Lista de obras -

1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro.

artículo científico publicado en 2017

4. Global Approach to Biomedicine: Functional Genomics and Proteomics

artículo científico publicado en 2008

A novel bis-phenanthridine triamine with pH controlled binding to nucleotides and nucleic acids.

artículo científico publicado en 2005

Accurate models for P-gp drug recognition induced from a cancer cell line cytotoxicity screen

artículo científico publicado en 2013

Adenovirally mediated p53 overexpression diversely influence the cell cycle of HEp-2 and CAL 27 cell lines upon cisplatin and methotrexate treatment.

artículo científico publicado en 2009

Amino substituted benzimidazo[1,2-a]quinolines: Antiproliferative potency, 3D QSAR study and DNA binding properties

artículo científico publicado en 2016

Anilides and quinolones with nitrogen-bearing substituents from benzothiophene and thienothiophene series: synthesis, photochemical synthesis, cytostatic evaluation, 3D-derived QSAR analysis and DNA-binding properties

artículo científico publicado en 2013

Antibacterial and antiproliferative activity of novel 2-benzimidazolyl- and 2-benzothiazolyl-substituted benzo[b]thieno-2-carboxamides

artículo científico publicado en 2018

Antitumor potential of crown ethers: structure-activity relationships, cell cycle disturbances, and cell death studies of a series of ionophores.

artículo científico publicado en 2007

Antiviral and cytostatic evaluation of the novel 6-acyclic chain substituted thymine derivatives

artículo científico publicado en 2005

Atypical cytostatic mechanism of N-1-sulfonylcytosine derivatives determined by in vitro screening and computational analysis.

artículo científico publicado en 2007

Benzimidazole derivatives related to 2,3-acrylonitriles, benzimidazo[1,2-a]quinolines and fluorenes: synthesis, antitumor evaluation in vitro and crystal structure determination

artículo científico publicado en 2010

C5-Morpholinomethylation of N1-sulfonylcytosines by a one-pot microwave assisted Mannich reaction

artículo científico publicado en 2018

Cationic side-chains control DNA/RNA binding properties and antiproliferative activity of dicationic dibenzotetraaza[14]annulene derivatives

artículo científico publicado en 2010

Chloroquine Urea Derivatives: Synthesis and Antitumor Activity in Vitro

scientific article published on 01 December 2018

Competing photochemical reactions of bis-naphthols and their photoinduced antiproliferative activity

artículo científico publicado en 2019

Could LogP be a principal determinant of biological activity in 18-crown-6 ethers? Synthesis of biologically active adamantane-substituted diaza-crowns

artículo científico publicado en 2011

Crown ethers reverse P-glycoprotein-mediated multidrug resistance in cancer cells

artículo científico publicado en 2018

Design, Synthesis and Biological Evaluation of Novel Primaquine-Cinnamic Acid Conjugates of the Amide and Acylsemicarbazide Type.

artículo científico publicado en 2016

Dimeric calixarenes: a new family of major-groove binders.

artículo científico publicado en 2012

Effect of indomethacin on E-cadherin and beta-catenin expression in HT-29 colon cancer cells.

artículo científico publicado en 2005

Enhancement of antiproliferative activity by phototautomerization of anthrylphenols.

artículo científico publicado en 2015

Evaluation of antiproliferative effect of N-(alkyladamantyl)phthalimides in vitro

artículo científico publicado en 2012

Experimental and Computational Study of the Antioxidative Potential of Novel Nitro and Amino Substituted Benzimidazole/Benzothiazole-2-Carboxamides with Antiproliferative Activity

artículo científico publicado en 2019

Fenoprofen and ketoprofen amides as potential antitumor agents.

artículo científico publicado en 2007

Global Approach to Biomedicine: Functional Genomics and Proteomics.

artículo científico publicado en 2005

Global approach to perinatal medicine: functional genomics and proteomics.

artículo científico publicado en 2005

Guanidiniocarbonyl-pyrrole-aryl conjugates as nucleic acid sensors: switch of binding mode and spectroscopic responses by introducing additional binding sites into the linker.

