Lista de obras -

"Thinking" vs. "Talking": Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress

artículo científico publicado en 2017

'Til cell death do us part: nitric oxide and mechanisms of hepatotoxicity

artículo científico publicado en 2004

A Biohybrid Device for the Systemic Control of Acute Inflammation

artículo científico publicado en 2012

A Computational, Tissue-Realistic Model of Pressure Ulcer Formation in Individuals with Spinal Cord Injury

artículo científico publicado en 2015

A DNA microarray study of nitric oxide-induced genes in mouse hepatocytes: implications for hepatic heme oxygenase-1 expression in ischemia/reperfusion

article

A Multiscale Agent-Based in silico Model of Liver Fibrosis Progression

artículo científico publicado en 2014

A Role for Angiotensin II in the Activation of Extracellular Signal-Regulated Kinases in the Liver During Hemorrhagic Shock ⬇️

artículo científico publicado el 1 de octubre de 2003

A Systems Engineering Perspective on Homeostasis and Disease

artículo científico publicado en 2013

A computational analysis of dynamic, multi-organ inflammatory crosstalk induced by endotoxin in mice

artículo científico publicado en 2018

A mathematical simulation of the inflammatory response to anthrax infection

artículo científico publicado en 2008

A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury

artículo científico publicado en 2008

A reduced mathematical model of the acute inflammatory response II. Capturing scenarios of repeated endotoxin administration

artículo científico publicado en 2006

A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation

artículo científico publicado en 2006

A roadmap from single-cell transcriptome to patient classification for the immune response to trauma

artículo científico publicado en 2020

A simple mathematical model of signaling resulting from the binding of lipopolysaccharide with Toll-like receptor 4 demonstrates inherent preconditioning behavior

artículo científico publicado en 2008

A three-dimensional mathematical and computational model of necrotizing enterocolitis.

artículo científico publicado en 2012

A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine* ⬇️

artículo científico publicado el 1 de abril de 2012

Agent-based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-beta1.

artículo científico publicado en 2007

Agent-based models in translational systems biology.

artículo científico publicado en 2009

Agent-based models of inflammation in translational systems biology: A decade later

artículo científico publicado en 2019

An Aging-Related Single-Nucleotide Polymorphism is Associated With Altered Clinical Outcomes and Distinct Inflammatory Profiles in Aged Blunt Trauma Patients

artículo científico publicado en 2020

An Enrichment Strategy Yields Seven Novel Single Nucleotide Polymorphisms Associated with Mortality and Altered TH17 Responses Following Blunt Trauma

artículo científico publicado en 2017

An agent-based model of inflammation and fibrosis following particulate exposure in the lung ⬇️

artículo científico publicado el 6 de marzo de 2011

An ensemble of models of the acute inflammatory response to bacterial lipopolysaccharide in rats: Results from parameter space reduction

artículo científico publicado en 2008

An exploratory pathways analysis of temporal changes induced by spinal cord injury in the rat bladder wall: insights on remodeling and inflammation.

artículo científico publicado en 2009

Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure

artículo científico publicado en 2013

Association of a Functional Polymorphism in the CHRFAM7A Gene with Inflammatory Response Mediators and Neuropathic Pain after Spinal Cord Injury

artículo científico publicado en 2019

Augmenter of liver regeneration (ALR) is a novel biomarker of hepatocellular stress/inflammation: in vitro, in vivo and in silico studies

scientific journal article

Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective

artículo científico publicado en 2016

Automated parameter estimation for biological models using Bayesian statistical model checking

artículo científico publicado en 2015

Bayesian inference of the lung alveolar spatial model for the identification of alveolar mechanics associated with acute respiratory distress syndrome

artículo científico publicado en 2013

Biosimulation of acute phonotrauma: An extended model ⬇️

artículo científico publicado el 1 de noviembre de 2011

Central role for MCP-1/CCL2 in injury-induced inflammation revealed by in vitro, in silico, and clinical studies

artículo científico publicado en 2013

Combined in silico, in vivo, and in vitro studies shed insights into the acute inflammatory response in middle-aged mice

artículo científico publicado en 2013

Computational Analysis Supports IL-17A as a Central Driver of Neutrophil Extracellular Trap-Mediated Injury in Liver Ischemia Reperfusion

scientific article published on 30 November 2018

Computational Analysis Supports an Early, Type 17 Cell-Associated Divergence of Blunt Trauma Survival and Mortality

artículo científico publicado en 2016

Computational Modeling of Inflammation and Wound Healing

artículo científico publicado en 2013

Computational and systems biology in trauma and sepsis: current state and future perspectives.

artículo científico publicado en 2012

Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries

scientific article published on 04 June 2019

Cross-talk between nitric oxide and transforming growth factor-beta1 in malaria

artículo científico publicado en 2004

Data-Driven Modeling for Precision Medicine in Pediatric Acute Liver Failure

artículo científico publicado en 2016

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro

scientific article published on 01 August 2019

Delayed neutralization of interleukin 6 reduces organ injury, selectively suppresses inflammatory mediator, and partially normalizes immune dysfunction following trauma and hemorrhagic shock

artículo científico publicado en 2014

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

scientific article published on 01 May 2019

Diagnosis and Management of Polytraumatized Patients With Severe Extremity Trauma

artículo científico publicado en 2018

Differential inflammatory networks distinguish responses to bone marrow-derived versus adipose-derived mesenchymal stem cell therapies in vascularized composite allotransplantation.

artículo científico publicado en 2017

Diurnal Variation in Systemic Acute Inflammation and Clinical Outcomes Following Severe Blunt Trauma

scientific article published on 20 November 2019

Dynamic Profiling: Modeling the Dynamics of Inflammation and Predicting Outcomes in Traumatic Brain Injury Patients

artículo científico publicado en 2016

Early Detection of Pressure Ulcer Development Following Traumatic Spinal Cord Injury Using Inflammatory Mediators

artículo científico publicado en 2016

Early Dynamic Orchestration of Immunologic Mediators Identifies Multiply Injured Patients who are Tolerant or Sensitive to Hemorrhage

scientific article published on 20 October 2020

Early Immunologic Response in Multiply Injured Patients With Orthopaedic Injuries Is Associated With Organ Dysfunction

artículo científico publicado en 2019

Early growth response 1 mediates the systemic and hepatic inflammatory response initiated by hemorrhagic shock

artículo científico publicado en 2007

Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients.

artículo científico publicado en 2016

Elevations in Circulating sST2 Levels Are Associated With In-Hospital Mortality and Adverse Clinical Outcomes After Blunt Trauma

artículo científico publicado en 2019

Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism

artículo científico publicado en 2009

Equation-Based Models of Dynamic Biological Systems

Equation-based models of dynamic biological systems.

artículo científico publicado en 2008

Exercise training decreases hepatic injury via changes in immune response to liver ischemia/reperfusion in mice

scientific article published on 14 September 2020

Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress

artículo científico publicado en 2009

From data patterns to mechanistic models in acute critical illness.

artículo científico publicado en 2014

Gender-based reciprocal expression of transforming growth factor-beta1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis

artículo científico publicado en 2009

Global sensitivity analysis of a mathematical model of acute inflammation identifies nonlinear dependence of cumulative tissue damage on host interleukin-6 responses

artículo científico publicado en 2014

HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen

artículo científico publicado en 2019

Hemoadsorption reprograms inflammation in experimental gram-negative septic peritonitis: insights from in vivo and in silico studies

artículo científico publicado en 2012

Hemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase

artículo científico publicado en 2010

Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2.

artículo científico publicado en 2009

Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling

artículo científico publicado en 2007

Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation

scientific article published on 04 November 2005

Hepatic Encephalopathy in Children With Acute Liver Failure: Utility of Serum Neuromarkers

scientific article published on 01 July 2019

Hepatocytes enhance effects of lipopolysaccharide on liver nonparenchymal cells through close cell interactions

scientific article published on 01 May 2005

How implementation of systems biology into clinical trials accelerates understanding of diseases.

artículo científico publicado en 2014

Hybrid equation/agent-based model of ischemia-induced hyperemia and pressure ulcer formation predicts greater propensity to ulcerate in subjects with spinal cord injury

artículo científico publicado en 2013

Hypoxia-Induced Overexpression of BNIP3 is Not Dependent on Hypoxia-Inducible Factor 1α in Mouse Hepatocytes ⬇️

artículo científico publicado el 1 de agosto de 2011

IL-17A - A regulator in acute inflammation: Insights from in vitro, in vivo and in silico studies

artículo científico publicado en 2018

IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model.

artículo científico publicado en 2017

IRF3 Signaling within the Mouse Stroma Influences Sepsis Pathogenesis

artículo científico publicado en 2020

Identification of a novel pathway of transforming growth factor-β1 regulation by extracellular NAD+ in mouse macrophages: in vitro and in silico studies

artículo científico publicado en 2012

Identification of distinct monocyte phenotypes and correlation with circulating cytokine profiles in acute response to spinal cord injury: a pilot study.

scientific article published on 17 October 2013

Impact of Injury Severity on Dynamic Inflammation Networks Following Blunt Trauma.

artículo científico publicado en 2015

In Silico Augmentation of the Drug Development Pipeline: Examples from the study of Acute Inflammation.

artículo científico publicado en 2011

In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice

artículo científico publicado en 2006

In silico design of clinical trials: a method coming of age.

artículo científico publicado en 2004

In silico modeling: methods and applications to trauma and sepsis

artículo científico publicado en 2013

In silico models of acute inflammation in animals.

artículo científico publicado en 2006

In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain

artículo científico publicado en 2015

In vivo, in vitro, and in silico studies suggest a conserved immune module that regulates malaria parasite transmission from mammals to mosquitoes

artículo científico publicado en 2013

Individual-specific principal component analysis of circulating inflammatory mediators predicts early organ dysfunction in trauma patients.

artículo científico publicado en 2016

Inducible protein-10, a potential driver of neurally controlled interleukin-10 and morbidity in human blunt trauma

artículo científico publicado en 2014

Inflammation Following Traumatic Brain Injury in Humans: Insights from Data-Driven and Mechanistic Models into Survival and Death

artículo científico publicado en 2016

Inflammation and Disease: Modelling and Modulation of the Inflammatory Response to Alleviate Critical Illness

artículo científico publicado en 2018

Inflammatory Mediators Associated With Pressure Ulcer Development in Individuals With Pneumonia After Traumatic Spinal Cord Injury: A Pilot Study

artículo científico publicado en 2017

Injury-induced MRP8/MRP14 stimulates IP-10/CXCL10 in monocytes/macrophages

artículo científico publicado en 2014

Insights into the Role of Chemokines, Damage-Associated Molecular Patterns, and Lymphocyte-Derived Mediators from Computational Models of Trauma-Induced Inflammation

artículo científico publicado en 2015

Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock

scientific article published on January 2009

Intestinal and hepatic expression of BNIP3 in necrotizing enterocolitis: regulation by nitric oxide and peroxynitrite

artículo científico publicado en 2005

Lack of the receptor for advanced glycation end-products attenuates E. coli pneumonia in mice

artículo científico publicado en 2011

Linking Inflammation, Cardiorespiratory Variability, and Neural Control in Acute Inflammation via Computational Modeling

artículo científico publicado en 2012

Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury

scientific article published on 01 December 2008

Low levels of mammalian TGF-beta1 are protective against malaria parasite infection, a paradox clarified in the mosquito host

artículo científico publicado en 2007

MPPED2 Polymorphism Is Associated With Altered Systemic Inflammation and Adverse Trauma Outcomes

scientific article published on 08 November 2019

Machine Perfusion of Porcine Livers with Oxygen-Carrying Solution Results in Reprogramming of Dynamic Inflammation Networks

artículo científico publicado en 2016

Mammalian transforming growth factor beta1 activated after ingestion by Anopheles stephensi modulates mosquito immunity

artículo científico publicado en 2003

Mathematical Modeling of Early Cellular Innate and Adaptive Immune Responses to Ischemia/Reperfusion Injury and Solid Organ Allotransplantation

artículo científico publicado en 2015

Mathematical modeling in necrotizing enterocolitis--a new look at an ongoing problem

artículo científico publicado en 2007

Mathematical models of the acute inflammatory response.

artículo científico publicado en 2004

Mechanisms of hepatoprotection by nitric oxide

artículo científico publicado en 2002

Mechanistic simulations of inflammation: current state and future prospects.

artículo científico publicado en 2008

Modeling and Hemofiltration Treatment of Acute Inflammation

artículo científico publicado en 2016

Modeling the interactions of bacteria and Toll-like receptor-mediated inflammation in necrotizing enterocolitis

artículo científico publicado en 2012

Models of Lower Extremity Damage in Mice: Time Course of Organ Damage and Immune Response ⬇️

artículo científico publicado el 23 de diciembre de 2010

Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses

artículo científico publicado en 2021

Myocyte TLR4 enhances enteric and systemic inflammation driving late murine endotoxic ileus

artículo científico publicado en 2015

Neutrophil NAD(P)H oxidase is required for hemorrhagic shock-enhanced TLR2 up-regulation in alveolar macrophages in response to LPS

artículo científico publicado en 2007

Nitric oxide, a protective molecule in the cardiovascular system

artículo científico publicado en 2013

Nitric oxide-mediated inhibition of caspase-dependent T lymphocyte proliferation

artículo científico publicado en 2003

One-dimensional elastic continuum model of enterocyte layer migration

artículo científico publicado en 2007

Overexpression of the human inducible nitric oxide synthase gene enhances radiation-induced apoptosis in colorectal cancer cells via a caspase-dependent mechanism

artículo científico publicado en 2003

Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture

artículo científico publicado en 2008

Peroxisomal localization of inducible nitric oxide synthase in hepatocytes

artículo científico publicado en 2002

Persistence of elevated plasma CXCL8 concentrations following red blood cell transfusion in a trauma cohort.

artículo científico publicado en 2012

Precision Medicine for Critical Illness and Injury

artículo científico publicado en 2016

Prehospital Hypotension Is Associated With Altered Inflammation Dynamics and Worse Outcomes Following Blunt Trauma in Humans

artículo científico

Prehospital plasma is associated with distinct biomarker expression following injury

scientific article published on 31 March 2020

Prioritized Research for the Prevention, Treatment, and Reversal of Chronic Disease: Recommendations From the Lifestyle Medicine Research Summit

artículo científico publicado en 2020

Prospective Analyses of Cytokine Mediation of Sleep and Survival in the Context of Advanced Cancer

artículo científico publicado en 2018

Quality Control Measures and Validation in Gene Association Studies: Lessons for Acute Illness

artículo científico publicado en 2020

Racial Disparities and Sex-Based Outcomes Differences after Severe Injury ⬇️

artículo científico publicado el 21 de abril de 2012

Removal of inflammatory ascites is associated with dynamic modification of local and systemic inflammation along with prevention of acute lung injury: in vivo and in silico studies

artículo científico publicado en 2014

Resetting the transcription factor network reverses terminal chronic hepatic failure

artículo científico publicado en 2015

Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide

artículo científico publicado en 2002

Roles of dendritic cells in murine hepatic warm and liver transplantation-induced cold ischemia/reperfusion injury.

artículo científico publicado en 2013

SPARK: A Framework for Multi-Scale Agent-Based Biomedical Modeling

artículo científico publicado en 2010

Sepsis: Something old, something new, and a systems view

artículo científico publicado en 2011

Sepsis: from pattern to mechanism and back.

artículo científico publicado en 2012

Suppressed networks of inflammatory mediators characterize chronic venous insufficiency

artículo científico publicado en 2018

Systemic Arginine Depletion After a Murine Model of Surgery or Trauma ⬇️

artículo científico publicado el 16 de diciembre de 2011

Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells

artículo científico publicado en 2007

Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4

artículo científico publicado en 2006

Systemic inflammation and remote organ injury following trauma require HMGB1

artículo científico publicado en 2007

Systems biology and inflammation

artículo científico publicado en 2010

TWO AUTOCOVARIANCE-BASED MEASURES OF BALANCE IN PARKINSONIANS AND NORMAL CONTROLS.

artículo científico publicado en 2010

Temporal Patterns of Circulating Inflammation Biomarker Networks Differentiate Susceptibility to Nosocomial Infection Following Blunt Trauma in Humans.

artículo científico publicado en 2014

The acute inflammatory response in diverse shock states

artículo científico publicado en 2005

The central role of arginine catabolism in T-cell dysfunction and increased susceptibility to infection after physical injury

artículo científico publicado en 2014

The dynamics of acute inflammation

artículo científico publicado en 2004

The early evolving sex hormone environment is associated with significant outcome and inflammatory response differences after injury.

artículo científico publicado en 2015

The independent prognostic value of global epigenetic alterations: An analysis of single-cell ATAC-seq of circulating leukocytes from trauma patients followed by validation in whole blood leukocyte transcriptomes across three etiologies of critical

artículo científico publicado en 2022

The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis

artículo científico publicado en 2012

The nitric oxide donor S-nitrosoglutathione reduces apoptotic primary liver cell loss in a three-dimensional perfusion bioreactor culture model developed for liver support

artículo científico publicado en 2010

The role of NIGMS P50 sponsored team science in our understanding of multiple organ failure

artículo científico

The role of fracture-associated soft tissue injury in the induction of systemic inflammation and remote organ dysfunction after bilateral femur fracture

artículo científico publicado en 2008

The role of hepatic type 1 plasminogen activator inhibitor (PAI-1) during murine hemorrhagic shock.

artículo científico

The role of initial trauma in the host's response to injury and hemorrhage: insights from a correlation of mathematical simulations and hepatic transcriptomic analysis

artículo científico publicado en 2006

Thresholded area over the curve of spectrometric tissue oxygen saturation as an indicator of volume resuscitability in porcine hemorrhagic shock

artículo científico publicado en 2007

Time for trauma immunology

artículo científico publicado en 2017

Toll-Like Receptor 4 on both Myeloid Cells and Dendritic Cells Is Required for Systemic Inflammation and Organ Damage after Hemorrhagic Shock with Tissue Trauma in Mice

artículo científico publicado en 2017

Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock

artículo científico publicado en 2006

Toward computational identification of multiscale "tipping points" in acute inflammation and multiple organ failure

artículo científico publicado en 2012

Transcriptomic response of murine liver to severe injury and hemorrhagic shock: a dual-platform microarray analysis.

artículo científico publicado en 2011

Transforming growth factor-beta in critical illness

artículo científico publicado en 2005

Translational Systems Biology of Inflammation: Potential Applications to Personalized Medicine ⬇️

artículo científico publicado el 1 de septiembre de 2010

Translational systems approaches to the biology of inflammation and healing

artículo científico publicado en 2010

Translational systems biology and voice pathophysiology

artículo científico publicado en 2010

Translational systems biology of inflammation

artículo científico publicado en 2008

Translational systems biology: introduction of an engineering approach to the pathophysiology of the burn patient

artículo científico publicado en 2008

Trauma in silico: Individual-specific mathematical models and virtual clinical populations.

artículo científico publicado en 2015

Unsupervised Clustering Analysis Based on MODS Severity Identifies Four Distinct Organ Dysfunction Patterns in Severely Injured Blunt Trauma Patients

artículo científico publicado en 2020

Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study

artículo científico publicado en 2009

Using a mathematical model to analyze the role of probiotics and inflammation in necrotizing enterocolitis

artículo científico publicado en 2010

What's New in Shock, June 2018?

scientific article published on 01 June 2018

X chromosome-linked IRAK-1 polymorphism is a strong predictor of multiple organ failure and mortality postinjury.

artículo científico publicado en 2014

Young and Aged Blunt Trauma Patients Display Major Differences in Circulating Inflammatory Mediator Profiles after Severe Injury

scientific article published on 16 November 2018

Lista de obras de

"Thinking" vs. "Talking": Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress

'Til cell death do us part: nitric oxide and mechanisms of hepatotoxicity

A Biohybrid Device for the Systemic Control of Acute Inflammation

A Computational, Tissue-Realistic Model of Pressure Ulcer Formation in Individuals with Spinal Cord Injury

A DNA microarray study of nitric oxide-induced genes in mouse hepatocytes: implications for hepatic heme oxygenase-1 expression in ischemia/reperfusion

A Multiscale Agent-Based in silico Model of Liver Fibrosis Progression

A Role for Angiotensin II in the Activation of Extracellular Signal-Regulated Kinases in the Liver During Hemorrhagic Shock ⬇️

A Systems Engineering Perspective on Homeostasis and Disease

A computational analysis of dynamic, multi-organ inflammatory crosstalk induced by endotoxin in mice

A mathematical simulation of the inflammatory response to anthrax infection

A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury

A reduced mathematical model of the acute inflammatory response II. Capturing scenarios of repeated endotoxin administration

A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation

A roadmap from single-cell transcriptome to patient classification for the immune response to trauma

A simple mathematical model of signaling resulting from the binding of lipopolysaccharide with Toll-like receptor 4 demonstrates inherent preconditioning behavior

A three-dimensional mathematical and computational model of necrotizing enterocolitis.

A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine* ⬇️

Agent-based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-beta1.

Agent-based models in translational systems biology.

Agent-based models of inflammation in translational systems biology: A decade later

An Aging-Related Single-Nucleotide Polymorphism is Associated With Altered Clinical Outcomes and Distinct Inflammatory Profiles in Aged Blunt Trauma Patients

An Enrichment Strategy Yields Seven Novel Single Nucleotide Polymorphisms Associated with Mortality and Altered TH17 Responses Following Blunt Trauma

An agent-based model of inflammation and fibrosis following particulate exposure in the lung ⬇️

An ensemble of models of the acute inflammatory response to bacterial lipopolysaccharide in rats: Results from parameter space reduction

An exploratory pathways analysis of temporal changes induced by spinal cord injury in the rat bladder wall: insights on remodeling and inflammation.

Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure

Association of a Functional Polymorphism in the CHRFAM7A Gene with Inflammatory Response Mediators and Neuropathic Pain after Spinal Cord Injury

Augmenter of liver regeneration (ALR) is a novel biomarker of hepatocellular stress/inflammation: in vitro, in vivo and in silico studies

Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective

Automated parameter estimation for biological models using Bayesian statistical model checking

Bayesian inference of the lung alveolar spatial model for the identification of alveolar mechanics associated with acute respiratory distress syndrome

Biosimulation of acute phonotrauma: An extended model ⬇️

Central role for MCP-1/CCL2 in injury-induced inflammation revealed by in vitro, in silico, and clinical studies

Combined in silico, in vivo, and in vitro studies shed insights into the acute inflammatory response in middle-aged mice

Computational Analysis Supports IL-17A as a Central Driver of Neutrophil Extracellular Trap-Mediated Injury in Liver Ischemia Reperfusion

Computational Analysis Supports an Early, Type 17 Cell-Associated Divergence of Blunt Trauma Survival and Mortality

Computational Modeling of Inflammation and Wound Healing

Computational and systems biology in trauma and sepsis: current state and future perspectives.

Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries

Cross-talk between nitric oxide and transforming growth factor-beta1 in malaria

Data-Driven Modeling for Precision Medicine in Pediatric Acute Liver Failure

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro

Delayed neutralization of interleukin 6 reduces organ injury, selectively suppresses inflammatory mediator, and partially normalizes immune dysfunction following trauma and hemorrhagic shock

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

Diagnosis and Management of Polytraumatized Patients With Severe Extremity Trauma

Differential inflammatory networks distinguish responses to bone marrow-derived versus adipose-derived mesenchymal stem cell therapies in vascularized composite allotransplantation.

Diurnal Variation in Systemic Acute Inflammation and Clinical Outcomes Following Severe Blunt Trauma

Dynamic Profiling: Modeling the Dynamics of Inflammation and Predicting Outcomes in Traumatic Brain Injury Patients

Early Detection of Pressure Ulcer Development Following Traumatic Spinal Cord Injury Using Inflammatory Mediators

Early Dynamic Orchestration of Immunologic Mediators Identifies Multiply Injured Patients who are Tolerant or Sensitive to Hemorrhage

Early Immunologic Response in Multiply Injured Patients With Orthopaedic Injuries Is Associated With Organ Dysfunction

Early growth response 1 mediates the systemic and hepatic inflammatory response initiated by hemorrhagic shock

Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients.

Elevations in Circulating sST2 Levels Are Associated With In-Hospital Mortality and Adverse Clinical Outcomes After Blunt Trauma

Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism

Equation-Based Models of Dynamic Biological Systems

Equation-based models of dynamic biological systems.

Exercise training decreases hepatic injury via changes in immune response to liver ischemia/reperfusion in mice

Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress

From data patterns to mechanistic models in acute critical illness.

Gender-based reciprocal expression of transforming growth factor-beta1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis

Global sensitivity analysis of a mathematical model of acute inflammation identifies nonlinear dependence of cumulative tissue damage on host interleukin-6 responses

HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen

Hemoadsorption reprograms inflammation in experimental gram-negative septic peritonitis: insights from in vivo and in silico studies

Hemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase

Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2.

Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling

Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation

Hepatic Encephalopathy in Children With Acute Liver Failure: Utility of Serum Neuromarkers

Hepatocytes enhance effects of lipopolysaccharide on liver nonparenchymal cells through close cell interactions

How implementation of systems biology into clinical trials accelerates understanding of diseases.

Hybrid equation/agent-based model of ischemia-induced hyperemia and pressure ulcer formation predicts greater propensity to ulcerate in subjects with spinal cord injury

Hypoxia-Induced Overexpression of BNIP3 is Not Dependent on Hypoxia-Inducible Factor 1α in Mouse Hepatocytes ⬇️

IL-17A - A regulator in acute inflammation: Insights from in vitro, in vivo and in silico studies

IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model.

IRF3 Signaling within the Mouse Stroma Influences Sepsis Pathogenesis

Identification of a novel pathway of transforming growth factor-β1 regulation by extracellular NAD+ in mouse macrophages: in vitro and in silico studies

Identification of distinct monocyte phenotypes and correlation with circulating cytokine profiles in acute response to spinal cord injury: a pilot study.

Impact of Injury Severity on Dynamic Inflammation Networks Following Blunt Trauma.