Lista de obras -

(2S,3R,4S,4aR)-2,3,4,7-Tetra-hydroxy-3,4,4a,5-tetra-hydro-[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one hemihydrate

artículo científico publicado en 2012

5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells

artículo científico publicado en 2016

A harmine-derived beta-carboline displays anti-cancer effects in vitro by targeting protein synthesis.

artículo científico publicado en 2017

A new series of acetohydroxamates shows in vitro and in vivo anticancer activity against melanoma

artículo científico publicado en 2019

A solution to the stereochemical problems posed by amaryllidaceae constituents using a highly syn-selective arylcuprate conjugate addition to γ-amino and γ-carbamato-α,β-enoates

artículo científico publicado en 2006

Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells

artículo científico publicado en 2015

Activity of natural and synthetic polygodial derivatives against Trypanosoma cruzi amastigotes, trypomastigotes and epimastigotes

scientific article published on 28 April 2019

Algae metabolites: from in vitro growth inhibitory effects to promising anticancer activity

scientific article published on 01 May 2019

Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells

artículo científico publicado en 2010

An approach to pancratistatins via ring-closing metathesis: efficient synthesis of novel 1-aryl-1-deoxyconduritols F. cv

scientific article published on 01 March 2004

Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis.

artículo científico publicado en 2011

Antiproliferative activity of 2,3-disubstituted indoles toward apoptosis-resistant cancers cells

artículo científico publicado en 2013

Antiproliferative and apoptosis inducing properties of pyrano[3,2-c]pyridones accessible by a one-step multicomponent synthesis

artículo científico publicado en 2007

Aryliodine(III) diacetates as substrates for Pd–Ag catalyzed arylation of alkenes ⬇️

artículo científico publicado el 17 de agosto de 2011

Aspergillus candidus is a newly recognized source of sphaeropsidin A: Isolation, semi-synthetic derivatization and anticancer evaluation

artículo científico publicado en 2017

Biological evaluation of structurally diverse amaryllidaceae alkaloids and their synthetic derivatives: discovery of novel leads for anticancer drug design

artículo científico publicado en 2009

Bulbispermine: a crinine-type Amaryllidaceae alkaloid exhibiting cytostatic activity toward apoptosis-resistant glioma cells

artículo científico publicado en 2012

C-H functionalization directed by transformable nitrogen heterocycles: synthesis of ortho-oxygenated arylnaphthalenes from arylphthalazines

artículo científico publicado en 2013

C1,C2-ether derivatives of the Amaryllidaceae alkaloid lycorine: retention of activity of highly lipophilic analogues against cancer cells.

artículo científico publicado en 2013

Chemistry and biology of ophiobolin A and its congeners

scientific article published on 07 February 2019

Chemistry, biology, and medicinal potential of narciclasine and its congeners ⬇️

artículo científico publicado en 2008

Chemoenzymatic synthesis of Amaryllidaceae constituents and biological evaluation of their C-1 analogues. The next generation synthesis of 7-deoxypancratistatin and trans-dihydrolycoricidine

artículo científico publicado en 2010

Convenient one-step synthesis of a medicinally relevant benzopyranopyridine system

artículo científico publicado en 2006

Covalent modification of biological targets with natural products through Paal-Knorr pyrrole formation.

artículo científico publicado en 2017

Crystal structure and absolute configuration of sphaeropsidin A and its 6- O - p -bromobenzoate

Data in support of a harmine-derived beta-carboline in vitro effects in cancer cells through protein synthesis

artículo científico publicado en 2017

Deciphering the chemical instability of sphaeropsidin A under physiological conditions - degradation studies and structural elucidation of the major metabolite

artículo científico publicado en 2020

Discovery and investigation of antiproliferative and apoptosis-inducing properties of new heterocyclic podophyllotoxin analogues accessible by a one-step multicomponent synthesis

artículo científico publicado en 2007

Effect of polygodial and its direct derivatives on the mammalian Na/K-ATPase activity

artículo científico publicado en 2018

Effects of crude aqueous medicinal plant extracts on growth and invasion of breast cancer cells.

