Lista de obras -

A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells

artículo científico publicado en 2014

Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels

artículo científico publicado en 2005

Activity and specificity of the bacterial PD-(D/E)XK homing endonuclease I-Ssp6803I.

artículo científico publicado en 2008

Alteration of enzyme specificity by computational loop remodeling and design

artículo científico publicado en 2009

Bacterial Cytosine Deaminase Mutants Created by Molecular Engineering Show Improved 5-Fluorocytosine-Mediated Cell Killing In vitro and In vivo

artículo científico publicado en 2009

Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

artículo científico publicado en 2010

Computational Design of an Unnatural Amino Acid Dependent Metalloprotein with Atomic Level Accuracy

artículo científico publicado en 2013

Computational design of a new hydrogen bond network and at least a 300-fold specificity switch at a protein-protein interface

artículo científico publicado en 2006

Computational design of ligand-binding proteins with high affinity and selectivity

artículo científico publicado en 2013

Computational protein design enables a novel one-carbon assimilation pathway.

artículo científico publicado en 2015

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

artículo científico publicado en 2012

Computational redesign of endonuclease DNA binding and cleavage specificity

artículo científico publicado en 2006

Computational redesign of protein-protein interaction specificity

artículo científico publicado en 2004

Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs

artículo científico publicado en 2010

Computational thermostabilization of an enzyme

artículo científico publicado en 2005

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

artículo científico publicado en 2016

Control of repeat-protein curvature by computational protein design

artículo científico publicado en 2015

DNA recognition by the SwaI restriction endonuclease involves unusual distortion of an 8 base pair A:T-rich target

artículo científico publicado en 2017

De novo computational design of retro-aldol enzymes

artículo científico publicado en 2008

Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

artículo científico publicado en 2003

Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces

artículo científico publicado en 2021

Design, activity, and structure of a highly specific artificial endonuclease

artículo científico publicado en 2002

Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance

artículo científico publicado en 2016

Engineering and functionalization of large circular tandem repeat protein nanoparticles

artículo científico publicado en 2020

Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases

artículo científico publicado en 2012

Engineering of customized meganucleases via in vitro compartmentalization and in cellulo optimization

artículo científico publicado en 2015

Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space ⬇️

artículo científico publicado el 14 de febrero de 2012

Exploitation of binding energy for catalysis and design

artículo científico publicado en 2009

Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleases

artículo científico publicado en 2007

Folding, DNA Recognition, and Function of GIY-YIG Endonucleases: Crystal Structures of R.Eco29kI ⬇️

artículo científico publicado el 26 de agosto de 2010

Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease

scholarly article

Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins

artículo científico publicado en 2009

High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display

artículo científico publicado en 2009

Homing endonuclease I-CreI derivatives with novel DNA target specificities

artículo científico publicado en 2006

Increased Diels-Alderase activity through backbone remodeling guided by Foldit players

artículo científico publicado en 2012

Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity

artículo científico publicado en 2016

Isolation and characterization of new homing endonuclease specificities at individual target site positions

artículo científico publicado en 2004

LAHEDES: the LAGLIDADG homing endonuclease database and engineering server ⬇️

artículo científico publicado el 8 de mayo de 2012

Microseed matrix screening to improve crystals of yeast cytosine deaminase

artículo científico publicado en 2004

Mis-translation of a computationally designed protein yields an exceptionally stable homodimer: implications for protein engineering and evolution

artículo científico publicado en 2006

NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase.

artículo científico publicado en 2002

Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition

artículo científico publicado en 2020

Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation

artículo científico publicado en 2009

Precise assembly of complex beta sheet topologies from de novo designed building blocks

artículo científico publicado en 2015

Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy

artículo científico publicado en 2004

Rational design of α-helical tandem repeat proteins with closed architectures

artículo científico publicado en 2015

Recognition of DNA substrates by T4 bacteriophage polynucleotide kinase

artículo científico publicado en 2004

Recognition of a common rDNA target site in archaea and eukarya by analogous LAGLIDADG and His-Cys box homing endonucleases

artículo científico publicado en 2008

Redesign of extensive protein-DNA interfaces of meganucleases using iterative cycles of in vitro compartmentalization

artículo científico publicado en 2014

Structural Analyses of Covalent Enzyme–Substrate Analog Complexes Reveal Strengths and Limitations of De Novo Enzyme Design

artículo científico publicado en 2012

Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor

artículo científico publicado en 2003

Structure, subunit organization and behavior of the asymmetric Type IIT restriction endonuclease BbvCI

artículo científico publicado en 2019

Structures of the Rare-Cutting Restriction Endonuclease NotI Reveal a Unique Metal Binding Fold Involved in DNA Binding

artículo científico publicado en 2008

Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activities

artículo científico publicado en 2004

Tapping natural reservoirs of homing endonucleases for targeted gene modification

artículo científico publicado en 2011

The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy

artículo científico publicado en 2003

The Structural Basis of Asymmetry in DNA Binding and Cleavage as Exhibited by the I-SmaMI LAGLIDADG Meganuclease

artículo científico publicado en 2015

The Structure of a Bacterial DUF199/WhiA Protein: Domestication of an Invasive Endonuclease

artículo científico publicado en 2009

The crystal structure and mutational analysis of human NUDT9

artículo científico publicado en 2003

The design and in vivo evaluation of engineered I-OnuI-based enzymes for HEG gene drive ⬇️

artículo científico publicado en 2013

The structure of Escherichia coli cytosine deaminase

artículo científico publicado en 2002

The tertiary structure and domain organization of coagulation factor VIII

artículo científico publicado en 2008

Thermodynamics of DNA target site recognition by homing endonucleases.

artículo científico publicado en 2007

Tuning DNA binding affinity and cleavage specificity of an engineered gene-targeting nuclease via surface display, flow cytometry and cellular analyses

artículo científico publicado en 2017

Unintended specificity of an engineered ligand-binding protein facilitated by unpredicted plasticity of the protein fold

scientific article published on 01 October 2018

Unusual Target Site Disruption by the Rare-Cutting HNH Restriction Endonuclease PacI

artículo científico publicado en 2010

Yeast cytosine deaminase mutants with increased thermostability impart sensitivity to 5-fluorocytosine

artículo científico publicado en 2008

megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering

artículo científico publicado en 2013

Lista de obras de

A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells

Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels

Activity and specificity of the bacterial PD-(D/E)XK homing endonuclease I-Ssp6803I.

Alteration of enzyme specificity by computational loop remodeling and design

Bacterial Cytosine Deaminase Mutants Created by Molecular Engineering Show Improved 5-Fluorocytosine-Mediated Cell Killing In vitro and In vivo

Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

Computational Design of an Unnatural Amino Acid Dependent Metalloprotein with Atomic Level Accuracy

Computational design of a new hydrogen bond network and at least a 300-fold specificity switch at a protein-protein interface

Computational design of ligand-binding proteins with high affinity and selectivity

Computational protein design enables a novel one-carbon assimilation pathway.

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

Computational redesign of endonuclease DNA binding and cleavage specificity

Computational redesign of protein-protein interaction specificity

Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs

Computational thermostabilization of an enzyme

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

Control of repeat-protein curvature by computational protein design

DNA recognition by the SwaI restriction endonuclease involves unusual distortion of an 8 base pair A:T-rich target

De novo computational design of retro-aldol enzymes

Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces

Design, activity, and structure of a highly specific artificial endonuclease

Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance

Engineering and functionalization of large circular tandem repeat protein nanoparticles

Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases

Engineering of customized meganucleases via in vitro compartmentalization and in cellulo optimization

Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space ⬇️

Exploitation of binding energy for catalysis and design

Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleases

Folding, DNA Recognition, and Function of GIY-YIG Endonucleases: Crystal Structures of R.Eco29kI ⬇️

Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease

Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins

High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display

Homing endonuclease I-CreI derivatives with novel DNA target specificities

Increased Diels-Alderase activity through backbone remodeling guided by Foldit players

Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity

Isolation and characterization of new homing endonuclease specificities at individual target site positions

LAHEDES: the LAGLIDADG homing endonuclease database and engineering server ⬇️

Microseed matrix screening to improve crystals of yeast cytosine deaminase

Mis-translation of a computationally designed protein yields an exceptionally stable homodimer: implications for protein engineering and evolution

NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase.

Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition

Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation

Precise assembly of complex beta sheet topologies from de novo designed building blocks

Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy

Rational design of α-helical tandem repeat proteins with closed architectures

Recognition of DNA substrates by T4 bacteriophage polynucleotide kinase

Recognition of a common rDNA target site in archaea and eukarya by analogous LAGLIDADG and His-Cys box homing endonucleases

Redesign of extensive protein-DNA interfaces of meganucleases using iterative cycles of in vitro compartmentalization

Structural Analyses of Covalent Enzyme–Substrate Analog Complexes Reveal Strengths and Limitations of De Novo Enzyme Design

Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor

Structure, subunit organization and behavior of the asymmetric Type IIT restriction endonuclease BbvCI

Structures of the Rare-Cutting Restriction Endonuclease NotI Reveal a Unique Metal Binding Fold Involved in DNA Binding

Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activities

Tapping natural reservoirs of homing endonucleases for targeted gene modification

The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy

The Structural Basis of Asymmetry in DNA Binding and Cleavage as Exhibited by the I-SmaMI LAGLIDADG Meganuclease

The Structure of a Bacterial DUF199/WhiA Protein: Domestication of an Invasive Endonuclease

The crystal structure and mutational analysis of human NUDT9

The design and in vivo evaluation of engineered I-OnuI-based enzymes for HEG gene drive ⬇️

The structure of Escherichia coli cytosine deaminase

The tertiary structure and domain organization of coagulation factor VIII

Thermodynamics of DNA target site recognition by homing endonucleases.

Tuning DNA binding affinity and cleavage specificity of an engineered gene-targeting nuclease via surface display, flow cytometry and cellular analyses

Unintended specificity of an engineered ligand-binding protein facilitated by unpredicted plasticity of the protein fold

Unusual Target Site Disruption by the Rare-Cutting HNH Restriction Endonuclease PacI

Yeast cytosine deaminase mutants with increased thermostability impart sensitivity to 5-fluorocytosine

megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering