Lista de obras -

A Novel YAP1 Inhibitor targets CSCs-enriched Radiation Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma.

artículo científico publicado en 2017

ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer

artículo científico publicado en 2015

ALDH-1 expression levels predict response or resistance to preoperative chemoradiation in resectable esophageal cancer patients.

artículo científico publicado en 2013

AMPK modulates Hippo pathway activity to regulate energy homeostasis

artículo científico publicado en 2015

Activation of YAP1 is associated with poor prognosis and response to taxanes in ovarian cancer

artículo científico publicado en 2014

An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2

artículo científico publicado en 2016

Bile acids activate YAP to promote liver carcinogenesis

artículo científico publicado en 2013

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

artículo científico publicado en 2009

Consensus subtypes of hepatocellular carcinoma associated with clinical outcomes and genomic phenotypes

artículo científico publicado en 2022

Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin

artículo científico publicado en 2009

Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells

artículo científico publicado en 2012

Functional genetic analysis of mouse chromosome 11

artículo científico publicado en 2003

Galectin-3 Mediates Tumor Cell-Stroma Interactions by Activating Pancreatic Stellate Cells to Produce Cytokines via Integrin Signaling.

artículo científico publicado en 2017

Galectin-3 expression is prognostic in diffuse type gastric adenocarcinoma, confers aggressive phenotype, and can be targeted by YAP1/BET inhibitors

artículo científico publicado en 2017

Hesr, a mediator of the Notch signaling, functions in heart and vessel development

artículo científico publicado en 2005

Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers.

artículo científico publicado en 2011

Hippo Pathway Kinase Mst1 Is Required for Long-Lived Humoral Immunity

scientific article published on 26 November 2018

Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties

artículo científico publicado en 2014

Hippo pathway coactivators Yap and Taz are required to coordinate mammalian liver regeneration

artículo científico publicado en 2018

Hippo signaling impedes adult heart regeneration.

artículo científico publicado en 2013

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

scientific journal article

Hippo signaling: growth control and beyond

artículo científico publicado en 2011

Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

scientific article published on 26 March 2019

Inactivation of Hippo Pathway Is Significantly Associated with Poor Prognosis in Hepatocellular Carcinoma

artículo científico publicado en 2015

Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer

scientific article published on 06 August 2018

Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ.

artículo científico publicado en 2016

Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription

scientific article published on 02 April 2020

Loss of transforming growth factor β adaptor protein β-2 spectrin leads to delayed liver regeneration in mice ⬇️

artículo científico publicado el 1 de mayo de 2011

Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo ⬇️

artículo científico publicado el 28 de mayo de 2013

Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer

artículo científico publicado en 2014

Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis

article published in the Proceedings of the National Academy of Sciences of the United States of America

Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system

artículo científico publicado en 2005

Multiplex profiling of peritoneal metastases from gastric adenocarcinoma identified novel targets and molecular subtypes that predict treatment response

artículo científico publicado en 2019

Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification

artículo científico publicado en 2010

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis

artículo científico publicado en 2018

Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction

scientific journal article

Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning

scientific journal article

Targeting Hippo coactivator YAP1 through BET bromodomain inhibition in esophageal adenocarcinoma

scientific article published on 16 March 2020

The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer

artículo científico publicado en 2015

The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number

scientific article published on 25 October 2018

The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz

artículo científico publicado en 2018

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

artículo científico publicado en 2014

Transcriptional co-repressor function of the hippo pathway transducers YAP and TAZ.

artículo científico publicado en 2015

Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model

artículo científico publicado en 2013

Tumor-associated macrophage infiltration is highly associated with PD-L1 expression in gastric adenocarcinoma.

artículo científico publicado en 2017

Uncoupling skeletal and connective tissue patterning: conditional deletion in cartilage progenitors reveals cell-autonomous requirements for Lmx1b in dorsal-ventral limb patterning.

artículo científico publicado en 2010

YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression

scientific article published on 01 December 2019

YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme

artículo científico publicado en 2017

YAP1 mediates gastric adenocarcinoma peritoneal metastases that are attenuated by YAP1 inhibition

scientific article published on 27 April 2020

YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer - Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer

artículo científico publicado en 2018

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

artículo científico publicado en 2019

Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer

artículo científico publicado en 2014

Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma

artículo científico publicado en 2015

Lista de obras de

A Novel YAP1 Inhibitor targets CSCs-enriched Radiation Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma.

ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer

ALDH-1 expression levels predict response or resistance to preoperative chemoradiation in resectable esophageal cancer patients.

AMPK modulates Hippo pathway activity to regulate energy homeostasis

Activation of YAP1 is associated with poor prognosis and response to taxanes in ovarian cancer

An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2

Bile acids activate YAP to promote liver carcinogenesis

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

Consensus subtypes of hepatocellular carcinoma associated with clinical outcomes and genomic phenotypes

Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin

Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells

Functional genetic analysis of mouse chromosome 11

Galectin-3 Mediates Tumor Cell-Stroma Interactions by Activating Pancreatic Stellate Cells to Produce Cytokines via Integrin Signaling.

Galectin-3 expression is prognostic in diffuse type gastric adenocarcinoma, confers aggressive phenotype, and can be targeted by YAP1/BET inhibitors

Hesr, a mediator of the Notch signaling, functions in heart and vessel development

Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers.

Hippo Pathway Kinase Mst1 Is Required for Long-Lived Humoral Immunity

Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties

Hippo pathway coactivators Yap and Taz are required to coordinate mammalian liver regeneration

Hippo signaling impedes adult heart regeneration.

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

Hippo signaling: growth control and beyond

Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

Inactivation of Hippo Pathway Is Significantly Associated with Poor Prognosis in Hepatocellular Carcinoma

Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer

Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ.

Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription

Loss of transforming growth factor β adaptor protein β-2 spectrin leads to delayed liver regeneration in mice ⬇️

Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo ⬇️

Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer

Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis

Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system

Multiplex profiling of peritoneal metastases from gastric adenocarcinoma identified novel targets and molecular subtypes that predict treatment response

Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis

Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction

Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning

Targeting Hippo coactivator YAP1 through BET bromodomain inhibition in esophageal adenocarcinoma

The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer

The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number

The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

Transcriptional co-repressor function of the hippo pathway transducers YAP and TAZ.

Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model

Tumor-associated macrophage infiltration is highly associated with PD-L1 expression in gastric adenocarcinoma.

Uncoupling skeletal and connective tissue patterning: conditional deletion in cartilage progenitors reveals cell-autonomous requirements for Lmx1b in dorsal-ventral limb patterning.

YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression

YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme

YAP1 mediates gastric adenocarcinoma peritoneal metastases that are attenuated by YAP1 inhibition

YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer - Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer

Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma