Lista de obras -

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.

artículo científico publicado en 2014

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

artículo científico publicado en 2015

A protocol and guide for the in vitro rat hepatocyte DNA-repair assay

artículo científico publicado en 1987

A protocol and guide for the in vivo rat hepatocyte DNA-repair assay

artículo científico publicado en 1987

A strategy for the application of transgenic rodent mutagenesis assays

artículo científico publicado en 1996

Analysis of the mutagenic potential of ENU and MMS in germ cells of male C57BL/6 lacI transgenic mice

artículo científico publicado en 1997

Biodistribution, Toxicology, and Radiation Dosimetry of 5-HT1A-Receptor Agonist Positron Emission Tomography Ligand [11C]CUMI-101 ⬇️

artículo científico publicado el 12 de octubre de 2011

Biodistribution, toxicity and radiation dosimetry studies of the serotonin transporter radioligand 4-[18F]-ADAM in rats and monkeys

artículo científico publicado en 2009

Chromium (VI) at plausible drinking water concentrations is not genotoxic in the in vivo bone marrow micronucleus or liver unscheduled DNA synthesis assays.

artículo científico publicado en 1996

Comparative mutagenicity testing of a drug candidate, U-48753E: mechanism of induction of gene mutations in mammalian cells and quantitation of potential hazard

artículo científico publicado en 1989

Comparative studies on the genotoxic activity of mainstream smoke condensate from cigarettes which burn or only heat tobacco

artículo científico publicado en 1990

Detection of DNA damage in primary cultures of rat hepatocytes following in vivo and in vitro exposure to genotoxic agents

artículo científico publicado en 1982

Detection of genotoxic carcinogens in the in vivo-in vitro hepatocyte DNA repair assay

artículo científico publicado en 1982

Detection of unscheduled DNA synthesis in hepatocytes isolated from rats treated with genotoxic agents: an in vivo- in vitro assay for potential carcinogens and mutagens

artículo científico publicado en 1980

Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models.

artículo científico publicado en 2010

Dosing regimens for transgenic animal mutagenesis assays

artículo científico publicado en 1993

Effects of soya bean flakes and liquorice root extract on enzyme induction and toxicity in B6C3F1 mice

artículo científico publicado en 1993

Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection

artículo científico publicado en 2017

Evaluation of Antitrypanosomal Dihydroquinolines for Hepatotoxicity, Mutagenicity, and Methemoglobin Formation In Vitro

artículo científico publicado en 2014

Evaluation of Cardiac Toxicity Biomarkers in Rats from Different Laboratories

artículo científico publicado en 2016

Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: in vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies

artículo científico publicado en 2012

Evaluation of chemopreventive agents for genotoxic activity

artículo científico publicado en 2007

Evaluation of mutant frequencies of chemically induced tumors and normal tissues in lambda/cII transgenic mice.

artículo científico publicado en 2005

Evaluation of positive controls for the in vitro unscheduled DNA synthesis assay using hepatocytes from induced (Aroclor 1254) and uninduced male cynomolgus monkey.

artículo científico publicado en 1997

Evaluation of the Activity of Lamivudine and Zidovudine against Ebola Virus

artículo científico publicado en 2016

Evaluation of the potential of riddelliine to induce unscheduled DNA synthesis, S-phase synthesis, or micronuclei following in vivo treatment with multiple doses

artículo científico publicado en 1993

Evaluation of unscheduled DNA synthesis (UDS) and replicative DNA synthesis (RDS) following treatment of rats and mice with p-dichlorobenzene.

artículo científico publicado en 1998

Examination of genotoxicity, toxicity and morphologic alterations in hepatocytes following in vivo or in vitro exposure to methapyrilene ⬇️

artículo científico publicado el 1 de junio de 1988

Factors that affect the sensitivity of the in vivo-in vitro hepatocyte DNA repair assay in the male rat

scientific article published on 01 November 1987

Gene expression analysis reveals new possible mechanisms of vancomycin-induced nephrotoxicity and identifies gene markers candidates

scientific article published on 16 October 2008

Gene expression profiling of mouse host response to Listeria monocytogenes infection

artículo científico publicado en 2005

Genetic toxicology studies comparing the activity of sidestream smoke from cigarettes which burn or only heat tobacco

artículo científico publicado en 1990

Genetic toxicology testing of the antimalarial drugs chloroquine and a new analog, AQ-13.

artículo científico publicado en 2001

Genotoxicity and carcinogenicity studies of soy isoflavones

artículo científico publicado en 2002

Genotoxicity and toxicity of the potential cancer-preventive agent polyphenon E.

