Lista de obras -

A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines

scientific article published on 10 July 2019

A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma.

artículo científico publicado en 2012

A community computational challenge to predict the activity of pairs of compounds

artículo científico publicado en 2014

A community effort to assess and improve drug sensitivity prediction algorithms.

artículo científico publicado en 2014

A multi-center study on factors influencing the reproducibility of in vitro drug-response studies

A multi-encoder variational autoencoder controls multiple transformational features in single-cell image analysis

artículo científico publicado en 2022

A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses

artículo científico publicado en 2022

A robust prognostic signature for hormone-positive node-negative breast cancer

artículo científico publicado en 2013

A scalable, open-source implementation of a large-scale mechanistic model for single cell proliferation and death signaling

artículo científico publicado en 2022

A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047.

artículo científico publicado en 2009

ATM suppresses SATB1-induced malignant progression in breast epithelial cells

artículo científico publicado en 2012

Abstract 731: Integrative genomic analysis to identify emergent enzalutamide resistance mechanisms in castration-resistant prostate cancer

article

Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes

artículo científico publicado en 2017

An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer

artículo científico publicado en 2022

Analysis of molecular inversion probe performance for allele copy number determination

artículo científico publicado en 2007

Annot: a Django-based sample, reagent, and experiment metadata tracking system

scientific article published on 01 November 2019

BET bromodomain inhibition blocks the function of a critical AR-independent master regulator network in lethal prostate cancer

scientific article published on 17 April 2019

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

artículo científico publicado en 2009

Bayesian inference of signaling network topology in a cancer cell line

artículo científico publicado en 2012

Cabozantinib and dasatinib synergize to induce tumor regression in non-clear cell renal cell carcinoma

artículo científico publicado en 2021

Cellular androgen content influences enzalutamide agonism of F877L mutant androgen receptor.

artículo científico publicado en 2016

Combating subclonal evolution of resistant cancer phenotypes

artículo científico publicado en 2017

Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling.

artículo científico publicado en 2016

Correction: Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer

artículo científico publicado en 2017

Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer

artículo científico publicado en 2015

Erratum to: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

artículo científico publicado en 2017

Erratum to: Modeling precision treatment of breast cancer

artículo científico publicado en 2015

FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer

artículo científico publicado en 2016

Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

artículo científico publicado en 2016

HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer

artículo científico publicado en 2017

How Machine Learning Will Transform Biomedicine

scientific article published on 01 April 2020

Individual Cells Can Resolve Variations in Stimulus Intensity along the IGF-PI3K-AKT Signaling Axis

scientific article published on 11 December 2019

Inferring causal molecular networks: empirical assessment through a community-based effort

artículo científico publicado en 2016

Integrated analysis of breast cancer cell lines reveals unique signaling pathways

artículo científico publicado en 2009

Integrating mathematical modeling with high throughput imaging explains how polyploid populations behave in nutrient-sparse environments

scientific article published on 16 September 2020

Integrative molecular network analysis identifies emergent enzalutamide resistance mechanisms in prostate cancer.

artículo científico publicado en 2017

LSD1 activates a lethal prostate cancer gene network independently of its demethylase function.

artículo científico publicado en 2018

Maintenance of MYC expression promotes de novo resistance to BET bromodomain inhibition in castration-resistant prostate cancer

artículo científico publicado en 2019

Metrics other than potency reveal systematic variation in responses to cancer drugs.

artículo científico publicado en 2013

Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes.

artículo científico publicado en 2018

Modeling precision treatment of breast cancer

artículo científico publicado en 2013

Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.

artículo científico publicado en 2014

Pathway-Enriched Gene Signature Associated with 53BP1 Response to PARP Inhibition in Triple-Negative Breast Cancer.

artículo científico publicado en 2017

Publisher Correction: Combating subclonal evolution of resistant cancer phenotypes

artículo científico publicado en 2018

Quantification of sensitivity and resistance of breast cancer cell lines to anti-cancer drugs using GR metrics

artículo científico publicado en 2017

Src and STAT3 inhibitors synergize to promote tumor inhibition in renal cell carcinoma

artículo científico publicado en 2015

Subtype and pathway specific responses to anticancer compounds in breast cancer

artículo científico publicado en 2011

Targeting the Mevalonate Pathway to Overcome Acquired Anti-HER2 Treatment Resistance in Breast Cancer

scientific article published on 16 August 2019

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

artículo científico publicado en 2017

Therapeutic Clues from an Integrated Omic Assessment of East Asian Triple Negative Breast Cancers

article

Transcriptional signatures in histologic structures within glioblastoma tumors may predict personalized drug sensitivity and survival

scientific article published on 01 January 2020

Tumor-Derived Cell Lines as Molecular Models of Cancer Pharmacogenomics

artículo científico publicado en 2016

Upregulation of ER Signaling as an Adaptive Mechanism of Cell Survival in HER2-Positive Breast Tumors Treated with Anti-HER2 Therapy.

artículo científico publicado en 2015

Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in Cancer

scientific article published on 21 May 2019

Variational Autoencoding Tissue Response to Microenvironment Perturbation

scientific article published on 01 February 2019

Lista de obras de

A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines

A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma.

A community computational challenge to predict the activity of pairs of compounds

A community effort to assess and improve drug sensitivity prediction algorithms.

A multi-center study on factors influencing the reproducibility of in vitro drug-response studies

A multi-encoder variational autoencoder controls multiple transformational features in single-cell image analysis

A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses

A robust prognostic signature for hormone-positive node-negative breast cancer

A scalable, open-source implementation of a large-scale mechanistic model for single cell proliferation and death signaling

A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047.

ATM suppresses SATB1-induced malignant progression in breast epithelial cells

Abstract 731: Integrative genomic analysis to identify emergent enzalutamide resistance mechanisms in castration-resistant prostate cancer

Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes

An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer

Analysis of molecular inversion probe performance for allele copy number determination

Annot: a Django-based sample, reagent, and experiment metadata tracking system

BET bromodomain inhibition blocks the function of a critical AR-independent master regulator network in lethal prostate cancer

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

Bayesian inference of signaling network topology in a cancer cell line

Cabozantinib and dasatinib synergize to induce tumor regression in non-clear cell renal cell carcinoma

Cellular androgen content influences enzalutamide agonism of F877L mutant androgen receptor.

Combating subclonal evolution of resistant cancer phenotypes

Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling.

Correction: Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer

Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer

Erratum to: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

Erratum to: Modeling precision treatment of breast cancer

FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer

Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer

How Machine Learning Will Transform Biomedicine

Individual Cells Can Resolve Variations in Stimulus Intensity along the IGF-PI3K-AKT Signaling Axis

Inferring causal molecular networks: empirical assessment through a community-based effort

Integrated analysis of breast cancer cell lines reveals unique signaling pathways

Integrating mathematical modeling with high throughput imaging explains how polyploid populations behave in nutrient-sparse environments

Integrative molecular network analysis identifies emergent enzalutamide resistance mechanisms in prostate cancer.

LSD1 activates a lethal prostate cancer gene network independently of its demethylase function.

Maintenance of MYC expression promotes de novo resistance to BET bromodomain inhibition in castration-resistant prostate cancer

Metrics other than potency reveal systematic variation in responses to cancer drugs.

Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes.

Modeling precision treatment of breast cancer

Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.

Pathway-Enriched Gene Signature Associated with 53BP1 Response to PARP Inhibition in Triple-Negative Breast Cancer.

Publisher Correction: Combating subclonal evolution of resistant cancer phenotypes

Quantification of sensitivity and resistance of breast cancer cell lines to anti-cancer drugs using GR metrics

Src and STAT3 inhibitors synergize to promote tumor inhibition in renal cell carcinoma

Subtype and pathway specific responses to anticancer compounds in breast cancer

Targeting the Mevalonate Pathway to Overcome Acquired Anti-HER2 Treatment Resistance in Breast Cancer

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

Therapeutic Clues from an Integrated Omic Assessment of East Asian Triple Negative Breast Cancers

Transcriptional signatures in histologic structures within glioblastoma tumors may predict personalized drug sensitivity and survival

Tumor-Derived Cell Lines as Molecular Models of Cancer Pharmacogenomics

Upregulation of ER Signaling as an Adaptive Mechanism of Cell Survival in HER2-Positive Breast Tumors Treated with Anti-HER2 Therapy.

Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in Cancer

Variational Autoencoding Tissue Response to Microenvironment Perturbation