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4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer

scientific article published on 20 March 2019

A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation.

artículo científico publicado en 2010

A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells

artículo científico publicado en 2011

A systems genetics approach identifies CXCL14, ITGAX, and LPCAT2 as novel aggressive prostate cancer susceptibility genes.

artículo científico publicado en 2014

Antisense oligonucleotides targeting the progesterone receptor inhibit hormone-independent breast cancer growth in mice

artículo científico publicado en 2005

Associated expressions of FGFR-2 and FGFR-3: from mouse mammary gland physiology to human breast cancer

artículo científico publicado en 2011

Association of estrogen receptor-alpha and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the host microenvironment

artículo científico publicado en 2007

Breast Cancer Mortality in Older and Younger Breast Cancer Patients in California

artículo científico publicado en 2018

Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis

artículo científico publicado en 2012

Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis.

artículo científico publicado en 2008

Cholecystokinin receptor antagonist halts progression of pancreatic cancer precursor lesions and fibrosis in mice

artículo científico publicado en 2014

Classical membrane progesterone receptors in murine mammary carcinomas: agonistic effects of progestins and RU-486 mediating rapid non-genomic effects.

artículo científico publicado en 2010

Comparative toxicity and efficacy of engineered anthrax lethal toxin variants with broad anti-tumor activities

artículo científico publicado en 2014

DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays

artículo científico publicado en 2012

Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer

artículo científico publicado en 2011

Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis

artículo científico publicado en 2006

Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation

artículo científico publicado en 2005

Detecting cancer metastasis and accompanying protein biomarkers at single cell levels using a 3D-printed microfluidic immunoarray

artículo científico publicado en 2020

Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography

artículo científico publicado en 2004

Differential effects of raloxifene, tamoxifen and fulvestrant on a murine mammary carcinoma

artículo científico publicado en 2003

Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice

artículo científico publicado en 2010

Efficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin

artículo científico publicado en 2011

Establishment of two hormone-responsive mouse mammary carcinoma cell lines derived from a metastatic mammary tumor

artículo científico publicado en 2004

Estrogen or antiprogestin treatment induces complete regression of pulmonary and axillary metastases in an experimental model of breast cancer progression

artículo científico publicado en 2005

Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promoters

scientific journal article

Evidence for two progesterone receptor binding sites in murine mammary carcinomas

artículo científico publicado en 2003

Expression and Genetic Loss of Function Analysis of the HAT/DESC Cluster Proteases TMPRSS11A and HAT ⬇️

artículo científico publicado el 10 de agosto de 2011

Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data.

artículo científico publicado en 2012

Expression of plasmid DNA in the salivary gland epithelium: novel approaches to study dynamic cellular processes in live animals

artículo científico publicado en 2009

Germline genetic variation modulates tumor progression and metastasis in a mouse model of neuroendocrine prostate carcinoma.

artículo científico publicado en 2013

Global gene expression profile of nasopharyngeal carcinoma by laser capture microdissection and complementary DNA microarrays.

artículo científico publicado en 2004

Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis.

artículo científico publicado en 2014

Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.

artículo científico publicado en 2014

Immune consequences of decreasing tumor vasculature with antiangiogenic tyrosine kinase inhibitors in combination with therapeutic vaccines.

artículo científico publicado en 2014

Inhibition of Mammalian target of rapamycin by rapamycin causes the regression of carcinogen-induced skin tumor lesions.

artículo científico publicado en 2008

Inhibition of mTOR Signaling and Clinical Activity of Rapamycin in Head and Neck Cancer in a Window of Opportunity Trial

scientific article published on 12 November 2018

Inhibition of mammary tumor growth by estrogens: is there a specific role for estrogen receptors alpha and beta?

artículo científico publicado en 2009

Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth

artículo científico publicado en 2010

Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes

artículo científico publicado en 2010

Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin

artículo científico publicado en 2005

Involvement of matrix metalloproteinase activity in hormone-induced mammary tumor regression

artículo científico publicado en 2006

Isolation of a stromal cell line from an early passage of a mouse mammary tumor line: a model for stromal parenchymal interactions.

artículo científico publicado en 2005

MPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary carcinomas with different hormonal requirements.

artículo científico publicado en 2010

Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature

artículo científico publicado en 2007

Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions

artículo científico publicado en 2012

Mifepristone inhibits MPA-and FGF2-induced mammary tumor growth but not FGF2-induced mammary hyperplasia

artículo científico publicado el 1 de enero de 2010

Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma

artículo científico publicado en 2010

Novel, low cost, highly effective, handmade steroid pellets for experimental studies

artículo científico publicado en 2013

Nuclear localization of heme oxygenase-1 is associated with tumor progression of head and neck squamous cell carcinomas.

artículo científico publicado en 2012

Nuclear staining of fgfr-2/stat-5 and runx-2 in mucinous breast cancer

artículo científico publicado en 2015

PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis.

artículo científico publicado en 2011

Prevention of tumor growth driven by PIK3CA and HPV oncogenes by targeting mTOR signaling with metformin in oral squamous carcinomas expressing OCT3.

artículo científico publicado en 2015

Progesterone Receptor Isoform Ratio: A Breast Cancer Prognostic and Predictive Factor for Antiprogestin Responsiveness.

artículo científico publicado en 2017

Progesterone receptor expression in medroxyprogesterone acetate-induced murine mammary carcinomas and response to endocrine treatment

artículo científico publicado en 2003

Progesterone receptors--animal models and cell signalling in breast cancer. Diverse activation pathways for the progesterone receptor: possible implications for breast biology and cancer

artículo científico publicado en 2002

Progestin and antiprogestin responsiveness in breast cancer is driven by the PRA/PRB ratio via AIB1 or SMRT recruitment to the CCND1 and MYC promoters.

artículo científico publicado en 2014

Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells

artículo científico publicado en 2005

Proteome-wide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and tandem mass spectrometry.

artículo científico publicado en 2005

Proteomic analysis of laser-captured paraffin-embedded tissues: a molecular portrait of head and neck cancer progression.

artículo científico publicado en 2008

Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter

artículo científico publicado en 2006

Reversal of antiprogestin resistance and progesterone receptor isoform ratio in acquired resistant mammary carcinomas

artículo científico publicado en 2008

SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis

artículo científico publicado en 2014

Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation

artículo científico publicado en 2010

Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma

artículo científico publicado en 2013

TMPRSS13 deficiency impairs stratum corneum formation and epidermal barrier acquisition

scientific journal article

Targeting progesterone receptors in breast cancer.

artículo científico

The MPA mouse breast cancer model: evidence for a role of progesterone receptors in breast cancer.

scientific article published on 03 February 2009

The effectiveness of nano chemotherapeutic particles combined with mifepristone depends on the PR isoform ratio in preclinical models of breast cancer

artículo científico publicado en 2014

The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies

artículo científico publicado en 2014

Tipifarnib as a Precision Therapy for HRAS-Mutant Head and Neck Squamous Cell Carcinomas

artículo científico publicado en 2020

Transcriptional signature primes human oral mucosa for rapid wound healing.

artículo científico publicado en 2018

Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis

artículo científico publicado en 2022

Tumor-induced osteomalacia

artículo científico publicado en 2011

Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcoma

artículo científico publicado en 2010

WISP1/CCN4: a potential target for inhibiting prostate cancer growth and spread to bone

artículo científico publicado en 2013

mTOR as a molecular target in HPV-associated oral and cervical squamous carcinomas

artículo científico publicado en 2012

mTOR co-targeting in cetuximab resistance in head and neck cancers harboring PIK3CA and RAS mutations

artículo científico publicado en 2014

mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.

artículo científico publicado en 2012

p21, p27 and p53 in estrogen and antiprogestin-induced tumor regression of experimental mouse mammary ductal carcinomas.

artículo científico publicado en 2002

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