Lista de obras -

ASH2L regulates ubiquitylation signaling to MLL: trans-regulation of H3 K4 methylation in higher eukaryotes

artículo científico publicado en 2013

Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction

artículo científico publicado en 2010

Characterization and pharmacologic targeting of EZH2, a fetal retinal protein and epigenetic regulator, in human retinoblastoma

artículo científico publicado en 2015

Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia

artículo científico publicado en 2017

Cryo-EM structure of the human MLL1 core complex bound to the nucleosome

artículo científico publicado en 2019

Developmental ROS individualizes organismal stress resistance and lifespan

scientific article published on 04 December 2019

Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase

scientific article published on 14 May 2020

Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.

artículo científico publicado en 2017

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity

artículo científico publicado en 2021

Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer

artículo científico publicado en 2016

Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy

artículo científico publicado en 2020

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

artículo científico publicado en 2015

H1 linker histones silence repetitive elements by promoting both histone H3K9 methylation and chromatin compaction

artículo científico publicado en 2020

Hepatic HuR modulates lipid homeostasis in response to high-fat diet

artículo científico publicado en 2020

High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction

artículo científico publicado en 2013

Hijacked in cancer: the KMT2 (MLL) family of methyltransferases

artículo científico publicado en 2015

Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation

artículo científico publicado en 2020

MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency

artículo científico publicado en 2016

MLL1 Inhibition and Vitamin D Signaling Cooperate to Facilitate the Expanded Pluripotency State

scientific article published on 01 November 2019

Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia

artículo científico publicado en 2020

Modulating Protein-Protein Interactions with Visible-Light-Responsive Peptide Backbone Photoswitches

scientific article published on 25 April 2019

PRDM16 Suppresses MLL1r Leukemia via Intrinsic Histone Methyltransferase Activity

artículo científico publicado en 2016

Publisher Correction: Cryo-EM structure of the human MLL1 core complex bound to the nucleosome

scientific article published on 27 February 2020

RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.

artículo científico publicado en 2017

Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis

artículo científico publicado en 2018

Structural basis for activity regulation of MLL family methyltransferases

artículo científico publicado en 2016

Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer.

artículo científico publicado en 2017

Targeting Mll1 H3K4 methyltransferase activity to guide cardiac lineage specific reprogramming of fibroblasts.

artículo científico publicado en 2016

The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation

artículo científico publicado en 2011

The Targetable Epigenetic Tumor Protein EZH2 is Enriched in Intraocular Medulloepithelioma.

artículo científico publicado en 2016

Two mammalian MOF complexes regulate transcription activation by distinct mechanisms

artículo científico publicado en 2009

p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells

scientific article published on 01 January 2020

Lista de obras de

ASH2L regulates ubiquitylation signaling to MLL: trans-regulation of H3 K4 methylation in higher eukaryotes

Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction

Characterization and pharmacologic targeting of EZH2, a fetal retinal protein and epigenetic regulator, in human retinoblastoma

Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia

Cryo-EM structure of the human MLL1 core complex bound to the nucleosome

Developmental ROS individualizes organismal stress resistance and lifespan

Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase

Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity

Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer

Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

H1 linker histones silence repetitive elements by promoting both histone H3K9 methylation and chromatin compaction

Hepatic HuR modulates lipid homeostasis in response to high-fat diet

High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction

Hijacked in cancer: the KMT2 (MLL) family of methyltransferases

Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation

MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency

MLL1 Inhibition and Vitamin D Signaling Cooperate to Facilitate the Expanded Pluripotency State

Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia

Modulating Protein-Protein Interactions with Visible-Light-Responsive Peptide Backbone Photoswitches

PRDM16 Suppresses MLL1r Leukemia via Intrinsic Histone Methyltransferase Activity

Publisher Correction: Cryo-EM structure of the human MLL1 core complex bound to the nucleosome

RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.

Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis

Structural basis for activity regulation of MLL family methyltransferases

Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer.

Targeting Mll1 H3K4 methyltransferase activity to guide cardiac lineage specific reprogramming of fibroblasts.

The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation

The Targetable Epigenetic Tumor Protein EZH2 is Enriched in Intraocular Medulloepithelioma.

Two mammalian MOF complexes regulate transcription activation by distinct mechanisms

p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells