Lista de obras -

5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes.

artículo científico publicado en 2018

A combined structural and biochemical approach reveals translocation and stalling of UvrB on the DNA lesion as a mechanism of damage verification in bacterial nucleotide excision repair

scientific article published on 06 November 2019

AP2-like cis element is required for calretinin gene promoter activity in cells of neuronal phenotype differentiated from multipotent human cell line DEV.

artículo científico publicado en 2002

Ca2+-dependent translocation of the calcyclin-binding protein in neurons and neuroblastoma NB-2a cells

scientific journal article

CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family

artículo científico publicado en 2002

Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins

artículo científico publicado en 2003

Catalytic mechanism of RNA backbone cleavage by ribonuclease H from quantum mechanics/molecular mechanics simulations

artículo científico publicado en 2011

Coordination between the polymerase and RNase H activity of HIV-1 reverse transcriptase

artículo científico publicado en 2017

Crosslink and shield: protecting abasic sites from error-prone repair

scientific article published on 01 July 2019

Crystal Structures of RNase H2 in Complex with Nucleic Acid Reveal the Mechanism of RNA-DNA Junction Recognition and Cleavage

artículo científico publicado en 2010

Crystal structure of RNase H3–substrate complex reveals parallel evolution of RNA/DNA hybrid recognition

artículo científico publicado en 2014

Crystal structure of RuvC resolvase in complex with Holliday junction substrate

artículo científico publicado en 2013

Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding

artículo científico publicado en 2014

Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis

artículo científico publicado en 2020

Disulfide bridge cross-linking between protein and the RNA backbone as a tool to study RNase H1

scientific article published on 06 September 2020

Evolutionary history and activity of RNase H1-like proteins in Arabidopsis thaliana

artículo científico publicado en 2020

Human REXO2 controls short mitochondrial RNAs generated by mtRNA processing and decay machinery to prevent accumulation of double-stranded RNA

scientific article published on 04 May 2020

Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain

artículo científico publicado en 2004

Introduction to high-resolution cryo-electron microscopy

artículo científico publicado en 2016

Mechanism of polypurine tract primer generation by HIV-1 reverse transcriptase

artículo científico publicado en 2017

Novel insights from structural analysis of lentiviral and gammaretroviral reverse transcriptases in complex with RNA/DNA hybrids

artículo científico publicado en 2013

Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins

scientific article published on 10 April 2020

RNase H2 roles in genome integrity revealed by unlinking its activities

artículo científico publicado en 2013

RNases H: Structure and mechanism

artículo científico publicado en 2019

Recognition and processing of branched DNA substrates by Slx1-Slx4 nuclease

artículo científico publicado en 2019

Retroviral integrase superfamily: the structural perspective

artículo científico publicado en 2009

RuvC uses dynamic probing of the Holliday junction to achieve sequence specificity and efficient resolution

scientific article published on 10 September 2019

Sequence-specific cleavage of the RNA strand in DNA-RNA hybrids by the fusion of ribonuclease H with a zinc finger

artículo científico publicado en 2012

Single-molecule imaging of UvrA and UvrB recruitment to DNA lesions in living Escherichia coli.

artículo científico publicado en 2016

Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD

artículo científico publicado en 2008

Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release

artículo científico publicado en 2006

Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect

artículo científico publicado en 2021

Structural Studies of RNases H2 as an Example of Crystal Structure Determination of Protein-Nucleic Acid Complexes

artículo científico publicado en 2017

Structural analysis of human 2′-O-ribose methyltransferases involved in mRNA cap structure formation

artículo científico publicado en 2014

Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid

artículo científico publicado en 2013

Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components.

artículo científico publicado en 2018

Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease

artículo científico publicado en 2015

Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression

artículo científico publicado en 2014

Structural and functional modules in RNA interference

scientific article published on 26 May 2009

Structure and mechanism of CutA, RNA nucleotidyl transferase with an unusual preference for cytosine

artículo científico publicado en 2020

Structure and mechanism of nucleases regulated by SLX4.