artículo científico publicado en 2010

Guanidiniocarbonylpyrrole-aryl derivatives: structure tuning for spectrophotometric recognition of specific DNA and RNA sequences and for antiproliferative activity

artículo científico publicado en 2010

Hydantoin derivatives of L- and D-amino acids: synthesis and evaluation of their antiviral and antitumoral activity

artículo científico publicado en 2006

Labeling of Proteins by BODIPY-Quinone Methides Utilizing Anti-Kasha Photochemistry

scientific article published on 26 December 2019

Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity

artículo científico publicado en 2018

Medicine on a small scale ⬇️

artículo científico publicado el 1 de noviembre de 2003

Near-visible light generation of a quinone methide from 3-hydroxymethyl-2-anthrol

artículo científico publicado en 2014

New sorafenib derivatives: synthesis, antiproliferative activity against tumour cell lines and antimetabolic evaluation

artículo científico publicado en 2012

Novel 1-acyl-4-substituted semicarbazide derivatives of primaquine - synthesis, cytostatic, antiviral and antioxidative studies

artículo científico publicado en 2012

Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations

artículo científico publicado en 2007

Novel NSAID 1-acyl-4-cycloalkyl/arylsemicarbazides and 1-acyl-5-benzyloxy/hydroxy carbamoylcarbazides as potential anticancer agents and antioxidants ⬇️

artículo científico publicado el 3 de marzo de 2012

Novel amidino substituted 2-phenylbenzothiazoles: synthesis, antitumor evaluation in vitro and acute toxicity testing in vivo.

artículo científico publicado en 2009

Novel amidino-substituted thienyl- and furylvinylbenzimidazole: derivatives and their photochemical conversion into corresponding diazacyclopenta[c]fluorenes. synthesis, interactions with DNA and RNA, and antitumor evaluation. 4.

artículo científico publicado en 2008

Novel biologically active nitro and amino substituted benzimidazo[1,2-a]quinolines.

artículo científico publicado en 2011

Novel cyano- and N-isopropylamidino-substituted derivatives of benzo[b]thiophene-2-carboxanilides and benzo[b]thieno[2,3-c]quinolones: synthesis, photochemical synthesis, crystal structure determination, and antitumor evaluation. 2.

artículo científico publicado en 2005

Novel cyano- and amidino-substituted derivatives of styryl-2-benzimidazoles and benzimidazo[1,2-a]quinolines. Synthesis, photochemical synthesis, DNA binding, and antitumor evaluation, part 3.

artículo científico publicado en 2007

Novel cyano- and amidino-substituted derivatives of thieno[2,3-b]- and thieno[3,2-b]thiophene-2-carboxanilides and thieno[3',2':4,5]thieno- and thieno[2',3':4,5]thieno [2,3-c]quinolones: synthesis, photochemical synthesis, DNA binding, and antitumor

artículo científico publicado en 2006

Novel cyano- and amidinobenzothiazole derivatives: synthesis, antitumor evaluation, and X-ray and quantitative structure-activity relationship (QSAR) analysis.

artículo científico publicado en 2009

Novel derivatives of pyridylbenzo[b]thiophene-2-carboxamides and benzo[b]thieno[2,3-c]naphthyridin-2-ones: minor structural variations provoke major differences of antitumor action mechanisms

artículo científico publicado en 2009

Novel pentamidine derivatives: synthesis, anti-tumor properties and polynucleotide-binding activities

artículo científico publicado en 2011

Novel side-chain glucosylated and adamantylated [Asp(2)/Glu(2)]enkephalin analogs: synthesis and in vitro growth inhibition of human tumor cells

artículo científico publicado en 2009

Novel substituted benzothiophene and thienothiophene carboxanilides and quinolones: synthesis, photochemical synthesis, DNA-binding properties, antitumor evaluation and 3D-derived QSAR analysis

artículo científico publicado en 2012

Novel thiosemicarbazone derivatives as potential antitumor agents: Synthesis, physicochemical and structural properties, DNA interactions and antiproliferative activity.

artículo científico publicado en 2008

Palladium(II) complexes of quinolinylaminophosphonates: Synthesis, structural characterization, antitumor and antimicrobial activity ⬇️

artículo científico publicado el 24 de marzo de 2011

Photochemical Formation of Anthracene Quinone Methide Derivatives

artículo científico publicado en 2017

Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery

artículo científico publicado en 2018

Photoinduced switch of a DNA/RNA inactive molecule into a classical intercalator

artículo científico publicado en 2005

Photosolvolysis of bulky (4-hydroxyphenyl)naphthalene derivatives.

artículo científico publicado en 2013

Putative mechanisms of antitumor activity of cyano-substituted heteroaryles in HeLa cells.

artículo científico publicado en 2010

Selective photocytotoxicity of anthrols on cancer stem-like cells: The effect of quinone methides or reactive oxygen species

artículo científico publicado en 2017

Specific sensing of poly G by the aluminum-salophen complex.

