Lista de obras -

A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA.

artículo científico publicado en 2006

A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation

artículo científico publicado en 2008

Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases

artículo científico publicado en 2011

Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response

artículo científico publicado en 2015

An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex

scientific article published on 16 December 2020

Autoregulation of kinase dephosphorylation by ATP binding in AGC protein kinases.

artículo científico publicado en 2012

Bridging a DNA Break to Leave a Poly(ADP-Ribose) Mark on Chromatin

artículo científico publicado en 2020

CARM1 regulates replication fork speed and stress response by stimulating PARP1

artículo científico publicado en 2020

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo

artículo científico publicado en 2020

Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY

artículo científico publicado en 2011

Crystal structure of TB-RBP, a novel RNA-binding and regulating protein

artículo científico publicado en 2002

DNA and RNA ligases: structural variations and shared mechanisms

artículo científico publicado en 2008

DNA ligases: structure, reaction mechanism, and function

artículo científico publicado en 2006

Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity

scientific article published on 24 May 2019

Discovery and Structure–Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2 H )-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors

artículo científico publicado en 2014

Dual roles of PARP-1 promote cancer growth and progression

artículo científico publicado en 2012

Dynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation

artículo científico publicado en 2020

Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition

artículo científico publicado en 2021

Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage

scientific article published on 16 August 2016

Human DNA ligase I completely encircles and partially unwinds nicked DNA

artículo científico publicado en 2004

Human DNA ligases I, III, and IV-purification and new specific assays for these enzymes

artículo científico publicado en 2006

Hydrofluoric Acid-Based Derivatization Strategy To Profile PARP-1 ADP-Ribosylation by LC-MS/MS

artículo científico publicado en 2018

Identification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channels

artículo científico publicado en 2012

NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains

artículo científico publicado en 2018

New players to the field of ADP-ribosylation make the final cut

artículo científico publicado en 2013

PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification

artículo científico publicado en 2018

PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain

artículo científico publicado en 2015

PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis

artículo científico publicado en 2013

PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1.

artículo científico publicado en 2014

PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage

artículo científico publicado en 2015

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation

artículo científico publicado en 2021

Poly(ADP-ribose) polymerase enzymes and the maintenance of genome integrity

scientific article published on 21 November 2019

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks

artículo científico publicado en 2019

Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors.

artículo científico publicado en 2017

Purification of DNA Damage-Dependent PARPs from E. coli for Structural and Biochemical Analysis

artículo científico publicado en 2017

Purification of human PARP-1 and PARP-1 domains from Escherichia coli for structural and biochemical analysis

artículo científico publicado el 1 de enero de 2011

Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs

artículo científico

RNA ligase does the AMP shuffle

artículo científico publicado en 2006

Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity.

artículo científico publicado en 2011

Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex

artículo científico publicado en 2014

Signal-induced PARP1-Erk synergism mediates IEG expression

scholarly article in Signal transduction and targeted therapy, vol. 4 no. 1, 2019

Structural Basis for Calmodulin as a Dynamic Calcium Sensor ⬇️

artículo científico publicado el 9 de mayo de 2012

Structural Basis for DNA Damage–Dependent Poly(ADP-ribosyl)ation by Human PARP-1 ⬇️

artículo científico publicado el 11 de mayo de 2012

Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1.

artículo científico publicado en 2015

Structural Implications for Selective Targeting of PARPs

artículo científico publicado en 2013

Structural analyses of the Group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations

scientific article published on 28 February 2020

Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose 4,6-dehydratase

artículo científico publicado en 2019

Structural basis for allosteric PARP-1 retention on DNA breaks

artículo científico publicado en 2020

Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling

artículo científico

Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo

artículo científico publicado en 2016

Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt Signaling

artículo científico publicado en 2016

Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification

artículo científico publicado en 2016

Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer

artículo científico publicado en 2013

The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1

artículo científico publicado en 2009

The Smc5/6 Core Complex Is a Structure-Specific DNA Binding and Compacting Machine

scientific article published on 07 December 2020

The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction

artículo científico publicado en 2010

The comings and goings of PARP-1 in response to DNA damage

artículo científico publicado en 2018

The nucleosomal surface is the main target of histone ADP-ribosylation in response to DNA damage

artículo científico publicado en 2017

The rise and fall of poly(ADP-ribose): An enzymatic perspective

artículo científico

Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase

artículo científico publicado en 2020

Unfolding of core nucleosomes by PARP-1 revealed by spFRET microscopy

artículo científico publicado en 2017

Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation

artículo científico publicado en 2013

Lista de obras de

A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA.

A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation

Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases

Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response

An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex

Autoregulation of kinase dephosphorylation by ATP binding in AGC protein kinases.

Bridging a DNA Break to Leave a Poly(ADP-Ribose) Mark on Chromatin

CARM1 regulates replication fork speed and stress response by stimulating PARP1

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo

Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO DNA-DEPENDENT PARP-1 ACTIVITY

Crystal structure of TB-RBP, a novel RNA-binding and regulating protein

DNA and RNA ligases: structural variations and shared mechanisms

DNA ligases: structure, reaction mechanism, and function

Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity

Discovery and Structure–Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2 H )-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors

Dual roles of PARP-1 promote cancer growth and progression

Dynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation

Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition

Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage

Human DNA ligase I completely encircles and partially unwinds nicked DNA

Human DNA ligases I, III, and IV-purification and new specific assays for these enzymes

Hydrofluoric Acid-Based Derivatization Strategy To Profile PARP-1 ADP-Ribosylation by LC-MS/MS

Identification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channels

NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains

New players to the field of ADP-ribosylation make the final cut

PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification

PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain

PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis

PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1.

PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation

Poly(ADP-ribose) polymerase enzymes and the maintenance of genome integrity

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks

Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors.

Purification of DNA Damage-Dependent PARPs from E. coli for Structural and Biochemical Analysis

Purification of human PARP-1 and PARP-1 domains from Escherichia coli for structural and biochemical analysis

Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs

RNA ligase does the AMP shuffle

Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity.

Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex

Signal-induced PARP1-Erk synergism mediates IEG expression

Structural Basis for Calmodulin as a Dynamic Calcium Sensor ⬇️

Structural Basis for DNA Damage–Dependent Poly(ADP-ribosyl)ation by Human PARP-1 ⬇️

Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1.

Structural Implications for Selective Targeting of PARPs

Structural analyses of the Group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations

Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose 4,6-dehydratase

Structural basis for allosteric PARP-1 retention on DNA breaks

Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling

Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo

Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt Signaling

Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification

Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer

The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1

The Smc5/6 Core Complex Is a Structure-Specific DNA Binding and Compacting Machine

The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction

The comings and goings of PARP-1 in response to DNA damage

The nucleosomal surface is the main target of histone ADP-ribosylation in response to DNA damage

The rise and fall of poly(ADP-ribose): An enzymatic perspective

Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase

Unfolding of core nucleosomes by PARP-1 revealed by spFRET microscopy

Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation