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A <i>Saccharomyces cerevisiae</i> model and screen to define the functional consequences of oncogenic histone missense mutations

artículo científico publicado en 2022

A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons

artículo científico publicado en 2020

A Genetic Screen Links the Disease-Associated Nab2 RNA-Binding Protein to the Planar Cell Polarity Pathway in Drosophila melanogaster

scientific article published on 17 August 2020

A PY-NLS nuclear targeting signal is required for nuclear localization and function of the Saccharomyces cerevisiae mRNA-binding protein Hrp1.

artículo científico publicado en 2008

A Saccharomyces cerevisiae Model for Overexpression of Ntg1 a Base Excision DNA Repair Protein Reveals Novel Genetic Interactions

artículo científico publicado en 2022

A budding yeast model for human disease mutations in the <i>EXOSC2</i> cap subunit of the RNA exosome complex

artículo científico publicado en 2021

A compendium of RNA-binding motifs for decoding gene regulation.

artículo científico publicado en 2013

A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly(A) tail length

artículo científico publicado en 2014

A hierarchy of nuclear localization signals governs the import of the regulatory factor X complex subunits and MHC class II expression

artículo científico publicado en 2004

A long and winding road to the RNA world

artículo científico publicado en 2015

A yeast model system for functional analysis of the Niemann-Pick type C protein 1 homolog, Ncr1p

artículo científico publicado en 2005

A-Tail of Telomerase RNA Maturation

scientific article published on 01 May 2019

Actively transcribed GAL genes can be physically linked to the nuclear pore by the SAGA chromatin modifying complex

artículo científico publicado en 2006

Air1 Zinc Knuckles 4 and 5 and a Conserved IWRXY Motif Are Critical for the Function and Integrity of the Trf4/5-Air1/2-Mtr4 Polyadenylation (TRAMP) RNA Quality Control Complex

artículo científico publicado el 30 de agosto de 2011

An Antibody to Detect Alanine-Expanded PABPN1: A New Tool to Study Oculopharyngeal Muscular Dystrophy

artículo científico publicado en 2015

An endogenous PI3K interactome promoting astrocyte mediated neuroprotection identifies a novel association with RNA binding protein ZC3H14

artículo científico publicado en 2020

An interaction between two RNA binding proteins, Nab2 and Pub1, links mRNA processing/export and mRNA stability.

artículo científico publicado en 2007

Analysis of a predicted nuclear localization signal: implications for the intracellular localization and function of the Saccharomyces cerevisiae RNA-binding protein Scp160.

artículo científico publicado en 2007

Author response for "Dissecting the Roles of Cse1 and Nup2 in Classical &lt;scp&gt;NLS‐Cargo&lt;/scp&gt; Release &lt;i&gt;in vivo&lt;/i&gt;"

artículo científico publicado en 2020

Author response for "Dissecting the Roles of Cse1 and Nup2 in Classical &lt;scp&gt;NLS‐Cargo&lt;/scp&gt; Release &lt;i&gt;in vivo&lt;/i&gt;"

artículo científico publicado en 2020

Automated quantification of the subcellular localization of multicompartment proteins via Q-SCAn

artículo científico publicado en 2013

BERing the burden of damage: Pathway crosstalk and posttranslational modification of base excision repair proteins regulate DNA damage management

artículo científico

Biallelic variants in the RNA exosome gene EXOSC5 are associated with developmental delays, short stature, cerebellar hypoplasia and motor weakness

artículo científico publicado en 2020

Biochemical Isolation of Myonuclei from Mouse Skeletal Muscle Tissue.

artículo científico publicado en 2017

Biochemical isolation of myonuclei employed to define changes to the myonuclear proteome that occur with aging

artículo científico

Both KH and non-KH domain sequences are required for polyribosome association of Scp160p in yeast

artículo científico publicado en 2004

Characterization of the Probiotic Yeast Saccharomyces boulardii in the Healthy Mucosal Immune System

artículo científico publicado en 2016

Characterization of the auto-inhibitory sequence within the N-terminal domain of importin alpha

scientific article published on 02 April 2003

Classical nuclear localization signals: definition, function, and interaction with importin alpha

artículo científico publicado en 2006

Control of mRNA stability contributes to low levels of nuclear poly(A) binding protein 1 (PABPN1) in skeletal muscle

artículo científico publicado en 2013

Crystallization and Initial X-Ray Diffraction Characterization of Complexes of FxFG Nucleoporin Repeats with Nuclear Transport Factors

Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy

artículo científico publicado en 2019

Dissecting the Roles of Cse1 and Nup2 in Classical NLS-Cargo Release in vivo

artículo científico publicado en 2020

Dissection of the karyopherin alpha nuclear localization signal (NLS)-binding groove: functional requirements for NLS binding

artículo científico publicado en 2003

Distinct roles for classical nuclear import receptors in the growth of multinucleated muscle cells

artículo científico publicado el 30 de junio de 2011

Domain analysis of the Saccharomyces cerevisiae heterogeneous nuclear ribonucleoprotein, Nab2p. Dissecting the requirements for Nab2p-facilitated poly(A) RNA export

artículo científico publicado en 2002

Dynamic compartmentalization of base excision repair proteins in response to nuclear and mitochondrial oxidative stress

artículo científico publicado en 2009

Enteropathogenic Escherichia coli Tir is an SH2/3 ligand that recruits and activates tyrosine kinases required for pedestal formation

artículo científico publicado en 2007

Expanding the definition of the classical bipartite nuclear localization signal

artículo científico publicado en 2009

Functional Analysis of the Hydrophobic Patch on Nuclear Transport Factor 2 Involved in Interactions with the Nuclear Porein Vivo

artículo científico publicado en 2001

Functional heterologous protein expression by genetically engineered probiotic yeast Saccharomyces boulardii

artículo científico publicado en 2014

Functional overlap between conserved and diverged KH domains in Saccharomyces cerevisiae SCP160.

artículo científico publicado en 2007

Functional significance of the interaction between the mRNA-binding protein, Nab2, and the nuclear pore-associated protein, Mlp1, in mRNA export

artículo científico publicado en 2008

Gleaning Insights from Fecal Microbiota Transplantation and Probiotic Studies for the Rational Design of Combination Microbial Therapies.

artículo científico publicado en 2017

H2B ubiquitylation controls the formation of export-competent mRNP.

artículo científico publicado en 2012

Hot trends erupting in the nuclear transport field. Workshop on mechanisms of nuclear transport

artículo científico publicado en 2004

Identification of SUMO modification sites in the base excision repair protein, Ntg1.

artículo científico publicado en 2016

Identification of genes that function in the biogenesis and localization of small nucleolar RNAs in Saccharomyces cerevisiae.

artículo científico publicado en 2008

Importin alpha can migrate into the nucleus in an importin beta- and Ran-independent manner

artículo científico publicado en 2002

Importin α: a multipurpose nuclear-transport receptor

artículo científico publicado en 2004

In vivo Characterization of the Critical Interaction between the RNA Exosome and the Essential RNA Helicase Mtr4 in Saccharomyces cerevisiae

artículo científico publicado en 2022

In vivo characterization of the critical interaction between the RNA exosome and the essential RNA helicase Mtr4 in Saccharomyces cerevisiae

artículo científico publicado en 2023

Insight into the RNA Exosome Complex Through Modeling Pontocerebellar Hypoplasia Type 1b Disease Mutations in Yeast

artículo científico publicado en 2016

Links between mRNA splicing, mRNA quality control, and intellectual disability

artículo científico publicado en 2016

Loss of nuclear poly(A)-binding protein 1 causes defects in myogenesis and mRNA biogenesis.

artículo científico publicado en 2009

Macromolecular transport between the nucleus and the cytoplasm: Advances in mechanism and emerging links to disease

artículo científico publicado en 2014

Mechanisms Regulating Protein Localization.

artículo científico

Mechanisms of nuclear mRNA quality control

artículo científico publicado en 2009

Messenger RNA export from the nucleus: a series of molecular wardrobe changes

artículo científico publicado en 2009

Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans

scientific journal article

Nab2p is required for poly(A) RNA export in Saccharomyces cerevisiae and is regulated by arginine methylation via Hmt1p

artículo científico publicado en 2002

Nab3 facilitates the function of the TRAMP complex in RNA processing via recruitment of Rrp6 independent of Nrd1

artículo científico publicado en 2015

New kid on the ID block: neural functions of the Nab2/ZC3H14 class of Cys₃His tandem zinc-finger polyadenosine RNA binding proteins

artículo científico publicado en 2012

Non-equivalence of nuclear import among nuclei in multinucleated skeletal muscle cells.

artículo científico publicado en 2017

Novel mouse models of oculopharyngeal muscular dystrophy (OPMD) reveal early onset mitochondrial defects and suggest loss of PABPN1 may contribute to pathology.

artículo científico publicado en 2017

Nuclear RanGTP is not required for targeting small nucleolar RNAs to the nucleolus

artículo científico publicado en 2003

Nuclear localization signal receptor affinity correlates with in vivo localization in Saccharomyces cerevisiae

scientific article published on 19 June 2006

Nuclear poly(A) binding protein 1 (PABPN1) and Matrin3 interact in muscle cells and regulate RNA processing

artículo científico publicado en 2017

Nuclear protein transport

artículo científico publicado en 2002

Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer.

artículo científico publicado en 2018

PABPN1: molecular function and muscle disease

artículo científico

Poly(A) RNA-binding proteins and polyadenosine RNA: new members and novel functions

artículo científico publicado en 2014

Poly(A) tail-mediated gene regulation by opposing roles of Nab2 and Pab2 nuclear poly(A)-binding proteins in pre-mRNA decay

artículo científico publicado en 2013

Post-transcriptional regulation of Pabpn1 by the RNA binding protein HuR

Post-transcriptional regulation of programmed cell death 4 (PDCD4) mRNA by the RNA-binding proteins human antigen R (HuR) and T-cell intracellular antigen 1 (TIA1)

artículo científico publicado en 2014

Practical advice for mentoring and supporting faculty colleagues in STEM fields: Views from mentor and mentee perspectives

artículo científico publicado en 2021

Proactive strategies for an inclusive faculty search process

artículo científico publicado en 2022

Process or perish: quality control in mRNA biogenesis

artículo científico publicado en 2005

Proteomic analysis reveals that wildtype and alanine-expanded nuclear poly(A)-binding protein exhibit differential interactions in skeletal muscle

artículo científico publicado en 2019

Quantitative structural analysis of importin-β flexibility: paradigm for solenoid protein structures

artículo científico publicado en 2010

RNA-binding proteins and gene regulation in myogenesis

artículo científico publicado el 6 de octubre de 2011

Recognition of polyadenosine RNA by the zinc finger domain of nuclear poly(A) RNA-binding protein 2 (Nab2) is required for correct mRNA 3'-end formation.

artículo científico publicado en 2010

Recognition of polyadenosine RNA by zinc finger proteins

artículo científico publicado en 2007

Regulation of base excision repair in eukaryotes by dynamic localization strategies

artículo científico

Regulation of base excision repair: Ntg1 nuclear and mitochondrial dynamic localization in response to genotoxic stress

artículo científico publicado en 2010

Regulation of nuclear import by phosphorylation adjacent to nuclear localization signals

artículo científico publicado en 2004

Saccharomyces cerevisiae Npc2p is a functionally conserved homologue of the human Niemann-Pick disease type C 2 protein, hNPC2.

artículo científico publicado en 2005

Should INO Stay or Should INO Go: A DNA “Zip Code” Mediates Gene Retention at the Nuclear Pore

artículo científico publicado el 8 de octubre de 2010

Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein

artículo científico publicado en 2009

Structural Basis for Polyadenosine-RNA Binding by Nab2 Zn Fingers and Its Function in mRNA Nuclear Export

artículo científico publicado en 2012

Structural Basis for the Function of the Saccharomyces cerevisiae Gfd1 Protein in mRNA Nuclear Export

artículo científico publicado en 2010

Structural basis for Nup2p function in cargo release and karyopherin recycling in nuclear import

artículo científico publicado el 15 de octubre de 2003

Structural basis for the interaction between NTF2 and nucleoporin FxFG repeats

artículo científico publicado en 2002

Structure of the N-Terminal Mlp1-Binding Domain of the Saccharomyces cerevisiae mRNA-Binding Protein, Nab2

artículo científico publicado en 2008

Structure-function relationships in the Nab2 polyadenosine-RNA binding Zn finger protein family

The C-terminal domain of myosin-like protein 1 (Mlp1p) is a docking site for heterogeneous nuclear ribonucleoproteins that are required for mRNA export

artículo científico publicado en 2003

The Ccr4-Not complex interacts with the mRNA export machinery

artículo científico publicado en 2011

The Chromatin Remodeler ISW1 Is a Quality Control Factor that Surveys Nuclear mRNP Biogenesis

artículo científico publicado en 2016

The Conserved, Disease-Associated RNA Binding Protein dNab2 Interacts with the Fragile X Protein Ortholog in Drosophila Neurons

artículo científico publicado en 2017

The DEAD-box protein Dbp5 controls mRNA export by triggering specific RNA:protein remodeling events

artículo científico publicado en 2007

The Disease-Associated Proteins Drosophila Nab2 and Ataxin-2 Interact with Shared RNAs and Coregulate Neuronal Morphology

artículo científico publicado en 2021

The Drosophila ortholog of the Zc3h14 RNA binding protein acts within neurons to pattern axon projection in the developing brain

artículo científico publicado en 2015

The Evolutionarily-conserved Polyadenosine RNA Binding Protein, Nab2, Cooperates with Splicing Machinery to Regulate the Fate of pre-mRNA.

artículo científico publicado en 2016

The Nab2 RNA binding protein promotes sex-specific splicing of Sex lethal in Drosophila neuronal tissue

artículo científico publicado en 2020

The Nab2 RNA-binding protein patterns dendritic and axonal projections through a planar cell polarity-sensitive mechanism

artículo científico publicado en 2022

The Polyadenosine RNA-binding Protein, Zinc Finger Cys3His Protein 14 (ZC3H14), Regulates the Pre-mRNA Processing of a Key ATP Synthase Subunit mRNA.

artículo científico publicado en 2016

The RNA Exosome and Human Disease

artículo científico publicado en 2020

The RNA binding protein Nab2 genetically interacts with multiple RNA exosome cofactors to regulate target RNAs

artículo científico publicado en 2022

The RNA binding protein Nab2 regulates the proteome of the developing Drosophila brain

artículo científico publicado en 2020

The RNA exosome and RNA exosome-linked disease.

artículo científico publicado en 2017

The RNA helicase DDX1 associates with the nuclear RNA exosome and modulates R-loops

artículo científico publicado en 2023

The RNA-binding protein Nab2 regulates the proteome of the developing Drosophila brain

artículo científico publicado en 2021

The RNA-binding protein, ZC3H14, is required for proper poly(A) tail length control, expression of synaptic proteins, and brain function in mice.

artículo científico publicado en 2017

The Ty1 integrase protein can exploit the classical nuclear protein import machinery for entry into the nucleus

artículo científico publicado en 2008

The auto-inhibitory function of importin alpha is essential in vivo

artículo científico publicado en 2002

The classical nuclear localization signal receptor, importin-alpha, is required for efficient transition through the G1/S stage of the cell cycle in Saccharomyces cerevisiae

artículo científico publicado en 2008

The current state of eukaryotic DNA base damage and repair

artículo científico publicado en 2015

The long and the short of it: The role of the zinc finger polyadenosine RNA binding protein, Nab2, in control of poly(A) tail length

artículo científico publicado el 28 de marzo de 2012

The mating response cascade does not modulate changes in the steady-state level of target mRNAs through control of mRNA stability

artículo científico publicado en 2009

The mitogen-activated protein kinase Slt2 regulates nuclear retention of non-heat shock mRNAs during heat shock-induced stress

artículo científico publicado en 2010

The polyadenosine RNA-binding protein ZC3H14 interacts with the THO complex and coordinately regulates the processing of neuronal transcripts

artículo científico publicado en 2018

The subcellular localization of the Niemann-Pick Type C proteins depends on the adaptor complex AP-3.

artículo científico publicado en 2007

Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice

artículo científico publicado en 2016

Ubiquitin-mediated mRNP dynamics and surveillance prior to budding yeast mRNA export

artículo científico publicado en 2010

Use of a Grant Writing Class in Training PhD Students

artículo científico publicado en 2016