Lista de obras -

2-Difluoromethylene-4-methylenepentanoic Acid, A Paradoxical Probe Able To Mimic the Signaling Role of 2-Oxoglutaric Acid in Cyanobacteria

scientific article published on 05 May 2011

3-Aryl-2-[1H-benzotriazol-1-yl]acrylonitriles: a novel class of potent tubulin inhibitors

artículo científico publicado en 2011

3D Homology Model of Sigma1 Receptor

artículo científico publicado en 2017

A 3D-pharmacophore model for sigma2 receptors based on a series of substituted benzo[d]oxazol-2(3H)-one derivatives

artículo científico publicado en 2010

A dual targeting dendrimer-mediated siRNA delivery system for effective gene silencing in cancer therapy

article

A self-assembling amphiphilic dendrimer nanotracer for SPECT imaging

scientific article published on 01 December 2019

Another brick in the wall. Validation of the σ1 receptor 3D model by computer-assisted design, synthesis, and activity of new σ1 ligands

artículo científico publicado en 2012

Antimycobacterial activity of new 3,5-disubstituted 1,3,4-oxadiazol-2(3H)-one derivatives. Molecular modeling investigations.

artículo científico publicado en 2009

Are two better than one? A novel double-mutant KIT in GIST that responds to Imatinib

artículo científico publicado en 2013

Chemical, pharmacological, and in vitro metabolic stability studies on enantiomerically pure RC-33 compounds: promising neuroprotective agents acting as σ₁ receptor agonists

artículo científico publicado en 2013

Copper(ii) binding to flexible triethanolamine-core PAMAM dendrimers: a combined experimental/in silico approach

artículo científico publicado en 2014

Direct Identification of α-Bisabolol Enantiomers in an Essential Oil Using a Combined Ion Mobility-Mass Spectrometry/Quantum Chemistry Approach

artículo científico publicado en 2020

Evolution from Covalent to Self-Assembled PAMAM-Based Dendrimers as Nanovectors for siRNA Delivery in Cancer by Coupled In Silico-Experimental Studies. Part I: Covalent siRNA Nanocarriers

artículo científico publicado en 2019

Evolution from Covalent to Self-Assembled PAMAM-Based Dendrimers as Nanovectors for siRNA Delivery in Cancer by Coupled in Silico-Experimental Studies. Part II: Self-Assembled siRNA Nanocarriers

scientific article published on 10 July 2019

Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3)

artículo científico publicado en 2015

Homology Model and Docking-Based Virtual Screening for Ligands of the σ1 Receptor.

artículo científico publicado en 2011

Identification of RC-33 as a potent and selective σ1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells. Part 2: g-Scale synthesis, physicochemical characterization and in vitro metabolic stability

artículo científico publicado en 2013

Identification, pharmacological evaluation and binding mode analysis of novel chromene and chromane based σ1 receptor ligands

artículo científico publicado en 2014

Imatinib response in two GIST patients carrying two hitherto functionally uncharacterized PDGFRA mutations: an imaging, biochemical and molecular modeling study

artículo científico publicado en 2011

Impact of siRNA overhangs for dendrimer-mediated siRNA delivery and gene silencing.

artículo científico publicado en 2013

Improving selectivity preserving affinity: New piperidine-4-carboxamide derivatives as effective sigma-1-ligands

scientific article published on 12 December 2014

In vitro and in silico studies of MDM2/MDMX isoforms predict Nutlin-3A sensitivity in well/de-differentiated liposarcomas

artículo científico publicado en 2013

Mimicking the 2-oxoglutaric acid signalling function using molecular probes: insights from structural and functional investigations

artículo científico publicado en 2014

Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells

artículo científico publicado en 2017

Mix and Match: Coassembly of Amphiphilic Dendrimers and Phospholipids Creates Robust, Modular, and Controllable Interfaces

artículo científico publicado en 2016

Molecular dynamics reveal BCR-ABL1 polymutants as a unique mechanism of resistance to PAN-BCR-ABL1 kinase inhibitor therapy.

artículo científico publicado en 2014

Nanomechanical DNA resonators for sensing and structural analysis of DNA-ligand complexes

artículo científico publicado en 2019

New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties

artículo científico publicado en 2019

Perceptions and Misconceptions in Molecular Recognition: Key Factors in Self-Assembling Multivalent (SAMul) Ligands/Polyanions Selectivity

scientific article published on 24 February 2020

Quinolizidine-Derived Lucanthone and Amitriptyline Analogues Endowed with Potent Antileishmanial Activity

artículo científico publicado en 2020

Rationalizing the F⋯S interaction discovered within a tetrafluorophenylazido-containing bola-phospholipid

artículo científico publicado en 2012

Self-Assembled Nanomicelles as Curcumin Drug Delivery Vehicles: Impact on Solitary Fibrous Tumor Cell Protein Expression and Viability

artículo científico publicado en 2018

Self-assembled multivalent (SAMul) ligand systems with enhanced stability in the presence of human serum

scientific article published on 01 August 2019

Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors

article published in the Proceedings of the National Academy of Sciences of the United States of America

Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma.

artículo científico publicado en 2014

Structural Requirements of 2-Oxoglutaric Acid Analogues To Mimic Its Signaling Function

scientific article published on 29 August 2013

Synergistic experimental/computational studies on arylazoenamine derivatives that target the bovine viral diarrhea virus RNA-dependent RNA polymerase.

artículo científico publicado en 2010

Synthesis and Structure-Affinity Relationships of Spirocyclic Benzopyrans with Exocyclic Amino Moiety

artículo científico publicado en 2019

Synthesis and receptor binding studies of some new arylcarboxamide derivatives as sigma-1 ligands

artículo científico publicado en 2014

Synthesis, biological evaluation, and three-dimensional in silico pharmacophore model for sigma(1) receptor ligands based on a series of substituted benzo[d]oxazol-2(3H)-one derivatives

artículo científico publicado en 2009

Through the open door: Preferential binding of dasatinib to the active form of BCR-ABL unveiled by in silico experiments

artículo científico publicado en 2013

Unchain My Blood: Lessons Learned from Self-Assembled Dendrimers as Nanoscale Heparin Binders

scientific article published on 20 August 2019

β-Catenin in desmoid-type fibromatosis: deep insights into the role of T41A and S45F mutations on protein structure and gene expression.

artículo científico publicado en 2017

Lista de obras de

2-Difluoromethylene-4-methylenepentanoic Acid, A Paradoxical Probe Able To Mimic the Signaling Role of 2-Oxoglutaric Acid in Cyanobacteria

3-Aryl-2-[1H-benzotriazol-1-yl]acrylonitriles: a novel class of potent tubulin inhibitors

3D Homology Model of Sigma1 Receptor

A 3D-pharmacophore model for sigma2 receptors based on a series of substituted benzo[d]oxazol-2(3H)-one derivatives

A dual targeting dendrimer-mediated siRNA delivery system for effective gene silencing in cancer therapy

A self-assembling amphiphilic dendrimer nanotracer for SPECT imaging

Another brick in the wall. Validation of the σ1 receptor 3D model by computer-assisted design, synthesis, and activity of new σ1 ligands

Antimycobacterial activity of new 3,5-disubstituted 1,3,4-oxadiazol-2(3H)-one derivatives. Molecular modeling investigations.

Are two better than one? A novel double-mutant KIT in GIST that responds to Imatinib

Chemical, pharmacological, and in vitro metabolic stability studies on enantiomerically pure RC-33 compounds: promising neuroprotective agents acting as σ₁ receptor agonists

Copper(ii) binding to flexible triethanolamine-core PAMAM dendrimers: a combined experimental/in silico approach

Direct Identification of α-Bisabolol Enantiomers in an Essential Oil Using a Combined Ion Mobility-Mass Spectrometry/Quantum Chemistry Approach

Evolution from Covalent to Self-Assembled PAMAM-Based Dendrimers as Nanovectors for siRNA Delivery in Cancer by Coupled In Silico-Experimental Studies. Part I: Covalent siRNA Nanocarriers

Evolution from Covalent to Self-Assembled PAMAM-Based Dendrimers as Nanovectors for siRNA Delivery in Cancer by Coupled in Silico-Experimental Studies. Part II: Self-Assembled siRNA Nanocarriers

Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3)

Homology Model and Docking-Based Virtual Screening for Ligands of the σ1 Receptor.

Identification of RC-33 as a potent and selective σ1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells. Part 2: g-Scale synthesis, physicochemical characterization and in vitro metabolic stability

Identification, pharmacological evaluation and binding mode analysis of novel chromene and chromane based σ1 receptor ligands

Imatinib response in two GIST patients carrying two hitherto functionally uncharacterized PDGFRA mutations: an imaging, biochemical and molecular modeling study

Impact of siRNA overhangs for dendrimer-mediated siRNA delivery and gene silencing.

Improving selectivity preserving affinity: New piperidine-4-carboxamide derivatives as effective sigma-1-ligands

In vitro and in silico studies of MDM2/MDMX isoforms predict Nutlin-3A sensitivity in well/de-differentiated liposarcomas

Mimicking the 2-oxoglutaric acid signalling function using molecular probes: insights from structural and functional investigations

Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells

Mix and Match: Coassembly of Amphiphilic Dendrimers and Phospholipids Creates Robust, Modular, and Controllable Interfaces

Molecular dynamics reveal BCR-ABL1 polymutants as a unique mechanism of resistance to PAN-BCR-ABL1 kinase inhibitor therapy.

Nanomechanical DNA resonators for sensing and structural analysis of DNA-ligand complexes

New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties

Perceptions and Misconceptions in Molecular Recognition: Key Factors in Self-Assembling Multivalent (SAMul) Ligands/Polyanions Selectivity

Quinolizidine-Derived Lucanthone and Amitriptyline Analogues Endowed with Potent Antileishmanial Activity

Rationalizing the F⋯S interaction discovered within a tetrafluorophenylazido-containing bola-phospholipid

Self-Assembled Nanomicelles as Curcumin Drug Delivery Vehicles: Impact on Solitary Fibrous Tumor Cell Protein Expression and Viability

Self-assembled multivalent (SAMul) ligand systems with enhanced stability in the presence of human serum

Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors

Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma.

Structural Requirements of 2-Oxoglutaric Acid Analogues To Mimic Its Signaling Function

Synergistic experimental/computational studies on arylazoenamine derivatives that target the bovine viral diarrhea virus RNA-dependent RNA polymerase.

Synthesis and Structure-Affinity Relationships of Spirocyclic Benzopyrans with Exocyclic Amino Moiety

Synthesis and receptor binding studies of some new arylcarboxamide derivatives as sigma-1 ligands

Synthesis, biological evaluation, and three-dimensional in silico pharmacophore model for sigma(1) receptor ligands based on a series of substituted benzo[d]oxazol-2(3H)-one derivatives

Through the open door: Preferential binding of dasatinib to the active form of BCR-ABL unveiled by in silico experiments

Unchain My Blood: Lessons Learned from Self-Assembled Dendrimers as Nanoscale Heparin Binders

β-Catenin in desmoid-type fibromatosis: deep insights into the role of T41A and S45F mutations on protein structure and gene expression.