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161533 TriKE stimulates NK-cell function to overcome myeloid-derived suppressor cells in MDS

artículo científico publicado en 2018

3D Bioprinted In Vitro Metastatic Models via Reconstruction of Tumor Microenvironments

scientific article published on 21 January 2019

A bispecific immunotoxin (DTAT13) targeting human IL-13 receptor (IL-13R) and urokinase-type plasminogen activator receptor (uPAR) in a mouse xenograft model

artículo científico publicado en 2004

A bispecific recombinant cytotoxin (DTEGF13) targeting human interleukin-13 and epidermal growth factor receptors in a mouse xenograft model of prostate cancer

artículo científico publicado en 2007

A bispecific recombinant immunotoxin, DT2219, targeting human CD19 and CD22 receptors in a mouse xenograft model of B-cell leukemia/lymphoma

artículo científico publicado en 2005

A correlation between conditioning and engraftment in recipients of MHC-mismatched T cell-depleted murine bone marrow transplants

scientific article published on 01 August 1985

A critical role for CD48 antigen in regulating alloengraftment and lymphohematopoietic recovery after bone marrow transplantation

artículo científico publicado en 1998

A deimmunized bispecific ligand-directed toxin that shows an impressive anti-pancreatic cancer effect in a systemic nude mouse orthotopic model

artículo científico publicado en 2012

A murine cytokine fusion toxin specifically targeting the murine granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor on normal committed bone marrow progenitor cells and GM-CSF-dependent tumor cells ⬇️

artículo científico publicado el 1 de octubre de 1995

A new drug delivery method of bispecific ligand-directed toxins, which reduces toxicity and promotes efficacy in a model of orthotopic pancreatic cancer

artículo científico publicado en 2010

A novel bispecific ligand-directed toxin designed to simultaneously target EGFR on human glioblastoma cells and uPAR on tumor neovasculature

artículo científico publicado en 2010

A novel brain metastasis xenograft model for convection‑enhanced delivery of targeted toxins via a micro‑osmotic pump system enabled for real‑time bioluminescence imaging

artículo científico publicado en 2015

A novel reduced immunogenicity bispecific targeted toxin simultaneously recognizing human epidermal growth factor and interleukin-4 receptors in a mouse model of metastatic breast carcinoma

artículo científico publicado en 2009

A trispecific killer engager molecule against CLEC12A effectively induces NK-cell mediated killing of AML cells

artículo científico publicado en 2020

Absence of a facilitory role for NK 1.1-positive donor cells in engraftment across a major histocompatibility barrier in mice

scientific article published on 01 May 1988

Adult bone marrow-derived pluripotent hematopoietic stem cells are engraftable when transferred in utero into moderately anemic fetal recipients.

artículo científico publicado en 1995

Allogeneic NK cells eradicate myeloblasts but not neoplastic mast cells in systemic mastocytosis associated with acute myeloid leukemia.

artículo científico publicado en 2017

Allogeneic and autologous bone marrow transplantation for acute lymphoblastic leukemia

scientific article published on 01 January 1990

Allogeneic and autologous bone marrow transplantation for high risk acute lymphoblastic leukemia

artículo científico publicado el 1 de enero de 1992

Anti-CD2 (T, p50) intact ricin immunotoxins for GVHD-prophylaxis in allogeneic bone marrow transplantation

artículo científico publicado en 1986

Anti-CD3 epsilon F(ab')2 fragments inhibit T cell expansion in vivo during graft-versus-host disease or the primary immune response to nominal antigen ⬇️

artículo científico publicado el 15 de diciembre de 1997

Anti-CD3 immunotoxin prevents low-dose STZ/interferon-induced autoimmune diabetes in mouse

artículo científico publicado en 1992

Anti-T cell monoclonal antibodies conjugated to ricin as potential reagents for human GVHD prophylaxis: effect on the generation of cytotoxic T cells in both peripheral blood and bone marrow

scientific article published on 01 February 1984

Anti-T-cell reagents for human bone marrow transplantation: ricin linked to three monoclonal antibodies

artículo científico publicado en 1983

Anti-glioblastoma effect of a recombinant bispecific cytotoxin cotargeting human IL-13 and EGF receptors in a mouse xenograft model

artículo científico publicado en 2007

Anti-graft-versus-host disease effect of DT390-anti-CD3sFv, a single-chain Fv fusion immunotoxin specifically targeting the CD3 epsilon moiety of the T-cell receptor.

artículo científico publicado en 1996

Antigenic modulation by anti-CD5 immunotoxins

artículo científico publicado en 1986

Antitumor protection from the murine T-cell leukemia/lymphoma EL4 by the continuous subcutaneous coadministration of recombinant macrophage-colony stimulating factor and interleukin-2

artículo científico publicado en 1993

Assessment of immunocompetence by limiting dilution analysis in long-term T cell depletion chimeras transplanted across the MHC barrier

artículo científico publicado en 1985

Assessment of multi-organ system engraftment by genotypic typing using restriction fragment-length polymorphisms and by phenotypic typing using a microcytotoxicity assay

artículo científico publicado en 1986

Augmentation of donor bone marrow engraftment in histoincompatible murine recipients by granulocyte/macrophage colony-stimulating factor

artículo científico publicado en 1988

Autologous bone marrow transplantation for progressive non-Hodgkin's lymphoma: clinical impact of immunophenotype and in vitro purging

artículo científico publicado en 1991

Autologous bone marrow transplantation in high-risk remission T-lineage acute lymphoblastic leukemia using immunotoxins plus 4-hydroperoxycyclophosphamide for marrow purging

scientific article published on 01 November 1990

B lymphocyte regulation of human hematopoiesis

artículo científico publicado en 1985

Bioengineering a unique deimmunized bispecific targeted toxin that simultaneously recognizes human CD22 and CD19 receptors in a mouse model of B-cell metastases

artículo científico publicado en 2010

Bispecific Targeting of EGFR and Urokinase Receptor (uPAR) Using Ligand-Targeted Toxins in Solid Tumors

artículo científico publicado en 2020

Bispecific and trispecific killer cell engagers directly activate human NK cells through CD16 signaling and induce cytotoxicity and cytokine production

artículo científico publicado en 2012

Bispecific targeting of EGFR and uPAR in a mouse model of head and neck squamous cell carcinoma ⬇️

artículo científico publicado el 20 de julio de 2012

Blockade of CD40 ligand-CD40 interaction impairs CD4+ T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation

scientific article published on 01 January 1997

Bone marrow purging with immunotoxins for treatment of T cell acute lymphoblastic leukemia (T-ALL)

scientific article published on 01 January 1990

Bone marrow transplantation across major histocompatability barriers in mice. III. Treatment of donor grafts with monoclonal antibodies directed against Lyt determinants ⬇️

artículo científico publicado el 1 de febrero de 1982

Bone marrow transplantation across major histocompatibility barriers in mice. Effect of elimination of T cells from donor grafts by treatment with monoclonal Thy-1.2 plus complement or antibody alone

artículo científico publicado en 1981

Bone marrow transplantation across major histocompatibility barriers in mice. II. T cell requirement for engraftment in total lymphoid irradiation-conditioned recipients ⬇️

artículo científico publicado el 1 de marzo de 1982

Bone marrow transplantation across major histocompatibility barriers in mice. IV. Graft-versus-host disease in TLI-conditioned mice

scientific article published on 01 May 1982

Bone marrow transplantation across major histocompatibility barriers. V. Protection of mice from lethal graft-vs.-host disease by pretreatment of donor cells with monoclonal anti-Thy-1.2 coupled to the toxin ricin

artículo científico publicado en 1982

Bone marrow transplantation for acute lymphocytic leukemia utilizing total body irradiation followed by high doses of cytosine arabinoside: lack of superiority over cyclophosphamide-containing conditioning regimens

artículo científico publicado en 1990

CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells against primary MDS and MDSC CD33+ targets

artículo científico publicado en 2014

CD28/B7 interactions are required for sustaining the graft-versus-leukemia effect of delayed post-bone marrow transplantation splenocyte infusion in murine recipients of myeloid or lymphoid leukemia cells ⬇️

artículo científico publicado el 1 de octubre de 1997

CD4(+) T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand (CD40L:CD154) antibody lose their graft-versus-host disease lethality capacity but retain nominal antigen responses ⬇️

artículo científico publicado el 1 de agosto de 1998

CD4+ and CD8+ T cells each can utilize a perforin-dependent pathway to mediate lethal graft-versus-host disease in major histocompatibility complex-disparate recipients ⬇️

artículo científico publicado el 27 de agosto de 1997

Cell-type-specific cytotoxicity of anti-CD4 and anti-CD8 ricin immunotoxins against human alloreactive T-cell clones

scientific article published on 01 November 1989

Chimeric fusion proteins--diphtheria toxin-based

artículo científico publicado el 1 de septiembre de 2001

Coblockade of the LFA1:ICAM and CD28/CTLA4:B7 pathways is a highly effective means of preventing acute lethal graft-versus-host disease induced by fully major histocompatibility complex-disparate donor grafts

scientific article published on 01 May 1995

Combined ex vivo treatment with immunotoxins and mafosfamid: a novel immunochemotherapeutic approach for elimination of neoplastic T cells from autologous marrow grafts

artículo científico publicado en 1985

Combined immunochemotherapy of human solid tumors in nude mice

artículo científico publicado en 1987

Comparison of autologous and allogeneic bone marrow transplantation for treatment of high-risk refractory acute lymphoblastic leukemia

artículo científico publicado en 1987

Cytotoxic effect of anti-Mr 67,000 protein immunotoxins on human tumors in a nude mouse model

artículo científico publicado en 1985

Cytotoxic effects of anti-CD5 radioimmunotoxins on human tumors in vitro and in a nude mouse model

scientific article published on 01 December 1988

Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia

artículo científico publicado en 2009

Depressed leukocyte reconstitution and engraftment in murine recipients of T cell-depleted histoincompatible marrow pretreated with interleukin 3

artículo científico publicado en 1988

Design, Characterization, and Evaluation of scFvCD133/rGelonin: A CD133-Targeting Recombinant Immunotoxin for Use in Combination with Photochemical Internalization

artículo científico publicado en 2019

Development of a Deimmunized Bispecific Immunotoxin dDT2219 against B-Cell Malignancies.

artículo científico publicado en 2018

Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice ⬇️

artículo científico publicado el 1 de noviembre de 1998

Diphtheria toxin-based targeted toxin therapy for brain tumors ⬇️

artículo científico publicado el 22 de mayo de 2013

Early Reconstitution of NK and γδ T Cells and Its Implication for the Design of Post-Transplant Immunotherapy

artículo científico publicado en 2018

Effect of IL-7 or IL-4 on reconstitution of donor lymphoid cells in congenic murine bone marrow transplantation

artículo científico publicado el 1 de julio de 1995

Effect of recombinant human macrophage colony-stimulating factor in irradiated murine recipients of T-cell-depleted allogeneic or non-depleted syngeneic bone marrow transplants ⬇️

artículo científico publicado el 15 de marzo de 1992

Efficacy of antiangiogenic targeted toxins against glioblastoma multiforme

Elimination of clonogenic T-leukemic cells from human bone marrow using anti-Mr 65,000 protein immunotoxins ⬇️

artículo científico publicado el 1 de julio de 1984

Engineering of Anti-CD133 Trispecific Molecule Capable of Inducing NK Expansion and Driving Antibody-Dependent Cell-Mediated Cytotoxicity

artículo científico publicado en 2017

Engraftment of severe combined immune deficient mice receiving allogeneic bone marrow via In utero or postnatal transfer.

artículo científico publicado en 1998

Enhanced survival but reduced engraftment in murine recipients of recombinant granulocyte/macrophage colony-stimulating factor following transplantation of T-cell-depleted histoincompatible bone marrow

scientific article published on 01 October 1988

Evaluation of 18-F-fluoro-2-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) as a staging and monitoring tool for dogs with stage-2 splenic hemangiosarcoma - A pilot study.

artículo científico publicado en 2017

Evaluation of a bispecific biological drug designed to simultaneously target glioblastoma and its neovasculature in the brain ⬇️

artículo científico publicado el 4 de febrero de 2011

Ex-vivo treatment of donor bone marrow with anti-T-cell immunotoxins for prevention of graft-versus-host disease ⬇️

artículo científico publicado el 3 de marzo de 1984

FK506 inhibits graft-versus-host disease and bone marrow graft rejection in murine recipients of MHC disparate donor grafts by interfering with mature peripheral T cell expansion post-transplantation

artículo científico publicado en 1994

Gene therapy of murine solid tumors with T cells transduced with a retroviral vascular endothelial growth factor--immunotoxin target gene

artículo científico publicado en 2002

General strategies in in vivo animal modeling

artículo científico publicado el 1 de enero de 1992

Generation of BiKEs and TriKEs to Improve NK Cell-Mediated Targeting of Tumor Cells

artículo científico publicado en 2016

Genetic alteration of a bispecific ligand-directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancy

scientific article published on 26 March 2009

Graft-versus-host disease prevention in allogeneic bone marrow transplantation from histocompatible siblings. A pilot study using immunotoxins for T cell depletion of donor bone marrow

scientific article published on 01 July 1987

Hemangiosarcoma and its cancer stem cell sub-population are effectively killed by a toxin targeted through epidermal growth factor and urokinase receptors.

artículo científico publicado en 2013

Hemangiosarcoma and its cancer stem cell subpopulation are effectively killed by a toxin targeted through epidermal growth factor and urokinase receptors

artículo científico publicado en 2013

Heterodimeric bispecific single-chain variable-fragment antibodies against EpCAM and CD16 induce effective antibody-dependent cellular cytotoxicity against human carcinoma cells

artículo científico publicado en 2013

IL15 Trispecific Killer Engagers (TriKE) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced Function

artículo científico publicado en 2016

Identification and characterization of a novel scFv recognizing human and mouse CD133.

artículo científico publicado en 2013

Immunotoxin pharmacokinetics: a comparison of the anti-glioblastoma bi-specific fusion protein (DTAT13) to DTAT and DTIL13.

artículo científico publicado en 2006

Immunotoxin targeting CD133(+) breast carcinoma cells

artículo científico publicado en 2013

Immunotoxin therapy for CNS tumor

artículo científico publicado en 2003

Immunotoxins Targeting B cell Malignancy-Progress and Problems With Immunogenicity

artículo científico publicado en 2018

Immunotoxins for ex vivo marrow purging in autologous bone marrow transplantation for acute nonlymphocytic leukemia

artículo científico publicado en 1988

Immunotoxins show rapid entry of diphtheria toxin but not ricin via the T3 antigen

scientific article published on 01 January 1986

Impact of repeated cycles of EGF bispecific angiotoxin (eBAT) administered at a reduced interval from doxorubicin chemotherapy in dogs with splenic haemangiosarcoma

scientific article published on 18 March 2020

Improved survival and leukocyte reconstitution without detrimental effects on engraftment in murine recipients of human recombinant granulocyte colony-stimulating factor after transplantation of T-cell-depleted histoincompatible bone marrow

artículo científico publicado en 1989

In utero engraftment of fully H-2-incompatible versus congenic adult bone marrow transferred into nonanemic or anemic murine fetal recipients.

artículo científico publicado en 1993

In utero transfer of adult bone marrow cells into recipients with severe combined immunodeficiency disorder yields lymphoid progeny with T- and B-cell functional capabilities

scientific article published on 01 December 1995

In vivo T-cell receptor ligation facilitates alloengraftment and prevents lethal graft-versus-host disease (GVHD) in mice

artículo científico publicado en 1993

In vivo administration of anti-CD3 monoclonal antibodies or immunotoxins in murine recipients of allogeneic T cell-depleted marrow for the promotion of engraftment ⬇️

artículo científico publicado el 1 de septiembre de 1991

In vivo administration of recombinant human granulocyte/macrophage colony-stimulating factor in acute lymphoblastic leukemia patients receiving purged autografts.

artículo científico publicado en 1989

In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice

artículo científico publicado en 1994

In vivo inhibition of cytokine responsiveness and graft-versus-host disease mortality by rapamycin leads to a clinical-pathological syndrome discrete from that observed with cyclosporin A

artículo científico publicado en 1996

In vivo or in vitro anti-CD3 epsilon chain monoclonal antibody therapy for the prevention of lethal murine graft-versus-host disease across the major histocompatibility barrier in mice.

artículo científico publicado en 1994

Increased efficacy in selective elimination of leukemic cell line clonogenic cells by a combination of monoclonal antibodies BA-1, BA-2, BA-3 + complement and mafosfamid (ASTA Z 7557)

artículo científico publicado en 1986

Increasing anticarcinoma activity of an anti-erbB2 recombinant immunotoxin by the addition of an anti-EpCAM sFv.

artículo científico publicado en 2007

Infusion of anti-B7.1 (CD80) and anti-B7.2 (CD86) monoclonal antibodies inhibits murine graft-versus-host disease lethality in part via direct effects on CD4+ and CD8+ T cells

artículo científico publicado en 1996

Interleukin-1 alpha-mediated promotion of long-term alloengraftment and short-term neutrophil expansion does not require the presence of either donor or host T cells

scientific article published on 01 September 1996

Interleukin-1 or tumor necrosis factor-alpha antagonists do not inhibit graft-versus-host disease induced across the major histocompatibility barrier in mice

scientific article published on 01 December 1995

Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts

scientific article published on 01 February 1995

Interleukin-10 dose-dependent regulation of CD4+ and CD8+ T cell-mediated graft-versus-host disease

artículo científico publicado en 1998

Intracerebral infusion of the bispecific targeted toxin DTATEGF in a mouse xenograft model of a human metastatic non-small cell lung cancer.

artículo científico publicado en 2012

Intracranial elimination of human glioblastoma brain tumors in nude rats using the bispecific ligand-directed toxin, DTEGF13 and convection enhanced delivery

artículo científico publicado en 2009

Intracranial therapy of glioblastoma with the fusion protein DTAT in immunodeficient mice

artículo científico publicado en 2007

Intracranial therapy of glioblastoma with the fusion protein DTIL13 in immunodeficient mice.

artículo científico publicado en 2006

Keratinocyte growth factor administered before conditioning ameliorates graft-versus-host disease after allogeneic bone marrow transplantation in mice

artículo científico publicado en 1998

Kupffer cell engraftment across the major histocompatibility barrier in mice: bone marrow origin, class II antigen expression, and antigen-presenting capacity.

artículo científico publicado en 1990

Laboratory preparation of a deglycosylated ricin toxin A chain containing immunotoxin directed against a CD7 T lineage differentiation antigen for phase I human clinical studies involving T cell malignancies

artículo científico publicado en 1996

Lack of GVHD across classical, single minor histocompatibiliTy (miH) locus barriers in mice

scientific article published on 01 February 1996

Lethal murine graft-versus-host disease induced by donor gamma/delta expressing T cells with specificity for host nonclassical major histocompatibility complex class Ib antigens

artículo científico publicado en 1996

Malignant progenitors from patients with CD87+ acute myelogenous leukemia are sensitive to a diphtheria toxin-urokinase fusion protein

artículo científico publicado en 2002

Marrow purging in autologous bone marrow transplantation for T-lineage acute lymphoblastic leukemia: efficacy of ex vivo treatment with immunotoxins and 4-hydroperoxycyclophosphamide against fresh leukemic marrow progenitor cells

artículo científico publicado en 1987

Molecular modification of a recombinant anti-CD3epsilon-directed immunotoxin by inducing terminal cysteine bridging enhances anti-GVHD efficacy and reduces organ toxicity in a lethal murine model

artículo científico publicado en 2000

Molecular modification of a recombinant, bivalent anti-human CD3 immunotoxin (Bic3) results in reduced in vivo toxicity in mice

artículo científico publicado en 2005

Monoclonal antibodies and immunotoxins in bone marrow transplantation: purging marrow of ALL or GVHD cells with preservation of stem cells

scientific article published on 01 January 1985

Monoclonal antibody toxin conjugates for experimental graft-versus-host disease prophylaxis. Reagents selectively reactive with T cells and not murine stem cells

artículo científico publicado en 1983

Monoclonal antibody-toxin conjugates reactive against human T lymphocytes. A comparison of antibody linked to intact ricin toxin with antibody linked to ricin A chain ⬇️

artículo científico publicado el 1 de abril de 1984

Murine gamma/delta-expressing T cells affect alloengraftment via the recognition of nonclassical major histocompatibility complex class Ib antigens

artículo científico publicado en 1996

Murine recipients of fully mismatched donor marrow are protected from lethal graft-versus-host disease by the in vivo administration of rapamycin but develop an autoimmune-like syndrome

artículo científico publicado en 1993

Mutagenic Deimmunization of Diphtheria Toxin for Use in Biologic Drug Development

artículo científico publicado en 2015

NK-Cell-Mediated Targeting of Various Solid Tumors Using a B7-H3 Tri-Specific Killer Engager In Vitro and In Vivo

scientific article published on 18 September 2020

Natural killer cells unleashed: Checkpoint receptor blockade and BiKE/TriKE utilization in NK-mediated anti-tumor immunotherapy

artículo científico publicado en 2017

Nonmitogenic anti-CD3F(ab')2 fragments inhibit lethal murine graft-versus-host disease induced across the major histocompatibility barrier

artículo científico publicado en 1993

Novel CD19-targeted TriKE restores NK cell function and proliferative capacity in CLL

artículo científico publicado en 2019

Opposing roles of CD28:B7 and CTLA-4:B7 pathways in regulating in vivo alloresponses in murine recipients of MHC disparate T cells

scientific article published on 01 June 1999

Peptide toxins directed at the matrix dissolution systems of cancer cells

artículo científico publicado en 2002

Phase I study of a bispecific ligand-directed toxin targeting CD22 and CD19 (DT2219) for refractory B-cell malignancies

artículo científico publicado en 2015

Potent Cytolytic Activity and Specific IL15 Delivery in a 2nd Generation Trispecific Killer Engager

artículo científico publicado en 2020

Preclinical studies targeting normal and leukemic hematopoietic cells with Yttrium-90-labeled anti-CD45 antibody in vitro and in vivo in nude mice

artículo científico publicado en 2003

Pretreatment of murine donor grafts with L-leucyl-L-leucine methyl ester: elimination of graft-versus-host disease without detrimental effects on engraftment

artículo científico publicado en 1990

Prevention of murine graft-versus-host disease and bone marrow alloengraftment across the major histocompatibility barrier after donor graft preincubation with anti-LFA1 immunotoxin

artículo científico publicado en 1991

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia.

artículo científico publicado en 2010

Promotion of murine marrow alloengraftment and hematopoietic recovery across the major histocompatibility barrier by administration of recombinant human interleukin-1 alpha ⬇️

artículo científico publicado el 15 de septiembre de 1992

Radioimmunotherapy of CD22-expressing Daudi tumors in nude mice with a 90Y-labeled anti-CD22 monoclonal antibody

artículo científico publicado en 2005

Radiotherapy in mice with yttrium-90-labeled anti-Ly1 monoclonal antibody: therapy of established graft-versus-host disease induced across the major histocompatibility barrier

scientific article published on 01 April 1991

Radiotherapy in mice with yttrium-90-labeled anti-Ly1 monoclonal antibody: therapy of the T cell lymphoma EL4

artículo científico publicado en 1991

Radiotherapy of CD19 expressing Daudi tumors in nude mice with Yttrium-90-labeled anti-CD19 antibody

artículo científico publicado en 2004

Radiotherapy of CD45-expressing Daudi tumors in nude mice with yttrium-90-labeled, PEGylated anti-CD45 antibody

artículo científico publicado en 2007

Rapamycin inhibits the generation of graft-versus-host disease- and graft-versus-leukemia-causing T cells by interfering with the production of Th1 or Th1 cytotoxic cytokines ⬇️

artículo científico publicado el 1 de junio de 1998

Rapamycin prolongs survival of murine recipients of fully allogeneic donor grafts when administered during the graft-versus-host disease process

artículo científico publicado en 1993

Rapamycin, a potent inhibitor of T-cell function, prevents graft rejection in murine recipients of allogeneic T-cell-depleted donor marrow

artículo científico publicado en 1994

Reactivity of murine cytokine fusion toxin, diphtheria toxin390-murine interleukin-3 (DT390-mIL-3), with bone marrow progenitor cells

artículo científico publicado en 1996

Recent advances in graft‐versus‐host disease (GVHD) prevention ⬇️

artículo científico publicado el 1 de junio de 1997

Recombinant granulocyte/macrophage-colony stimulating factor in human and murine bone marrow transplantation

artículo científico publicado en 1988

Renal dysfunction accounts for the dose limiting toxicity of DT390anti- CD3sFv, a potential new recombinant anti-GVHD immunotoxin ⬇️

artículo científico publicado el 1 de septiembre de 1997

Retroviral immunotoxin gene therapy of acute myelogenous leukemia in mice using cytotoxic T cells transduced with an interleukin 4/diphtheria toxin gene.

artículo científico publicado en 2000

Retroviral immunotoxin gene therapy of leukemia in mice using leukemia-specific T cells transduced with an interleukin-3/Bax fusion protein gene

artículo científico publicado en 2003

Retroviral-mediated transfer of the murine interleukin-3 gene engineered for intracellular retention results in a myeloproliferative syndrome but is associated with circulating interleukin-3 levels.

artículo científico publicado en 1993

Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR.

artículo científico publicado en 2017

Short-course total-lymphoid irradiation combined with total-body irradiation to facilitate engraftment of T cell-depleted marrow across a major histocompatibility barrier in mice

artículo científico publicado en 1988

Successful treatment of human acute T-cell leukemia in SCID mice using the anti-CD7-deglycosylated ricin A-chain immunotoxin DA7 ⬇️

artículo científico publicado el 1 de marzo de 1992

T cell depletion for graft-versus-host-disease prophylaxis. A perspective on engraftment in mice and humans

artículo científico

T cell depletion with anti-CD5 immunotoxin in histocompatible bone marrow transplantation. The correlation between residual CD5 negative T cells and subsequent graft-versus-host disease ⬇️

artículo científico publicado el 1 de septiembre de 1990

Targeting CD133 in an in vivo ovarian cancer model reduces ovarian cancer progression ⬇️

artículo científico publicado el 27 de mayo de 2013

Targeting EGFR and uPAR on human rhabdomyosarcoma, osteosarcoma, and ovarian adenocarcinoma with a bispecific ligand-directed toxin

Targeting glioblastoma multiforme with an IL-13/diphtheria toxin fusion protein in vitro and in vivo in nude mice

artículo científico publicado en 2002

Targeting myeloid leukemia with a DT(390)-mIL-3 fusion immunotoxin: ex vivo and in vivo studies in mice

artículo científico publicado en 1999

Targeting natural killer cells to acute myeloid leukemia in vitro with a CD16 x 33 bispecific killer cell engager and ADAM17 inhibition

artículo científico publicado en 2013

Targeting pediatric sarcoma with a bispecific ligand immunotoxin targeting urokinase and epidermal growth factor receptors

artículo científico publicado en 2017

Targeting the over-expressed urokinase-type plasminogen activator receptor on glioblastoma multiforme

artículo científico publicado en 2003

Targeting tumor-initiating cancer cells with dCD133KDEL shows impressive tumor reductions in a xenotransplant model of human head and neck cancer

artículo científico publicado en 2011

Targeting urokinase-type plasminogen activator receptor on human glioblastoma tumors with diphtheria toxin fusion protein DTAT.

artículo científico publicado en 2002

Tetraspecific scFv construct provides NK cell mediated ADCC and self-sustaining stimuli via insertion of IL-15 as a cross-linker

artículo científico publicado en 2016

The critical early proinflammatory events associated with idiopathic pneumonia syndrome in irradiated murine allogeneic recipients are due to donor T cell infusion and potentiated by cyclophosphamide

artículo científico publicado en 1997

The diphtheria toxin/urokinase fusion protein (DTAT) is selectively toxic to CD87 expressing leukemic cells

artículo científico publicado en 2003

The effect of T subset depletion on the incidence of lethal graft-versus-host disease in a murine major-histocompatibility-complex-mismatched transplantation system

artículo científico publicado en 1987

The role of B7 costimulation by murine acute myeloid leukemia in the generation and function of a CD8+ T-cell line with potent in vivo graft-versus-leukemia properties.

artículo científico publicado en 1997

The role of T cell subsets in regulating the in vivo efficacy of CTLA4-Ig in preventing graft-versus-host disease in recipients of fully MHC or multiple minor histocompatibility-disparate donor inocula

artículo científico publicado en 1994

The role of host T cell subsets in bone marrow rejection directed to isolated major histocompatibility complex class I versus class II differences of bm1 and bm12 mutant mice

artículo científico publicado en 1994

The role of ricin B chain in the intracellular trafficking of anti-CD5 immunotoxins

artículo científico publicado en 1989

Therapy for ongoing graft-versus-host disease induced across the major or minor histocompatibility barrier in mice with anti-CD3F(ab')2-ricin toxin A chain immunotoxin

scientific article published on 01 December 1995

Therapy of Patients with T-cell Lymphomas and Leukemias Using an Anti-CD7 Monoclonal Antibody-Rich a Chain Immunotoxin ⬇️

artículo científico publicado el 1 de julio de 1997

Toxicity and efficacy of anti-T-cell ricin toxin A chain immunotoxins in a murine model of established graft-versus-host disease induced across the major histocompatibility barrier

artículo científico publicado en 1991

Transgenic mice expressing either bovine growth hormone (bGH) or human GH releasing hormone (hGRH) have increased splenic progenitor cell colony formation and DNA synthesis in vitro and in vivo

artículo científico publicado en 1995

Treatment of mice with anti-CD3 mAb induces endothelial vascular cell adhesion molecule-1 expression

artículo científico publicado en 1994

Trispecific killer engager CD16xIL15xCD33 potently induces NK cell activation and cytotoxicity against neoplastic mast cells

artículo científico publicado en 2018

Use of a novel colony assay to evaluate the cytotoxicity of an immunotoxin containing pokeweed antiviral protein against blast progenitor cells freshly obtained from patients with common B-lineage acute lymphoblastic leukemia

artículo científico publicado en 1986

Use of colony assays and anti-T cell immunotoxins to elucidate the immunobiologic features of leukemic progenitor cells in T-lineage acute lymphoblastic leukemia

artículo científico publicado en 1988

Use of multiple T cell-directed intact ricin immunotoxins for autologous bone marrow transplantation

scientific article published on 01 September 1985

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