Lista de obras - Sabine Specht - Dominio Público Uruguay

A histochemical study of the Nras/let-60 activity in filarial nematodes

artículo científico publicado en 2015

An Integrated Multiomics Approach to Identify Candidate Antigens for Serodiagnosis of Human Onchocerciasis

artículo científico publicado en 2015

Analysis of nematode motion using an improved light-scatter based system

artículo científico publicado en 2015

CCL17 controls mast cells for the defense against filarial larval entry

artículo científico publicado en 2011

Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages

artículo científico publicado en 2015

Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.

artículo científico publicado en 2018

Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial

artículo científico publicado en 2017

Corallopyronin A Specifically Targets and Depletes Essential Obligate Wolbachia Endobacteria From Filarial Nematodes In Vivo ⬇️

artículo científico publicado el 14 de mayo de 2012

Criteria for the differentiation between young and old Onchocerca volvulus filariae

artículo científico publicado en 2009

Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial

artículo científico publicado en 2015

Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trial.

artículo científico publicado en 2012

Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis

artículo científico publicado en 2006

Efficacy of 2- and 4-week rifampicin treatment on the Wolbachia of Onchocerca volvulus

artículo científico publicado en 2008

Efficacy of 5-week doxycycline treatment on adult Onchocerca volvulus

artículo científico publicado en 2008

Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti

artículo científico publicado en 2012

Epithelial cell lines of the cotton rat (Sigmodon hispidus) are highly susceptible in vitro models to zoonotic Bunya-, Rhabdo-, and Flaviviruses

artículo científico publicado en 2016

Ex vivo responses of Plasmodium falciparum clinical isolates to conventional and new antimalarial drugs in Niger

artículo científico publicado en 2013

Filaria-induced IL-10 suppresses murine cerebral malaria

artículo científico publicado en 2010

Filarial infection induces protection against P. berghei liver stages in mice

artículo científico publicado en 2008

Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization

artículo científico publicado en 2022

Helminth infection with Litomosoides sigmodontis induces regulatory T cells and inhibits allergic sensitization, airway inflammation, and hyperreactivity in a murine asthma model

artículo científico publicado en 2008

Helpful or a hindrance: co-infections with helminths during malaria

artículo científico publicado en 2014

Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines

artículo científico publicado en 2012

Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells.

artículo científico publicado en 2015

Immunization with L. sigmodontis microfilariae reduces peripheral microfilaraemia after challenge infection by inhibition of filarial embryogenesis

artículo científico publicado en 2012

Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels

artículo científico publicado en 2014

In Vitro and In Vivo Antimalarial Activity Assays of Seeds from Balanites aegyptiaca: Compounds of the Extract Show Growth Inhibition and Activity against Plasmodial Aminopeptidase

artículo científico publicado en 2011

Increased early local immune responses and altered worm development in high-dose infections of mice susceptible to the filaria Litomosoides sigmodontis

artículo científico publicado en 2004

Induction of pro-inflammatory mediators in Plasmodium berghei infected BALB/c mice breaks blood-brain-barrier and leads to cerebral malaria in an IL-12 dependent manner ⬇️

artículo científico publicado el 12 de mayo de 2011

Interleukin-10 (IL-10) counterregulates IL-4-dependent effector mechanisms in Murine Filariasis

artículo científico publicado en 2004

Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection

scientific journal article

Lymphatic vascularisation and involvement of Lyve-1+ macrophages in the human onchocerca nodule

artículo científico publicado en 2009

Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline

artículo científico publicado en 2011

Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial

artículo científico publicado en 2010

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds

artículo científico publicado en 2019

Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung.

artículo científico publicado en 2017

Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages

artículo científico publicado en 2002

NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae

artículo científico publicado en 2016

Newly acquired Onchocerca volvulus filariae after doxycycline treatment

artículo científico publicado en 2009

Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness

artículo científico publicado en 2013

Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro

artículo científico publicado en 2020

Pleural cellular reaction to the filarial infection Litomosoides sigmodontis is determined by the moulting process, the worm alteration, and the host strain

artículo científico publicado en 2008

Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals

artículo científico publicado en 2015

Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis

artículo científico publicado en 2008

Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis

artículo científico publicado en 2014

ST2 deficiency does not impair type 2 immune responses during chronic filarial infection but leads to an increased microfilaremia due to an impaired splenic microfilarial clearance

artículo científico publicado en 2014

Synergism of gamma interferon and interleukin-5 in the control of murine filariasis

artículo científico publicado en 2003

The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens

artículo científico publicado en 2011

The guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria-inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase

artículo científico publicado en 2008

The human parasite Loa loa in cytokine and cytokine receptor gene knock out BALB/c mice: survival, development and localization ⬇️

artículo científico publicado el 21 de febrero de 2012

Therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness

artículo científico publicado en 2014

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

artículo científico publicado en 2007

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

scientific article published in 2008

Lista de obras de Sabine Specht

A histochemical study of the Nras/let-60 activity in filarial nematodes

An Integrated Multiomics Approach to Identify Candidate Antigens for Serodiagnosis of Human Onchocerciasis

Analysis of nematode motion using an improved light-scatter based system

CCL17 controls mast cells for the defense against filarial larval entry

Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages

Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.

Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial

Corallopyronin A Specifically Targets and Depletes Essential Obligate Wolbachia Endobacteria From Filarial Nematodes In Vivo ⬇️

Criteria for the differentiation between young and old Onchocerca volvulus filariae

Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial

Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trial.

Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis

Efficacy of 2- and 4-week rifampicin treatment on the Wolbachia of Onchocerca volvulus

Efficacy of 5-week doxycycline treatment on adult Onchocerca volvulus

Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti

Epithelial cell lines of the cotton rat (Sigmodon hispidus) are highly susceptible in vitro models to zoonotic Bunya-, Rhabdo-, and Flaviviruses

Ex vivo responses of Plasmodium falciparum clinical isolates to conventional and new antimalarial drugs in Niger

Filaria-induced IL-10 suppresses murine cerebral malaria

Filarial infection induces protection against P. berghei liver stages in mice

Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization

Helminth infection with Litomosoides sigmodontis induces regulatory T cells and inhibits allergic sensitization, airway inflammation, and hyperreactivity in a murine asthma model

Helpful or a hindrance: co-infections with helminths during malaria

Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines

Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells.

Immunization with L. sigmodontis microfilariae reduces peripheral microfilaraemia after challenge infection by inhibition of filarial embryogenesis

Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels

In Vitro and In Vivo Antimalarial Activity Assays of Seeds from Balanites aegyptiaca: Compounds of the Extract Show Growth Inhibition and Activity against Plasmodial Aminopeptidase

Increased early local immune responses and altered worm development in high-dose infections of mice susceptible to the filaria Litomosoides sigmodontis

Induction of pro-inflammatory mediators in Plasmodium berghei infected BALB/c mice breaks blood-brain-barrier and leads to cerebral malaria in an IL-12 dependent manner ⬇️

Interleukin-10 (IL-10) counterregulates IL-4-dependent effector mechanisms in Murine Filariasis

Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection

Lymphatic vascularisation and involvement of Lyve-1+ macrophages in the human onchocerca nodule

Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline

Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds

Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung.

Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages

NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae

Newly acquired Onchocerca volvulus filariae after doxycycline treatment

Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness

Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro

Pleural cellular reaction to the filarial infection Litomosoides sigmodontis is determined by the moulting process, the worm alteration, and the host strain

Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals

Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis

Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis

ST2 deficiency does not impair type 2 immune responses during chronic filarial infection but leads to an increased microfilaremia due to an impaired splenic microfilarial clearance

Synergism of gamma interferon and interleukin-5 in the control of murine filariasis

The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens

The guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria-inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase

The human parasite Loa loa in cytokine and cytokine receptor gene knock out BALB/c mice: survival, development and localization ⬇️

Therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study