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A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes

artículo científico publicado en 2015

A biobank of patient-derived pediatric brain tumor models

artículo científico publicado en 2018

A family of drug transporters: the multidrug resistance-associated proteins.

artículo científico publicado en 2000

A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors

artículo científico publicado en 2017

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

artículo científico publicado en 1997

A single supratentorial high-grade neuroepithelial tumor with two distinct BCOR mutations, exceptionally long complete remission and survival

scientific article published on 08 May 2020

AI-08SUBGROUP-SPECIFIC DEREGULATION OF COAGULATION AND ANGIOGENIC GENE EXPRESSION PROFILES IN MEDULLOBLASTOMA- EVIDENCE FOR CROSS-TALK BETWEEN GROWTH FACTOR AND COAGULATION PATHWAYS

AT-03ATYPICAL TERATOID/RHABDOID TUMOUR IS A GENETICALLY HOMOGENEOUS BUT EPIGENETICALLY HETEROGENEOUS DISEASE THAT IS DEFINED BY SUBGROUP SPECIFIC SUPER-ENHANCERS.

artículo científico publicado en 2015

AT-10ATYPICAL TERATOID RHABDOID TUMORS AND POORLY DIFFERENTIATED CHORDOMAS: DISTINCT MOLECULAR ENTITIES WITH SMARCB1/INI1 LOSS AND DISMAL PROGNOSIS.

artículo científico publicado en 2016

AT-11CRIBRIFORM NEUROEPITHELIAL TUMOR (CRINET): MOLECULAR CHARACTERIZATION OF A SMARCB1-DEFICIENT NON-RHABDOID TUMOR WITH FAVORABLE LONG-TERM OUTCOME.

artículo científico publicado en 2016

AT-13THE EU-RHAB EXPERIENCE: CLINICAL, GENETIC AND SURVIVAL DATA DEFINE A STANDARD OF CARE AND ARE THE BASIS FOR CLINICAL TRIALS.

artículo científico publicado en 2016

ATRT-05. USING DROSOPHILA TO EXPLORE THE FUNCTIONAL RELEVANCE OF GENES AFFECTED BY EPIGENETIC ALTERATIONS IN ATYPICAL TERATOID/RHABDOID TUMORS (AT/RT)

ATRT-06. CLINICAL AND MOLECULAR RISK FACTORS IN CHILDREN WITH ATYPICAL TERATOID/RHABDOID TUMOUR (AT/RT) - EVIDENCE FROM THE EU-RHAB REGISTRY

ATRT-07. MURINE SOX2-POSITIVE EARLY PRECURSOR CELLS GIVE RISE TO RHABDOID TUMORS WITH FEATURES OF THE HUMAN ATRT-MYC GROUP.

artículo científico publicado en 2018

ATRT-07. TARGETING PRIMARY CILIOGENESIS IN ATYPICAL TERATOID/RHABDOID TUMORS

artículo científico publicado en 2019

ATRT-09. CHROMATIN SEGMENTATION ANALYSES IN ATYPICAL TERATOID/RHABDOID TUMORS REVEAL H3K27ME3-MEDIATED EPIGENETIC SILENCING OF TUMOR SUPPRESSOR GENES AND IDENTIFY A NOVEL ROLE OF EZH2, ASSOCIATED WITH ACTIVE CHROMATIN.

artículo científico publicado en 2017

ATRT-09. INTEGRATIVE ANALYSES OF GENE REGULATORY LANDSCAPES REVEAL RHABDOID TUMOR SUBGROUPS WITH POSSIBLE IMMUNE MODULATION THROUGH EPIGENETIC DYSREGULATION

artículo científico publicado en 2019

ATRT-09. WHOLE GENOME AND EPIGENOME CHARACTERIZATION LINKS ATRT-MYC TO A SUBGROUP OF RENAL RHABDOID TUMORS

artículo científico publicado en 2018

ATRT-11. MOLECULAR SUBGROUPS OF ATYPICAL TERATOID/RHABDOID TUMOR (ATRT): TOWARDS A CONSENSUS

artículo científico publicado en 2018

ATRT-21. COMPARATIVE INTEGRATIVE ANALYSIS OF PRIMARY AND RELAPSED ATYPICAL TERATOID/RHABDOID TUMORS (AT/RTs)

artículo científico publicado en 2018

ATRT-24. CHROMATIN SEGMENTATION IN ATRT REVEALS AN IMPORTANT ROLE FOR RESIDUAL SWI/SNF MEMBERS

ATRT-34. TARGETING PRIMARY CILIOGENESIS IN ATYPICAL TERATOID/RHABDOID TUMORS

artículo científico publicado en 2018

ATRT-SHH comprises three molecular subgroups with characteristic clinical and histopathological features and prognostic significance

artículo científico publicado en 2022

ATYPICAL TERATOID RHABDOID TUMOUR

Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling

artículo científico publicado en 2018

Aberrant immunostaining pattern of the CD24 glycoprotein in clinical samples and experimental models of pediatric medulloblastomas

artículo científico publicado en 2015

Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.

artículo científico publicado en 2012

Abstract 3089: (Epi)genetic profiling enables molecular re-classification of CNS-primitive neuroectodermal tumors

Abstract 3094: Epigenetic classification of ependymal brain tumors across age groups

Abstracts

article by L. Bie et al published 1 April 2013 in Neuro-Oncology

Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016.

artículo científico publicado en 2017

Active medulloblastoma enhancers reveal subgroup-specific cellular origins

artículo científico publicado en 2016

Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles

artículo científico publicado en 2016

Age and DNA-methylation subgroup as potential independent risk factors for treatment stratification in children with Atypical Teratoid/Rhabdoid Tumors (ATRT)

artículo científico publicado en 2019

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

scientific article published on 11 March 2020

Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines ⬇️

artículo científico publicado el 15 de agosto de 1997

Analysis of the antiproliferative effects of 3-deazaneoplanocin A in combination with standard anticancer agents in rhabdoid tumor cell lines

artículo científico publicado en 2015

Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.

artículo científico publicado en 1999

Arhgap36-dependent activation of Gli transcription factors

artículo científico publicado en 2014

Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information.

artículo científico publicado en 2018

Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1.

artículo científico publicado en 2014

Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

artículo científico publicado en 2016

Atypical teratoid/rhabdoid tumor arising in a malignant glioma

artículo científico publicado en 2016

Atypical teratoid/rhabdoid tumors (ATRTs) with SMARCA4 mutation are molecularly distinct from SMARCB1-deficient cases

artículo científico publicado en 2020

Author Correction: The landscape of genomic alterations across childhood cancers

artículo científico publicado en 2018

BAF complexes facilitate decatenation of DNA by topoisomerase IIα

artículo científico publicado en 2013

Biological and clinical heterogeneity of MYCN-amplified medulloblastoma.

artículo científico publicado en 2011

Brain Tumor Epidemiology - A Hub within Multidisciplinary Neuro-oncology. Report on the 15th Brain Tumor Epidemiology Consortium (BTEC) Annual Meeting, Vienna, 2014.

artículo científico publicado en 2015

CBMT-05. ROLE OF THE let7-eEF2K AXIS IN MYC-DRIVEN MEDULLOBLASTOMA ADAPTATION TO NUTRIENT DEPRIVATION

CS-16 * THE eEF2 KINASE IS CRITICAL FOR BRAIN TUMOURS ADAPTATION TO METABOLIC STRESS

CSIG-15. PROTEOMIC AND PHOSPHOPROTEOMIC ANALYSIS OF HUMAN MEDULLOBLASTOMA REVEALS DISTINCT ACTIVATED PATHWAYS BETWEEN SUBGROUPS

Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme.

artículo científico publicado en 2017

Coagulation and angiogenic gene expression profiles are defined by molecular subgroups of medulloblastoma: evidence for growth factor-thrombin cross-talk

artículo científico publicado en 2014

Combined BRD4 and CDK9 inhibition as a new therapeutic approach in malignant rhabdoid tumors

artículo científico publicado en 2017

Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities

artículo científico publicado en 2015

Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation

scientific article published on 27 December 2018

Corrigendum to: Molecular subgrouping of atypical teratoid/rhabdoid tumors-a reinvestigation and current consensus

artículo científico publicado en 2020

Corrigendum: Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

artículo científico publicado en 2012

Coverage bias and sensitivity of variant calling for four whole-genome sequencing technologies

artículo científico publicado en 2013

Cribriform neuroepithelial tumor: molecular characterization of a SMARCB1-deficient non-rhabdoid tumor with favorable long-term outcome

artículo científico publicado en 2016

Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells

artículo científico publicado en 2013

Cytogenetic prognostication within medulloblastoma subgroups

artículo científico publicado en 2014

DNA methylation profiling is a method of choice for molecular verification of pediatric WNT-activated medulloblastomas

artículo científico publicado en 2019

DNA methylation-based classification of central nervous system tumours.

artículo científico publicado en 2018

DNA methylation-based classification of ependymomas in adulthood: implications for diagnosis and treatment

artículo científico publicado en 2018

DNA-methylation profiling discloses significant advantages over NanoString method for molecular classification of medulloblastoma

artículo científico publicado en 2017

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

artículo científico publicado en 2014

Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation.

artículo científico publicado en 2018

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

scientific article published in Nature Communications

Defining the molecular features of radiation-induced glioma: A systematic review and meta-analysis

publication published on 01 January 2021

Desmoplastic myxoid tumor, SMARCB1-mutant: clinical, histopathological and molecular characterization of a pineal region tumor encountered in adolescents and adults

scientific article published on 16 November 2019

Desmoplastic/nodular medulloblastomas (DNMB) and medulloblastomas with extensive nodularity (MBEN) disclose similar epigenetic signatures but different transcriptional profiles

artículo científico publicado en 2019

Diagnostics of Paediatric Supratentorial RELA Ependymomas: Integration of information from Histopathology, Genetics, DNA Methylation and Imaging

article

Differential expression and methylation of brain developmental genes define location-specific subsets of pilocytic astrocytoma

artículo científico

Diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC) - a molecularly defined glioneuronal CNS tumour class displaying recurrent monosomy 14

artículo científico publicado en 2019

Dissecting the genomic complexity underlying medulloblastoma

artículo científico publicado en 2012

Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system

artículo científico publicado en 2013

Divergent clonal selection dominates medulloblastoma at recurrence

artículo científico publicado en 2016

Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth

artículo científico publicado en 2020

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

artículo científico publicado en 2012

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA

artículo científico publicado en 1998

Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma.

artículo científico publicado en 1999

EMBR-01. MOLECULAR AND CLINICAL HETEROGENEITY IN HISTOLOGICALLY-DIAGNOSED CNS-PNET PATIENTS PROSPECTIVELY TREATED AS A SINGLE ENTITY: A REPORT FROM THE CHILDREN’S ONCOLOGY GROUP ACNS0332 TRIAL.

artículo científico publicado en 2018

EMBR-04. WHAT THE FOX SAY? A MOLECULAR ANALYSIS OF FOXR2 IN PEDIATRIC BRAIN TUMORS.

artículo científico publicado en 2018

EMBR-10. GENOMIC COMPLEXITY AND EVOLUTION OF EMBRYONAL TUMORS WITH MULTILAYERED ROSETTES (ETMR)

EMBR-12. IMPROVED DIAGNOSTIC ALGORITHM FOR DIFFERENTIAL DIAGNOSTICS OF CNS EMBRYONAL TUMORS (FORMER CNS-PNET) BY NEUROPATHOLOGICAL RE-EVALUATION OF 256 CASES AND CROSSVALIDATION BY METHYLATION CLASSIFICATION

EMBR-15. DIAGNOSTIC RE-EVALUATION AND POOLED CLINICAL DATA ANALYSIS OF PATIENTS WITH PREVIOUS DIAGNOSIS OF CNS-PNET

EP-03MOLECULAR CLASSIFICATION OF EPENDYMAL TUMORS ACROSS ALL CNS COMPARTMENTS, HISTOPATHOLOGICAL GRADES AND AGE GROUPS.

artículo científico publicado en 2015

EPEN-04. CXorf67 MIMICS ONCOGENIC HISTONE H3 K27M MUTATIONS AND FUNCTIONS AS INTRINSIC INHIBITOR OF PRC2 FUNCTION IN AGGRESSIVE POSTERIOR FOSSA EPENDYMOMA

artículo científico publicado en 2019

EPEN-05. CXorf67 EXPRESSION IS A PUTATIVE DRIVER OF PFA EPENDYMOMA

EPEN-06. YAP1 SUBGROUP SUPRATENTORIAL EPENDYMOMA REQUIRES TEAD AND NUCLEAR FACTOR I-MEDIATED TRANSCRIPTIONAL PROGRAMS FOR TUMORIGENESIS

artículo científico publicado en 2019

EPEN-07. OVEREXPRESSION AND MUTATIONS OF CXORF67 IN ‘INFANT-TYPE’ POSTERIOR FOSSA TYPE-A (PFA) EPENDYMOMAS

article published in 2018

EPEN-10. ROLE OF DNA METHYLATION ANALYSIS IN RECURRENT PAEDIATRIC EPENDYMOMA.

artículo científico publicado en 2018

EPEN-23. MOLECULAR HETEROGENEITY AMONG PEDIATRIC POSTERIOR FOSSA EPENDYMOMA

EPEN-24. YAP1 FUSION PROTEINS MEDIATE ONCOGENIC ACTIVITY IN EPENDYMOMA VIA INTERACTION WITH TEAD TRANSCRIPTION FACTORS.

artículo científico publicado en 2018

EPEN-28. HETEROGENEITY WITHIN THE PFB EPENDYMOMA SUBGROUP.

artículo científico publicado en 2018

EPENDYMOMA

article

EPIG-04THE CHROMATIN LANDSCAPE OF MEDULLOBLASTOMA.

artículo científico publicado en 2015

EPN-07IMPACT OF CHROMOSOMAL ABERRATIONS AND MOLECULAR SUBTYPE ON TELOMERASE ACTIVATION IN PEDIATRIC EPENDYMOMA.

artículo científico publicado en 2016

EPN-12PEDIATRIC SUPRATENTORIAL EPENDYMOMA: COMPARISON BETWEEN IMMUNOHISTOCHEMISTRY, FISH AND DNA METHYLATION ANALYSIS FOR RELA REARRANGEMENT AND HISTOLOGICAL CORRELATION.

artículo científico publicado en 2016

EPN-30YAP1-MAMLD1 FUSIONS ALONE ARE SUFFICIENT TO FORM SUPRATENTORIAL EPENDYMOMA-LIKE TUMORS IN MICE.

artículo científico publicado en 2016

EPN-31MOLECULAR REFINEMENT OF PEDIATRIC POSTERIOR FOSSA EPENDYMOMA.

artículo científico publicado en 2016

EPN-34EPIGENOMIC ANALYSIS OF EPENDYMAL TUMORS IDENTIFIES SUBGROUP SPECIFIC ENHANCERS CONTROLLING DISTINCT REGULATORY CIRCUITRIES.

artículo científico publicado en 2016

EPND-01. THE ACTIVE REGULATORY LANDSCAPE OF EPENDYMAL TUMORS.

artículo científico publicado en 2017

EPND-02. GENOMIC COPY NUMBER ALTERATIONS IN EPENDYOMOMA.

artículo científico publicado en 2017

EPND-07. MOLECULAR HETEROGENEITY AMONG PEDIATRIC POSTERIOR FOSSA EPENDYMOMA.

artículo científico publicado en 2017

EPND-13. YAP1-MAMLD1 FUSIONS ALONE ARE SUFFICIENT TO FORM SUPRATENTORIAL EPENDYMOMA-LIKE TUMORS IN MICE.

artículo científico publicado en 2017

ETMR-like infantile cerebellar embryonal tumors in the extended morphologic spectrum of DICER1-related tumors

scientific article published on 16 November 2018

ETMR: a tumor entity in its infancy

scientific article published on 29 June 2020

EZH2-regulated DAB2IP is a medulloblastoma tumor suppressor and a positive marker for survival

artículo científico publicado en 2012

EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma

artículo científico publicado en 2019

Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity

artículo científico publicado en 2013

Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

scientific article published on 13 June 2019

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

artículo científico publicado en 2014

Epidemiology, molecular classification and WHO grading of ependymoma

artículo científico publicado en 2017

Epigenetic Silencing of DKK3 in medulloblastoma.

