complex landscape of isoforms and regulatory networks of p63 in human cells and tissues.

artículo científico publicado en 2015

A novel ataxia-telangiectasia mutated autoregulatory feedback mechanism in murine embryonic stem cells

artículo científico publicado en 2009

A novel p53 phosphorylation site within the MDM2 ubiquitination signal: I. phosphorylation at SER269 in vivo is linked to inactivation of p53 function

artículo científico publicado en 2010

AGR2 associates with HER2 expression predicting poor outcome in subset of estrogen receptor negative breast cancer patients.

artículo científico publicado en 2017

AGR2 oncoprotein inhibits p38 MAPK and p53 activation through a DUSP10-mediated regulatory pathway

artículo científico publicado en 2015

AGR2 predicts tamoxifen resistance in postmenopausal breast cancer patients

artículo científico publicado en 2013

AGR2 silencing contributes to metformin-dependent sensitization of colorectal cancer cells to chemotherapy

scientific article published on 04 September 2019

Acetylsalicylic Acid and its Potential for Chemoprevention of Colorectal Carcinoma

artículo científico publicado en 2018

Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2.

artículo científico publicado en 2004

Allosteric changes in HDM2 by the ATM phosphomimetic S395D mutation: implications on HDM2 function

scientific article published on 01 November 2019

Alterations of the Hsp70/Hsp90 chaperone and the HOP/CHIP co-chaperone system in cancer.

artículo científico publicado en 2012

An Ultrasensitive Biosensor for Detection of Femtogram Levels of the Cancer Antigen AGR2 Using Monoclonal Antibody Modified Screen-Printed Gold Electrodes

artículo científico publicado en 2021

Analysis of venom sac constituents from the solitary, aculeate wasp Cerceris rybyensis

artículo científico publicado en 2019

Anterior gradient 2 and mucin 4 expression mirrors tumor cell differentiation in pancreatic adenocarcinomas, but aberrant anterior gradient 2 expression predicts worse patient outcome in poorly differentiated tumors

artículo científico publicado en 2014

Anterior gradient 2: A novel player in tumor cell biology

artículo científico publicado el 2 de marzo de 2011

Anterior gradient protein 3 is associated with less aggressive tumors and better outcome of breast cancer patients

artículo científico publicado en 2015

Anticancer pentamethinium salt is a potent photosensitizer inducing mitochondrial disintegration and apoptosis upon red light illumination

artículo científico publicado en 2020

Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence.

artículo científico publicado en 2014

Biomarker discovery in low-grade breast cancer using isobaric stable isotope tags and two-dimensional liquid chromatography-tandem mass spectrometry (iTRAQ-2DLC-MS/MS) based quantitative proteomic analysis

artículo científico publicado en 2009

CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity

artículo científico publicado en 2021

Cancer-associated S100P protein binds and inactivates p53, permits therapy-induced senescence and supports chemoresistance

artículo científico publicado en 2016

Characterization of specific p63 and p63-N-terminal isoform antibodies and their application for immunohistochemistry

artículo científico publicado en 2013

Combined Proteomics and Transcriptomics Identifies Carboxypeptidase B1 and Nuclear Factor κB (NF-κB) Associated Proteins as Putative Biomarkers of Metastasis in Low Grade Breast Cancer

artículo científico publicado en 2015

Corrigendum: The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression

artículo científico publicado en 2017

DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation

artículo científico publicado en 2010

Deregulation of cell proliferation by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells reflects both genotoxic and nongenotoxic events

artículo científico publicado en 2004

Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma

artículo científico publicado en 2014

Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141

artículo científico publicado en 2005

Electrochemical chip-based genomagnetic assay for detection of high-risk human papillomavirus DNA.

artículo científico publicado en 2016

Emergent Role of IFITM1/3 towards Splicing Factor (SRSF1) and Antigen-Presenting Molecule (HLA-B) in Cervical Cancer

artículo científico publicado en 2022

Endoplasmic reticulum stress and apoptosis.

artículo científico publicado en 2006

Erratum to: ΔNp63 regulates cell proliferation, differentiation, adhesion, and migration in the BL2 subtype of basal-like breast cancer.

artículo científico publicado en 2016

Evaluation of cytotoxic activity of titanocene difluorides and determination of their mechanism of action in ovarian cancer cells

artículo científico publicado en 2015

Evidence for allosteric effects on p53 oligomerization induced by phosphorylation.

artículo científico publicado en 2017

Expression and Functional Characterization of miR-34c in Cervical Cancer

artículo científico publicado en 2018

Genomagnetic LAMP-based electrochemical test for determination of high-risk HPV16 and HPV18 in clinical samples

scientific article published on 11 August 2018

HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells

artículo científico publicado en 2014

HDM2 and HDMX Proteins in Human Cancer

artículo científico publicado en 2018

Hammock: a hidden Markov model-based peptide clustering algorithm to identify protein-interaction consensus motifs in large datasets.

artículo científico publicado en 2015

Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy

artículo científico publicado en 2004

Human Stress-inducible Hsp70 Has a High Propensity to Form ATP-dependent Antiparallel Dimers That Are Differentially Regulated by Cochaperone Binding

scientific article published on 20 November 2018

Hydrogen Deuterium Exchange Mass Spectrometry identifies the dominant paratope in CD20 antigen binding to the NCD1.2 monoclonal antibody

artículo científico publicado en 2020

IFI16 Preferentially Binds to DNA with Quadruplex Structure and Enhances DNA Quadruplex Formation

artículo científico publicado en 2016

Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2.

artículo científico publicado en 2013

Immunoassays of chemically modified polysaccharides, glycans in glycoproteins and ribose in nucleic acids

artículo científico publicado en 2016

Impaired pre-mRNA processing and altered architecture of 3' untranslated regions contribute to the development of human disorders

artículo científico

Impairment of carbonic anhydrase IX ectodomain cleavage reinforces tumorigenic and metastatic phenotype of cancer cells

artículo científico publicado en 2020

Importance of Membrane Proteins in the Treatment of Tumor Diseases and the Possibilities of Their Further Study

artículo científico publicado en 2018

Influence of mutation type on prognostic and predictive values of TP53 status in primary breast cancer patients.

artículo científico publicado en 2014

Inhibition of post-transcriptional RNA processing by CDK inhibitors and its implication in anti-viral therapy

artículo científico publicado en 2014

Intact protein profiling in breast cancer biomarker discovery: protein identification issue and the solutions based on 3D protein separation, bottom-up and top-down mass spectrometry

artículo científico publicado en 2013

Intracellular distribution of the ΔNp73 protein isoform in medulloblastoma cells: a study with newly generated rabbit polyclonal antibodies

artículo científico publicado el 22 de enero de 2013

Intrinsic proteotoxic stress levels vary and act as a predictive marker for sensitivity of cancer cells to Hsp90 inhibition

artículo científico publicado en 2018

Intronic polymorphisms in TP53 indicate lymph node metastasis in breast cancer.

artículo científico publicado en 2009

Investigations of the supercoil-selective DNA binding of wild type p53 suggest a novel mechanism for controlling p53 function

artículo científico publicado en 2004

Keratin 36, a specific marker of tongue filiform papillae, is downregulated in squamous cell carcinoma of the mobile tongue

artículo científico publicado en 2020

MB-88QUANTITATIVE PROTEOMIC PROFILING IN MEDULLOBLASTOMA RECAPITULATES SUBGROUPING BASED ON TRANSCRIPTIONAL PROFILES.

artículo científico publicado en 2016

MDM2SNP309 does not associate with elevated MDM2 protein expression or breast cancer risk

artículo científico publicado en 2008

Magnetic bead-based hybridization assay for electrochemical detection of microRNA

artículo científico publicado en 2014

Magnetic poly(glycidyl methacrylate) microspheres for protein capture.

artículo científico publicado en 2014

Mechanisms of anterior gradient-2 regulation and function in cancer

artículo científico

Microgradient separation technique for purification and fractionation of permethylated N-glycans before mass spectrometric analyses

artículo científico publicado en 2018

Mitochondrial Processes in Targeted Cancer Therapy

artículo científico publicado en 2018

Mutant p53 accumulation in human breast cancer is not an intrinsic property or dependent on structural or functional disruption but is regulated by exogenous stress and receptor status.

artículo científico publicado en 2014

Mutations in the TP53 gene affected recruitment of 53BP1 protein to DNA lesions, but level of 53BP1 was stable after γ-irradiation that depleted MDC1 protein in specific TP53 mutants

artículo científico publicado en 2017

N-Glycome changes reflecting resistance to platinum-based chemotherapy in ovarian cancer

artículo científico publicado en 2020

New ELISA technique for analysis of p53 protein/DNA binding properties.

artículo científico publicado en 2002

Novel Entropically Driven Conformation-specific Interactions with Tomm34 Protein Modulate Hsp70 Protein Folding and ATPase Activities

artículo científico publicado en 2016

Polycyclic aromatic hydrocarbons modulate cell proliferation in rat hepatic epithelial stem-like WB-F344 cells.

artículo científico publicado en 2004

Polymorphisms in p53 and the p53 pathway: roles in cancer susceptibility and response to treatment

artículo científico publicado en 2009

Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence.

artículo científico publicado en 2010

Possible Usage of p63 in Bioptic Diagnostics

artículo científico publicado en 2018

Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation status

artículo científico publicado en 2009

Preferential binding of hot spot mutant p53 proteins to supercoiled DNA in vitro and in cells.

artículo científico publicado en 2013

Prima-1 and APR-246 in Cancer Therapy

artículo científico publicado en 2018

Proteogenomic Platform for Identification of Tumor Specific Antigens

artículo científico publicado en 2018

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

artículo científico publicado en 2018

Quantitative Shotgun Proteomics Unveils Candidate Novel Esophageal Adenocarcinoma (EAC)-specific Proteins.

artículo científico publicado en 2017

Quantitative proteomic profiling of pleomorphic human sarcoma identifies CLIC1 as a dominant pro-oncogenic receptor expressed in diverse sarcoma types

artículo científico publicado en 2014

Radiation-induced astrocyte senescence is rescued by Δ133p53

artículo científico publicado en 2019

Recognition of DNA modified by antitumor cisplatin by “latent” and “active” protein p53

artículo científico publicado el 15 de abril de 2003

Regulation of AGR2 expression via 3'UTR shortening

artículo científico publicado en 2017

Restoring wild-type conformation and DNA-binding activity of mutant p53 is insufficient for restoration of transcriptional activity

artículo científico publicado en 2006

Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells

artículo científico publicado el 1 de noviembre de 2003

Role of tumor suppressor p53 domains in selective binding to supercoiled DNA.

artículo científico publicado en 2002

STAT3, stem cells, cancer stem cells and p63.

artículo científico publicado en 2018

Simian virus-40 infection inhibits DNA damage-induced enhancement of CD95 expression and function.

artículo científico publicado en 2002

Small molecular weight variants of p53 are expressed in human melanoma cells and are induced by the DNA-damaging agent cisplatin.

artículo científico publicado en 2008

Stat3 Tyrosine 705 and Serine 727 Phosphorylation Associate With Clinicopathological Characteristics and Distinct Tumor Cell Phenotypes in Triple-Negative Breast Cancer

artículo científico publicado en 2022

Suppression of AGR2 in a TGF-β-induced Smad regulatory pathway mediates epithelial-mesenchymal transition

artículo científico publicado en 2017

Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses.

artículo científico publicado en 2018

Surface-enhanced laser desorption ionization/time-of-flight mass spectrometry reveals significant artifacts in serum obtained from clot activator-containing collection devices

artículo científico publicado en 2006

Surface-enhanced laser desorption/ionization time-of-flight proteomic profiling of breast carcinomas identifies clinicopathologically relevant groups of patients similar to previously defined clusters from cDNA expression.

artículo científico publicado en 2008

Switching p53-dependent growth arrest to apoptosis via the inhibition of DNA damage-activated kinases

artículo científico publicado en 2010

TAp63 and ΔNp63 (p40) in prostate adenocarcinomas: ΔNp63 associates with a basal-like cancer stem cell population but not with metastasis

artículo científico publicado en 2020

Tamoxifen-Dependent Induction of AGR2 Is Associated with Increased Aggressiveness of Endometrial Cancer Cells

artículo científico publicado en 2017

Targeting Oncogenic Pathways in the Era of Personalized Oncology: A Systemic Analysis Reveals Highly Mutated Signaling Pathways in Cancer Patients and Potential Therapeutic Targets

artículo científico publicado en 2022

The MDM2 ligand Nutlin-3 differentially alters expression of the immune blockade receptors PD-L1 and CD276

artículo científico publicado en 2020

The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model

scientific article published on 11 September 2020

The Role of HSF1 Protein in Malignant Transformation

artículo científico publicado en 2018

The Role of HSP70 in Cancer and its Exploitation as a Therapeutic Target

artículo científico publicado en 2018

The assembly and intermolecular properties of the Hsp70-Tomm34-Hsp90 molecular chaperone complex

artículo científico

The cell type-specific effect of TAp73 isoforms on the cell cycle and apoptosis.

artículo científico publicado en 2008

The diverse oncogenic and tumour suppressor roles of p63 and p73 in cancer: a review by cancer site

artículo científico publicado en 2014

The effect of cellular environment and p53 status on the mode of action of the platinum derivative LA-12.

artículo científico publicado en 2009

The effects of IFITM1 and IFITM3 gene deletion on IFNγ stimulated protein synthesis

scientific article published on 02 April 2019

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression

artículo científico publicado en 2008

The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties.

artículo científico publicado en 2010

The interaction of the mitochondrial protein importer TOMM34 with HSP70 is regulated by TOMM34 phosphorylation and binding to 14-3-3 adaptors

scientific article published on 05 May 2020

The new platinum(IV) derivative LA-12 shows stronger inhibitory effect on Hsp90 function compared to cisplatin.

artículo científico publicado en 2010

The new platinum-based anticancer agent LA-12 induces retinol binding protein 4 in vivo

artículo científico publicado en 2011

The role of AGR2 and AGR3 in cancer: similar but not identical.

artículo científico publicado en 2015

The role of MAPK signal pathways during Francisella tularensis LVS infection-induced apoptosis in murine macrophages.

artículo científico publicado en 2005

The role of miR-409-3p in regulation of HPV16/18-E6 mRNA in human cervical high-grade squamous intraepithelial lesions

artículo científico publicado en 2019

The role of p63 in cancer, stem cells and cancer stem cells.

artículo científico publicado en 2011

The role of the 3' untranslated region in post-transcriptional regulation of protein expression in mammalian cells

artículo científico publicado el 1 de mayo de 2012

Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage

scientific article published on 27 March 2019

Tooth agenesis: What do we know and is there a connection to cancer?

artículo científico publicado en 2020

Variability in the Solid Cancer Cell Population and Its Consequences for Cancer Diagnostics and Treatment

artículo científico publicado en 2018

p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence

artículo científico publicado en 2009

p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes

artículo científico publicado en 2013

p63 isoforms in triple-negative breast cancer: ΔNp63 associates with the basal phenotype whereas TAp63 associates with androgen receptor, lack of BRCA mutation, PTEN and improved survival

artículo científico publicado en 2018

ΔNp63 activates EGFR signaling to induce loss of adhesion in triple-negative basal-like breast cancer cells.

artículo científico publicado en 2017

ΔNp63α expression induces loss of cell adhesion in triple-negative breast cancer cells

artículo científico publicado en 2016

∆Np63/p40 correlates with the location and phenotype of basal/mesenchymal cancer stem-like cells in human ER+ and HER2+ breast cancers

artículo científico publicado en 2019