artículo científico publicado en 2007

Effects of extracts from two Native American plants on proliferation of human breast and colon cancer cell lines in vitro

artículo científico publicado en 2006

Enantio- and Diastereodivergent Synthetic Route to Multifarious Cyclitols from D-Xylose via Ring-Closing Metathesis.

artículo científico publicado en 2008

Enantiodivergent formal synthesis of (+)- and (-)-cyclophellitol from D-xylose based on the latent symmetry concept.

artículo científico publicado en 2005

Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells.

artículo científico publicado en 2008

Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids

artículo científico publicado en 2013

Fischerindoline, a pyrroloindole sesquiterpenoid isolated from Neosartorya pseudofischeri, with in vitro growth inhibitory activity in human cancer cell lines

article

Fungal metabolite ophiobolin A as a promising anti-glioma agent: In vivo evaluation, structure-activity relationship and unique pyrrolylation of primary amines.

artículo científico publicado en 2015

Fungal metabolites with anticancer activity

artículo científico

Higginsianins A and B, Two Diterpenoid α-Pyrones Produced by Colletotrichum higginsianum, with in Vitro Cytostatic Activity ⬇️

artículo científico publicado en 2015

In Vitro Effects of Fungal Phytotoxins on Cancer Cell Viability: First Insight into Structure Activity Relationship of a Potent Metabolite of Cochliobolus australiensis Radicinin

scientific article published in 2022

In search of a cytostatic agent derived from the alkaloid lycorine: synthesis and growth inhibitory properties of lycorine derivatives

artículo científico publicado en 2011

Irreversible Protein Labeling by Paal-Knorr Conjugation

artículo científico publicado en 2017

Isatin derivatives with activity against apoptosis-resistant cancer cells

artículo científico publicado en 2016

Jonquailine, a new pretazettine-type alkaloid isolated from Narcissus jonquilla quail, with activity against drug-resistant cancer.

artículo científico publicado en 2015

Lipophilic prodrug conjugates allow facile and rapid synthesis of high-loading capacity liposomes without the need for post-assembly purification

artículo científico publicado en 2014

Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight

artículo científico publicado en 2009

Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the "Supply Problem"

artículo científico publicado en 2016

Marine Mollusk-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance.

artículo científico publicado en 2016

Marine-Derived Anticancer Agents: Clinical Benefits, Innovative Mechanisms, and New Targets

scientific article published on 02 June 2019

Metal-free transannulation reaction of indoles with nitrostyrenes: a simple practical synthesis of 3-substituted 2-quinolones.

artículo científico publicado en 2013

Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multidrug-Resistance Proteins

scientific article published on 25 January 2019

Multicomponent Synthesis of 2,3-Dihydrochromeno[4,3-d]pyrazolo[3,4-b]pyridine-1,6-diones: A Novel Heterocyclic Scaffold with Antibacterial Activity.

artículo científico publicado en 2011

Narciclasine as well as other Amaryllidaceae isocarbostyrils are promising GTP-ase targeting agents against brain cancers

artículo científico publicado en 2012

Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity

scientific article published on 19 August 2020

Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities

artículo científico publicado en 2015

Novel Topologically Complex Scaffold Derived from Alkaloid Haemanthamine.

artículo científico publicado en 2018

Novel polygodial analogs P3 and P27: Efficacious therapeutic agents disrupting mitochondrial function in oral squamous cell carcinoma

artículo científico publicado en 2018

Novel three-component synthesis and antiproliferative properties of diversely functionalized pyrrolines

artículo científico publicado en 2008

One-Pot, Three-Component Assembly of Indoloquinolines: Total Synthesis of Isocryptolepine

artículo científico publicado en 2017

One-pot multicomponent synthesis of diversely substituted 2-aminopyrroles. A short general synthesis of rigidins A, B, C, and D.

artículo científico publicado en 2011

One-step synthesis of heterocyclic privileged medicinal scaffolds by a multicomponent reaction of malononitrile with aldehydes and thiols

artículo científico publicado en 2007

One-step, three-component synthesis of pyridines and 1,4-dihydropyridines with manifold medicinal utility

scientific article published on 01 March 2006

Photo-Uncaging of a Microtubule-Targeted Rigidin Analogue in Hypoxic Cancer Cells and in a Xenograft Mouse Model

artículo científico publicado en 2019

Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria.

artículo científico publicado en 2018

Polygodial analog induces apoptosis in LNCaP prostate cancer cells.

artículo científico publicado en 2018

Polygodial, a Sesquiterpene Dialdehyde, Activates Apoptotic Signaling in Castration-Resistant Prostate Cancer Cell Lines by Inducing Oxidative Stress

artículo científico publicado en 2022

Reengineered epipodophyllotoxin

artículo científico publicado en 2012

Selectivity guidelines and a reductive elimination-based model for predicting the stereochemical course of conjugate addition reactions of organocuprates to gamma-alkoxy-alpha,beta-enoates

artículo científico publicado en 2006

Sesterterpenoids with Anticancer Activity

artículo científico publicado en 2015

Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli

artículo científico publicado en 2010

Single dish gradient screening of small molecule localization

artículo científico publicado en 2016

Sphaeropsidin A shows promising activity against drug-resistant cancer cells by targeting regulatory volume increase

artículo científico publicado en 2015

Structural simplification of bioactive natural products with multicomponent synthesis. 2. antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones

artículo científico publicado en 2008

Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents

artículo científico publicado en 2011

Structural simplification of bioactive natural products with multicomponent synthesis. 4. 4H-pyrano-[2,3-b]naphthoquinones with anticancer activity

artículo científico publicado en 2012

Structural simplification of bioactive natural products with multicomponent synthesis: dihydropyridopyrazole analogues of podophyllotoxin

artículo científico publicado en 2006

Synergistic action of substituted indole derivatives and clinically used antibiotics against drug-resistant bacteria

scientific article published on 02 June 2020

Synthesis and biological evaluation of aromatic analogues of conduritol F, L-chiro-inositol, and dihydroconduritol F structurally related to the amaryllidaceae anticancer constituents

artículo científico publicado en 2006

Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides

artículo científico publicado en 2016

Synthesis of C-1 homologues of pancratistatin and their preliminary biological evaluation

artículo científico publicado en 2011

Synthesis of Differentially Protected myo- and chiro-Inositols from D-Xylose; Stereoselectivity in Intramolecular SmI(2)-Promoted Pinacol Reactions

artículo científico publicado en 2008

Synthesis of Spiro[indole-3,5'-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles

scientific article published on 22 May 2019

Synthesis of structurally simplified analogues of pancratistatin: truncation of the cyclitol ring.

artículo científico publicado en 2009

Synthetic analogues of the montanine-type alkaloids with activity against apoptosis-resistant cancer cells

artículo científico publicado en 2018

Synthetic and Biological Studies of Sesquiterpene Polygodial: Activity of 9-Epipolygodial against Drug-Resistant Cancer Cells

artículo científico publicado en 2015

Synthetic and biological studies of tubulin targeting c2-substituted 7-deazahypoxanthines derived from marine alkaloid rigidins

artículo científico publicado en 2014

TOTAL SYNTHESES OF PANCRATISTATIN. A REVIEW.

artículo científico publicado en 2008

Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas

artículo científico publicado en 2010

The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth.

artículo científico publicado en 2018

The Rigidins: Isolation, Bioactivity, and Total Synthesis-Novel Pyrrolo[2,3-d]Pyrimidine Analogues Using Multicomponent Reactions

artículo científico publicado en 2018

Therapeutic agents triggering nonapoptotic cancer cell death

artículo científico publicado en 2013

Three-component synthesis and anticancer evaluation of polycyclic indenopyridines lead to the discovery of a novel indenoheterocycle with potent apoptosis inducing properties

artículo científico publicado en 2007

Toward a Cancer Drug of Fungal Origin

artículo científico publicado en 2015

Unnatural C-1 homologues of pancratistatin - Synthesis and promising biological activities

artículo científico publicado en 2012

Unprecedented C-2 arylation of indole with diazonium salts: Syntheses of 2,3-disubstituted indoles and their antimicrobial activity.