artículo científico publicado en 2013

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

artículo científico publicado en 2014

Epithelioid glioblastomas stratify into established diagnostic subsets upon integrated molecular analysis.

artículo científico publicado en 2017

Erratum: Corrigendum: Signatures of mutational processes in human cancer

artículo científico publicado en 2013

Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation.

artículo científico publicado en 2017

Evaluation of age-dependent treatment strategies for children and young adults with pineoblastoma: analysis of pooled European Society for Paediatric Oncology (SIOP-E) and US Head Start data.

artículo científico publicado en 2016

Evaluation of the similarity of gene expression data estimated with SAGE and Affymetrix GeneChips

artículo científico publicado en 2005

Expression of BARHL1 in medulloblastoma is associated with prolonged survival in mice and humans

artículo científico publicado en 2011

Extensive Molecular and Clinical Heterogeneity in Patients With Histologically Diagnosed CNS-PNET Treated as a Single Entity: A Report From the Children's Oncology Group Randomized ACNS0332 Trial

artículo científico publicado en 2018

FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma

artículo científico publicado en 2016

FORETINIB IS EFFECTIVE THERAPY FOR METASTATIC SONIC HEDGEHOG MEDULLOBLASTOMA.

artículo científico publicado en 2014

FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma

artículo científico publicado en 2011

Fanconi anemia gene mutations are not involved in sporadic Wilms tumor

scientific article published on 01 October 2010

Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.

artículo científico publicado en 2014

Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations

artículo científico publicado en 2012

Full transcriptome analysis of rhabdomyosarcoma, normal, and fetal skeletal muscle: statistical comparison of multiple SAGE libraries

artículo científico publicado en 2005

Functional loss of a noncanonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation

artículo científico publicado en 2020

Functional precision medicine identifies new therapeutic candidates for medulloblastoma

artículo científico publicado en 2020

Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors

scientific article published on 16 November 2018

GE-07DNA METHYLATION IN MEDULLOBLASTOMA AND MOLECULAR DIAGNOSTICS OF BRAIN TUMORS.

artículo científico publicado en 2015

GENE-02. CHROMOSOME CONFORMATION ANALYSIS OF EPENDYMOMA IDENTIFIES PUTATIVE TUMOR DEPENDENCY GENES ACTIVATED BY DISTAL ONCOGENIC ENHANCERS

artículo científico publicado en 2019

Gain of 1q As a Prognostic Biomarker in Wilms Tumors (WTs) Treated With Preoperative Chemotherapy in the International Society of Paediatric Oncology (SIOP) WT 2001 Trial: A SIOP Renal Tumours Biology Consortium Study

artículo científico publicado en 2016

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

artículo científico publicado en 2014

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

artículo científico publicado en 2012

Genomic and transcriptomic analyses match medulloblastoma mouse models to their human counterparts

artículo científico publicado en 2014

Genomic imbalances in rhabdomyosarcoma cell lines affect expression of genes frequently altered in primary tumors: an approach to identify candidate genes involved in tumor development

artículo científico publicado en 2009

Germline Elongator mutations in Sonic Hedgehog medulloblastoma

scientific article published on 01 April 2020

Glial papillary tumour of the spinal cord with SMARCB1/INI1-loss and favourable long-term outcome

artículo científico publicado en 2017

HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment.

artículo científico publicado en 2012

HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma

artículo científico publicado en 2016

HGNET-BCOR Tumors of the Cerebellum: Clinicopathologic and Molecular Characterization of 3 Cases

artículo científico publicado en 2017

Heterogeneity within the PF-EPN-B ependymoma subgroup

article

High impact of miRNA-4521 on FOXM1 expression in medulloblastoma

artículo científico publicado en 2019

Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity

artículo científico publicado en 2015

Histone deacetylase 10 promotes autophagy-mediated cell survival.

artículo científico publicado en 2013

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma

artículo científico publicado en 2012

Hypermutation of the inactive X chromosome is a frequent event in cancer

artículo científico publicado en 2013

ICGC PedBrain - dissecting the genomic complexity underlying medulloblastoma using whole-genome sequencing.

artículo científico publicado en 2012

Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration

scientific article published on 07 November 2019

Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells

artículo científico publicado en 2019

Identification of genes involved in the biology of atypical teratoid/rhabdoid tumours using Drosophila melanogaster

artículo científico publicado en 2014

Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome

artículo científico publicado en 2017

Inhibition of Rho-Associated Kinase Suppresses Medulloblastoma Growth

artículo científico publicado en 2019

Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2-mediated transport

artículo científico publicado en 2000

Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers

artículo científico publicado en 2015

Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features

artículo científico publicado en 2008

Integrated molecular analysis of adult sonic hedgehog (SHH)-activated medulloblastomas reveals two clinically relevant tumor subsets with VEGFA as potent prognostic indicator

artículo científico publicado en 2021

Integrated molecular characterization of IDH-mutant glioblastomas

artículo científico publicado en 2018

Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome

artículo científico publicado en 2011

Intraocular Medulloepitheliomas and Embryonal Tumors With Multilayered Rosettes of the Brain: Comparative Roles of LIN28A and C19MC.

artículo científico publicado en 2015

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.

artículo científico publicado en 2018

Joint binding of OTX2 and MYC in promotor regions is associated with high gene expression in medulloblastoma

artículo científico publicado en 2011

K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

artículo científico publicado en 2012

Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization

artículo científico publicado en 2015

LGG-11. REGULATION OF ONCOGENE-INDUCED SENESCENCE IN PILOCYTIC ASTROCYTOMA.

artículo científico publicado en 2018

LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR)

artículo científico publicado en 2012

Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors

scientific article published on 27 April 2020

Long-term survival in a case of ETANTR with histological features of neuronal maturation after therapy

artículo científico publicado en 2015

Loss of Smarc proteins impairs cerebellar development

artículo científico publicado en 2014

Low-dose Actinomycin-D treatment re-establishes the tumoursuppressive function of P53 in RELA-positive ependymoma

artículo científico publicado en 2016

MB-08MOLECULAR (RE-)CLASSIFICATION OF CNS-PRIMITIVE NEUROECTODERMAL TUMORS.

artículo científico publicado en 2015

MB-18DYSFUNCTION OF THE CHROMATIN REMODELER Chd7 CAUSES ABNORMAL CEREBELLAR DEVELOPMENT AND ACCELERATES MEDULLOBLASTOMA FORMATION.

artículo científico publicado en 2016

MB-46PROGNOSTIC RELEVANCE OF EPIGENETIC/BIOLOGICAL SUBGROUPS AND MYCC/MYCN GENE AMPLIFICATION IN A HOMOGENOUSLY TREATED METASTATIC MEDULLOBLASTOMA HIT2000 COHORT AGED 4-21 YEARS.

artículo científico publicado en 2016

MB-57INTERACTION OF HDAC2 AND MYC IN GROUP 3 MEDULLOBLASTOMA - A NOVEL THERAPEUTIC TARGET.

artículo científico publicado en 2016

MBCL-21. EARLY CHILDHOOD MEDULLOBLASTOMA: SUBGROUP-SPECIFIC SURVIVAL IN PATIENTS TREATED WITH SYSTEMIC CHEMOTHERAPY AND INTRAVENTRICULAR MTX TO AVOID CRANIOSPINAL RADIOTHERAPY

MBCL-28. PREDISPOSITION OF WNT-ACTIVATED MEDULLOBLASTOMA FOR PRIMARY INTRATUMORAL HEMORRHAGE

MBCL-40. UNFAVORABLE CLINICAL COURSE OF A WNT-ACTIVATED MEDULLOBLASTOMA

artículo científico publicado en 2018

MBCL-42. SECOND GENERATION MOLECULAR SUBGROUPING OF MEDULLOBLASTOMA: TOWARDS A WORKING CONSENSUS OF GROUP 3/4 SUBTYPES

MBCL-44. THE MOLECULAR AND CLINICAL LANDSCAPE OF INFANT MEDULLOBLASTOMA (iMB): RESULTS AND MOLECULAR ANALYSIS FROM A PROSPECTIVE, MULTICENTER PHASE II TRIAL (SJYC07)

MBRS-05. A p53 INDEPENDENT MOUSE MODEL OF GROUP 3 MEDULLOBLASTOMA

MBRS-07. BCOR LOSS IMPACTS SHH MEDULLOBLASTOMA FORMATION VIA TRANSCRIPTIONAL UP-REGULATION OF

MBRS-12. INTERFERENCE WITH THE FUNCTION OF MYC IN GROUP 3 MEDULLOBLASTOMA.

artículo científico publicado en 2018

MBRS-33. RNA-SEQUENCING OF MEDULLOBLASTOMA PATIENT-DERIVED ORTHOTOPIC XENOGRAFT (PDOX) MODELS ENABLES IDENTIFICATION OF BOTH TUMOR AND MICROENVIRONMENT SPECIFIC BIOMARKERS

MBRS-57. TARGETING METABOLIC ADAPTATION IN MYC/MYCN AMPLIFIED PEDIATRIC MEDULLOBLASTOMA AND NEUROBLASTOMA

MBRS-65. CHEMI-GENOMIC ANALYSIS OF PATIENT-DERIVED XENOGRAFTS TO IDENTIFY PERSONALIZED THERAPIES FOR MEDULLOBLASTOMA.

artículo científico publicado en 2018

MEDU-11. MOLECULAR CHARACTERIZATION OF ETMRs REVEALS A ROLE FOR R-LOOP MEDIATED CHROMOSOMAL INSTABILITY

artículo científico publicado en 2019

MEDU-17. HIGH IMPACT OF miRNA-4521 ON FOXM1 EXPRESSION IN MEDULLOBLASTOMA

MEDU-20. TARGETING OF MYC BY HDAC INHIBITION IN MYC AMPLIFIED GROUP 3 MEDULLOBLASTOMA.

artículo científico publicado en 2017

MEDU-21. LOSS OF THE TRANSCRIPTIONAL CO-REPRESSOR BCOR LEADS TO OVEREXPRESSION OF THE GROWTH FACTOR IGF2 AND SHH MEDULLOBLASTOMA TUMOR FORMATION

MEDULLOBLASTOMA

MEDULLOBLASTOMA

MOLECULAR (RE-)CLASSIFICATION OF CNS-PRIMITIVE NEUROECTODERMAL TUMORS.

artículo científico publicado en 2014

MPTH-15MOLECULAR RECLASSIFICATION OF CNS-PRIMITIVE NEUROECTODERMAL TUMORS INTO WELL-KNOWN AND NOVEL TUMOR ENTITIES.

artículo científico publicado en 2015

MPTH-26MOLECULAR REFINEMENT OF PEDIATRIC POSTERIOR FOSSA EPENDYMOMA.

artículo científico publicado en 2015

MRI Features of Histologically Diagnosed Supratentorial Primitive Neuroectodermal Tumors and Pineoblastomas in Correlation with Molecular Diagnoses and Outcomes: A Report from the Children's Oncology Group ACNS0332 Trial

scientific article published on 10 October 2019

MRP3, an organic anion transporter able to transport anti-cancer drugs

artículo científico publicado en 1999

MYC Drives Group 3 Medulloblastoma through Transformation of Sox2+ Astrocyte Progenitor Cells

artículo científico publicado en 2019

MYCN amplification drives an aggressive form of spinal ependymoma

scientific article published on 14 August 2019

Magnetic resonance imaging surrogates of molecular subgroups in atypical teratoid / rhabdoid tumor (ATRT)

artículo científico publicado en 2018

Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group.

artículo científico publicado en 2013

Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress

artículo científico publicado en 2016

Medulloblastomics: the end of the beginning

scientific article published on December 2012

Medulloepithelioma with peculiar clinical presentation, stem cell phenotype and aberrant DNA-methylation profile.

artículo científico publicado en 2015

Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study.

artículo científico publicado en 2013

MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma.

artículo científico publicado en 2011

Mismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours

artículo científico publicado en 2012

Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells

artículo científico publicado en 2020

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

artículo científico publicado en 2015

Molecular analyses reveal close similarities between small cell carcinoma of the ovary, hypercalcemic type and atypical teratoid/rhabdoid tumor

artículo científico publicado en 2015

Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation

artículo científico publicado en 2021

Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours

artículo científico publicado en 2019

Molecular characterization of histopathological ependymoma variants

scientific article published on 02 November 2019

Molecular characterization of medulloblastomas with extensive nodularity (MBEN).

artículo científico publicado en 2018

Molecular diagnostics of CNS embryonal tumors

artículo científico publicado en 2010

Molecular dissection of ependymomas

artículo científico publicado en 2015

Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas

artículo científico publicado en 2018

Molecular progression of SHH-activated medulloblastomas

scientific article published on 27 April 2019

Molecular risk stratification of medulloblastoma patients based on immunohistochemical analysis of MYC, LDHB, and CCNB1 expression

artículo científico publicado en 2008

Molecular subgrouping of Atypical Teratoid / Rhabdoid Tumors (ATRT) - a reinvestigation and current consensus

artículo científico publicado en 2019

Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations

scientific article published on 25 November 2019

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

artículo científico publicado en 2012

Molecular subgroups of medulloblastoma: the current consensus

artículo científico publicado en 2012

Multiple mechanisms of MYCN dysregulation in Wilms tumour

artículo científico publicado en 2015

Mutations in ABCC6 cause pseudoxanthoma elasticum

artículo científico publicado en 2000

Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas

artículo científico publicado en 2013

Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors

artículo científico publicado en 2015

Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile

artículo científico publicado en 2018

NEURO/MEDICAL ONCOLOGY

Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression

artículo científico publicado en 2013

Nestin expression identifies ependymoma patients with poor outcome

artículo científico publicado en 2012

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

artículo científico publicado en 2016

Newly Diagnosed Metastatic Intracranial Ependymoma in Children: Frequency, Molecular Characteristics, Treatment, and Outcome in the Prospective HIT Series

artículo científico publicado en 2019

Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets

artículo científico publicado en 2015

Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age.

artículo científico publicado en 2015

Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort

scientific article published on 24 April 2020

Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells

artículo científico publicado en 2017

OMICS AND PROGNSTIC MARKERS

article

OS5.2 FGFR a novel target in malignant pediatric ependymoma

OS6.1 Molecular characterization of astroblastoma.

artículo científico publicado en 2016

OTX1 and OTX2 expression correlates with the clinicopathologic classification of medulloblastomas

artículo científico publicado en 2006

OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells

artículo científico publicado en 2011

OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels

artículo científico publicado en 2012

Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma.

artículo científico publicado en 2018

Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma.

artículo científico publicado en 2018

Overexpression of minichromosome maintenance protein 10 in medulloblastoma and its clinical implications.

artículo científico publicado en 2017

P04.01RELA FUSION DEFINES CLINICOPATHOLOGIC SUBSETS OF SUPRATENTORIAL EPENDYMOMA: A STUDY FROM THE COLLABORATIVE EPENDYMOMA RESEARCH NETWORK.

artículo científico publicado en 2014

PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation.

artículo científico publicado en 2011

PATH-32. MOLECULAR HETEROGENEITY AMONG PEDIATRIC POSTERIOR FOSSA EPENDYMOMA

PCLN-05. A BIOBANK OF PATIENT-DERIVED MOLECULARLY CHARACTERIZED ORTHOTOPIC PEDIATRIC BRAIN TUMOR MODELS FOR PRECLINICAL RESEARCH

PCLN-06. NOVEL TUMOR-DERIVED MODELS OF CNS HGNET-BCOR PROVIDE INSIGHTS INTO UNDERLYING MOLECULAR MECHANISMS AND INNOVATIVE THERAPEUTIC OPTIONS

PCM-16MOLECULAR CHARACTERIZATION OF ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS.

artículo científico publicado en 2016

PCM-20PRE-CLINICAL DRUG SCREEN IN A PDX ETMR MOUSE MODEL.

artículo científico publicado en 2016

PDCT-05. MOLECULAR DIAGNOSTICS REVEAL 60% HIGHER SURVIVAL FOR MOLECULARLY-VERIFIED VERSUS HISTOPATHOLOGICALLY-DIAGNOSED PEDIATRIC SUPRATENTORIAL CENTRAL NERVOUS SYSTEM EMBRYONAL TUMORS AND PINEOBLASTOMAS; A REPORT FROM THE CHILDREN’S ONCOLOGY GROUP

PDTM-13. OVEREXPRESSION OF MYC ALONE IS SUFFICIENT TO INITIATE GROUP 3 MEDULLOBLASTOMA

PDTM-23. THE ACTIVE REGULATORY LANDSCAPE OF EPENDYMAL TUMORS

PDTM-46. TARGETING METABOLIC ADAPTATION IN MYC DRIVEN PEDIATRIC NEURONAL TUMORS

artículo científico publicado en 2017

PDTM-49. GLOBAL REDUCTION IN H3K27me3, SIMILAR TO H3K27M MUTANT GLIOMAS, IS A MOLECULAR SURROGATE FOR PEDIATRIC POSTERIOR FOSSA- GROUP A EPENDYMOMAS

artículo científico publicado en 2017

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

artículo científico publicado en 2017

PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas

scientific article published on 03 December 2013

PM-09ESTABLISHMENT AND MOLECULAR CHARACTERIZATION OF PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS.

artículo científico publicado en 2015

PNR-09EVALUATION OF AGE-DEPENDENT TREATMENT STRATEGIES FOR CHILDREN AND YOUNG ADULTS WITH PINEOBLASTOMA: ANALYSIS OF POOLED SIOP-E AND HEAD START DATA.

artículo científico publicado en 2016

PNR-12GENOME-WIDE PROFILING OF EMBRYONAL TUMORS WITH MULTILAYERED ROSETTES (ETMR).

artículo científico publicado en 2016

PNR-21FOUR NEW BRAIN TUMOR ENTITIES EMERGE FROM MOLECULAR CLASSIFICATION OF CNS PNETs

artículo científico publicado en 2016

PNR-33MOLECULAR RE-EVALUATION OF INSTITUTIONALLY DIAGNOSED CNS-PNETS: CLINICAL CONSEQUENCES OF CONFINED DIAGNOSTIC GROUPS.

artículo científico publicado en 2016

PROGNOSTIC SIGNIFICANCE OF CLINICAL, HISTOPATHOLOGICAL, AND MOLECULAR CHARACTERISTICS OF MEDULLOBLASTOMAS IN THE PROSPECTIVE HIT2000 MULTICENTER CLINICAL TRIAL COHORT

PTPS-11ATYPICAL TERATOID/RHABDOID TUMOUR IS AN EPIGENETICALLY HETEROGENEOUS DISEASE CHARACTERIZED BY SUBGROUP SPECIFIC SUPER-ENHANCERS.

artículo científico publicado en 2015

Papillary Tumor of the Pineal Region: A Distinct Molecular Entity

artículo científico publicado en 2015

Peptide transport by the multidrug resistance protein MRP1.

artículo científico publicado en 2001

Pilocytic Astrocytoma demethylation and transcriptional landscapes link bZIP transcription factors to immune response

artículo científico publicado en 2020

Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis.

artículo científico publicado en 2016

Potential Importance of Early Focal Radiotherapy Following Gross Total Resection for Long-Term Survival in Children With Embryonal Tumors With Multilayered Rosettes

artículo científico publicado en 2020

Pre-clinical drug screen reveals topotecan, actinomycin D and volasertib as potential new therapeutic candidates for ETMR brain tumor patients

artículo científico

Predicting relapse in patients with medulloblastoma by integrating evidence from clinical and genomic features

artículo científico publicado en 2011

Predisposition of Wingless Subgroup Medulloblastoma for Primary Tumor Hemorrhage

scientific article published on 01 April 2020

Preoperative systemic levels of VEGFA, IL-7, IL-17A, and TNF-β delineate two distinct groups of children with brain tumors

artículo científico publicado en 2016

Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis

scientific article published on 20 November 2020

Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort

artículo científico publicado en 2014

Prognostic value and functional consequences of cell cycle inhibitor p27Kip1 loss in medulloblastoma

artículo científico publicado en 2013

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

artículo científico publicado en 2016

Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups

scientific article published on 01 September 2018

Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma

artículo científico publicado en 2014

Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

artículo científico publicado en 2011

Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

artículo científico publicado en 2013

Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors

artículo científico publicado en 2021

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

artículo científico publicado en 2013

Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas

artículo científico publicado en 2013

Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma

artículo científico publicado en 2020

Reduced histone H3 K27 trimethylation is encountered in about 50% of atypical teratoid/rhabdoid tumors (AT/RT) but is not associated with molecular subgroup status and outcome

artículo científico publicado en 2017

Regulation of cell cycle genes and induction of senescence by overexpression of OTX2 in medulloblastoma cell lines

artículo científico publicado en 2010

Rhabdoid Tumor Predisposition Syndrome

artículo científico publicado en 2017

RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading glioblastomas

scientific article published on 06 May 2019

Risk stratification of childhood medulloblastoma in the molecular era: the current consensus

artículo científico publicado en 2016

Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial

scientific article published on 16 May 2018

Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays

artículo científico publicado en 2013

SMAD dependent signaling plays a detrimental role in a fly model of SMARCB1-deficiency and the biology of atypical teratoid/rhabdoid tumors

artículo científico publicado en 2017

SMARCB1 loss interacts with neuronal differentiation state to block maturation and impact cell stability

artículo científico publicado en 2020

Sarcoma classification by DNA methylation profiling

artículo científico publicado en 2021

Scaling of gene expression data allowing the comparison of different gene expression platforms

artículo científico publicado en 2008

Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes

scientific article published on 10 May 2019

Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations

artículo científico publicado en 2013

Sellar Region Atypical Teratoid/Rhabdoid Tumors (ATRT) in Adults Display DNA Methylation Profiles of the ATRT-MYC Subgroup

artículo científico publicado en 2018

Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma.

