Lista de obras -

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

article

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

article

A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing.

artículo científico publicado en 2010

A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury.

artículo científico publicado en 2007

Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction.

artículo científico publicado en 2011

Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid

artículo científico publicado en 2009

Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase

artículo científico publicado en 2017

Assessing Therapeutic Efficacy of MEK Inhibition in a KRASG12C-Driven Mouse Model of Lung Cancer

artículo científico publicado en 2018

Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation.

artículo científico publicado en 2016

CDK4/6 Inhibition Augments Anti-Tumor Immunity by Enhancing T Cell Activation.

artículo científico publicado en 2017

Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events

artículo científico publicado en 2011

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

artículo científico

Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis

artículo científico publicado en 2009

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

scientific article published on 01 November 2018

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

scientific article published on 01 January 2019

Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane

artículo científico publicado en 2010

Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low‐density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release ⬇️

artículo científico publicado el 1 de mayo de 2012

Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases ⬇️

artículo científico publicado el 1 de junio de 2011

Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade

artículo científico publicado en 2020

Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis

artículo científico publicado en 2013

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

artículo científico publicado en 2017

Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation

artículo científico publicado en 2009

Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration

artículo científico publicado en 2015

Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease

artículo científico publicado en 2012

Mapping the immune environment in clear cell renal carcinoma by single-cell genomics

artículo científico publicado en 2021

Mechanisms of Resistance to Immune Checkpoint Blockade

artículo científico publicado en 2019

Mechanisms of resistance to immune checkpoint inhibitors

artículo científico publicado en 2018

Molecular and Genomic Determinants of Response to Immune Checkpoint Inhibition in Cancer.

artículo científico publicado en 2017

Molecular targeting of acid ceramidase: implications to cancer therapy.

artículo científico publicado en 2008

Neutral Sphingomyelinase-2 Mediates Growth Arrest by Retinoic Acid through Modulation of Ribosomal S6 Kinase ⬇️

artículo científico publicado el 2 de mayo de 2011

Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.

artículo científico publicado en 2006

Refining Targeted Therapy Opportunities for BRAF-Mutant Melanoma

artículo científico publicado en 2017

Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation.

artículo científico publicado en 2010

Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase ⬇️

artículo científico publicado el 18 de febrero de 2011

Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway

artículo científico publicado en 2008

Response to Crizotinib in a Patient With Lung Adenocarcinoma Harboring a MET Splice Site Mutation

artículo científico publicado en 2015

Roles and regulation of secretory and lysosomal acid sphingomyelinase

artículo científico publicado en 2009

Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain

artículo científico publicado en 2012

Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism

artículo científico publicado en 2010

Targeting TANK-binding kinase 1 (TBK1) in cancer

scientific article published on 22 September 2020

Treatment of Advanced Melanoma in 2020 and Beyond

artículo científico publicado en 2020

Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses.

artículo científico publicado en 2018

Lista de obras de

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing.

A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury.

Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction.

Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid

Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase

Assessing Therapeutic Efficacy of MEK Inhibition in a KRASG12C-Driven Mouse Model of Lung Cancer

Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation.

CDK4/6 Inhibition Augments Anti-Tumor Immunity by Enhancing T Cell Activation.

Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane

Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low‐density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release ⬇️

Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases ⬇️

Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade

Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation

Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration

Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease

Mapping the immune environment in clear cell renal carcinoma by single-cell genomics

Mechanisms of Resistance to Immune Checkpoint Blockade

Mechanisms of resistance to immune checkpoint inhibitors

Molecular and Genomic Determinants of Response to Immune Checkpoint Inhibition in Cancer.

Molecular targeting of acid ceramidase: implications to cancer therapy.

Neutral Sphingomyelinase-2 Mediates Growth Arrest by Retinoic Acid through Modulation of Ribosomal S6 Kinase ⬇️

Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.

Refining Targeted Therapy Opportunities for BRAF-Mutant Melanoma

Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation.

Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase ⬇️

Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway

Response to Crizotinib in a Patient With Lung Adenocarcinoma Harboring a MET Splice Site Mutation

Roles and regulation of secretory and lysosomal acid sphingomyelinase

Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain

Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism

Targeting TANK-binding kinase 1 (TBK1) in cancer

Treatment of Advanced Melanoma in 2020 and Beyond

Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses.