Lista de obras -

5-Stabilized phosphatidylinositol 3,4,5-trisphosphate analogues bind Grp1 PH, inhibit phosphoinositide phosphatases, and block neutrophil migration

artículo científico publicado en 2010

A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with SHIP2 Provides a Rationale for Drug Discovery ⬇️

artículo científico publicado el 27 de febrero de 2012

A diverse family of inositol 5-phosphatases playing a role in growth and development in Dictyostelium discoideum

artículo científico publicado en 2002

A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN).

artículo científico publicado en 2006

Abnormal elevated PTEN expression in the mouse antrum of a model of GIST KitK641E/K641E ⬇️

artículo científico publicado el 3 de julio de 2011

Astrocytic IP3/Ca2+ Signaling Modulates Theta Rhythm and REM Sleep

artículo científico publicado en 2017

Benzene polyphosphates as tools for cell signalling: inhibition of inositol 1,4,5-trisphosphate 5-phosphatase and interaction with the PH domain of protein kinase Balpha.

artículo científico publicado en 2008

Biphenyl 2,3',4,5',6-pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca2+ responses in rat hepatocytes

artículo científico publicado en 2007

ENDOGLIN/CD105 is expressed in KIT positive cells in the gut and in gastrointestinal stromal tumours ⬇️

artículo científico publicado el 1 de febrero de 2012

Evidence of SHIP2 Ser132 phosphorylation, its nuclear localization and stability

artículo científico publicado en 2011

Fibroblasts derived from patients with opsismodysplasia display SHIP2-specific cell migration and adhesion defects

artículo científico publicado en 2017

How does SHIP1/2 balance PtdIns(3,4)P2 and does it signal independently of its phosphatase activity? ⬇️

artículo científico publicado el 7 de mayo de 2013

Hydrogen peroxide and epidermal growth factor activate phosphatidylinositol 3-kinase and increase sodium transport in A6 cell monolayers.

artículo científico publicado en 2005

Hyperosmotic stress stimulates inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate formation independently of bis-diphosphoinositol tetrakisphosphate modulation

artículo científico publicado en 2005

Hyperplasia of interstitial cells of cajal in sprouty homolog 4 deficient mice

artículo científico publicado en 2015

IPMK and β-catenin mediate PLC-β1-dependent signaling in myogenic differentiation

artículo científico publicado en 2016

Identification and subcellular distribution of endogenous Ins(1,4,5)P(3) 3-kinase B in mouse tissues

scientific journal article

Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells

artículo científico publicado en 2018

Inhibition of insulin-stimulated hydrogen peroxide production prevents stimulation of sodium transport in A6 cell monolayers

artículo científico publicado en 2009

Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells

artículo científico publicado en 2007

Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte development ⬇️

artículo científico publicado el 28 de septiembre de 2003

Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils

artículo científico publicado en 2007

Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis

scientific journal article

Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology

artículo científico publicado en 2014

Inositol(1,4,5)P3 3-kinase isoenzymes: Catalytic properties and importance of targeting to F-actin to understand function

artículo científico

Kit K641E oncogene up-regulates Sprouty homolog 4 and trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours

artículo científico publicado en 2009

Multivalent benzene polyphosphate derivatives are non-Ca2+-mobilizing Ins(1,4,5)P3 receptor antagonists

artículo científico publicado en 2012

Neurotensin Receptor 1 Is Expressed in Gastrointestinal Stromal Tumors but Not in Interstitial Cells of Cajal ⬇️

artículo científico publicado el 18 de febrero de 2011

Phosphatidylinositol 3,4,5-trisphosphate modulation in SHIP2-deficient mouse embryonic fibroblasts

artículo científico publicado en 2005

Phosphatidylinositol 3,4,5-trisphosphate: an early mediator of insulin-stimulated sodium transport in A6 cells

artículo científico publicado en 2004

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle

artículo científico publicado en 2013

Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST).

artículo científico publicado en 2017

Phosphoinositide phosphatases in a network of signalling reactions

artículo científico publicado en 2007

Reactive blue 2 inhibition of cyclic AMP-dependent differentiation of rat C6 glioma cells by purinergic receptor-independent inactivation of phosphatidylinositol 3-kinase

artículo científico publicado en 2004

SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels

artículo científico publicado en 2003

SHIP1/2 interaction with tyrosine phosphorylated peptides mimicking an immunoreceptor signalling motif

artículo científico publicado en 2006

SHIP2 (SH2 domain-containing inositol phosphatase 2) SH2 domain negatively controls SHIP2 monoubiquitination in response to epidermal growth factor

artículo científico publicado en 2009

SHIP2 controls PtdIns(3,4,5)P(3) levels and PKB activity in response to oxidative stress

artículo científico publicado en 2007

SHIP2 controls plasma membrane PI(4,5)P2 thereby participating in the control of cell migration in 1321 N1 glioblastoma cells

artículo científico publicado en 2016

SHIP2 interaction with the cytoskeletal protein Vinexin

artículo científico publicado en 2005

SHIP2 multiple functions: A balance between a negative control of PtdIns(3,4,5)P3 level, a positive control of PtdIns(3,4)P2 production, and intrinsic docking properties ⬇️

artículo científico publicado el 1 de septiembre de 2011

SHIP2 overexpression strongly reduces the proliferation rate of K562 erythroleukemia cell line

artículo científico publicado en 2002

SHIP2 regulates epithelial cell polarity through its lipid product, which binds to Dlg1, a pathway subverted by hepatitis C virus core protein ⬇️

artículo científico publicado el 22 de mayo de 2013

SHIP2 signaling in normal and pathological situations: Its impact on cell proliferation

artículo científico

SHIP2 signalling at the plasma membrane, in the nucleus and at focal contacts ⬇️

artículo científico publicado el 13 de septiembre de 2012

SHIP2: Structure, Function and Inhibition

artículo científico publicado en 2016

The Host Phosphoinositide 5-Phosphatase SHIP2 Regulates Dissemination of Vaccinia Virus ⬇️

artículo científico publicado el 4 de mayo de 2011

The SHIP2 interactor Myo1c is required for cell migration in 1321 N1 glioblastoma cells

artículo científico publicado en 2016

The Shigella type III effector IpgD recodes Ca2+ signals during invasion of epithelial cells.

artículo científico publicado en 2017

The absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts

artículo científico publicado en 2007

The association between the SH2-containing inositol polyphosphate 5-Phosphatase 2 (SHIP2) and the adaptor protein APS has an impact on biochemical properties of both partners

artículo científico publicado en 2008

The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2

artículo científico publicado en 2003

The impact of phosphoinositide 5-phosphatases on phosphoinositides in cell function and human disease

artículo científico publicado en 2018

The influence of anionic lipids on SHIP2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase activity

scientific article published on 23 May 2006

The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system

scientific journal article

The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases

artículo científico publicado en 2018

The role of calmodulin for inositol 1,4,5-trisphosphate receptor function

artículo científico publicado en 2002

The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases

artículo científico publicado en 2003

The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells ⬇️

artículo científico publicado el 15 de agosto de 2003

Thyrotropin stimulates the generation of inositol 1,4,5-trisphosphate in human thyroid cells

artículo científico publicado en 2005

Lista de obras de

5-Stabilized phosphatidylinositol 3,4,5-trisphosphate analogues bind Grp1 PH, inhibit phosphoinositide phosphatases, and block neutrophil migration

A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with SHIP2 Provides a Rationale for Drug Discovery ⬇️

A diverse family of inositol 5-phosphatases playing a role in growth and development in Dictyostelium discoideum

A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN).

Abnormal elevated PTEN expression in the mouse antrum of a model of GIST KitK641E/K641E ⬇️

Astrocytic IP3/Ca2+ Signaling Modulates Theta Rhythm and REM Sleep

Benzene polyphosphates as tools for cell signalling: inhibition of inositol 1,4,5-trisphosphate 5-phosphatase and interaction with the PH domain of protein kinase Balpha.

Biphenyl 2,3',4,5',6-pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca2+ responses in rat hepatocytes

ENDOGLIN/CD105 is expressed in KIT positive cells in the gut and in gastrointestinal stromal tumours ⬇️

Evidence of SHIP2 Ser132 phosphorylation, its nuclear localization and stability

Fibroblasts derived from patients with opsismodysplasia display SHIP2-specific cell migration and adhesion defects

How does SHIP1/2 balance PtdIns(3,4)P2 and does it signal independently of its phosphatase activity? ⬇️

Hydrogen peroxide and epidermal growth factor activate phosphatidylinositol 3-kinase and increase sodium transport in A6 cell monolayers.

Hyperosmotic stress stimulates inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate formation independently of bis-diphosphoinositol tetrakisphosphate modulation

Hyperplasia of interstitial cells of cajal in sprouty homolog 4 deficient mice

IPMK and β-catenin mediate PLC-β1-dependent signaling in myogenic differentiation

Identification and subcellular distribution of endogenous Ins(1,4,5)P(3) 3-kinase B in mouse tissues

Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells

Inhibition of insulin-stimulated hydrogen peroxide production prevents stimulation of sodium transport in A6 cell monolayers

Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells

Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte development ⬇️

Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils

Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis

Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology

Inositol(1,4,5)P3 3-kinase isoenzymes: Catalytic properties and importance of targeting to F-actin to understand function

Kit K641E oncogene up-regulates Sprouty homolog 4 and trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours

Multivalent benzene polyphosphate derivatives are non-Ca2+-mobilizing Ins(1,4,5)P3 receptor antagonists

Neurotensin Receptor 1 Is Expressed in Gastrointestinal Stromal Tumors but Not in Interstitial Cells of Cajal ⬇️

Phosphatidylinositol 3,4,5-trisphosphate modulation in SHIP2-deficient mouse embryonic fibroblasts

Phosphatidylinositol 3,4,5-trisphosphate: an early mediator of insulin-stimulated sodium transport in A6 cells

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle

Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST).

Phosphoinositide phosphatases in a network of signalling reactions

Reactive blue 2 inhibition of cyclic AMP-dependent differentiation of rat C6 glioma cells by purinergic receptor-independent inactivation of phosphatidylinositol 3-kinase

SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels

SHIP1/2 interaction with tyrosine phosphorylated peptides mimicking an immunoreceptor signalling motif

SHIP2 (SH2 domain-containing inositol phosphatase 2) SH2 domain negatively controls SHIP2 monoubiquitination in response to epidermal growth factor

SHIP2 controls PtdIns(3,4,5)P(3) levels and PKB activity in response to oxidative stress

SHIP2 controls plasma membrane PI(4,5)P2 thereby participating in the control of cell migration in 1321 N1 glioblastoma cells

SHIP2 interaction with the cytoskeletal protein Vinexin

SHIP2 multiple functions: A balance between a negative control of PtdIns(3,4,5)P3 level, a positive control of PtdIns(3,4)P2 production, and intrinsic docking properties ⬇️

SHIP2 overexpression strongly reduces the proliferation rate of K562 erythroleukemia cell line

SHIP2 regulates epithelial cell polarity through its lipid product, which binds to Dlg1, a pathway subverted by hepatitis C virus core protein ⬇️

SHIP2 signaling in normal and pathological situations: Its impact on cell proliferation

SHIP2 signalling at the plasma membrane, in the nucleus and at focal contacts ⬇️

SHIP2: Structure, Function and Inhibition

The Host Phosphoinositide 5-Phosphatase SHIP2 Regulates Dissemination of Vaccinia Virus ⬇️

The SHIP2 interactor Myo1c is required for cell migration in 1321 N1 glioblastoma cells

The Shigella type III effector IpgD recodes Ca2+ signals during invasion of epithelial cells.

The absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts

The association between the SH2-containing inositol polyphosphate 5-Phosphatase 2 (SHIP2) and the adaptor protein APS has an impact on biochemical properties of both partners

The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2

The impact of phosphoinositide 5-phosphatases on phosphoinositides in cell function and human disease

The influence of anionic lipids on SHIP2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase activity

The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system

The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases

The role of calmodulin for inositol 1,4,5-trisphosphate receptor function

The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases

The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells ⬇️

Thyrotropin stimulates the generation of inositol 1,4,5-trisphosphate in human thyroid cells