artículo científico publicado en 2015

Signatures of mutational processes in human cancer

artículo científico publicado en 2013

Silencing of SPRY1 triggers complete regression of rhabdomyosarcoma tumors carrying a mutated RAS gene

artículo científico publicado en 2010

Single cell derived mRNA signals across human kidney tumors

scientific article published on 23 June 2021

Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma

artículo científico publicado en 2020

Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours

Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas.

artículo científico publicado en 2016

Somatostatin receptor subtype 2 (sst₂) is a potential prognostic marker and a therapeutic target in medulloblastoma

artículo científico publicado en 2013

Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem

artículo científico publicado en 2012

Sox2+ cells in Sonic Hedgehog-subtype medulloblastoma resist p53-mediated cell-cycle arrest response and drive therapy-induced recurrence

scientific article published on 01 May 2019

Spatial heterogeneity in medulloblastoma

artículo científico publicado en 2017

Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies.

artículo científico publicado en 2000

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

artículo científico publicado en 2018

Spinal cord atypical teratoid/rhabdoid tumors in children: Clinical, genetic, and outcome characteristics in a representative European cohort

scientific article published on 01 October 2019

Statistical comparison of two or more SAGE libraries: one tag at a time

artículo científico publicado en 2008

Subgroup-specific localization of human medulloblastoma based on pre-operative MRI.

artículo científico publicado en 2014

Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma

artículo científico publicado en 2013

Subgroup-specific prognostic signaling and metabolic pathways in pediatric medulloblastoma

artículo científico publicado en 2019

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

artículo científico publicado en 2012

TB-17A COMPREHENSIVE PAN-CANCER ANALYSIS OF CHILDHOOD MALIGNANCIES.

artículo científico publicado en 2016

TCF4 (E2-2) harbors tumor suppressive functions in SHH medulloblastoma

artículo científico publicado en 2019

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

artículo científico publicado en 2013

THER-02. TARGETING DNA DAMAGE REPAIR IN MYC-DRIVEN PEDIATRIC BRAIN TUMORS

artículo científico publicado en 2019

TMOD-05. MOLECULAR CHARACTERIZATION OF ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS AND THEIR USE IN PRECLINICAL EXPERIMENTS.

artículo científico publicado en 2017

TMOD-11. HUMAN STEM CELL BASED MODEL OF MEDULLOBLASTOMA

TMOD-41. TWO NOVEL SETS OF PATIENT DERIVED ORTHOTOPIC XENOGRAFT MOUSE MODELS (PDOX) ESTABLISHED FROM MATCHING PRIMARY AND RECURRENT PEDIATRIC BRAIN TUMORS

TUMOUR BIOLOGY

Targeting Polo-like kinase 1 in SMARCB1 deleted atypical teratoid rhabdoid tumor

artículo científico publicado en 2017

Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma

artículo científico publicado en 2015

Targeting fibroblast growth factor receptors to combat aggressive ependymoma

artículo científico publicado en 2021

Telomerase activation in posterior fossa group A ependymomas is associated with dismal prognosis and chromosome 1q gain

artículo científico publicado en 2017

Telomere dysfunction and chromothripsis

artículo científico publicado en 2016

The AHR pathway represses TGFβ-SMAD3 signalling and has a potent tumour suppressive role in SHH medulloblastoma

scientific article published on 10 January 2020

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma

artículo científico publicado en 2014

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

artículo científico publicado en 2018

The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors

artículo científico publicado en 2014

The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants

artículo científico publicado en 2014

The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants

artículo científico publicado en 2016

The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation

artículo científico publicado en 2013

The genetic landscape of choroid plexus tumors in children and adults

artículo científico publicado en 2020

The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells

artículo científico publicado en 2013

The landscape of genomic alterations across childhood cancers

artículo científico publicado en 2018

The molecular landscape of ETMR at diagnosis and relapse

scientific article published on 04 December 2019

The multidrug resistance protein family.

artículo científico publicado en 1999

The role of chromatin remodeling in medulloblastoma.

artículo científico publicado en 2013

The whole-genome landscape of medulloblastoma subtypes

artículo científico publicado en 2017

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis

artículo científico publicado en 2016

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

artículo científico publicado en 2017

Tissue Factor Regulation by miR-520g in Primitive Neuronal Brain Tumor Cells: A Possible Link between Oncomirs and the Vascular Tumor Microenvironment

artículo científico publicado en 2015

Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker

scientific article published on 28 November 2019

Transitioning from genotypes to epigenotypes: why the time has come for medulloblastoma epigenomics

artículo científico

Treatment of Children and Adolescents With Metastatic Medulloblastoma and Prognostic Relevance of Clinical and Biologic Parameters

artículo científico publicado en 2016

Two molecularly distinct atypical teratoid/rhabdoid tumors (or tumor components) occurring in an infant with rhabdoid tumor predisposition syndrome 1

artículo científico publicado en 2019

Tyrosinase immunohistochemistry can be employed for the diagnosis of atypical teratoid/rhabdoid tumours of the tyrosinase subgroup (ATRT-TYR)

scientific article published on 11 May 2019

Ultra high-risk PFA ependymoma is characterized by loss of chromosome 6q

artículo científico publicado en 2021

Update on molecular and genetic alterations in adult medulloblastoma

artículo científico publicado en 2012

WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma

artículo científico publicado en 2014

Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance

artículo científico publicado en 2015

YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis

scientific article published on 02 September 2019

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