artículo científico publicado en 2016

Structure of UvrA nucleotide excision repair protein in complex with modified DNA

artículo científico publicado en 2011

Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription

artículo científico publicado en 2007

The Pet127 protein is a mitochondrial 5'-to-3' exoribonuclease from the PD-(D/E)XK superfamily involved in RNA maturation and intron degradation in yeasts

artículo científico publicado en 2022

The RNase H Domain: Structure, Function and Mechanism

article published in 2013

The RNase H-like superfamily: new members, comparative structural analysis and evolutionary classification ⬇️

artículo científico publicado en 2014

The expression of Rpb10, a small subunit common to RNA polymerases, is modulated by the R3H domain-containing Rbs1 protein and the Upf1 helicase

artículo científico publicado en 2020

The siRNA suppressor RTL1 is redox-regulated through glutathionylation of a conserved cysteine in the double-stranded-RNA-binding domain

artículo científico publicado en 2017

The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutières syndrome defects

artículo científico publicado en 2011

Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry

artículo científico publicado en 2014

Ty3 reverse transcriptase complexed with an RNA/DNA hybrid shows structural and functional asymmetry.

artículo científico publicado en 2013

cGAS surveillance of micronuclei links genome instability to innate immunity

artículo científico publicado en 2017

mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation

artículo científico publicado en 2017

Lista de obras de

5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes.

A combined structural and biochemical approach reveals translocation and stalling of UvrB on the DNA lesion as a mechanism of damage verification in bacterial nucleotide excision repair

AP2-like cis element is required for calretinin gene promoter activity in cells of neuronal phenotype differentiated from multipotent human cell line DEV.

Ca2+-dependent translocation of the calcyclin-binding protein in neurons and neuroblastoma NB-2a cells

CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family

Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins

Catalytic mechanism of RNA backbone cleavage by ribonuclease H from quantum mechanics/molecular mechanics simulations

Coordination between the polymerase and RNase H activity of HIV-1 reverse transcriptase

Crosslink and shield: protecting abasic sites from error-prone repair

Crystal Structures of RNase H2 in Complex with Nucleic Acid Reveal the Mechanism of RNA-DNA Junction Recognition and Cleavage

Crystal structure of RNase H3–substrate complex reveals parallel evolution of RNA/DNA hybrid recognition

Crystal structure of RuvC resolvase in complex with Holliday junction substrate

Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding

Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis

Disulfide bridge cross-linking between protein and the RNA backbone as a tool to study RNase H1

Evolutionary history and activity of RNase H1-like proteins in Arabidopsis thaliana

Human REXO2 controls short mitochondrial RNAs generated by mtRNA processing and decay machinery to prevent accumulation of double-stranded RNA

Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain

Introduction to high-resolution cryo-electron microscopy

Mechanism of polypurine tract primer generation by HIV-1 reverse transcriptase

Novel insights from structural analysis of lentiviral and gammaretroviral reverse transcriptases in complex with RNA/DNA hybrids

Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins

RNase H2 roles in genome integrity revealed by unlinking its activities

RNases H: Structure and mechanism

Recognition and processing of branched DNA substrates by Slx1-Slx4 nuclease

Retroviral integrase superfamily: the structural perspective

RuvC uses dynamic probing of the Holliday junction to achieve sequence specificity and efficient resolution

Sequence-specific cleavage of the RNA strand in DNA-RNA hybrids by the fusion of ribonuclease H with a zinc finger

Single-molecule imaging of UvrA and UvrB recruitment to DNA lesions in living Escherichia coli.

Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD

Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release

Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect

Structural Studies of RNases H2 as an Example of Crystal Structure Determination of Protein-Nucleic Acid Complexes

Structural analysis of human 2′-O-ribose methyltransferases involved in mRNA cap structure formation

Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid

Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components.

Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease

Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression

Structural and functional modules in RNA interference

Structure and mechanism of CutA, RNA nucleotidyl transferase with an unusual preference for cytosine

Structure and mechanism of nucleases regulated by SLX4.

Structure of UvrA nucleotide excision repair protein in complex with modified DNA

Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription

The Pet127 protein is a mitochondrial 5'-to-3' exoribonuclease from the PD-(D/E)XK superfamily involved in RNA maturation and intron degradation in yeasts

The RNase H Domain: Structure, Function and Mechanism

The RNase H-like superfamily: new members, comparative structural analysis and evolutionary classification ⬇️

The expression of Rpb10, a small subunit common to RNA polymerases, is modulated by the R3H domain-containing Rbs1 protein and the Upf1 helicase

The siRNA suppressor RTL1 is redox-regulated through glutathionylation of a conserved cysteine in the double-stranded-RNA-binding domain

The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutières syndrome defects

Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry

Ty3 reverse transcriptase complexed with an RNA/DNA hybrid shows structural and functional asymmetry.

cGAS surveillance of micronuclei links genome instability to innate immunity

mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation