Lista de obras -

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

artículo científico publicado en 2020

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

artículo científico publicado en 2008

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

artículo científico publicado en 2019

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

artículo científico publicado en 2007

BAK core dimers bind lipids and can be bridged by them

scientific article published on 14 September 2020

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

artículo científico publicado en 2013

Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

artículo científico publicado en 2009

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis

artículo científico publicado en 2021

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

artículo científico publicado en 2017

Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes

artículo científico publicado en 2010

Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid-binding residues

artículo científico publicado en 2020

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.

artículo científico publicado en 2013

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues

scientific article published on 19 June 2020

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P position of PEXEL peptidomimetics

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

artículo científico publicado en 2009

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

artículo científico publicado en 2021

Insights into Duffy Binding-like Domains through the Crystal Structure and Function of the Merozoite Surface Protein MSPDBL2 from Plasmodium falciparum

artículo científico publicado en 2012

Ion currents through Kir potassium channels are gated by anionic lipids

artículo científico publicado en 2022

Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis

artículo científico publicado en 2011

Physiological restraint of Bak by Bcl-xL is essential for cell survival

artículo científico publicado en 2016

Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1

artículo científico publicado en 2013

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

artículo científico publicado en 2011

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes

artículo científico publicado en 2015

Structural insights into the degradation of Mcl-1 induced by BH3 domains

artículo científico publicado en 2007

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

scientific article published on 03 June 2019

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

artículo científico publicado en 2006

The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments

artículo científico publicado en 2012

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

artículo científico publicado en 2013

Lista de obras de

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

BAK core dimers bind lipids and can be bridged by them

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes

Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid-binding residues

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P position of PEXEL peptidomimetics

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

Insights into Duffy Binding-like Domains through the Crystal Structure and Function of the Merozoite Surface Protein MSPDBL2 from Plasmodium falciparum

Ion currents through Kir potassium channels are gated by anionic lipids

Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis

Physiological restraint of Bak by Bcl-xL is essential for cell survival

Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes

Structural insights into the degradation of Mcl-1 induced by BH3 domains

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism