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-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice

artículo científico publicado en 2018

15d-PGJ-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice

artículo científico publicado en 2018

5-lipoxygenase deficiency reduces acetaminophen-induced hepatotoxicity and lethality

artículo científico publicado en 2013

9The PI3Kγ/AKT signaling pathway mediates peripheral antinociceptive action of dipyrone

scientific article published on 26 September 2020

Apocynin and Nox2 regulate NF-κB by modifying thioredoxin-1 redox-state.

artículo científico publicado en 2016

Bosentan, a mixed endothelin receptor antagonist, inhibits superoxide anion-induced pain and inflammation in mice

artículo científico publicado en 2015

Budlein A, a Sesquiterpene Lactone From , Alleviates Pain and Inflammation in a Model of Acute Gout Arthritis in Mice

scholarly article by Victor Fattori et al published 2018 in Frontiers in Pharmacology

CCR2 Expression in Neutrophils Plays a Critical Role in Their Migration Into the Joints in Rheumatoid Arthritis

artículo científico publicado en 2015

CCR2-deficient mice are protected to sepsis by the disruption of the inflammatory monocytes emigration from the bone marrow

scientific article published on 05 October 2020

CCR4-dependent reduction in the number and suppressor function of CD4Foxp3 cells augments IFN-γ-mediated pulmonary inflammation and aggravates tuberculosis pathogenesis

scientific article published on 21 December 2018

CCR5-Positive Inflammatory Monocytes are Crucial for Control of Sepsis

scientific article published on 01 November 2019

Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis

artículo científico publicado en 2018

Cinnamoyloxy-mammeisin Isolated from Geopropolis Attenuates Inflammatory Process by Inhibiting Cytokine Production: Involvement of MAPK, AP-1, and NF-κB.

artículo científico publicado en 2016

Contribution of spinal cord glial cells to L. amazonensis experimental infection-induced pain in BALB/c mice

artículo científico publicado en 2019

Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-κB activation

artículo científico publicado en 2015

DF2755A, a novel non-competitive allosteric inhibitor of CXCR1/2, reduces inflammatory and post-operative pain

artículo científico publicado en 2015

DMH-CBD, a cannabidiol analog with reduced cytotoxicity, inhibits TNF production by targeting NF-kB activity dependent on A2A receptor

scientific article published on 20 February 2019

Differential regulation of oxidative stress and cytokine production by endothelin ETA and ETB receptors in superoxide anion-induced inflammation and pain in mice

artículo científico publicado en 2016

Diosmin reduces chronic constriction injury-induced neuropathic pain in mice

artículo científico publicado en 2017

Frontline Science: Blood-circulating leukocytes fail to infiltrate the spinal cord parenchyma after spared nerve injury

artículo científico publicado en 2019

Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway

artículo científico publicado en 2015

Hesperidin Methylchalcone Suppresses Experimental Gout Arthritis in Mice by Inhibiting NF-κB Activation

artículo científico publicado en 2018

Hydrogen sulfide augments neutrophil migration through enhancement of adhesion molecule expression and prevention of CXCR2 internalization: role of ATP-sensitive potassium channels

artículo científico publicado en 2008

IL-1α promotes liver inflammation and necrosis during blood-stage Plasmodium chabaudi malaria

artículo científico publicado en 2019

IL-27 Counteracts Neuropathic Pain Development Through Induction of IL-10

artículo científico publicado en 2019

IL-33 enhances macrophage release of IL-1β and promotes pain and inflammation in gouty arthritis

scientific article published on 04 September 2020

IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy

scientific article published on 14 May 2010

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

artículo científico publicado en 2021

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis

artículo científico publicado en 2018

Interleukin-10 limits intense acute swimming-induced muscle mechanical hyperalgesia in mice

artículo científico publicado en 2015

Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of Staphylococcus aureus-Induced Septic Arthritis

artículo científico publicado en 2018

Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis

artículo científico publicado en 2017

Lipopolysaccharide induces inflammatory hyperalgesia triggering a TLR4/MyD88-dependent cytokine cascade in the mice paw

artículo científico publicado en 2014

Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis

artículo científico publicado en 2015

MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression

artículo científico publicado en 2020

Mechanisms underlying the hyperalgesic responses triggered by joint activation of TLR4.

artículo científico publicado en 2016

Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization

artículo científico publicado en 2016

Molecular basis of carrageenan-induced cytokines production in macrophages

artículo científico publicado en 2020

Morphological, cellular, and molecular basis of brain infection in COVID-19 patients

artículo científico publicado en 2022

NLRP12 controls arthritis severity by acting as a checkpoint inhibitor of Th17 cell differentiation

artículo científico publicado en 2020

Naringenin mitigates titanium dioxide (TiO)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NFκB

scholarly article by Marília F Manchope et al published 28 October 2018 in Inflammation Research

Naringenin mitigates titanium dioxide (TiO2)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NFκB

scholarly article by Marília F. Manchope et al published 28 October 2018 in Inflammation Research

Neuroimmune-Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia

artículo científico publicado en 2017

Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis

artículo científico publicado en 2016

Neutrophil extracellular traps mediate joint hyperalgesia induced by immune inflammation

artículo científico publicado en 2020

Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway

artículo científico publicado en 2014

PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation

artículo científico publicado en 2020

Paclitaxel Reduces Tumor Growth by Reprogramming Tumor-Associated Macrophages to an M1 Profile in a TLR4-Dependent Manner

scientific article published on 13 August 2018

Pericytes modulate myelination in the central nervous system

artículo científico publicado en 2017

Probucol attenuates lipopolysaccharide-induced leukocyte recruitment and inflammatory hyperalgesia: effect on NF-кB activation and cytokine production

artículo científico publicado en 2017

Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects

artículo científico publicado en 2017

Pyrrolidine dithiocarbamate inhibits superoxide anion-induced pain and inflammation in the paw skin and spinal cord by targeting NF-κB and oxidative stress

artículo científico publicado en 2016

Regulation of type 17 helper T-cell function by nitric oxide during inflammation

artículo científico publicado en 2011

Regulatory T cells counteract neuropathic pain through inhibition of the Th1 response at the site of peripheral nerve injury

scientific article published on 26 March 2020

Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation

scientific article published on 31 March 2019

S100A9 plays a pivotal role in a mouse model of herpetic neuralgia via TLR4/TNF pathway

artículo científico publicado en 2020

SARS-CoV-2 triggered neutrophil extracellular traps (NETs) mediate COVID-19 pathology

artículo científico publicado en 2020

SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology

artículo científico publicado en 2020

STING regulates metabolic reprogramming in macrophages via HIF-1α during Brucella infection

artículo científico publicado en 2021

Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain

artículo científico publicado en 2015

Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of Th17 cells in the lymph nodes

artículo científico publicado en 2018

Superoxide anion-induced pain and inflammation depends on TNFα/TNFR1 signaling in mice

artículo científico publicado en 2015

TGF-β signalling defect is linked to low CD39 expression on regulatory T cells and methotrexate resistance in rheumatoid arthritis.

artículo científico publicado en 2018

TGFβ1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of T17 cells by an AHR-independent mechanism

artículo científico publicado en 2018

Targeting IL-33/ST2 signaling: regulation of immune function and analgesia

artículo científico publicado en 2017

Targeting interleukin-1β reduces intense acute swimming-induced muscle mechanical hyperalgesia in mice

artículo científico publicado en 2014

Targeting nitric oxide as a key modulator of sepsis, arthritis and pain

scientific article published on 30 April 2019

The Atypical Chemokine Receptor ACKR2 is Protective Against Sepsis

artículo científico publicado en 2017

The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development

artículo científico publicado en 2019

The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NFκB and macrophage release of IL-1β

The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-κB activation

artículo científico publicado en 2016

The nitroxyl donor, Angeli's salt, reduces chronic constriction injury-induced neuropathic pain

artículo científico publicado en 2016

Toll-like receptor 9 activation in neutrophils impairs chemotaxis and reduces sepsis outcome

artículo científico publicado en 2012

Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines and NF-κB.

artículo científico publicado en 2015

α1-Acid glycoprotein decreases neutrophil migration and increases susceptibility to sepsis in diabetic mice

artículo científico publicado en 2012