artículo científico

Sterically congested adamantylnaphthalene quinone methides.

artículo científico publicado en 2012

Sterically congested quinone methides in photodehydration reactions of 4-hydroxybiphenyl derivatives and investigation of their antiproliferative activity

artículo científico publicado en 2011

Substituted adamantylphthalimides: Synthesis, antiviral and antiproliferative activity

artículo científico publicado en 2020

Synthesis and antiproliferative activity of amino-substituted benzimidazo[1,2-α]quinolines as mesylate salts designed by 3D-QSAR analysis

artículo científico publicado en 2017

Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives

artículo científico publicado en 2007

Synthesis and characterisation of thiosemicarbazonato molybdenum(VI) complexes and their in vitro antitumor activity.

artículo científico publicado en 2009

Synthesis of modified pyrimidine bases and positive impact of chemically reactive substituents on their in vitro antiproliferative activity.

artículo científico publicado en 2008

Synthesis, X-ray crystal structural study, antiviral and cytostatic evaluations of the novel unsaturated acyclic and epoxide nucleoside analogues

artículo científico publicado en 2006

Synthesis, X-ray crystal structure study and antitumoral evaluations of 5,6-disubstituted pyrimidine derivatives.

artículo científico publicado en 2010

Synthesis, antiproliferative activity and DNA binding properties of novel 5-aminobenzimidazo[1,2-a]quinoline-6-carbonitriles

artículo científico publicado en 2014

Synthesis, antiproliferative activity and DNA/RNA-binding properties of mono- and bis-(1,2,3-triazolyl)-appended benzimidazo[1,2-a]quinoline derivatives

scientific article published on 06 November 2019

Synthesis, antitumor evaluation and DNA binding studies of novel amidino-benzimidazolyl substituted derivatives of furyl-phenyl- and thienyl-phenyl-acrylates, naphthofurans and naphthothiophenes

artículo científico publicado en 2008

Synthesis, antiviral and antitumor activity of 2-substituted-5-amidino-benzimidazoles.

artículo científico publicado en 2007

Synthesis, cytostatic activity and ADME properties of C-5 substituted and N-acyclic pyrimidine derivatives

artículo científico publicado en 2011

Synthesis, photochemical synthesis, DNA binding and antitumor evaluation of novel cyano- and amidino-substituted derivatives of naphtho-furans, naphtho-thiophenes, thieno-benzofurans, benzo-dithiophenes and their acyclic precursors

artículo científico publicado en 2006

Synthesis, structural studies and antitumoral evaluation of C-6 alkyl and alkenyl side chain pyrimidine derivatives

artículo científico publicado en 2009

Synthesis, structural studies, and cytostatic evaluation of 5,6-di-O-modified L-ascorbic acid derivatives.

artículo científico publicado en 2006

The dicationic derivatives of DBTAA: Interactions with DNA/RNA and antiproliferative effects on human cell lines.

artículo científico publicado en 2006

The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations

artículo científico publicado en 2006

The novel L- and D-amino acid derivatives of hydroxyurea and hydantoins: synthesis, X-ray crystal structure study, and cytostatic and antiviral activity evaluations.

artículo científico publicado en 2005

The novel ketoprofen amides--synthesis and biological evaluation as antioxidants, lipoxygenase inhibitors and cytostatic agents

artículo científico publicado en 2010

The novel pyrimidine and purine derivatives of l-ascorbic acid: synthesis, one- and two-dimensional 1H and 13C NMR study, cytostatic and antiviral evaluation

artículo científico publicado en 2005

The size of the aryl linker between two polyaza-cyclophane moieties controls the binding selectivity to ds-RNA vs. ds-DNA.

artículo científico publicado en 2013

Zwitterionic biphenyl quinone methides in photodehydration reactions of 3-hydroxybiphenyl derivatives: laser flash photolysis and antiproliferation study.

artículo científico publicado en 2012

Lista de obras de

1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro.

4. Global Approach to Biomedicine: Functional Genomics and Proteomics

A novel bis-phenanthridine triamine with pH controlled binding to nucleotides and nucleic acids.

Accurate models for P-gp drug recognition induced from a cancer cell line cytotoxicity screen

Adenovirally mediated p53 overexpression diversely influence the cell cycle of HEp-2 and CAL 27 cell lines upon cisplatin and methotrexate treatment.

