Lista de obras -

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism

artículo científico publicado en 2018

A plasma proteogenomic signature for fibromuscular dysplasia

artículo científico publicado en 2020

ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques

artículo científico publicado en 2008

Additional Candidate Genes for Human Atherosclerotic Disease Identified Through Annotation Based on Chromatin Organization

artículo científico publicado en 2017

An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease

artículo científico publicado en 2021

ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytes

artículo científico publicado en 2008

Association analyses based on false discovery rate implicate new loci for coronary artery disease ⬇️

artículo científico

Blood levels of dual-specificity phosphatase-1 independently predict risk for post-operative morbidities causing prolonged hospitalization after coronary artery bypass grafting

artículo científico publicado en 2011

Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.

artículo científico publicado en 2017

Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases.

artículo científico publicado en 2016

Carotid plaque age is a feature of plaque stability inversely related to levels of plasma insulin

artículo científico publicado en 2011

Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade

artículo científico publicado en 2020

Contribution of Gene Regulatory Networks to Heritability of Coronary Artery Disease

artículo científico publicado en 2019

Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease

artículo científico publicado en 2016

DGAT1 participates in the effect of HNF4A on hepatic secretion of triglyceride-rich lipoproteins

artículo científico publicado en 2010

Detecting multivariate differentially expressed genes

artículo científico publicado en 2007

Detection of compound mode of action by computational integration of whole-genome measurements and genetic perturbations

artículo científico publicado en 2006

Differences in apolipoprotein and lipid composition between human chylomicron remnants and very low density lipoproteins isolated from fasting and postprandial plasma ⬇️

artículo científico publicado el 1 de julio de 1998

EnsembleCNV: an ensemble machine learning algorithm to identify and genotype copy number variation using SNP array data

scholarly article by Zhongyang Zhang et al published 23 April 2019 in Nucleic Acids Research

Evidence of highly regulated genes (in-Hubs) in gene networks of Saccharomyces cerevisiae

artículo científico publicado en 2008

Expression quantitative trait Loci acting across multiple tissues are enriched in inherited risk for coronary artery disease

artículo científico publicado en 2015

Functional and transcriptomic insights into pathogenesis of R9C phospholamban mutation using human induced pluripotent stem cell-derived cardiomyocytes

artículo científico publicado en 2018

Functional investigation of the coronary artery disease gene SVEP1

artículo científico publicado en 2020

Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus

artículo científico publicado en 2018

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

artículo científico publicado en 2018

Genetic regulation of the placental transcriptome underlies birth weight and risk of childhood obesity

scientific article published on 31 December 2018

Global analysis of A-to-I RNA editing reveals association with common disease variants

artículo científico publicado en 2018

HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology

artículo científico

Hormonal regulation of circulating C-reactive protein in men.

artículo científico publicado en 2005

Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia

artículo científico publicado en 2007

Human Validation of Genes Associated With a Murine Atherosclerotic Phenotype

artículo científico publicado en 2016

Human Y Chromosome Exerts Pleiotropic Effects on Susceptibility to Atherosclerosis

artículo científico publicado en 2019

Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes

artículo científico publicado en 2021

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

artículo científico publicado en 2016

Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits

artículo científico publicado en 2019

JCAD Gene at the 10p11 Coronary Artery Disease Locus Regulates Hippo Signaling in Endothelial Cells.

artículo científico publicado en 2018

Lim domain binding 2: a key driver of transendothelial migration of leukocytes and atherosclerosis

artículo científico publicado en 2014

Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis: JACC Macrophage in CVD Series (Part 2)

artículo científico publicado en 2018

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci ⬇️

artículo científico publicado en 2016

Model-based clustering of multi-tissue gene expression data

artículo científico publicado en 2020

Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: the Stockholm Atherosclerosis Gene Expression (STAGE) study

artículo científico publicado en 2009

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

artículo científico publicado en 2018

Multiple independent mechanisms link gene polymorphisms in the region of ZEB2 with risk of coronary artery disease

artículo científico publicado en 2020

Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets

artículo científico publicado en 2018

Network analysis reveals a causal role of mitochondrial gene activity in atherosclerotic lesion formation

artículo científico publicado en 2017

On reliable discovery of molecular signatures

artículo científico publicado en 2009

Opportunities and challenges for transcriptome-wide association studies

artículo científico publicado en 2019

PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data

research article

Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19 patients

artículo científico publicado en 2020

Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis

artículo científico publicado en 2014

Poliovirus Receptor-Related 2: A Cholesterol-Responsive Gene Affecting Atherosclerosis Development by Modulating Leukocyte Migration

artículo científico publicado en 2017

Postprandial enrichment of remnant lipoproteins with apoC-I in healthy normolipidemic men with early asymptomatic atherosclerosis

artículo científico publicado en 2002

Prediction of Causal Candidate Genes in Coronary Artery Disease Loci

artículo científico publicado en 2015

Preservation Analysis of Macrophage Gene Coexpression Between Human and Mouse Identifies PARK2 as a Genetically Controlled Master Regulator of Oxidative Phosphorylation in Humans

artículo científico publicado en 2016

Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

artículo científico publicado en 2019

Publisher Correction: Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination

artículo científico publicado en 2020

Reverse engineering of gene networks with LASSO and nonlinear basis functions

artículo científico publicado en 2009

Sex differences in human adipose tissue gene expression and genetic regulation involve adipogenesis

scientific article published on 23 September 2020

Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination

artículo científico publicado en 2020

Single-cell immune landscape of human atherosclerotic plaques

artículo científico publicado en 2019

Smoking is Associated to DNA Methylation in Atherosclerotic Carotid Lesions

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease ⬇️

artículo científico publicado en 2017

Systematic analysis of chromatin interactions at disease associated loci links novel candidate genes to inflammatory bowel disease

artículo científico publicado en 2016

Systems Pharmacology Identifies an Arterial Wall Regulatory Gene Network Mediating Coronary Artery Disease Side Effects of Antiretroviral Therapy

artículo científico publicado en 2019

Systems and genome-wide approaches unite to provide a route to personalized medicine

artículo científico publicado en 2012

Systems biology of innate immunity

artículo científico publicado en 2006

The Low Density Lipoprotein Receptor Prevents Secretion of Dense ApoB100-containing Lipoproteins from the Liver ⬇️

artículo científico publicado el 28 de octubre de 2003

The State of Systems Genetics in 2017.

artículo científico publicado en 2017

The Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis

artículo científico publicado en 2020

The apolipoprotein CI content of triglyceride-rich lipoproteins independently predicts early atherosclerosis in healthy middle-aged men.

artículo científico publicado en 2005

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.

artículo científico publicado en 2009

Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Multi-organ whole-genome measurements and reverse engineering to uncover gene networks underlying complex traits

artículo científico publicado en 2006

Transcription Regulatory Networks Analysis Using CAGE

Transcriptional network dynamics in macrophage activation

artículo científico

Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes

artículo científico publicado en 2008

Transcriptome-wide association studies: opportunities and challenges

Transient triglyceridemia in healthy normolipidemic men increases cellular processing of large very low density lipoproteins by fibroblasts in vitro ⬇️

artículo científico publicado el 1 de febrero de 1998

Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the Athero-Express Genomics Study

artículo científico publicado en 2015

alona: a web server for single cell RNA-seq analysis

artículo científico publicado en 2020

kruX: matrix-based non-parametric eQTL discovery

artículo científico

Lista de obras de

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism

A plasma proteogenomic signature for fibromuscular dysplasia

ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques

Additional Candidate Genes for Human Atherosclerotic Disease Identified Through Annotation Based on Chromatin Organization

An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease

ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytes

Association analyses based on false discovery rate implicate new loci for coronary artery disease ⬇️

Blood levels of dual-specificity phosphatase-1 independently predict risk for post-operative morbidities causing prolonged hospitalization after coronary artery bypass grafting

Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.

Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases.

Carotid plaque age is a feature of plaque stability inversely related to levels of plasma insulin

Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade

Contribution of Gene Regulatory Networks to Heritability of Coronary Artery Disease

Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease

DGAT1 participates in the effect of HNF4A on hepatic secretion of triglyceride-rich lipoproteins

Detecting multivariate differentially expressed genes

Detection of compound mode of action by computational integration of whole-genome measurements and genetic perturbations

Differences in apolipoprotein and lipid composition between human chylomicron remnants and very low density lipoproteins isolated from fasting and postprandial plasma ⬇️

EnsembleCNV: an ensemble machine learning algorithm to identify and genotype copy number variation using SNP array data

Evidence of highly regulated genes (in-Hubs) in gene networks of Saccharomyces cerevisiae

Expression quantitative trait Loci acting across multiple tissues are enriched in inherited risk for coronary artery disease

Functional and transcriptomic insights into pathogenesis of R9C phospholamban mutation using human induced pluripotent stem cell-derived cardiomyocytes

Functional investigation of the coronary artery disease gene SVEP1

Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

Genetic regulation of the placental transcriptome underlies birth weight and risk of childhood obesity

Global analysis of A-to-I RNA editing reveals association with common disease variants

HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology

Hormonal regulation of circulating C-reactive protein in men.

Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia

Human Validation of Genes Associated With a Murine Atherosclerotic Phenotype

Human Y Chromosome Exerts Pleiotropic Effects on Susceptibility to Atherosclerosis

Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits

JCAD Gene at the 10p11 Coronary Artery Disease Locus Regulates Hippo Signaling in Endothelial Cells.

Lim domain binding 2: a key driver of transendothelial migration of leukocytes and atherosclerosis

Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis: JACC Macrophage in CVD Series (Part 2)

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci ⬇️

Model-based clustering of multi-tissue gene expression data

Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: the Stockholm Atherosclerosis Gene Expression (STAGE) study

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Multiple independent mechanisms link gene polymorphisms in the region of ZEB2 with risk of coronary artery disease

Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets

Network analysis reveals a causal role of mitochondrial gene activity in atherosclerotic lesion formation

On reliable discovery of molecular signatures

Opportunities and challenges for transcriptome-wide association studies

PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data

Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19 patients

Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis

Poliovirus Receptor-Related 2: A Cholesterol-Responsive Gene Affecting Atherosclerosis Development by Modulating Leukocyte Migration

Postprandial enrichment of remnant lipoproteins with apoC-I in healthy normolipidemic men with early asymptomatic atherosclerosis

Prediction of Causal Candidate Genes in Coronary Artery Disease Loci

Preservation Analysis of Macrophage Gene Coexpression Between Human and Mouse Identifies PARK2 as a Genetically Controlled Master Regulator of Oxidative Phosphorylation in Humans

Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Publisher Correction: Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination

Reverse engineering of gene networks with LASSO and nonlinear basis functions

Sex differences in human adipose tissue gene expression and genetic regulation involve adipogenesis

Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination

Single-cell immune landscape of human atherosclerotic plaques

Smoking is Associated to DNA Methylation in Atherosclerotic Carotid Lesions

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease ⬇️

Systematic analysis of chromatin interactions at disease associated loci links novel candidate genes to inflammatory bowel disease

Systems Pharmacology Identifies an Arterial Wall Regulatory Gene Network Mediating Coronary Artery Disease Side Effects of Antiretroviral Therapy

Systems and genome-wide approaches unite to provide a route to personalized medicine

Systems biology of innate immunity

The Low Density Lipoprotein Receptor Prevents Secretion of Dense ApoB100-containing Lipoproteins from the Liver ⬇️

The State of Systems Genetics in 2017.

The Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis

The apolipoprotein CI content of triglyceride-rich lipoproteins independently predicts early atherosclerosis in healthy middle-aged men.

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.

Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Multi-organ whole-genome measurements and reverse engineering to uncover gene networks underlying complex traits

Transcription Regulatory Networks Analysis Using CAGE

Transcriptional network dynamics in macrophage activation

Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes

Transcriptome-wide association studies: opportunities and challenges

Transient triglyceridemia in healthy normolipidemic men increases cellular processing of large very low density lipoproteins by fibroblasts in vitro ⬇️

Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the Athero-Express Genomics Study

alona: a web server for single cell RNA-seq analysis