artículo científico publicado en 2003

Genotoxicity, toxicity, and carcinogenicity of the antihistamine methapyrilene

artículo científico publicado en 1987

In Vitro and In Vivo Activity of Amiodarone Against Ebola Virus

artículo científico publicado en 2018

In Vivo Activity of Amodiaquine against Ebola Virus Infection

scientific article published on 27 December 2019

In vivo measurement of unscheduled DNA synthesis and S-phase synthesis as an indicator of hepatocarcinogenesis in rodents

artículo científico publicado en 1987

In vivo transgenic mutation assays

artículo científico publicado en 2003

In vivo transgenic mutation assays

scientific article published on 01 January 2000

Increased CCL2 expression and macrophage/monocyte migration during microbicide-induced vaginal irritation

artículo científico publicado en 2009

Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats

scientific article published on 11 May 2019

Induction of hepatic cell proliferation and unscheduled DNA synthesis in mouse hepatocytes following in vivo treatment.

artículo científico publicado en 1985

Induction of hepatic mutations in lacI transgenic mice

artículo científico publicado en 1993

Induction of unscheduled DNA synthesis in primary cultures of rat pancreatic cells following in vivo and in vitro treatment with genotoxic agents

scientific article published on 01 January 1984

Induction of unscheduled DNA synthesis in primary cultures of rat, mouse, hamster, monkey, and human hepatocytes

artículo científico publicado en 1988

Induction of unscheduled DNA synthesis in rat hepatocytes following in vivo treatment with dinitrotoluene

scientific article published on 01 January 1982

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials

artículo científico publicado en 2012

Lead optimization of antimalarial propafenone analogues.

artículo científico publicado en 2012

Measurement of unscheduled DNA synthesis and S-phase synthesis in rodent hepatocytes following in vivo treatment: testing of 24 compounds.

artículo científico publicado en 1989

Measurement of unscheduled DNA synthesis in rat kidney cells following in vivo treatment with genotoxic agents

artículo científico publicado en 1985

Metabolism, Pharmacokinetics, Tissue Distribution, and Stability Studies of the Prodrug Analog of an Anti-Hepatitis B Virus Dinucleoside Phosphorothioate ⬇️

artículo científico publicado el 10 de febrero de 2012

Microarray evaluation of the Listeria monocytogenes infection and amoxicillin treatment in mice

artículo científico publicado en 2008

Micronucleated erythrocyte frequency in peripheral blood of B6C3F(1) mice from short-term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program.

artículo científico publicado en 2000

Mutagenic response to benzene and tris(2,3-dibromopropyl)-phosphate in the lambda lacI transgenic mouse mutation assay: a standardized approach to in vivo mutation analysis

artículo científico publicado en 1996

Mutagenicity databases

artículo científico publicado en 1993

Mutational spectrum of dimethylnitrosamine in the liver of 3- and 6-week-old lacI transgenic mice

artículo científico publicado en 1999

Neurological assessments after treatment with the antimalarial β-arteether in neonatal and adult rats

artículo científico publicado en 2011

New candidate biomarkers in the female genital tract to evaluate microbicide toxicity

artículo científico publicado en 2014

Nonprofit organizations and pharmaceutical research and development

article

Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs

artículo científico publicado en 2010

Pharmacokinetics and dose-range finding toxicity of a novel anti-HIV active integrase inhibitor

artículo científico publicado en 2014

Pharmacokinetics of the antimalarial drug, AQ-13, in rats and cynomolgus macaques

artículo científico publicado en 2004

Preclinical Evaluations To Identify Optimal Linezolid Regimens for Tuberculosis Therapy

artículo científico publicado en 2015

Preclinical acute toxicity studies and dosimetry estimates of the novel sigma-1 receptor radiotracer, [18F]SFE.

artículo científico publicado en 2006

Preclinical pharmacokinetic, toxicological and biomarker evaluation of SR16157, a novel dual-acting steroid sulfatase inhibitor and selective estrogen receptor modulator ⬇️

artículo científico publicado el 25 de agosto de 2010

Preclinical studies on the pharmacokinetics, safety, and toxicology of oxfendazole: toward first in human studies

artículo científico publicado en 2015

Professional toxicology societies: web based resources

artículo científico publicado en 2001

Pyridine does not induce unscheduled DNA synthesis (UDS) in hepatocytes of male B6C3F1 mice treated in vivo

scientific article published on 01 September 2000

Quantitative proteomics for cardiac biomarker discovery using isoproterenol-treated nonhuman primates

artículo científico publicado en 2014

Radiation-induced point mutations, deletions and micronuclei in lacI transgenic mice

artículo científico publicado en 1994

Role of gut flora in the genotoxicity of dinitrotoluene

artículo científico publicado en 1982

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

artículo científico publicado en 2009

Serum biomarkers reveal long-term cardiac injury in isoproterenol-treated African green monkeys

artículo científico publicado en 2013

Skin irritation, basal epithelial cell proliferation, and carcinogenicity evaluations of a representative specialty acrylate and methacrylate

artículo científico publicado en 2003

Spectrum of mutations in kidney, stomach, and liver from lacI transgenic mice recovered after treatment with tris(2,3-dibromopropyl)phosphate

artículo científico publicado en 1996

Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120

article

Tenofovir disoproxil fumarate: toxicity, toxicokinetics, and toxicogenomics analysis after 13 weeks of oral administration in mice

artículo científico publicado en 2015

The in vitro unscheduled DNA synthesis (UDS) assay in rat primary hepatocytes: evaluation of 24 drug candidates

artículo científico publicado en 1989

The role of cell proliferation in chemical carcinogenesis.

artículo científico

The role of hyperplasia in liver carcinogenesis

artículo científico publicado en 1990

Toxicity of a quinocarmycin analog, DX-52-1, in rats and dogs in relation to clinical outcome

artículo científico publicado en 2003

Toxicity of dolastatin 10 in mice, rats and dogs and its clinical relevance

scientific article published on 01 January 1999

Transgenic Animal Models for Detection of In Vivo Mutations ⬇️

artículo científico publicado el 1 de enero de 1995

Transgenic animal models for measuring mutations in vivo

artículo científico publicado en 1994

Transgenic animals in toxicology.

artículo científico publicado en 1994

Transgenic models for detection of mutations in tumors and normal tissues of rodents

artículo científico publicado en 1995

Transgenic mouse mutation assay systems can play an important role in regulatory mutagenicity testing in vivo for the detection of site-of-contact mutagens

artículo científico publicado en 1999

Vaccination with a recombinant vaccinia vaccine containing the B7-1 co-stimulatory molecule causes no significant toxicity and enhances T cell-mediated cytotoxicity

artículo científico publicado en 2000

WITHDRAWN: Neurological assessments after treatment with the antimalarial β-arteether in neonatal and adult rats ⬇️

artículo científico publicado el 2 de marzo de 2011

Lista de obras de

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

A protocol and guide for the in vitro rat hepatocyte DNA-repair assay

A protocol and guide for the in vivo rat hepatocyte DNA-repair assay

A strategy for the application of transgenic rodent mutagenesis assays

Analysis of the mutagenic potential of ENU and MMS in germ cells of male C57BL/6 lacI transgenic mice

Biodistribution, Toxicology, and Radiation Dosimetry of 5-HT1A-Receptor Agonist Positron Emission Tomography Ligand [11C]CUMI-101 ⬇️

Biodistribution, toxicity and radiation dosimetry studies of the serotonin transporter radioligand 4-[18F]-ADAM in rats and monkeys

Chromium (VI) at plausible drinking water concentrations is not genotoxic in the in vivo bone marrow micronucleus or liver unscheduled DNA synthesis assays.

Comparative mutagenicity testing of a drug candidate, U-48753E: mechanism of induction of gene mutations in mammalian cells and quantitation of potential hazard

Comparative studies on the genotoxic activity of mainstream smoke condensate from cigarettes which burn or only heat tobacco

Detection of DNA damage in primary cultures of rat hepatocytes following in vivo and in vitro exposure to genotoxic agents

Detection of genotoxic carcinogens in the in vivo-in vitro hepatocyte DNA repair assay

Detection of unscheduled DNA synthesis in hepatocytes isolated from rats treated with genotoxic agents: an in vivo- in vitro assay for potential carcinogens and mutagens

Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models.

Dosing regimens for transgenic animal mutagenesis assays

Effects of soya bean flakes and liquorice root extract on enzyme induction and toxicity in B6C3F1 mice

Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection

Evaluation of Antitrypanosomal Dihydroquinolines for Hepatotoxicity, Mutagenicity, and Methemoglobin Formation In Vitro

Evaluation of Cardiac Toxicity Biomarkers in Rats from Different Laboratories

Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: in vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies

Evaluation of chemopreventive agents for genotoxic activity

Evaluation of mutant frequencies of chemically induced tumors and normal tissues in lambda/cII transgenic mice.

Evaluation of positive controls for the in vitro unscheduled DNA synthesis assay using hepatocytes from induced (Aroclor 1254) and uninduced male cynomolgus monkey.

Evaluation of the Activity of Lamivudine and Zidovudine against Ebola Virus

Evaluation of the potential of riddelliine to induce unscheduled DNA synthesis, S-phase synthesis, or micronuclei following in vivo treatment with multiple doses

Evaluation of unscheduled DNA synthesis (UDS) and replicative DNA synthesis (RDS) following treatment of rats and mice with p-dichlorobenzene.

Examination of genotoxicity, toxicity and morphologic alterations in hepatocytes following in vivo or in vitro exposure to methapyrilene ⬇️

Factors that affect the sensitivity of the in vivo-in vitro hepatocyte DNA repair assay in the male rat

Gene expression analysis reveals new possible mechanisms of vancomycin-induced nephrotoxicity and identifies gene markers candidates

Gene expression profiling of mouse host response to Listeria monocytogenes infection

Genetic toxicology studies comparing the activity of sidestream smoke from cigarettes which burn or only heat tobacco

Genetic toxicology testing of the antimalarial drugs chloroquine and a new analog, AQ-13.

Genotoxicity and carcinogenicity studies of soy isoflavones

Genotoxicity and toxicity of the potential cancer-preventive agent polyphenon E.

Genotoxicity, toxicity, and carcinogenicity of the antihistamine methapyrilene

In Vitro and In Vivo Activity of Amiodarone Against Ebola Virus

In Vivo Activity of Amodiaquine against Ebola Virus Infection

In vivo measurement of unscheduled DNA synthesis and S-phase synthesis as an indicator of hepatocarcinogenesis in rodents

In vivo transgenic mutation assays

In vivo transgenic mutation assays

Increased CCL2 expression and macrophage/monocyte migration during microbicide-induced vaginal irritation

Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats

Induction of hepatic cell proliferation and unscheduled DNA synthesis in mouse hepatocytes following in vivo treatment.

Induction of hepatic mutations in lacI transgenic mice

Induction of unscheduled DNA synthesis in primary cultures of rat pancreatic cells following in vivo and in vitro treatment with genotoxic agents

Induction of unscheduled DNA synthesis in primary cultures of rat, mouse, hamster, monkey, and human hepatocytes

Induction of unscheduled DNA synthesis in rat hepatocytes following in vivo treatment with dinitrotoluene

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials

Lead optimization of antimalarial propafenone analogues.

Measurement of unscheduled DNA synthesis and S-phase synthesis in rodent hepatocytes following in vivo treatment: testing of 24 compounds.

Measurement of unscheduled DNA synthesis in rat kidney cells following in vivo treatment with genotoxic agents

Metabolism, Pharmacokinetics, Tissue Distribution, and Stability Studies of the Prodrug Analog of an Anti-Hepatitis B Virus Dinucleoside Phosphorothioate ⬇️

Microarray evaluation of the Listeria monocytogenes infection and amoxicillin treatment in mice

Micronucleated erythrocyte frequency in peripheral blood of B6C3F(1) mice from short-term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program.

Mutagenic response to benzene and tris(2,3-dibromopropyl)-phosphate in the lambda lacI transgenic mouse mutation assay: a standardized approach to in vivo mutation analysis

Mutagenicity databases

Mutational spectrum of dimethylnitrosamine in the liver of 3- and 6-week-old lacI transgenic mice

Neurological assessments after treatment with the antimalarial β-arteether in neonatal and adult rats

New candidate biomarkers in the female genital tract to evaluate microbicide toxicity

Nonprofit organizations and pharmaceutical research and development

Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs

Pharmacokinetics and dose-range finding toxicity of a novel anti-HIV active integrase inhibitor

Pharmacokinetics of the antimalarial drug, AQ-13, in rats and cynomolgus macaques

Preclinical Evaluations To Identify Optimal Linezolid Regimens for Tuberculosis Therapy

Preclinical acute toxicity studies and dosimetry estimates of the novel sigma-1 receptor radiotracer, [18F]SFE.

Preclinical pharmacokinetic, toxicological and biomarker evaluation of SR16157, a novel dual-acting steroid sulfatase inhibitor and selective estrogen receptor modulator ⬇️

Preclinical studies on the pharmacokinetics, safety, and toxicology of oxfendazole: toward first in human studies

Professional toxicology societies: web based resources

Pyridine does not induce unscheduled DNA synthesis (UDS) in hepatocytes of male B6C3F1 mice treated in vivo

Quantitative proteomics for cardiac biomarker discovery using isoproterenol-treated nonhuman primates

Radiation-induced point mutations, deletions and micronuclei in lacI transgenic mice

Role of gut flora in the genotoxicity of dinitrotoluene

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

Serum biomarkers reveal long-term cardiac injury in isoproterenol-treated African green monkeys

Skin irritation, basal epithelial cell proliferation, and carcinogenicity evaluations of a representative specialty acrylate and methacrylate

Spectrum of mutations in kidney, stomach, and liver from lacI transgenic mice recovered after treatment with tris(2,3-dibromopropyl)phosphate

Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120

Tenofovir disoproxil fumarate: toxicity, toxicokinetics, and toxicogenomics analysis after 13 weeks of oral administration in mice