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A Multipronged Method for Unveiling Subtle Structural-Functional Defects of Mutant Chaperone Molecules Causing Human Chaperonopathies

artículo científico publicado en 2019

A Novel CCT5 Missense Variant Associated with Early Onset Motor Neuropathy

artículo científico publicado en 2020

A human CCT5 gene mutation causing distal neuropathy impairs hexadecamer assembly in an archaeal model

artículo científico publicado en 2014

Alcoholic Liver Disease: A Mouse Model Reveals Protection by Lactobacillus fermentum

artículo científico publicado en 2016

Alzheimer's Disease and Molecular Chaperones: Current Knowledge and the Future of Chaperonotherapy

artículo científico publicado en 2016

Breaking the mould: archaea with all four chaperoning systems

artículo científico publicado en 2003

Bridging human chaperonopathies and microbial chaperonins

scientific article published on 15 March 2019

CD1A-positive cells and HSP60 (HSPD1) levels in keratoacanthoma and squamous cell carcinoma

artículo científico publicado en 2015

Changes in immunohistochemical levels and subcellular localization after therapy and correlation and colocalization with CD68 suggest a pathogenetic role of Hsp60 in ulcerative colitis

artículo científico publicado en 2011

Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes

artículo científico publicado en 2010

Chaperonin of Group I: Oligomeric Spectrum and Biochemical and Biological Implications

artículo científico publicado en 2017

Chaperonology: The Third Eye on Brain Gliomas.

artículo científico publicado en 2018

Chaperonomics, a new tool to study ageing and associated diseases

artículo científico publicado en 2006

Chaperonopathies and chaperonotherapy

artículo científico publicado en 2007

Chaperonopathies and chaperonotherapy. Hsp60 as therapeutic target in cancer: potential benefits and risks

artículo científico publicado en 2013

Chaperonopathies by defect, excess, or mistake

artículo científico publicado en 2007

Chaperonopathies of senescence and the scrambling of interactions between the chaperoning and the immune systems

artículo científico publicado en 2010

Chaperonopathies: Diseases in Which Mortalin and Other Hsp-Chaperones Play a Role in Etiology and Pathogenesis

Chlamydia trachomatis infection and anti-Hsp60 immunity: the two sides of the coin

artículo científico publicado en 2009

Circulating Molecular Chaperones in Subjects with Amnestic Mild Cognitive Impairment and Alzheimer's Disease: Data from the Zabùt Aging Project

artículo científico publicado en 2018

Convergent sets of data from in vivo and in vitro methods point to an active role of Hsp60 in chronic obstructive pulmonary disease pathogenesis

artículo científico publicado en 2011

Corrigendum to “Hsp60 and AChR cross-reactivity in myasthenia gravis: An update.” [J. Neurol. Sci. 292 (2010) 117–118]

scholarly article published in Journal of the Neurological Sciences

Data mining-based statistical analysis of biological data uncovers hidden significance: clustering Hashimoto's thyroiditis patients based on the response of their PBMC with IL-2 and IFN-γ secretion to stimulation with Hsp60.

artículo científico publicado en 2014

Doxorubicin anti-tumor mechanisms include Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence.

artículo científico publicado en 2016

Editorial: Pathologic Conditions of the Human Nervous and Muscular Systems Associated with Mutant Chaperones: Molecular and Mechanistic Aspects.

artículo científico publicado en 2018

Effect of heat stress on promoter binding by transcription factors in the cytosol of the archaeon Methanosarcina mazeii

artículo científico publicado en 2002

Elevated blood Hsp60, its structural similarities and cross-reactivity with thyroid molecules, and its presence on the plasma membrane of oncocytes point to the chaperonin as an immunopathogenic factor in Hashimoto's thyroiditis

artículo científico publicado en 2013

Evolution of a protein-folding machine: genomic and evolutionary analyses reveal three lineages of the archaeal hsp70(dnaK) gene

artículo científico publicado en 2006

Evolution of assisted protein folding: the distribution of the main chaperoning systems within the phylogenetic domain archaea

artículo científico publicado en 2004

Exosomal Chaperones and miRNAs in Gliomagenesis: State-of-Art and Theranostics Perspectives

artículo científico publicado en 2018

Exosomal HSP60: a potentially useful biomarker for diagnosis, assessing prognosis, and monitoring response to treatment

artículo científico

Extracellular Vesicle-Mediated Cell⁻Cell Communication in the Nervous System: Focus on Neurological Diseases

artículo científico publicado en 2019

Genetic disorders involving molecular-chaperone genes: a perspective

artículo científico publicado en 2005

Gut microbiota imbalance and chaperoning system malfunction are central to ulcerative colitis pathogenesis and can be counteracted with specifically designed probiotics: a working hypothesis

artículo científico

HSP60 activity on human bronchial epithelial cells.

artículo científico publicado en 2017

Heat shock protein 60 levels in tissue and circulating exosomes in human large bowel cancer before and after ablative surgery

artículo científico publicado en 2015

Heat shock protein-60 and risk for cardiovascular disease

artículo científico publicado en 2011

Heat-shock protein 60 kDa and atherogenic dyslipidemia in patients with untreated mild periodontitis: a pilot study

artículo científico publicado en 2012

Hsp10 nuclear localization and changes in lung cells response to cigarette smoke suggest novel roles for this chaperonin.

artículo científico publicado en 2014

Hsp10: anatomic distribution, functions, and involvement in human disease

artículo científico publicado en 2013

Hsp60 Post-translational Modifications: Functional and Pathological Consequences

artículo científico publicado en 2020

Hsp60 and AChR cross-reactivity in myasthenia gravis: An update

artículo científico publicado en 2010

Hsp60 and Hsp10 increase in colon mucosa of Crohn’s disease and ulcerative colitis

artículo científico publicado en 2010

Hsp60 and heme oxygenase-1 (Hsp32) in acute myocardial infarction

artículo científico publicado en 2011

Hsp60 and human aging: Les liaisons dangereuses

artículo científico

Hsp60 as a Novel Target in IBD Management: A Prospect

artículo científico publicado en 2019

Hsp60 chaperonopathies and chaperonotherapy: targets and agents

artículo científico publicado en 2013

Hsp60 expression, new locations, functions and perspectives for cancer diagnosis and therapy

artículo científico publicado en 2008

Hsp60 is actively secreted by human tumor cells

artículo científico publicado en 2010

Hsp60 response in experimental and human temporal lobe epilepsy

artículo científico publicado en 2015

Hsp60, a novel target for antitumor therapy: structure-function features and prospective drugs design

artículo científico

Hsp60: molecular anatomy and role in colorectal cancer diagnosis and treatment

artículo científico publicado en 2011

Human Hsp10 and Early Pregnancy Factor (EPF) and their relationship and involvement in cancer and immunity: current knowledge and perspectives

artículo científico publicado en 2009

Human Hsp60 with its mitochondrial import signal occurs in solution as heptamers and tetradecamers remarkably stable over a wide range of concentrations

artículo científico publicado en 2014

Human molecular chaperones share with SARS-CoV-2 antigenic epitopes potentially capable of eliciting autoimmunity against endothelial cells: possible role of molecular mimicry in COVID-19

scientific article published on 04 August 2020

Immunohistochemistry of Human Hsp60 in Health and Disease: From Autoimmunity to Cancer

artículo científico publicado en 2018

Immunohistochemistry of Human Hsp60 in Health and Disease: From Autoimmunity to Cancer

article

Immunomorphological Pattern of Molecular Chaperones in Normal and Pathological Thyroid Tissues and Circulating Exosomes: Potential Use in Clinics

artículo científico publicado en 2019

Is molecular mimicry the culprit in the autoimmune hemolytic anemia affecting COVID-19 patients?

artículo científico publicado en 2020

Isolation and Characterization of a Thermophilic, Sulfate Reducing Archaebacterium, Archaeoglobus fulgidus Strain Z

article

Lipid chaperones and associated diseases: a group of chaperonopathies defining a new nosological entity with implications for medical research and practice

artículo científico publicado en 2020

Methanogenic archaea in health and disease: a novel paradigm of microbial pathogenesis

artículo científico publicado en 2008

Missense Mutations of Human Hsp60: A Computational Analysis to Unveil Their Pathological Significance

artículo científico publicado en 2020

Molecular Biology of Stress Genes in Methanogens: Potential for Bioreactor Technology ⬇️

artículo científico publicado el 1 de enero de 2003

Molecular chaperones in tumors of salivary glands

scientific article published on 16 April 2020

Molecular chaperones: multiple functions, pathologies, and potential applications

artículo científico publicado en 2007

Molecular mechanisms in chaperonopathies: clues to understanding the histopathological abnormalities and developing novel therapies

scientific article published on 22 November 2019

Molecular mimicry may explain multi-organ damage in COVID-19

artículo científico publicado en 2020

Muscle Histopathological Abnormalities in a Patient With a CCT5 Mutation Predicted to Affect the Apical Domain of the Chaperonin Subunit

scientific article published on 01 January 2022

Muscle Histopathological Abnormalities in a Patient With a CCT5 Mutation Predicted to Affect the Apical Domain of the Chaperonin Subunit

artículo científico publicado en 2022

Myelin Pathology: Involvement of Molecular Chaperones and the Promise of Chaperonotherapy

scientific article published on 30 October 2019

Novel chaperonins in a prokaryote

artículo científico publicado en 2005

Prokaryotic Chaperonins as Experimental Models for Elucidating Structure-Function Abnormalities of Human Pathogenic Mutant Counterparts

scientific article published on January 2016

Quantitative analysis of the impact of a human pathogenic mutation on the CCT5 chaperonin subunit using a proxy archaeal ortholog.

artículo científico publicado en 2017

Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer

artículo científico publicado en 2016

Role of Molecular Chaperones in Carcinogenesis: Mechanism, Diagnosis, and Treatment

scientific article published on 20 April 2020

Sick chaperones and ageing: a perspective

artículo científico publicado en 2002

Sick chaperones, cellular stress, and disease

artículo científico publicado en 2005

Skeletal muscle Heat shock protein 60 increases after endurance training and induces peroxisome proliferator-activated receptor gamma coactivator 1 α1 expression

artículo científico publicado en 2016

Surface plasmon resonance for measuring TBP-promoter interaction

artículo científico publicado en 2002

The Role of Molecular Chaperones in Virus Infection and Implications for Understanding and Treating COVID-19

artículo científico publicado en 2020

The dissociation of the Hsp60/pro-Caspase-3 complex by bis(pyridyl)oxadiazole copper complex (CubipyOXA) leads to cell death in NCI-H292 cancer cells

artículo científico publicado en 2017

The future of molecular chaperones and beyond

artículo científico publicado en 2013

The genome of M. acetivorans reveals extensive metabolic and physiological diversity

artículo científico publicado en 2002

The histone deacetylase inhibitor SAHA induces HSP60 nitration and its extracellular release by exosomal vesicles in human lung-derived carcinoma cells.

artículo científico publicado en 2016

The molecular anatomy of human Hsp60 and its similarity with that of bacterial orthologs and acetylcholine receptor reveal a potential pathogenetic role of anti-chaperonin immunity in myasthenia gravis

artículo científico publicado en 2012

The odyssey of Hsp60 from tumor cells to other destinations includes plasma membrane-associated stages and Golgi and exosomal protein-trafficking modalities

artículo científico publicado en 2012

The pathology of cellular anti-stress mechanisms: a new frontier

artículo científico publicado en 2004

Transcription in the archaea: basal factors, regulation, and stress gene expression

artículo científico publicado en 2002

Transcription in the archaea: basal factors, regulation, and stress-gene expression

artículo científico publicado en 2002

Zebrafish as a Model for the Study of Chaperonopathies

artículo científico publicado en 2016

hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions

artículo científico publicado en 2008

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