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Alternative splicing reverses the cell-intrinsic and cell-extrinsic prooncogenic potentials of YAP1

artículo científico publicado en 2020

Anti-tumor activity of ESX1 on cancer cells harboring oncogenic K-ras mutation

artículo científico publicado en 2008

Association between diversity in the Src homology 2 domain--containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer

artículo científico

Attenuation of Helicobacter pylori CagA x SHP-2 signaling by interaction between CagA and C-terminal Src kinase

artículo científico publicado en 2002

Bacterial EPIYA effectors--where do they come from? What are they? Where are they going?

artículo científico publicado en 2012

Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites

artículo científico publicado en 2002

C-terminal Src kinase-mediated EPIYA phosphorylation of Pragmin creates a feed-forward C-terminal Src kinase activation loop that promotes cell motility

artículo científico publicado en 2016

CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5.

artículo científico publicado en 2012

CEACAM6 is upregulated by Helicobacter pylori CagA and is a biomarker for early gastric cancer.

artículo científico publicado en 2016

Carcinogenic mechanisms of Helicobacter pylori

artículo científico publicado el 1 de junio de 2009

Conditional gene silencing utilizing the lac repressor reveals a role of SHP-2 in cagA-positive Helicobacter pylori pathogenicity

artículo científico publicado en 2004

Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21

artículo científico publicado el 20 de septiembre de 2010

Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways.

artículo científico publicado en 2016

Deregulation of beta-catenin signal by Helicobacter pylori CagA requires the CagA-multimerization sequence

artículo científico publicado en 2008

Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling

scientific journal article

Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins

artículo científico publicado en 2017

Differential oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in mice.

artículo científico publicado en 2009

Distinct diversity of the cag pathogenicity island among Helicobacter pylori strains in Japan

artículo científico publicado en 2004

Distinct diversity of vacA, cagA, and cagE genes of Helicobacter pylori associated with peptic ulcer in Japan

artículo científico publicado en 2005

Downregulation of cyclin-dependent kinase inhibitor; p57(kip2), is involved in the cell cycle progression of vascular smooth muscle cells.

artículo científico publicado en 2005

EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells

artículo científico publicado en 2005

Effects of Helicobacter pylori CagA protein on the growth and survival of B lymphocytes, the origin of MALT lymphoma

artículo científico publicado el 13 de noviembre de 2003

Evaluating the origin and virulence of a Helicobacter pylori cagA-positive strain isolated from a non-human primate

scientific article published in Scientific Reports

Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA.

artículo científico publicado en 2016

Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells

artículo científico publicado en 2005

Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation

artículo científico publicado en 2004

Helicobacter pylori CagA oncoprotein interacts with SHIP2 to increase its delivery into gastric epithelial cells

scientific article published on 20 March 2020

Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesis

artículo científico publicado en 2005

Helicobacter pylori exploits host membrane phosphatidylserine for delivery, localization, and pathophysiological action of the CagA oncoprotein

artículo científico publicado en 2010

Helicobacter pylori induces IL-1β protein through the inflammasome activation in differentiated macrophagic cells

artículo científico publicado en 2016

Helicobacter pylori stimulates epithelial cell migration via CagA-mediated perturbation of host cell signaling

artículo científico publicado el 11 de diciembre de 2011

High-Molecular-Weight Hyaluronan Is a Hippo Pathway Ligand Directing Cell Density-Dependent Growth Inhibition via PAR1b

scientific article published on 09 May 2019

Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by Epstein-Barr virus

artículo científico publicado en 2016

Hyaluronan Degradation Promotes Cancer via Hippo-YAP Signaling: An Intervention Point for Cancer Therapy

artículo científico publicado en 2020

Identification of Helicobacter pylori and the cagA genotype in gastric biopsies using highly sensitive real-time PCR as a new diagnostic tool.

artículo científico publicado en 2005

Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA.

artículo científico publicado en 2006

Meta-analysis of the relationship between CagA seropositivity and gastric cancer

artículo científico publicado en 2004

Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein

artículo científico publicado en 2015

NF-kappa B-dependent induction of cyclin D1 by retinoblastoma protein (pRB) family proteins and tumor-derived pRB mutants

artículo científico publicado en 2003

Natural variant of the Helicobacter pylori CagA oncoprotein that lost the ability to interact with PAR1.

artículo científico publicado en 2014

PAR1b takes the stage in the morphogenetic and motogenetic activity of Helicobacter pylori CagA oncoprotein

artículo científico publicado en 2012

Paired-like homeodomain protein ESXR1 possesses a cleavable C-terminal region that inhibits cyclin degradation

artículo científico publicado en 2004

Paired-like homeoprotein ESXR1 acts as a sequence-specific transcriptional repressor of the human K-ras gene

artículo científico publicado en 2005

Polarity-regulating Kinase Partitioning-defective 1b (PAR1b) Phosphorylates Guanine Nucleotide Exchange Factor H1 (GEF-H1) to Regulate RhoA-dependent Actin Cytoskeletal Reorganization

artículo científico publicado el 9 de noviembre de 2011

Potentiation of Helicobacter pylori CagA Protein Virulence through Homodimerization

artículo científico publicado el 3 de agosto de 2011

Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells

artículo científico publicado en 2012

Role of pRB-family/E2F complex in the inhibition of IL-3-dependent lymphoid cell proliferation

artículo científico publicado en 2002

Role of partitioning-defective 1/microtubule affinity-regulating kinases in the morphogenetic activity of Helicobacter pylori CagA.

scientific article published on 24 June 2009

SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein

artículo científico publicado en 2001

Stability of Helicobacter pylori CagA oncoprotein in human gastric epithelial cells.

artículo científico publicado en 2009

Structural and functional diversity in the PAR1b/MARK2-binding region of Helicobacter pylori CagA.

artículo científico publicado en 2008

Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells

scientific article published on 05 September 2006

Tertiary structure-function analysis reveals the pathogenic signaling potentiation mechanism of Helicobacter pylori oncogenic effector CagA

artículo científico publicado en 2012

The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa

artículo científico publicado en 2002

The CagA protein of Helicobacter pylori suppresses the functions of dendritic cell in mice

artículo científico publicado en 2010

The diversity of vacA and cagA genes of Helicobacter pylori in East Asia

artículo científico publicado en 2004

Transcriptional Co-activator Functions of YAP and TAZ Are Inversely Regulated by Tyrosine Phosphorylation Status of Parafibromin

scientific article published on 15 February 2018

Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse

artículo científico publicado en 2008

YAP and TAZ, Hippo signaling targets, act as a rheostat for nuclear SHP2 function.

artículo científico publicado en 2013