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Lista de obras de Stuart Schreiber

6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate Metabolism to Protein Secretion via Modulation of Glutathione Levels

scientific article published on 13 June 2019

A Candidate Cell-Selective Anticancer Agent

A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering

artículo científico publicado en 2019

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

artículo científico publicado en 2019

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

artículo científico publicado en 2017

A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells

artículo científico publicado en 2012

A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake - Probe 3

A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake—Probe 1

artículo científico publicado en 2014

A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake—Probe 2

artículo científico publicado en 2014

A Small Molecule Inhibitor of the MITF Molecular Pathway

artículo científico publicado en 2014

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

artículo científico publicado en 2006

A cell-based, high-throughput screen for small molecule regulators of hepatitis C virus replication

artículo científico publicado en 2006

A dataset of images and morphological profiles of 30,000 small-molecule treatments using the Cell Painting assay

artículo científico publicado en 2017

A genetic basis for the variation in the vulnerability of cancer to DNA damage

artículo científico publicado en 2016

A human islet cell culture system for high-throughput screening

artículo científico publicado en 2011

A library of spirooxindoles based on a stereoselective three-component coupling reaction.

artículo científico publicado en 2004

A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold

artículo científico publicado en 2011

A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors

artículo científico publicado en 2018

A robust small-molecule microarray platform for screening cell lysates

artículo científico publicado en 2006

A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases

artículo científico publicado en 2011

A small molecule suppressor of FK506 that targets the mitochondria and modulates ionic balance in Saccharomyces cerevisiae

artículo científico publicado en 2003

A small molecule that binds Hedgehog and blocks its signaling in human cells

artículo científico publicado en 2009

A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.

artículo científico publicado en 2017

A small-molecule inducer of PDX1 expression identified by high-throughput screening.

artículo científico publicado en 2013

A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma

artículo científico publicado en 2012

AACR Cancer Progress Report 2012.

artículo científico publicado en 2012

AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.

artículo científico publicado en 2011

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

artículo científico publicado en 2015

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers

scientific article published on 26 May 2020

Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase

artículo científico publicado en 2020

Amino acid metabolic origin as an evolutionary influence on protein sequence in yeast

artículo científico publicado en 2009

An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

artículo científico publicado en 2020

An Oligomer-Based Approach to Skeletal Diversity in Small-Molecule Synthesis

artículo científico publicado en 2006

An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.

artículo científico publicado en 2013

Antisense oligonucleotides extend survival of prion-infected mice

artículo científico publicado en 2019

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

artículo científico publicado en 2014

Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection

artículo científico publicado en 2013

Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles

artículo científico publicado en 2014

Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake

artículo científico publicado en 2015

Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase

scientific article published on 01 September 2020

Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles.

artículo científico publicado en 2010

CTD2 Dashboard: a searchable web interface to connect validated results from the Cancer Target Discovery and Development Network

artículo científico publicado en 2017

Carbon metabolism-mediated myogenic differentiation

artículo científico publicado en 2010

Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase

artículo científico publicado en 2011

Characterization of the Prion Protein Binding Properties of Antisense Oligonucleotides

scientific article published on 18 December 2019

ChemBank: a small-molecule screening and cheminformatics resource database

artículo científico publicado en 2007

Chemical Genetic Analysis of Platelet Granule Secretion-Probe 1

artículo científico publicado en 2011

Chemical Genetic Analysis of Platelet Granule Secretion-Probe 2

artículo científico publicado en 2011

Chemical Genetic Analysis of Platelet Granule Secretion-Probe 3

artículo científico publicado en 2011

Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation

artículo científico publicado en 2003

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

artículo científico publicado en 2010

Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling

artículo científico publicado en 2010

Chemical genomic profiling of biological networks using graph theory and combinations of small molecule perturbations

artículo científico publicado en 2003

Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation

artículo científico publicado en 2015

Chemical probes and drug leads from advances in synthetic planning and methodology.

artículo científico publicado en 2018

Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation

artículo científico publicado en 2004

Chemoproteomics quantifies complexity ⬇️

artículo científico publicado el 1 de marzo de 2011

Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.

artículo científico publicado en 2012

Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells

artículo científico publicado en 2013

Complex alpha-pyrones synthesized by a gold-catalyzed coupling reaction

artículo científico publicado en 2007

Control of olefin geometry in macrocyclic ring-closing metathesis using a removable silyl group

artículo científico publicado en 2011

Copper-mediated amidation of heterocyclic and aromatic C-H bonds

artículo científico publicado en 2009

Correction: GW8510 Increases Insulin Expression in Pancreatic Alpha Cells through Activation of p53 Transcriptional Activity

artículo científico publicado en 2012

Correlating chemical sensitivity and basal gene expression reveals mechanism of action.

artículo científico publicado en 2015

Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

artículo científico publicado en 2012

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

scientific article published on 17 February 2020

DNA Barcoding a Complete Matrix of Stereoisomeric Small Molecules

scientific article published on 25 June 2019

DNA-Compatible [3 + 2] Nitrone-Olefin Cycloaddition Suitable for DEL Syntheses

scientific article published on 14 February 2019

Deacetylase enzymes: biological functions and the use of small-molecule inhibitors

artículo científico publicado en 2002

Decoding Products of Diversity Pathways from Stock Solutions Derived from Single Polymeric Macrobeads H.E.B. and L.P. contributed equally to this work. We thank the National Institute of General Medical Sciences (GM-52067) for the support of this re

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

artículo científico publicado en 2017

Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity.

artículo científico publicado en 2015

Development and validation of a T7 based linear amplification for genomic DNA ⬇️

artículo científico publicado el 9 de mayo de 2003

Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo

artículo científico publicado en 2016

Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia

artículo científico publicado en 2016

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

artículo científico publicado en 2011

DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets

artículo científico publicado en 2016

Diacylfuroxans Are Masked Nitrile Oxides That Inhibit GPX4 Covalently

scientific article published on 16 December 2019

Diastereoselective control of intramolecular aza-Michael reactions using achiral catalysts

scientific article published on 14 September 2011

Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2).

artículo científico publicado en 2014

Direct control of mitochondrial function by mTOR.

artículo científico publicado en 2009

Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia

Discovery and Evaluation of Fungicidal Anti-Cryptococcal Molecules

Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor.

artículo científico publicado en 2012

Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1.

artículo científico publicado en 2016

Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase

artículo científico publicado en 2017

Discovery of Inhibitors of Anti-Apoptotic Protein A1

artículo científico publicado en 2012

Discovery of Potent and Highly Selective Inhibitors of GSK3b

artículo científico publicado en 2014

Discovery of a Small Molecule Activator of the Hypoxia Inducible Factor Pathway

Discovery of a Small-Molecule Probe for V-ATPase Function

artículo científico publicado en 2015

Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction

artículo científico publicado en 2013

Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis

artículo científico publicado en 2003

Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake

artículo científico publicado en 2015

Discovery of histone deacetylase 8 selective inhibitors ⬇️

artículo científico publicado el 2 de febrero de 2011

Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma

artículo científico publicado en 2016

Discovery of small molecule probe that shows anti-tubercular activity via Mtb bioA (DAPA synthase) enzyme inhibition

Discovery of small-molecule enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death.

artículo científico publicado en 2013

Discovery of small-molecule modulators of the Sonic Hedgehog pathway.

artículo científico publicado en 2013

Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes ⬇️

artículo científico publicado el 23 de diciembre de 2010

Distinct biological network properties between the targets of natural products and disease genes

artículo científico publicado en 2010

Divergent Synthesis and Real-Time Biological Annotation of Optically Active Tetrahydrocyclopenta[c]pyranone Derivatives

artículo científico publicado en 2016

Diversity synthesis of complex pyridines yields a probe of a neurotrophic signaling pathway

artículo científico publicado en 2008

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria

artículo científico publicado en 2011

Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform

artículo científico publicado en 2002

Diversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors

artículo científico publicado en 2014

Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease

artículo científico publicado en 2013

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

artículo científico publicado en 2016

Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents

artículo científico publicado en 2014

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

artículo científico publicado en 2003

Domain-specific Quantification of Prion Protein in Cerebrospinal Fluid by Targeted Mass Spectrometry

artículo científico publicado en 2019

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition.

artículo científico publicado en 2017

Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments

artículo científico publicado en 2016

Elucidation of the physiology of non-replicating, drug tolerant Mycobacterium tuberculosis with the aid of the small molecule probe ML338

scholarly article published 22 November 2013

Empirical Bayes analysis of quantitative proteomics experiments

artículo científico publicado en 2009

Erratum: Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

artículo científico publicado en 2012

Erratum: Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

artículo científico publicado en 2015

Erratum: Corrigendum: The promise and peril of chemical probes

artículo científico publicado en 2015

Evaluating drug targets through human loss-of-function genetic variation

artículo científico publicado en 2020

Evaluating potential drug targets through human loss-of-function genetic variation

artículo científico publicado en 2019

Evolutionarily conserved optimization of amino acid biosynthesis.

artículo científico publicado en 2007

Expanding Stereochemical and Skeletal Diversity Using Petasis Reactions and 1,3-Dipolar Cycloadditions ⬇️

artículo científico publicado el 26 de octubre de 2010

Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips

artículo científico publicado en 2004

Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors

scientific article published on January 2007

GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity

artículo científico publicado en 2012

Gene Expression-Based Screen for Parkinson's Disease Identifies GW8510 as a Neuroprotective Agent.

artículo científico publicado en 2016

Genetic basis of individual differences in the response to small-molecule drugs in yeast

article

Global approaches to chromatin

artículo científico publicado en 2002

Global nucleosome occupancy in yeast

artículo científico publicado en 2004

Gold(I)-catalyzed coupling reactions for the synthesis of diverse small molecules using the build/couple/pair strategy

artículo científico publicado en 2009

HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of β-catenin in human iPSC-derived neuronal cells

artículo científico publicado en 2015

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

artículo científico publicado en 2015

High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth

artículo científico publicado en 2018

High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission

artículo científico publicado en 2015

High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria

artículo científico publicado en 2016

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

artículo científico publicado en 2016

Histone Variant H2A.Z Marks the 5′ Ends of Both Active and Inactive Genes in Euchromatin

article

Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum

artículo científico publicado en 2009

Identification of Ald6p as the target of a class of small-molecule suppressors of FK506 and their use in network dissection

artículo científico publicado en 2004

Identification of Small Molecule Inhibitors that Suppress Cytokine-Induced Apoptosis in Human Pancreatic Islet Cells

Identification of Small Molecules that Selectively Inhibit Fluconazole-Resistant Candida Albicans in the Presence of Fluconazole but not in its Absence - Probe 3

Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection

artículo científico publicado en 2011

Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection - Probe 1

Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection - Probe 3

Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells - Probe 3

Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells—Probe 2

Identification of a chemically validated target in replicating and non-replicating Mycobacterium tuberculosis with the aid of a small molecule probe

scholarly article published 4 April 2015

Identification of a selective small molecule inhibitor of breast cancer stem cells

artículo científico publicado en 2012

Identification of a small molecule that selectively activates alpha-synuclein translational expression

artículo científico publicado en 2011

Identification of a small molecule that selectively inhibits alpha-synuclein translational expression

artículo científico publicado en 2011

Identification of a small-molecule inhibitor of class Ia PI3Ks with cell-based screening

artículo científico publicado en 2007

Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.

artículo científico publicado en 2015

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

artículo científico publicado en 2012

Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence

Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence - Probe 2

Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 1

Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 2

Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 3

Identification of small-molecule inhibitors of Trypansoma cruzi replication

artículo científico publicado en 2011

Identifying cellular targets of small-molecule probes and drugs with biochemical enrichment and SILAC.

artículo científico publicado en 2012

Identifying the proteins to which small-molecule probes and drugs bind in cells

scholarly article

Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport

artículo científico publicado en 2015

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

artículo científico publicado en 2016

Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile.

artículo científico publicado en 2016

Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis

artículo científico publicado en 2012

Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects

artículo científico publicado en 2016

Integrated genetic and pharmacologic interrogation of rare cancers

artículo científico publicado en 2016

Integration of Growth Factor and Nutrient Signaling

artículo científico publicado en 2003

Integration of growth factor and nutrient signaling: implications for cancer biology

artículo científico publicado en 2003

Integrative radiogenomic profiling of squamous cell lung cancer

scientific article published on 26 August 2013

KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine

artículo científico publicado en 2015

Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling

artículo científico publicado en 2015

Large-scale chemical dissection of mitochondrial function

artículo científico publicado en 2008

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells

artículo científico publicado en 2014

Ligand-Enabled β-Methylene C(sp3 )-H Arylation of Masked Aliphatic Alcohols

scientific article published on 12 February 2020

Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.

artículo científico publicado en 2014

MB-103DiSCoVERing INNOVATIVE THERAPIES: COMBINING GENETICALLY ACCURATE DISEASE MODELS OF MEDULLOBLASTOMA WITH ADVANCED IN SILICO ANALYSIS TO IDENTIFY NOVEL THERAPEUTIC TARGETS.

artículo científico publicado en 2016

ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans

artículo científico publicado en 2013

ML238: An Antimalarial Small Molecule of a Unique Structural Class

Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.

artículo científico publicado en 2012

Macrocycloadditions leading to conformationally restricted small molecules

artículo científico publicado en 2006

Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors

artículo científico publicado en 2004

Metabolomic adaptations and correlates of survival to immune checkpoint blockade

scientific article published on 25 September 2019

Methylation of Histone H3 K4 Mediates Association of the Isw1p ATPase with Chromatin

artículo científico publicado en 2018

Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin

artículo científico publicado en 2003

Methylation of histone H3 Lys 4 in coding regions of active genes

artículo científico publicado en 2002

Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway.

artículo científico publicado en 2006

Modular, Stereocontrolled Cβ–H/Cα–C Activation of Alkyl Carboxylic Acids

artículo científico publicado en 2019

Modular, stereocontrolled C-H/C-C activation of alkyl carboxylic acids

scientific article published on 17 April 2019

Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays

artículo científico publicado en 2003

Multimodal small-molecule screening for human prion protein binders

artículo científico publicado en 2020

Multiplex cytological profiling assay to measure diverse cellular states

artículo científico publicado en 2013

NAMPT is the cellular target of STF-31-like small-molecule probes

artículo científico publicado en 2014

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.

artículo científico publicado en 2015

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

artículo científico publicado en 2013

Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing

scientific article published on 18 October 2019

Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

artículo científico publicado en 2012

Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements

artículo científico publicado en 2005

Perturbational profiling of nanomaterial biologic activity

artículo científico publicado en 2008

Phosphorylation-Inducing Chimeric Small Molecules

artículo científico publicado en 2020

Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates

artículo científico publicado en 2011

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

scientific article published on 16 September 2020

Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints

scientific article published on 10 August 2020

Prion protein quantification in cerebrospinal fluid as a tool for prion disease drug development

article

Prion protein quantification in human cerebrospinal fluid as a tool for prion disease drug development

artículo científico publicado en 2019

Quantifying fitness distributions and phenotypic relationships in recombinant yeast populations

artículo científico publicado en 2007

Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections

artículo científico publicado en 2011

Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming

artículo científico publicado en 2014

RETRACTED: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

artículo científico publicado en 2011

RWEN: response-weighted elastic net for prediction of chemosensitivity of cancer cell lines

artículo científico publicado en 2018

Real-Time Biological Annotation of Synthetic Compounds.

artículo científico publicado en 2016

Recent achievements and current trajectories of diversity-oriented synthesis

artículo científico publicado en 2019

Regulation of ferroptotic cancer cell death by GPX4

artículo científico publicado en 2014

Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space

scientific article published on 01 November 2004

Renal medullary carcinomas depend upon loss and are sensitive to proteasome inhibition

scientific article published on 12 March 2019

Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

artículo científico publicado en 2018

Revealing complex traits with small molecules and naturally recombinant yeast strains

artículo científico publicado en 2006

Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine

artículo científico publicado en 2020

Ring-opening and ring-closing reactions of a shikimic acid-derived substrate leading to diverse small molecules

artículo científico publicado en 2007

Rpd3p relocation mediates a transcriptional response to rapamycin in yeast

artículo científico publicado en 2004

SIR1, an upstream component in auxin signaling identified by chemical genetics

artículo científico publicado en 2003

STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability

artículo científico publicado en 2012

Screen for Inhibitors of STK33 Kinase Activity

artículo científico publicado en 2014

Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 1

artículo científico publicado en 2011

Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 2

artículo científico publicado en 2012

Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.

artículo científico

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

artículo científico publicado en 2020

Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules

artículo científico publicado en 2013

Short synthesis of skeletally and stereochemically diverse small molecules by coupling petasis condensation reactions to cyclization reactions

artículo científico publicado en 2006

Signaling network model of chromatin

artículo científico publicado en 2002

Skeletal diversity in small-molecule synthesis using ligand-controlled catalysis.

artículo científico publicado en 2007

Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages

artículo científico publicado en 2007

Small molecule modulation of the human chromatid decatenation checkpoint

artículo científico publicado en 2003

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

artículo científico publicado en 2007

Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles ⬇️

artículo científico publicado el 18 de octubre de 2010

Small molecules, big players: the National Cancer Institute's Initiative for Chemical Genetics

artículo científico publicado en 2006

Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis.

artículo científico publicado en 2010

Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

scientific article published on 01 August 2019

Small-molecule control of cytokine function: new opportunities for treating immune disorders

artículo científico publicado en 2014

Small-molecule diversity using a skeletal transformation strategy

scientific article published on 01 June 2005

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics

artículo científico publicado en 2015

Small-molecule fluorophores to detect cell-state switching in the context of high-throughput screening

artículo científico publicado en 2008

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

artículo científico publicado en 2010

Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma

artículo científico publicado en 2005

Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

artículo científico publicado en 2017

Small-molecule reagents for cellular pull-down experiments

artículo científico publicado en 2008

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells

artículo científico publicado en 2014

Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.

artículo científico publicado en 2017

Small-molecule targeting of brachyury transcription factor addiction in chordoma

scientific article published on 21 January 2019

SpectralNET--an application for spectral graph analysis and visualization

artículo científico publicado en 2005

Stereochemical and skeletal diversity arising from amino propargylic alcohols

artículo científico publicado en 2010

Stereospecific Palladium-Catalyzed C-H Arylation of Pyroglutamic Acid Derivatives at the C3 Position Enabled by 8-Aminoquinoline as a Directing Group

artículo científico publicado en 2017

Structural Biasing Elements for In-Cell Histone Deacetylase Paralog Selectivity ⬇️

artículo científico publicado el 14 de mayo de 2003

Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines.

article by Manmohan Sharma et al published 12 January 2021 in Nature Communications

Structure-activity relationships of GPX4 inhibitor warheads

scientific article published on 10 September 2020

Synergistic Effects of Stereochemistry and Appendages on the Performance Diversity of a Collection of Synthetic Compounds

scientific article published on 06 September 2018

Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog

artículo científico publicado en 2009

Syntheses of stereochemically diverse nine-membered ring-containing biaryls

artículo científico publicado en 2004

Syntheses of α-pyrones using gold-catalyzed coupling reactions

artículo científico publicado en 2011

Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole

artículo científico publicado en 2009

Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold

artículo científico publicado en 2009

Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp3)-H Arylation

artículo científico publicado en 2017

Synthesis of calcineurin-resistant derivatives of FK506 and selection of compensatory receptors

artículo científico publicado en 2002

Synthesis of oxazocenones via gold(I)-catalyzed 8-endo-dig hydroalkoxylation of alkynamides

artículo científico publicado en 2015

Synthesis of piperlogs and analysis of their effects on cells

scientific article published on September 2013

Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs

artículo científico publicado en 2012

Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis

artículo científico publicado en 2014

Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

artículo científico publicado en 2021

Targeting Dependency on the GPX4 Lipid Peroxide Repair Pathway for Cancer Therapy.

artículo científico publicado en 2018

The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells

artículo científico publicado en 2011

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

artículo científico publicado en 2008

The NIH's role in accelerating translational sciences

artículo científico publicado en 2012

The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods

artículo científico publicado en 2016

The identification and characterization of non-reactive inhibitor of Keap1-Nrf2 interaction through HTS using a fluorescence polarization assay

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

artículo científico publicado en 2015

The landscape of cancer cell line metabolism

scientific article published on 08 May 2019

The promise and peril of chemical probes

artículo científico publicado en 2015

The use of chromatin immunoprecipitation assays in genome-wide analyses of histone modifications

artículo científico publicado en 2004

Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor

artículo científico publicado en 2008

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

artículo científico publicado en 2014

Towards Diversity-Oriented, Stereoselective Syntheses of Biaryl- or Bis(aryl)metal-Containing Medium Rings

article

Towards a treatment for genetic prion disease: trials and biomarkers

artículo científico publicado en 2020

Towards patient-based cancer therapeutics

artículo científico publicado en 2010

Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms

artículo científico publicado en 2017

US immigration order strikes against biotech.

artículo científico publicado en 2017

Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries

artículo científico publicado en 2009

Unifying principles of bifunctional, proximity-inducing small molecules

scientific article published on 20 March 2020

Using expression and genotype to predict drug response in yeast

artículo científico publicado en 2009

Using genome-wide transcriptional profiling to elucidate small-molecule mechanism

artículo científico publicado en 2005

Vector algebra in the analysis of genome-wide expression data

artículo científico publicado en 2002

Water-Compatible Cycloadditions of Oligonucleotide-Conjugated Strained Allenes for DNA-Encoded Library Synthesis

scientific article published on 08 April 2020

Whole Genome Amplification by T7-Based Linear Amplification of DNA (TLAD): I. CIP Treatment of Samples and Tailing Reaction with Terminal Transferase ⬇️

artículo científico publicado el 1 de mayo de 2008

Whole Genome Amplification by T7-Based Linear Amplification of DNA (TLAD): II. Second-Strand Synthesis and In Vitro Transcription ⬇️

artículo científico publicado el 1 de mayo de 2008

Whole Genome Amplification by T7-Based Linear Amplification of DNA (TLAD): III. Sample Purification ⬇️

artículo científico publicado el 1 de mayo de 2008

Whole Genome Amplification by T7-Based Linear Amplification of DNA (TLAD): Overview ⬇️

artículo científico publicado el 1 de mayo de 2008

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