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"End-stage" neurofibrillary tangle pathology in preclinical Alzheimer's disease: fact or fiction?

artículo científico publicado en 2011

"New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS).

artículo científico publicado en 2016

5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity

artículo científico publicado en 2016

A Customized Quantitative PCR MicroRNA Panel Provides a Technically Robust Context for Studying Neurodegenerative Disease Biomarkers and Indicates a High Correlation Between Cerebrospinal Fluid and Choroid Plexus MicroRNA Expression.

artículo científico publicado en 2016

A novel monoclonal antibody against human Argonaute proteins reveals unexpected characteristics of miRNAs in human blood cells

artículo científico publicado en 2007

A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls.

artículo científico publicado en 2013

ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology

artículo científico publicado en 2014

ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target

artículo científico publicado en 2015

APOE DNA methylation is altered in Lewy body dementia.

artículo científico publicado en 2018

APOE ε4 increases risk for dementia in pure synucleinopathies

artículo científico publicado en 2013

APOE-ε2 and APOE-ε4 correlate with increased amyloid accumulation in cerebral vasculature

artículo científico publicado en 2013

Acetylcholinesterase inhibitor treatment is associated with relatively slow cognitive decline in patients with Alzheimer's disease and AD + DLB

artículo científico publicado en 2009

Adjusting for mortality when identifying risk factors for transitions to mild cognitive impairment and dementia

artículo científico publicado en 2013

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

artículo científico publicado en 2015

Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene

artículo científico publicado en 2020

Alzheimer disease pathology in subjects without dementia in 2 studies of aging: the Nun Study and the Adult Changes in Thought Study

artículo científico publicado en 2011

Alzheimer's Biomarkers are Correlated with Brain Connectivity in Older Adults Differentially during Resting and Task States.

artículo científico publicado en 2016

Alzheimer's disease and type 2 diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline

scientific article published on 09 October 2018

Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies

artículo científico publicado en 2011

Alzheimer's-type neuropathology in the precuneus is not increased relative to other areas of neocortex across a range of cognitive impairment

artículo científico publicado en 2008

An mRNA m7G cap binding-like motif within human Ago2 represses translation

artículo científico publicado en 2007

Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs

artículo científico publicado en 2015

Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study

artículo científico publicado en 2021

Anti-Argonaute RIP-Chip shows that miRNA transfections alter global patterns of mRNA recruitment to microribonucleoprotein complexes

artículo científico publicado en 2009

Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing

artículo científico publicado en 2013

Assessing the discriminant ability, reliability, and comparability of multiple short forms of the Boston Naming Test in an Alzheimer's disease center cohort

artículo científico publicado en 2015

Association between male gender and cortical Lewy body pathology in large autopsy series

artículo científico publicado en 2010

Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas

artículo científico publicado en 2023

Blood serum miRNA: non-invasive biomarkers for Alzheimer's disease

artículo científico publicado en 2011

Brain arteriolosclerosis

artículo científico publicado en 2020

Brain pathologies in extreme old age.

artículo científico publicado en 2015

Brain structure changes over time in normal and mildly impaired aged persons

artículo científico publicado en 2020

Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease.

artículo científico publicado en 2009

CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing.

artículo científico publicado en 2013

CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.

artículo científico publicado en 2017

CSF1R mutations link POLD and HDLS as a single disease entity

artículo científico publicado en 2013

Calcineurin proteolysis in astrocytes: Implications for impaired synaptic function

artículo científico publicado en 2016

Cancer history associates with a lower burden of dementia and Alzheimer’s‐type neuropathology in autopsied research volunteers

scientific article published in 2021

Cerebral amyloid angiopathy and its co-occurrence with Alzheimer's disease and other cerebrovascular neuropathologic changes

artículo científico publicado en 2015

Cerebrospinal fluid vascular endothelial growth factor

artículo científico publicado en 2015

Challenges and Considerations Related to Studying Dementia in Blacks/African Americans

artículo científico

Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies

artículo científico publicado en 2021

Circulating microRNAs in Alzheimer's disease: the search for novel biomarkers

artículo científico publicado en 2013

Clinico-Neuropathological Findings in the Oldest Old from the Georgia Centenarian Study

artículo científico publicado en 2019

Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity

artículo científico publicado en 2007

Clonal human (hNT) neuron grafts for stroke therapy: neuropathology in a patient 27 months after implantation

artículo científico publicado en 2002

Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature

artículo científico publicado en 2012

Detergent Insoluble Proteins and Inclusion Body-Like Structures Immunoreactive for PRKDC/DNA-PK/DNA-PKcs, FTL, NNT, and AIFM1 in the Amygdala of Cognitively Impaired Elderly Persons.

artículo científico publicado en 2017

Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology

artículo científico publicado en 2016

Dichotomous scoring of TDP-43 proteinopathy from specific brain regions in 27 academic research centers: associations with Alzheimer's disease and cerebrovascular disease pathologies

scholarly article by Yuriko Katsumata et al published 19 December 2018 in Acta neuropathologica communications

Diffuse Amyloid-β Plaques, Neurofibrillary Tangles, and the Impact of APOE in Elderly Persons' Brains Lacking Neuritic Amyloid Plaques

artículo científico publicado en 2018

Digital pathology and image analysis for robust high-throughput quantitative assessment of Alzheimer disease neuropathologic changes

artículo científico publicado en 2012

Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging

artículo científico publicado en 2015

Distinct White Matter Changes Associated with Cerebrospinal Fluid Amyloid-β1 - 42 and Hypertension

artículo científico publicado en 2018

Distinct clinicopathologic clusters of persons with TDP-43 proteinopathy

artículo científico publicado en 2020

Distribution and Quantity of Sites of John Cunningham Virus Persistence in Immunologically Healthy Patients: Correlation With John Cunningham Virus Antibody and Urine John Cunningham Virus DNA.

artículo científico publicado en 2017

Dysregulation of the Mitogen Granulin in Human Cancer through the miR-15/107 microRNA Gene Group ⬇️

artículo científico publicado el 30 de septiembre de 2010

Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy

artículo científico publicado en 2020

Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways

artículo científico publicado en 2007

Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease

scientific article published on 17 September 2018

Expression of miR-15/107 family microRNAs in human tissues and cultured rat brain cells.

artículo científico publicado en 2014

Focus on RNA isolation: obtaining RNA for microRNA (miRNA) expression profiling analyses of neural tissue

artículo científico publicado en 2008

GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology

artículo científico publicado en 2012

Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN, TMEM106B, ABCC9, and KCNMB2.

artículo científico publicado en 2017

Genome-wide association study and functional validation implicates JADE1 in tauopathy

artículo científico publicado en 2021

Genomics and CSF analyses implicate thyroid hormone in hippocampal sclerosis of aging

artículo científico publicado en 2016

Global Cerebral Atrophy Detected by Routine Imaging: Relationship with Age, Hippocampal Atrophy, and White Matter Hyperintensities.

artículo científico publicado en 2018

Hierarchical Clustering Analyses of Plasma Proteins in Subjects With Cardiovascular Risk Factors Identify Informative Subsets Based on Differential Levels of Angiogenic and Inflammatory Biomarkers

artículo científico publicado en 2020

High-throughput experimental studies to identify miRNA targets directly, with special focus on the mammalian brain

artículo científico publicado en 2010

Hippocampal Sclerosis but Not Normal Aging or Alzheimer Disease Is Associated With TDP-43 Pathology in the Basal Forebrain of Aged Persons

scientific article published on 12 March 2016

Hippocampal Sclerosis in Older Patients: Practical Examples and Guidance With a Focus on Cerebral Age-Related TDP-43 With Sclerosis

artículo científico publicado en 2017

Hippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the Literature

artículo científico publicado en 2015

Hippocampal Sclerosis of Aging, a Common Alzheimer's Disease 'Mimic': Risk Genotypes are Associated with Brain Atrophy Outside the Temporal Lobe

artículo científico publicado en 2016

Hippocampal Sclerosis, Argyrophilic Grain Disease, and Primary Age-Related Tauopathy

scientific article published on 01 February 2019

Hippocampal sclerosis in advanced age: clinical and pathological features.

artículo científico publicado en 2011

Hippocampal sclerosis of aging is a key Alzheimer's disease mimic: clinical-pathologic correlations and comparisons with both alzheimer's disease and non-tauopathic frontotemporal lobar degeneration

artículo científico publicado en 2014

Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease

artículo científico publicado en 2013

Human cerebral neuropathology of Type 2 diabetes mellitus

artículo científico publicado en 2008

Identification of Novel Tau Interactions with Endoplasmic Reticulum Proteins in Alzheimer's Disease Brain

artículo científico publicado en 2015

In situ hybridization is a necessary experimental complement to microRNA (miRNA) expression profiling in the human brain

artículo científico publicado en 2009

Individual microRNAs (miRNAs) display distinct mRNA targeting "rules"

artículo científico publicado en 2010

Is synaptic loss a unique hallmark of Alzheimer's disease?

artículo científico publicado en 2014

Limbic Predominant Age-Related TDP-43 Encephalopathy (LATE): Clinical and Neuropathological Associations

scientific article published on 01 March 2020

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report.

artículo científico publicado en 2019

Limbic-predominant age-related TDP-43 encephalopathy differs from frontotemporal lobar degeneration

scientific article published on 24 August 2020

Low sensitivity in clinical diagnoses of dementia with Lewy bodies

artículo científico publicado en 2009

Management of frontotemporal dementia: targeting symptom management in such a heterogeneous disease requires a wide range of therapeutic options

artículo científico

Maximizing Safety in the Conduct of Alzheimer's Disease Fluid Biomarker Research in the Era of COVID-19

scientific article published on 19 June 2020

Methodology for Subcellular Fractionation and MicroRNA Examination of Mitochondria, Mitochondria Associated ER Membrane (MAM), ER, and Cytosol from Human Brain

artículo científico publicado en 2020

MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study

artículo científico publicado en 2010

MicroRNA expression patterns in human anterior cingulate and motor cortex: A study of dementia with Lewy bodies cases and controls.

artículo científico publicado en 2017

MicroRNA in Situ Hybridization in the Human Entorhinal and Transentorhinal Cortex

artículo científico publicado en 2010

MicroRNAs (miRNAs) in neurodegenerative diseases

artículo científico publicado en 2008

MicroRNAs in CNS injury: Potential roles and therapeutic implications ⬇️

artículo científico publicado el 1 de enero de 2011

Microarray-based, high-throughput gene expression profiling of microRNAs

artículo científico

Mild cognitive impairment: statistical models of transition using longitudinal clinical data

artículo científico publicado en 2012

Mitochondria-associated microRNAs in rat hippocampus following traumatic brain injury.

artículo científico publicado en 2015

Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons

artículo científico publicado en 2008

Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).

artículo científico publicado en 2017

Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease

artículo científico publicado en 2015

NEDD4-mediated HSF1 degradation underlies α-synucleinopathy

artículo científico publicado en 2015

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

artículo científico publicado en 2012

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach

artículo científico publicado en 2011

Neuroinflammatory phenotype in early Alzheimer's disease

artículo científico publicado en 2012

Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis

artículo científico publicado en 2017

Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study

artículo científico publicado en 2021

Novel human ABCC9/SUR2 brain-expressed transcripts and an eQTL relevant to hippocampal sclerosis of aging

artículo científico publicado en 2015

Outcomes after diagnosis of mild cognitive impairment in a large autopsy series

artículo científico publicado en 2017

Overlapping but distinct TDP-43 and tau pathologic patterns in aged hippocampi

artículo científico publicado en 2017

PART, a distinct tauopathy, different from classical sporadic Alzheimer disease

artículo científico publicado en 2015

Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: white matter versus gray matter.

artículo científico publicado en 2010

Performance of a Condensed Protocol That Reduces Effort and Cost of NIA-AA Guidelines for Neuropathologic Assessment of Alzheimer Disease.

artículo científico publicado en 2017

Peripheral (deep) but not periventricular MRI white matter hyperintensities are increased in clinical vascular dementia compared to Alzheimer's disease

artículo científico publicado en 2016

Preclinical AD Workgroup staging: pathological correlates and potential challenges.

artículo científico publicado en 2011

Prediction of preclinical Alzheimer's disease: longitudinal rates of change in cognition

artículo científico publicado en 2011

Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults

scientific article published on 22 June 2020

Primary age-related tauopathy (PART): a common pathology associated with human aging

artículo científico publicado en 2014

Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease

artículo científico publicado en 2008

Publisher Correction: Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease

scientific article published on 01 January 2019

Quantitative neuropathological assessment to investigate cerebral multi-morbidity.

artículo científico publicado en 2014

RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain

artículo científico

Reassessment of risk genotypes (GRN, TMEM106B, and ABCC9 variants) associated with hippocampal sclerosis of aging pathology

artículo científico publicado en 2015

Relationship between Serum and Brain Carotenoids, α-Tocopherol, and Retinol Concentrations and Cognitive Performance in the Oldest Old from the Georgia Centenarian Study

artículo científico publicado en 2013

Relationship of Type 2 Diabetes to Human Brain Pathology

artículo científico publicado en 2018

Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies

artículo científico publicado en 2009

Reply: LATE to the PART-y

artículo científico publicado en 2019

Reply: Limbic-predominant age-related TDP-43 encephalopathy (LATE)

scientific article published on 01 August 2019

Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals

artículo científico publicado en 2016

Risk of incident clinical diagnosis of Alzheimer's disease-type dementia attributable to pathology-confirmed vascular disease

artículo científico publicado en 2016

Rod-shaped microglia morphology is associated with aging in 2 human autopsy series

artículo científico publicado en 2017

Self-Reported Memory Complaints: A Comparison of Demented and Unimpaired Outcomes

artículo científico publicado en 2016

Self-reported head injury and risk of late-life impairment and AD pathology in an AD center cohort

artículo científico publicado en 2014

Self-reported memory complaints: implications from a longitudinal cohort with autopsies

artículo científico publicado en 2014

Specific sequence determinants of miR-15/107 microRNA gene group targets

artículo científico publicado en 2011

TDP-43 proteinopathy in aging: Associations with risk-associated gene variants and with brain parenchymal thyroid hormone levels

scientific article published on 23 January 2019

Technical variables in high-throughput miRNA expression profiling: much work remains to be done

artículo científico publicado en 2008

The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases

artículo científico publicado en 2017

The Effect of Vascular Neuropathology on Late-life Cognition: Results from the SMART Project

artículo científico publicado en 2016

The MAPT H1 haplotype is associated with tangle-predominant dementia

artículo científico publicado en 2012

The MUC6/AP2A2 Locus and Its Relevance to Alzheimer's Disease: A Review

artículo científico publicado en 2020

The Mitochondria-Associated ER Membranes Are Novel Subcellular Locations Enriched for Inflammatory-Responsive MicroRNAs

scientific article published on 25 May 2020

The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable.

artículo científico publicado en 2018

The Revised National Alzheimer's Coordinating Center's Neuropathology Form-Available Data and New Analyses

artículo científico publicado en 2018

The Statistical Modeling of Aging and Risk of Transition Project: Data Collection and Harmonization Across 11 Longitudinal Cohort Studies of Aging, Cognition, and Dementia

The Utility of the National Alzheimer's Coordinating Center's Database for the Rapid Assessment of Evolving Neuropathologic Conditions

artículo científico publicado en 2020

The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1.

artículo científico publicado en 2008

The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases

artículo científico publicado en 2010

Thinking outside the box: Alzheimer-type neuropathology that does not map directly onto current consensus recommendations

artículo científico publicado en 2010

Tobacco Smoking and Dementia in a Kentucky Cohort: A Competing Risk Analysis

artículo científico publicado en 2019

Translating Alzheimer's disease-associated polymorphisms into functional candidates: a survey of IGAP genes and SNPs

artículo científico publicado en 2018

Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults

artículo científico publicado en 2017

University of Kentucky Sanders-Brown healthy brain aging volunteers: donor characteristics, procedures and neuropathology

artículo científico publicado en 2012

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

artículo científico publicado en 2014

White matter integrity is associated with cerebrospinal fluid markers of Alzheimer's disease in normal adults.

artículo científico publicado en 2014

Widespread tau seeding activity at early Braak stages.

artículo científico publicado en 2016

miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease

artículo científico publicado en 2010

miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1).

artículo científico publicado en 2016

miRNP:mRNA association in polyribosomes in a human neuronal cell line.

artículo científico publicado en 2004

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