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"Burst and slow complexes" in nonconvulsive epileptic status

scientific article published on 01 March 2006

3-[(2,4-Dimethoxy)benzylidene]-anabaseine dihydrochloride protects against 6-hydroxydopamine-induced parkinsonian neurodegeneration through α7 nicotinic acetylcholine receptor stimulation in rats

artículo científico publicado en 2012

A Cross-Sectional Study on Socioeconomic Systems Supporting Outpatients With Parkinson's Disease in Japan.

artículo científico publicado en 2015

A case of neuromyelitis optica presenting marked pleocytosis and hypoglycorrhachia

artículo científico publicado en 2016

A case presenting electrophysiological and immunological characteristics of Fisher syndrome and Lambert-Eaton myasthenic syndrome

scientific article published on 08 December 2020

A heterozygous missense mutation in adolescent-onset very long-chain acyl-CoA dehydrogenase deficiency with exercise-induced rhabdomyolysis

artículo científico publicado en 2015

A new form of congenital proprioceptive sensory neuropathy associated with arthrogryposis multiplex

artículo científico publicado en 2004

A novel lamin A/C gene mutation causing spinal muscular atrophy phenotype with cardiac involvement: report of one case

artículo científico publicado en 2015

A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner.

artículo científico publicado en 2016

ANCA-negative granulomatosis with polyangiitis presenting with orbital apex syndrome and recurrent pachymeningitis: A case report

artículo científico publicado en 2016

Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin

artículo científico publicado en 2006

Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients

artículo científico publicado en 2015

Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mous

artículo científico publicado en 2017

Alzheimer's disease and acetylcholine receptors.

artículo científico publicado en 2004

Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations

artículo científico publicado en 2005

An Anti-PM/Scl-75 Antibody-positive Japanese Woman Who Developed Inflammatory Myopathy

scientific article published on 07 June 2019

Analysis of resources assisting in coping with swallowing difficulties for patients with Parkinson's disease: a cross-sectional study.

artículo científico publicado en 2016

Anti-ryanodine receptor-positive acetylcholine receptor-negative myasthenia gravis: evidence of impaired excitation-contraction coupling

artículo científico publicado en 2011

Apoptotic and Oxidative Indicators in Alzheimer's Disease

scholarly article

Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out?

artículo científico publicado en 2003

Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease

artículo científico publicado en 2002

BDNF is induced by wild-type alpha-synuclein but not by the two mutants, A30P or A53T, in glioma cell line

artículo científico publicado en 2004

CD14 and Toll-Like Receptor 4 Promote Fibrillar Aβ42 Uptake by Microglia Through A Clathrin-Mediated Pathway

artículo científico publicado en 2019

Characterization of sequential N-cadherin cleavage by ADAM10 and PS1.

artículo científico publicado en 2006

Clinical and Radiological Characteristics of Intracranial Artery Dissection Using Recently Proposed Diagnostic Criteria

artículo científico publicado en 2019

Clinical outcome of patients with SREDA (subclinical rhythmic EEG discharge of adults).

artículo científico publicado en 2006

Cocaine and phenylephrine eye drop test for Parkinson disease.

artículo científico publicado en 2005

Colocalization of 14-3-3 proteins with SOD1 in Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model

artículo científico publicado en 2011

Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response

artículo científico publicado en 2002

Continuation of exercise is necessary to inhibit high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice

artículo científico publicado en 2013

Contribution of anti-ryanodine receptor antibody to impairment of excitation-contraction coupling in myasthenia gravis

artículo científico publicado en 2011

Copper enhances APP dimerization and promotes Aβ production

artículo científico publicado en 2013

Correlation of bite force with excitation-contraction coupling time of the masseter in myasthenia gravis

scientific article published on 12 March 2010

Dementia: progress in diagnosis and treatment; Topics, I. Basic knowledge of dementia and pathophysiology; 1. The concept and pathophysiology of dementia of Alzheimer-type ⬇️

artículo científico publicado el 10 de agosto de 2011

Development of moyamoya disease after non-herpetic acute limbic encephalitis: A case report.

artículo científico publicado en 2018

Developmental expression of neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus

artículo científico publicado en 2006

Differential expression profiles of PLC-beta1 and -delta1 in primary cultured rat cortical neurons treated with N-methyl-D-aspartate and peroxynitrite

artículo científico publicado en 2004

Disease model: Parkinson's disease.

artículo científico publicado en 2003

Dopamine facilitates alpha-synuclein oligomerization in human neuroblastoma SH-SY5Y cells

artículo científico publicado en 2009

Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone

artículo científico publicado en 2003

Dopamine receptors and Parkinson's disease

artículo científico publicado en 2011

Early administration of galantamine from preplaque phase suppresses oxidative stress and improves cognitive behavior in APPswe/PS1dE9 mouse model of Alzheimer's disease

artículo científico publicado en 2019

Early effect of tacrolimus in improving excitation-contraction coupling in myasthenia gravis

artículo científico publicado en 2012

Effect of local cooling on excitation-contraction coupling in myasthenic muscle: Another mechanism of ice-pack test in myasthenia gravis

artículo científico publicado en 2017

Effects of a DJ-1-Binding Compound on Spatial Learning and Memory Impairment in a Mouse Model of Alzheimer's Disease.

artículo científico publicado en 2016

Effects of hyperoxia and acrylonitrile on the phospholipase C isozyme protein levels in rat heart and brain

scientific journal article

Effects of mitochondrial dysfunction on glutamate receptor-mediated neurotoxicity in cultured rat spinal motor neurons.

artículo científico publicado en 2004

Enhancement of nicotinic receptors alleviates cytotoxicity in neurological disease models

artículo científico

Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice

artículo científico publicado en 2011

Epileptic polyopia with right temporal lobe epilepsy as studied by FDG-PET and MRI: a case report.

artículo científico publicado en 2006

Establishing a New Screening System for Mild Cognitive Impairment and Alzheimer's Disease with Mental Rotation Tasks that Evaluate Visuospatial Function

artículo científico publicado en 2018

Estradiol protects dopaminergic neurons in a MPP+Parkinson's disease model.

artículo científico publicado en 2002

Estrogens and Parkinson disease: novel approach for neuroprotection.

artículo científico publicado en 2003

Evaluation of Mitochondrial Oxidative Stress in the Brain of a Transgenic Mouse Model of Alzheimer's Disease by in vitro Electron Paramagnetic Resonance Spectroscopy

artículo científico publicado en 2019

Evaluation of oxidative stress in the brain of a transgenic mouse model of Alzheimer disease by in vivo electron paramagnetic resonance imaging

artículo científico publicado en 2015

Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice

artículo científico publicado en 2012

Fingolimod induces BAFF and expands circulating transitional B cells without activating memory B cells and plasma cells in multiple sclerosis

artículo científico publicado en 2017

Fingolimod suppresses bone resorption in female patients with multiple sclerosis

artículo científico publicado en 2016

Fisher syndrome with delayed facial weakness and taste impairment: a case report

artículo científico publicado en 2016

GSK3beta activity modifies the localization and function of presenilin 1.

artículo científico publicado en 2007

Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling

artículo científico publicado en 2012

Galantamine modulates nicotinic receptor and blocks Abeta-enhanced glutamate toxicity

artículo científico publicado en 2004

Galantamine-induced amyloid-{beta} clearance mediated via stimulation of microglial nicotinic acetylcholine receptors

artículo científico publicado en 2010

Generation of striatal neurons from human induced pluripotent stem cells by controlling extrinsic signals with small molecules

Gluten sensitivity in Japanese patients with adult-onset cerebellar ataxia.

artículo científico publicado en 2006

Heat shock protein-90-induced microglial clearance of exogenous amyloid-beta1-42 in rat hippocampus in vivo

artículo científico publicado en 2003

Heat-shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase: clues to a possible strategy for treating ALS.

artículo científico publicado en 2007

High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.

artículo científico publicado en 2015

High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity

artículo científico publicado en 2004

High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal

artículo científico publicado en 2001

Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.

artículo científico publicado en 2008

Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

artículo científico publicado en 2002

Hyperbilirubinemia protects against focal ischemia in rats

artículo científico publicado en 2003

Hyperemesis-induced Wernicke-Korsakoff Syndrome due to Hypergastrinemia during Long-term Treatment with Proton Pump Inhibitors

scientific article published on 14 July 2020

Hypersomnia caused by isolated angiitis of the CNS.

artículo científico publicado en 2005

Idiopathic normal pressure hydrocephalus has a different cerebrospinal fluid biomarker profile from Alzheimer's disease

artículo científico publicado en 2015

Impaired post-tetanic potentiation of muscle twitch in myasthenia gravis

artículo científico publicado en 2015

Improvement of focal ischemia-induced rat dopaminergic dysfunction by striatal transplantation of mouse embryonic stem cells

artículo científico publicado en 2006

Inhibitory effects of antiparkinsonian drugs and caspase inhibitors in a parkinsonian flatworm model

artículo científico publicado en 2003

Intracellular receptors for activated C-kinase in the postmortem human brain: no alteration in Alzheimer disease

artículo científico publicado en 1998

Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease

artículo científico publicado en 2009

Intravenous mesenchymal stem cell administration exhibits therapeutic effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration and glial activation in rats

artículo científico publicado en 2014

Involvement of WAVE accumulation in Abeta/APP pathology-dependent tangle modification in Alzheimer's disease

artículo científico publicado en 2009

Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta(1-42) in rat microglia

artículo científico publicado en 2003

Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells

artículo científico publicado en 2005

Ischemic Stroke with Protein S Deficiency Treated by Apixaban

artículo científico publicado en 2020

Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum

artículo científico publicado en 2002

Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgG abnormality in multiple sclerosis

artículo científico publicado en 2015

Latitude and HLA-DRB1*04:05 independently influence disease severity in Japanese multiple sclerosis: a cross-sectional study

artículo científico publicado en 2016

Load effect on background rhythms during motor execution: A magnetoencephalographic study

artículo científico publicado en 2016

Long-term clinical and radiological improvement of chronic acquired hepatocerebral degeneration after obliteration of portosystemic shunt: Report of a case

artículo científico publicado en 2014

Mesenchymal stem cells transmigrate across brain microvascular endothelial cell monolayers through transiently formed inter-endothelial gaps

scientific article published on 20 July 2011

Microglial Amyloid-β1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer's Disease

artículo científico publicado en 2012

Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins

artículo científico publicado en 2002

Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats

artículo científico publicado en 2007

Morphological change by overexpression of D385A dominant negative presenilin 1 in human neuroblastoma SH-SY5Y cells

artículo científico publicado en 2006

Mouse Bone Marrow-derived Microglia-like Cells Secrete Transforming Growth Factor-β1 and Promote Microglial Aβ Phagocytosis and Reduction of Brain Aβ

artículo científico publicado en 2020

Mutations in LGI1 gene in Japanese families with autosomal dominant lateral temporal lobe epilepsy: the first report from Asian families

artículo científico publicado en 2009

Myopericarditis in a case of anti-signal recognition particle (anti-SRP) antibody-positive myopathy.

artículo científico publicado en 2016

N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease

artículo científico publicado en 2010

N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio

artículo científico publicado en 2008

Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.

artículo científico publicado en 2007

Neuronal Survival and Death in Alzheimer Disease

Neuroprotective mechanisms of antiparkinsonian dopamine D2-receptor subfamily agonists

artículo científico publicado en 2003

Neuroprotective properties of Bcl-w in Alzheimer disease

artículo científico publicado en 2004

Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models

artículo científico publicado en 2009

Novel neuroprotective mechanisms of pramipexole, an anti-Parkinson drug, against endogenous dopamine-mediated excitotoxicity.

artículo científico publicado en 2006

N‐cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production ⬇️

artículo científico publicado el 20 de septiembre de 2011

Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson's disease patients

artículo científico publicado en 2016

PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model

artículo científico publicado en 2006

PI3K inhibition causes the accumulation of ubiquitinated presenilin 1 without affecting the proteasome activity

artículo científico publicado en 2009

Pharmacological characteristics of rotational behavior in hemiparkinsonian rats transplanted with mouse embryonic stem cell-derived neurons

artículo científico publicado en 2004

Phosphodiesterase inhibitors are neuroprotective to cultured spinal motor neurons

artículo científico publicado en 2003

Possible Involvement of Small Oligomers of Amyloid-β Peptides in 15-Deoxy-Δ12,14 Prostaglandin J2-Sensitive Microglial Activation

artículo científico publicado el 1 de abril de 2003

Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease

artículo científico publicado en 2003

Possible involvement of both mitochondria- and endoplasmic reticulum-dependent caspase pathways in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells

artículo científico publicado en 2002

Possible involvement of group I mGluRs in neuroprotective effect of theanine

artículo científico publicado en 2004

Presenilin 1 is involved in maturation and trafficking of N‐cadherin to the plasma membrane ⬇️

artículo científico publicado el 15 de octubre de 2003

Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).

artículo científico publicado en 2007

Presenilin 1 mediates retinoic acid-induced differentiation of SH-SY5Y cells through facilitation of Wnt signaling

artículo científico publicado en 2003

Progressive multifocal leukoencephalopathy after autologous peripheral blood stem cell transplantation in a patient with multiple myeloma treated with combination therapy

artículo científico publicado en 2016

Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease

artículo científico publicado en 2006

Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons in hemiparkinsonian rats.

artículo científico publicado en 2005

Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions

artículo científico publicado en 2003

Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade.

artículo científico publicado en 2002

Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons.

artículo científico publicado en 2005

Protein trafficking and Alzheimer's disease

artículo científico publicado en 2004

Proteome analysis of brain proteins in Alzheimer's disease: subproteomics following sequentially extracted protein preparation.

artículo científico publicado en 2004

Reconstruction of dopaminergic neural network and locomotion function in planarian regenerates

artículo científico publicado en 2007

Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia

artículo científico publicado en 2005

Relationship between dysphagia and depressive states in patients with Parkinson's disease

artículo científico publicado en 2011

Respiratory insufficiency with preserved diaphragmatic function in amyotrophic lateral sclerosis

artículo científico publicado en 2014

Response of serum carboxylated and undercarboxylated osteocalcin to risedronate monotherapy and combined therapy with vitamin K(2) in corticosteroid-treated patients: a pilot study

artículo científico publicado en 2010

Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron

artículo científico publicado en 2005

Role of Suppressor of Cytokine Signaling 3 (SOCS3) in Altering Activated Microglia Phenotype in APPswe/PS1dE9 Mice

artículo científico publicado en 2016

Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis

artículo científico publicado en 2003

Roles of Nicotinic Acetylcholine Receptors in the Pathology and Treatment of Alzheimer’s and Parkinson’s Diseases

SIRT1 deficiency interferes with membrane resealing after cell membrane injury

artículo científico publicado en 2019

Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats

artículo científico publicado en 2005

Severe Mononeuritis Multiplex due to Rheumatoid Vasculitis in Rheumatoid Arthritis in Sustained Clinical Remission for Decades

artículo científico publicado en 2019

Stimulating nicotinic receptors trigger multiple pathways attenuating cytotoxicity in models of Alzheimer's and Parkinson's diseases

artículo científico publicado en 2011

Stimulation of nicotinic acetylcholine receptors protects motor neurons.

artículo científico publicado en 2005

Streptococcus oralis Meningitis with Gingival Bleeding in a Patient: A Case Report and Review of the Literature

scientific article published on 30 September 2020

Successful intervention for overwhelming postsplenectomy infection caused by non-vaccine pneumococcal serotype 23A

artículo científico publicado en 2020

Synergistic effect of galantamine on nicotine-induced neuroprotection in hemiparkinsonian rat model

artículo científico publicado en 2008

Temporal changes of CD68 and α7 nicotinic acetylcholine receptor expression in microglia in Alzheimer's disease-like mouse models

artículo científico publicado en 2015

The Japanese Early-Stage Trial of High-Dose Methylcobalamin for Amyotrophic Lateral Sclerosis (JETALS): Protocol for a Randomized Controlled Trial

artículo científico publicado en 2018

The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease

artículo científico publicado en 2015

The role of the presenilin-1 homologue gene sel-12 of Caenorhabditis elegans in apoptotic activities

artículo científico publicado en 2003

The spectrum of clinicopathological features in pure autonomic neuropathy

artículo científico publicado en 2012

Therapeutic effects of human mesenchymal and hematopoietic stem cells on rotenone-treated parkinsonian mice.

artículo científico publicado en 2012

Therapy for Alzheimer-type dementia-status quo and future considerations

artículo científico publicado en 2013

Thyrotoxic myopathy mimicking myasthenic syndrome associated with thymic hyperplasia

artículo científico publicado en 2008

Tipping the apoptotic balance in Alzheimer's disease: the abortosis concept

artículo científico publicado en 2003

Toxin-Induced and Genetic Animal Models of Parkinson's Disease ⬇️

artículo científico publicado el 22 de diciembre de 2010

Transient oculomotor palsy correlated with nerve enhancement on MRI in chronic inflammatory demyelinating polyneuropathy

scientific article published on 16 November 2009

Transplantation of Mesenchymal Stem Cells Improves Amyloid-β Pathology by Modifying Microglial Function and Suppressing Oxidative Stress

artículo científico publicado en 2019

Transplantation of mouse embryonic stem cell-derived neurons into the striatum, subthalamic nucleus and substantia nigra, and behavioral recovery in hemiparkinsonian rats

artículo científico publicado en 2005

Transport and toxic mechanism for aluminum citrate in human neuroblastoma SH-SY5Y cells

artículo científico publicado en 2006

Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan

artículo científico publicado en 2006

[A case of Marchiafava-Bignami disease suggesting vasogenic edema].

artículo científico publicado en 2015

[A case of atypical Tolosa-Hunt syndrome with a contrast enhanced lesion of the oculomotor and trigeminal nerves on MRI]

artículo científico publicado en 2014

[A case of dural arteriovenous fistula of right cavernous sinus presenting bilateral eye symptoms]

artículo científico publicado en 2015

[A case with temporal lobe epilepsy associated with hypocalcemia due to primary hypoparathyroidism]

artículo científico publicado en 2006

[Anti-dementia drugs].

artículo científico publicado en 2012

[Current concepts regarding cortical dementia].

artículo científico publicado en 2015

[Development of therapies for Alzheimer's disease based on cholinergic hypothesis-status quo and future directions].

artículo científico publicado en 2013

[Dramatic seizure reduction with levetiracetam in adult Dravet syndrome: a case report]

artículo científico publicado en 2015

[Focal cortical dysplasia at the primary somatosensory cortex could manifest both intractable partial epilepsy and cortical reflex myoclonus]

artículo científico publicado en 2006

[Galantamine]

artículo científico publicado en 2011

[Lewy bodies: neuroprotective?]

scientific article published on 01 November 2006

[Nucleus basalis of Meynert and cholinergic neurotransmission].

artículo científico publicado en 2011

[Sporadic adult-onset neuronal intranuclear inclusion disease with abnormal electroretinogram, nerve conduction studies and somatosensory evoked potential]

artículo científico publicado en 2018

[Treatment outcome of patients with cranial base lesions of unknown etiology: focusing on infectious cases with multiple cranial nerve disorders]

artículo científico publicado en 2013

[Two cases of photosensitive seizure induced by barcode readers with red flashing lights]

artículo científico publicado en 2018

[Unilateral ptosis induced by pure midbrain infarction: a case report]

artículo científico publicado en 2020

p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly.

artículo científico publicado en 2005

α4 nicotinic acetylcholine receptor modulated by galantamine on nigrostriatal terminals regulates dopamine receptor-mediated rotational behavior

artículo científico publicado en 2016

α7 nicotinic acetylcholine receptor mediated neuroprotection in Parkinson's disease

artículo científico publicado en 2012

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