Amino substituted benzimidazo[1,2-a]quinolines: Antiproliferative potency, 3D QSAR study and DNA binding properties

Anilides and quinolones with nitrogen-bearing substituents from benzothiophene and thienothiophene series: synthesis, photochemical synthesis, cytostatic evaluation, 3D-derived QSAR analysis and DNA-binding properties

Antibacterial and antiproliferative activity of novel 2-benzimidazolyl- and 2-benzothiazolyl-substituted benzo[b]thieno-2-carboxamides

Antitumor potential of crown ethers: structure-activity relationships, cell cycle disturbances, and cell death studies of a series of ionophores.

Antiviral and cytostatic evaluation of the novel 6-acyclic chain substituted thymine derivatives

Atypical cytostatic mechanism of N-1-sulfonylcytosine derivatives determined by in vitro screening and computational analysis.

Benzimidazole derivatives related to 2,3-acrylonitriles, benzimidazo[1,2-a]quinolines and fluorenes: synthesis, antitumor evaluation in vitro and crystal structure determination

C5-Morpholinomethylation of N1-sulfonylcytosines by a one-pot microwave assisted Mannich reaction

Cationic side-chains control DNA/RNA binding properties and antiproliferative activity of dicationic dibenzotetraaza[14]annulene derivatives

Chloroquine Urea Derivatives: Synthesis and Antitumor Activity in Vitro

Competing photochemical reactions of bis-naphthols and their photoinduced antiproliferative activity

Could LogP be a principal determinant of biological activity in 18-crown-6 ethers? Synthesis of biologically active adamantane-substituted diaza-crowns

Crown ethers reverse P-glycoprotein-mediated multidrug resistance in cancer cells

Design, Synthesis and Biological Evaluation of Novel Primaquine-Cinnamic Acid Conjugates of the Amide and Acylsemicarbazide Type.

Dimeric calixarenes: a new family of major-groove binders.

Effect of indomethacin on E-cadherin and beta-catenin expression in HT-29 colon cancer cells.

Enhancement of antiproliferative activity by phototautomerization of anthrylphenols.

Evaluation of antiproliferative effect of N-(alkyladamantyl)phthalimides in vitro

Experimental and Computational Study of the Antioxidative Potential of Novel Nitro and Amino Substituted Benzimidazole/Benzothiazole-2-Carboxamides with Antiproliferative Activity

Fenoprofen and ketoprofen amides as potential antitumor agents.

Global Approach to Biomedicine: Functional Genomics and Proteomics.

Global approach to perinatal medicine: functional genomics and proteomics.

Guanidiniocarbonyl-pyrrole-aryl conjugates as nucleic acid sensors: switch of binding mode and spectroscopic responses by introducing additional binding sites into the linker.

Guanidiniocarbonylpyrrole-aryl derivatives: structure tuning for spectrophotometric recognition of specific DNA and RNA sequences and for antiproliferative activity

Hydantoin derivatives of L- and D-amino acids: synthesis and evaluation of their antiviral and antitumoral activity

Labeling of Proteins by BODIPY-Quinone Methides Utilizing Anti-Kasha Photochemistry

Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity

Medicine on a small scale ⬇️

Near-visible light generation of a quinone methide from 3-hydroxymethyl-2-anthrol

New sorafenib derivatives: synthesis, antiproliferative activity against tumour cell lines and antimetabolic evaluation

Novel 1-acyl-4-substituted semicarbazide derivatives of primaquine - synthesis, cytostatic, antiviral and antioxidative studies

Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations

Novel NSAID 1-acyl-4-cycloalkyl/arylsemicarbazides and 1-acyl-5-benzyloxy/hydroxy carbamoylcarbazides as potential anticancer agents and antioxidants ⬇️

Novel amidino substituted 2-phenylbenzothiazoles: synthesis, antitumor evaluation in vitro and acute toxicity testing in vivo.

Novel amidino-substituted thienyl- and furylvinylbenzimidazole: derivatives and their photochemical conversion into corresponding diazacyclopenta[c]fluorenes. synthesis, interactions with DNA and RNA, and antitumor evaluation. 4.

Novel biologically active nitro and amino substituted benzimidazo[1,2-a]quinolines.

Novel cyano- and N-isopropylamidino-substituted derivatives of benzo[b]thiophene-2-carboxanilides and benzo[b]thieno[2,3-c]quinolones: synthesis, photochemical synthesis, crystal structure determination, and antitumor evaluation. 2.

Novel cyano- and amidino-substituted derivatives of styryl-2-benzimidazoles and benzimidazo[1,2-a]quinolines. Synthesis, photochemical synthesis, DNA binding, and antitumor evaluation, part 3.

Novel cyano- and amidino-substituted derivatives of thieno[2,3-b]- and thieno[3,2-b]thiophene-2-carboxanilides and thieno[3',2':4,5]thieno- and thieno[2',3':4,5]thieno [2,3-c]quinolones: synthesis, photochemical synthesis, DNA binding, and antitumor

Novel cyano- and amidinobenzothiazole derivatives: synthesis, antitumor evaluation, and X-ray and quantitative structure-activity relationship (QSAR) analysis.

Novel derivatives of pyridylbenzo[b]thiophene-2-carboxamides and benzo[b]thieno[2,3-c]naphthyridin-2-ones: minor structural variations provoke major differences of antitumor action mechanisms

Novel pentamidine derivatives: synthesis, anti-tumor properties and polynucleotide-binding activities

Novel side-chain glucosylated and adamantylated [Asp(2)/Glu(2)]enkephalin analogs: synthesis and in vitro growth inhibition of human tumor cells

Novel substituted benzothiophene and thienothiophene carboxanilides and quinolones: synthesis, photochemical synthesis, DNA-binding properties, antitumor evaluation and 3D-derived QSAR analysis

Novel thiosemicarbazone derivatives as potential antitumor agents: Synthesis, physicochemical and structural properties, DNA interactions and antiproliferative activity.

Palladium(II) complexes of quinolinylaminophosphonates: Synthesis, structural characterization, antitumor and antimicrobial activity ⬇️

Photochemical Formation of Anthracene Quinone Methide Derivatives

Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery

Photoinduced switch of a DNA/RNA inactive molecule into a classical intercalator

Photosolvolysis of bulky (4-hydroxyphenyl)naphthalene derivatives.

Putative mechanisms of antitumor activity of cyano-substituted heteroaryles in HeLa cells.

Selective photocytotoxicity of anthrols on cancer stem-like cells: The effect of quinone methides or reactive oxygen species

Specific sensing of poly G by the aluminum-salophen complex.

Sterically congested adamantylnaphthalene quinone methides.

Sterically congested quinone methides in photodehydration reactions of 4-hydroxybiphenyl derivatives and investigation of their antiproliferative activity

Substituted adamantylphthalimides: Synthesis, antiviral and antiproliferative activity

Synthesis and antiproliferative activity of amino-substituted benzimidazo[1,2-α]quinolines as mesylate salts designed by 3D-QSAR analysis

Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives

Synthesis and characterisation of thiosemicarbazonato molybdenum(VI) complexes and their in vitro antitumor activity.

Synthesis of modified pyrimidine bases and positive impact of chemically reactive substituents on their in vitro antiproliferative activity.

Synthesis, X-ray crystal structural study, antiviral and cytostatic evaluations of the novel unsaturated acyclic and epoxide nucleoside analogues

Synthesis, X-ray crystal structure study and antitumoral evaluations of 5,6-disubstituted pyrimidine derivatives.

Synthesis, antiproliferative activity and DNA binding properties of novel 5-aminobenzimidazo[1,2-a]quinoline-6-carbonitriles

Synthesis, antiproliferative activity and DNA/RNA-binding properties of mono- and bis-(1,2,3-triazolyl)-appended benzimidazo[1,2-a]quinoline derivatives

Synthesis, antitumor evaluation and DNA binding studies of novel amidino-benzimidazolyl substituted derivatives of furyl-phenyl- and thienyl-phenyl-acrylates, naphthofurans and naphthothiophenes

Synthesis, antiviral and antitumor activity of 2-substituted-5-amidino-benzimidazoles.

Synthesis, cytostatic activity and ADME properties of C-5 substituted and N-acyclic pyrimidine derivatives

Synthesis, photochemical synthesis, DNA binding and antitumor evaluation of novel cyano- and amidino-substituted derivatives of naphtho-furans, naphtho-thiophenes, thieno-benzofurans, benzo-dithiophenes and their acyclic precursors

Synthesis, structural studies and antitumoral evaluation of C-6 alkyl and alkenyl side chain pyrimidine derivatives

Synthesis, structural studies, and cytostatic evaluation of 5,6-di-O-modified L-ascorbic acid derivatives.

The dicationic derivatives of DBTAA: Interactions with DNA/RNA and antiproliferative effects on human cell lines.

The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations

The novel L- and D-amino acid derivatives of hydroxyurea and hydantoins: synthesis, X-ray crystal structure study, and cytostatic and antiviral activity evaluations.

The novel ketoprofen amides--synthesis and biological evaluation as antioxidants, lipoxygenase inhibitors and cytostatic agents