artículo científico publicado en 2011

Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary amines

artículo científico publicado en 2015

[Corrigendum] Novel polygodial analogs P3 and P27: Efficacious therapeutic agents disrupting mitochondrial function in oral squamous cell carcinoma

scientific article published on 07 February 2020

Lista de obras de

(2S,3R,4S,4aR)-2,3,4,7-Tetra-hydroxy-3,4,4a,5-tetra-hydro-[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one hemihydrate

5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells

A harmine-derived beta-carboline displays anti-cancer effects in vitro by targeting protein synthesis.

A new series of acetohydroxamates shows in vitro and in vivo anticancer activity against melanoma

A solution to the stereochemical problems posed by amaryllidaceae constituents using a highly syn-selective arylcuprate conjugate addition to γ-amino and γ-carbamato-α,β-enoates

Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells

Activity of natural and synthetic polygodial derivatives against Trypanosoma cruzi amastigotes, trypomastigotes and epimastigotes

Algae metabolites: from in vitro growth inhibitory effects to promising anticancer activity

Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells

An approach to pancratistatins via ring-closing metathesis: efficient synthesis of novel 1-aryl-1-deoxyconduritols F. cv

Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis.

Antiproliferative activity of 2,3-disubstituted indoles toward apoptosis-resistant cancers cells

Antiproliferative and apoptosis inducing properties of pyrano[3,2-c]pyridones accessible by a one-step multicomponent synthesis

Aryliodine(III) diacetates as substrates for Pd–Ag catalyzed arylation of alkenes ⬇️

Aspergillus candidus is a newly recognized source of sphaeropsidin A: Isolation, semi-synthetic derivatization and anticancer evaluation

Biological evaluation of structurally diverse amaryllidaceae alkaloids and their synthetic derivatives: discovery of novel leads for anticancer drug design

Bulbispermine: a crinine-type Amaryllidaceae alkaloid exhibiting cytostatic activity toward apoptosis-resistant glioma cells

C-H functionalization directed by transformable nitrogen heterocycles: synthesis of ortho-oxygenated arylnaphthalenes from arylphthalazines

C1,C2-ether derivatives of the Amaryllidaceae alkaloid lycorine: retention of activity of highly lipophilic analogues against cancer cells.

Chemistry and biology of ophiobolin A and its congeners

Chemistry, biology, and medicinal potential of narciclasine and its congeners ⬇️

Chemoenzymatic synthesis of Amaryllidaceae constituents and biological evaluation of their C-1 analogues. The next generation synthesis of 7-deoxypancratistatin and trans-dihydrolycoricidine

Convenient one-step synthesis of a medicinally relevant benzopyranopyridine system

Covalent modification of biological targets with natural products through Paal-Knorr pyrrole formation.

Crystal structure and absolute configuration of sphaeropsidin A and its 6- O - p -bromobenzoate

Data in support of a harmine-derived beta-carboline in vitro effects in cancer cells through protein synthesis

Deciphering the chemical instability of sphaeropsidin A under physiological conditions - degradation studies and structural elucidation of the major metabolite

Discovery and investigation of antiproliferative and apoptosis-inducing properties of new heterocyclic podophyllotoxin analogues accessible by a one-step multicomponent synthesis

Effect of polygodial and its direct derivatives on the mammalian Na/K-ATPase activity

Effects of crude aqueous medicinal plant extracts on growth and invasion of breast cancer cells.

Effects of extracts from two Native American plants on proliferation of human breast and colon cancer cell lines in vitro

Enantio- and Diastereodivergent Synthetic Route to Multifarious Cyclitols from D-Xylose via Ring-Closing Metathesis.

Enantiodivergent formal synthesis of (+)- and (-)-cyclophellitol from D-xylose based on the latent symmetry concept.

Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells.

Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids

Fischerindoline, a pyrroloindole sesquiterpenoid isolated from Neosartorya pseudofischeri, with in vitro growth inhibitory activity in human cancer cell lines

Fungal metabolite ophiobolin A as a promising anti-glioma agent: In vivo evaluation, structure-activity relationship and unique pyrrolylation of primary amines.

Fungal metabolites with anticancer activity

Higginsianins A and B, Two Diterpenoid α-Pyrones Produced by Colletotrichum higginsianum, with in Vitro Cytostatic Activity ⬇️

In Vitro Effects of Fungal Phytotoxins on Cancer Cell Viability: First Insight into Structure Activity Relationship of a Potent Metabolite of Cochliobolus australiensis Radicinin

In search of a cytostatic agent derived from the alkaloid lycorine: synthesis and growth inhibitory properties of lycorine derivatives

Irreversible Protein Labeling by Paal-Knorr Conjugation

Isatin derivatives with activity against apoptosis-resistant cancer cells

Jonquailine, a new pretazettine-type alkaloid isolated from Narcissus jonquilla quail, with activity against drug-resistant cancer.

Lipophilic prodrug conjugates allow facile and rapid synthesis of high-loading capacity liposomes without the need for post-assembly purification

Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight

Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the "Supply Problem"

Marine Mollusk-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance.

Marine-Derived Anticancer Agents: Clinical Benefits, Innovative Mechanisms, and New Targets

Metal-free transannulation reaction of indoles with nitrostyrenes: a simple practical synthesis of 3-substituted 2-quinolones.

Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multidrug-Resistance Proteins

Multicomponent Synthesis of 2,3-Dihydrochromeno[4,3-d]pyrazolo[3,4-b]pyridine-1,6-diones: A Novel Heterocyclic Scaffold with Antibacterial Activity.

Narciclasine as well as other Amaryllidaceae isocarbostyrils are promising GTP-ase targeting agents against brain cancers

Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity

Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities

Novel Topologically Complex Scaffold Derived from Alkaloid Haemanthamine.

Novel polygodial analogs P3 and P27: Efficacious therapeutic agents disrupting mitochondrial function in oral squamous cell carcinoma

Novel three-component synthesis and antiproliferative properties of diversely functionalized pyrrolines

One-Pot, Three-Component Assembly of Indoloquinolines: Total Synthesis of Isocryptolepine

One-pot multicomponent synthesis of diversely substituted 2-aminopyrroles. A short general synthesis of rigidins A, B, C, and D.

One-step synthesis of heterocyclic privileged medicinal scaffolds by a multicomponent reaction of malononitrile with aldehydes and thiols

One-step, three-component synthesis of pyridines and 1,4-dihydropyridines with manifold medicinal utility

Photo-Uncaging of a Microtubule-Targeted Rigidin Analogue in Hypoxic Cancer Cells and in a Xenograft Mouse Model

Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria.

Polygodial analog induces apoptosis in LNCaP prostate cancer cells.

Polygodial, a Sesquiterpene Dialdehyde, Activates Apoptotic Signaling in Castration-Resistant Prostate Cancer Cell Lines by Inducing Oxidative Stress

Reengineered epipodophyllotoxin

Selectivity guidelines and a reductive elimination-based model for predicting the stereochemical course of conjugate addition reactions of organocuprates to gamma-alkoxy-alpha,beta-enoates

Sesterterpenoids with Anticancer Activity

Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli

Single dish gradient screening of small molecule localization

Sphaeropsidin A shows promising activity against drug-resistant cancer cells by targeting regulatory volume increase

Structural simplification of bioactive natural products with multicomponent synthesis. 2. antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones

Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents

Structural simplification of bioactive natural products with multicomponent synthesis. 4. 4H-pyrano-[2,3-b]naphthoquinones with anticancer activity

Structural simplification of bioactive natural products with multicomponent synthesis: dihydropyridopyrazole analogues of podophyllotoxin

Synergistic action of substituted indole derivatives and clinically used antibiotics against drug-resistant bacteria

Synthesis and biological evaluation of aromatic analogues of conduritol F, L-chiro-inositol, and dihydroconduritol F structurally related to the amaryllidaceae anticancer constituents

Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides