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5-aminoisoquinolinone attenuates social behavior deficits and immune abnormalities in the BTBR T+ Itpr3tf/J mouse model for autism

artículo científico publicado en 2020

A New Validated HPLC-MS/MS Method for Quantification and Pharmacokinetic Evaluation of Dovitinib, a Multi-Kinase Inhibitor, in Mouse Plasma

artículo científico publicado en 2020

Abatement by naringin of lomefloxacin-induced genomic instability in mice

artículo científico publicado en 2008

Activation of IL-17 receptor leads to increased oxidative inflammation in peripheral monocytes of autistic children.

artículo científico publicado en 2017

Activation of adenosine A2A receptor signaling regulates the expression of cytokines associated with immunologic dysfunction in BTBR T+ Itpr3tf/J mice.

artículo científico publicado en 2017

Acute lung injury leads to depression-like symptoms through upregulation of neutrophilic and neuronal NADPH oxidase signaling in a murine model.

artículo científico publicado en 2017

Adenosine A2A receptor modulates neuroimmune function through Th17/retinoid-related orphan receptor gamma t (RORγt) signaling in a BTBR T+ Itpr3tf/J mouse model of autism

artículo científico publicado en 2017

Adenosine A2A receptor signaling affects IL-21/IL-22 cytokines and GATA3/T-bet transcription factor expression in CD4+ T cells from a BTBR T+ Itpr3tf/J mouse model of autism.

artículo científico publicado en 2017

Airway oxidative stress causes vascular and hepatic inflammation via upregulation of IL-17A in a murine model of allergic asthma.

artículo científico publicado en 2016

Alleviation of Aflatoxin B1-Induced Genomic Damage by Proanthocyanidins via Modulation of DNA Repair.

artículo científico publicado en 2016

Amelioration of autoimmune arthritis by naringin through modulation of T regulatory cells and Th1/Th2 cytokines.

artículo científico publicado en 2014

An overview of nanosomes delivery mechanisms: trafficking, orders, barriers and cellular effects

artículo científico

Anti-inflammatory effect of Euphorbia hirta in an adjuvant-induced arthritic murine model

artículo científico publicado en 2014

Attenuation of the progression of adjuvant-induced arthritis by 3-aminobenzamide treatment

scientific article published on 17 January 2014

Beryllium chloride-induced oxidative DNA damage and alteration in the expression patterns of DNA repair-related genes.

artículo científico publicado en 2013

Bruton's tyrosine kinase inhibition attenuates oxidative stress in systemic immune cells and renal compartment during sepsis-induced acute kidney injury in mice

scientific article published on 07 November 2020

Bruton's tyrosine kinase inhibitor suppresses imiquimod-induced psoriasis-like inflammation in mice through regulation of IL-23/IL-17A in innate immune cells

scientific article published on 24 January 2020

CXC chemokine receptor 3 antagonist AMG487 shows potent anti-arthritic effects on collagen-induced arthritis by modifying B cell inflammatory profile

artículo científico publicado en 2020

CXCR3 antagonist AMG487 inhibits glucocorticoid-induced tumor necrosis factor-receptor-related protein and inflammatory mediators in CD45 expressing cells in collagen-induced arthritis mouse model

scientific article published on 15 April 2020

CXCR3 antagonist AMG487 suppresses rheumatoid arthritis pathogenesis and progression by shifting the Th17/Treg cell balance

scientific article published on 23 August 2019

Chitosan treatment abrogates hypercholesterolemia-induced erythrocyte's arginase activation.

artículo científico publicado en 2016

Chromosomal composition of micronuclei in mouse bone marrow treated with rifampicin and nicotine, analyzed by multicolor fluorescence in situ hybridization with pancentromeric DNA probe

artículo científico publicado en 2007

Cigarette smoking and hyperglycemia increase renal response to low levels of cadmium in welders: cystatin C as a sensitive marker

artículo científico publicado en 2014

Citalopram at the recommended human doses after long-term treatment is genotoxic for male germ cell

artículo científico publicado en 2012

Comet-FISH studies for evaluation of genetic damage of citalopram in somatic cells of the mouse

artículo científico publicado en 2013

Comparative aneugenicity of doxorubicin and its derivative idarubicin using fluorescence in situ hybridization techniques ⬇️

artículo científico publicado el 12 de agosto de 2011

Correction: Utility of Dexrazoxane for the Attenuation of Epirubicin-Induced Genetic Alterations in Mouse Germ Cells

artículo científico publicado en 2016

Crosstalk of Nanosystems Induced Extracellular Vesicles as Promising Tools in Biomedical Applications

artículo científico publicado en 2017

DAPTA, a C-C chemokine receptor 5 (CCR5) antagonist attenuates immune aberrations by downregulating Th9/Th17 immune responses in BTBR T+ Itpr3tf/J mice

artículo científico publicado en 2019

Deleterious Effects of Reactive Metabolites ⬇️

artículo científico publicado el 1 de julio de 2010

Design and Synthesis of N-Arylphthalimides as Inhibitors of Glucocorticoid-Induced TNF Receptor-Related Protein, Proinflammatory Mediators, and Cytokines in Carrageenan-Induced Lung Inflammation.

artículo científico publicado en 2015

Design, synthesis and anticancer activity of some novel thioureido-benzenesulfonamides incorporated biologically active moieties.

artículo científico publicado en 2016

Development and Validation of an HPLC-UV Detection Assay for the Determination of Clonidine in Mouse Plasma and Its Application to a Pharmacokinetic Study

scientific article published on 08 September 2020

Development and validation of HPLC-MS/MS method for the determination of lixivaptan in mouse plasma and its application in a pharmacokinetic study.

artículo científico publicado en 2017

Dexamethasone Attenuates LPS-induced Acute Lung Injury through Inhibition of NF-κB, COX-2, and Pro-inflammatory Mediators

artículo científico publicado en 2016

Dexrazoxane Averts Idarubicin-Evoked Genomic Damage by Regulating Gene Expression Profiling Associated With the DNA Damage-Signaling Pathway in BALB/c Mice.

artículo científico publicado en 2017

Dexrazoxane mitigates epirubicin-induced genotoxicity in mice bone marrow cells

artículo científico publicado en 2015

Differential regulation of Nrf2 is linked to elevated inflammation and nitrative stress in monocytes of children with autism

scientific article published on 23 December 2019

Diosmin downregulates the expression of T cell receptors, pro-inflammatory cytokines and NF-κB activation against LPS-induced acute lung injury in mice

artículo científico publicado en 2015

Dominant lethal mutations of topoisomerase II inhibitors etoposide and merbarone in male mice: a mechanistic study ⬇️

artículo científico publicado el 30 de diciembre de 2011

Downregulation in Helios transcription factor signaling is associated with immune dysfunction in blood leukocytes of autistic children.

artículo científico publicado en 2018

Dysregulated enzymatic antioxidant network in peripheral neutrophils and monocytes in children with autism

scientific article published on 23 August 2018

Dysregulation in IL-6 receptors is associated with upregulated IL-17A related signaling in CD4+ T cells of children with autism

scientific article published on 23 October 2019

Dysregulation of T cell immunoglobulin and mucin domain 3 (TIM-3) signaling in peripheral immune cells is associated with immune dysfunction in autistic children

scientific article published on 24 December 2018

Dysregulation of Th1, Th2, Th17, and T regulatory cell-related transcription factor signaling in children with autism.

artículo científico publicado en 2016

Dysregulation of the expression of HLA-DR, costimulatory molecule, and chemokine receptors on immune cells in children with autism

scientific article published on 26 October 2018

Effect of dihydrokainate on the capacity of repair of DNA damage and apoptosis induced by doxorubicin

artículo científico publicado en 2013

Elevated IL-16 expression is associated with development of immune dysfunction in children with autism

artículo científico publicado en 2018

Evaluation of Chromosomal Instability in Diabetic Rats Treated with Naringin ⬇️

artículo científico publicado el 20 de septiembre de 2011

Evaluation of DNA repair efficiency in autistic children by molecular cytogenetic analysis and transcriptome profiling

scientific article published on 14 November 2019

Gene expression of IQGAPs and Ras families in an experimental mouse model for hepatocellular carcinoma: a mechanistic study of cancer progression

artículo científico publicado en 2015

Genetic and epigenetic alterations induced by the small-molecule panobinostat: A mechanistic study at the chromosome and gene levels

artículo científico publicado en 2019

Grape seed proanthocyanidin extract has potent anti-arthritic effects on collagen-induced arthritis by modifying the T cell balance

artículo científico publicado en 2013

Grape seed proanthocyanidin extract protects against carrageenan-induced lung inflammation in mice through reduction of pro-inflammatory markers and chemokine expressions

artículo científico publicado en 2014

HPLC-fluorescence method for the enantioselective analysis of propranolol in rat serum using immobilized polysaccharide-based chiral stationary phase

artículo científico publicado en 2014

Histamine 4 receptor promotes expression of costimulatory B7.1/B7.2 molecules, CD28 signaling and cytokine production in stress-induced immune responses.

artículo científico publicado en 2015

IL-17A causes depression-like symptoms via NFκB and p38MAPK signaling pathways in mice: Implications for psoriasis associated depression

artículo científico publicado en 2017

Imbalance between the anti- and pro-inflammatory milieu in blood leukocytes of autistic children.

artículo científico publicado en 2016

Imiquimod-induced psoriasis-like skin inflammation is suppressed by BET bromodomain inhibitor in mice through RORC/IL-17A pathway modulation.

artículo científico publicado en 2015

Immune Alterations in CD8(+) T Cells Are Associated with Neuronal C-C and C-X-C Chemokine Receptor Regulation Through Adenosine A2A Receptor Signaling in a BTBR T(+) Itpr3(tf)/J Autistic Mouse Model.

artículo científico publicado en 2017

Immunosuppressive effects of Euphorbia hirta in experimental animals ⬇️

artículo científico publicado el 19 de junio de 2012

Increased oxidative stress in the cerebellum and peripheral immune cells leads to exaggerated autism-like repetitive behavior due to deficiency of antioxidant response in BTBR T + tf/J mice

artículo científico publicado en 2018

Influence of resveratrol on oxidative damage in genomic DNA and apoptosis induced by cisplatin ⬇️

artículo científico publicado el 28 de octubre de 2011

Inhibition of BET bromodomains restores corticosteroid responsiveness in a mixed granulocytic mouse model of asthma

artículo científico publicado en 2018

Inhibition of Bruton's tyrosine kinase and IL-2 inducible T-cell kinase suppresses both neutrophilic and eosinophilic airway inflammation in a cockroach allergen extract-induced mixed granulocytic mouse model of asthma using preventative and therape

artículo científico publicado en 2019

Inhibition of spleen tyrosine kinase signaling protects against acute lung injury through blockade of NADPH oxidase and IL-17A in neutrophils and γδ T cells respectively in mice

artículo científico publicado en 2019

Inhibition of tyrosine kinase signaling by tyrphostin AG126 downregulates the IL-21/IL-21R and JAK/STAT pathway in the BTBR mouse model of autism

scientific article published on 04 December 2019

Involvement of CD45 cells in the development of autism spectrum disorder through dysregulation of granulocyte-macrophage colony-stimulating factor, key inflammatory cytokines, and transcription factors

scientific article published on 04 April 2020

Involvement of histamine 4 receptor in the pathogenesis and progression of rheumatoid arthritis.

artículo científico publicado en 2014

Liquid chromatographic high-throughput analysis of the new ultra-short acting hypnotic 'HIE-124' and its metabolite in mice serum using a monolithic silica column

scientific article published on 16 November 2010

Methylmercury chloride exposure aggravates proinflammatory mediators and Notch-1 signaling in CD14+ and CD40+ cells and is associated with imbalance of neuroimmune function in BTBR T+ Itpr3tf/J mice

scientific article published on 06 November 2020

Modulation of Th1 cytokines and inflammatory mediators by Euphorbia hirta in animal model of adjuvant-induced arthritis.

artículo científico publicado en 2012

Modulation of irinotecan-induced genomic DNA damage by theanine ⬇️

artículo científico publicado el 6 de marzo de 2012

Modulatory effects of meloxicam on cardiotoxicity and antitumor activity of doxorubicin in mice

artículo científico publicado en 2014

Molecular cytogenetic evaluation of the aneugenic effects of teniposide in somatic and germinal cells of male mice

artículo científico publicado en 2011

Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells ⬇️

artículo científico publicado el 11 de noviembre de 2011

Molecular cytogenetic evaluation of the mechanism of micronuclei formation induced by camptothecin, topotecan, and irinotecan

artículo científico publicado en 2009

Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-κb, STAT3 and pro-inflammatory mediators and enhancement of IκBα and anti-inflammatory cytokines.

artículo científico publicado en 2015

Novel, selective sample stacking microemulsion electrokinetic capillary chromatography induced by reverse migrating pseudostationary phase for the determination of the new ultra-short acting hypnotic "HIE-124" in mice serum

artículo científico publicado en 2010

Nrf2 activator, sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signaling and rectification of oxidant-antioxidant imbalance in periphery and brain of BTBR T+tf/J mice

artículo científico publicado en 2019

Oxidative and inflammatory mediators are upregulated in neutrophils of autistic children: Role of IL-17A receptor signaling

artículo científico publicado en 2018

Pendimethalin induces oxidative stress, DNA damage, and mitochondrial dysfunction to trigger apoptosis in human lymphocytes and rat bone-marrow cells.

artículo científico publicado en 2017

Phorate-induced oxidative stress, DNA damage and transcriptional activation of p53 and caspase genes in male Wistar rats

artículo científico publicado en 2011

Poly(ADP-ribose) polymerase-1 inhibitor modulates T regulatory and IL-17 cells in the prevention of adjuvant induced arthritis in mice model

artículo científico publicado en 2014

Pravastatin chitosan nanogels-loaded erythrocytes as a new delivery strategy for targeting liver cancer

artículo científico publicado en 2015

Proanthocyanidins Produce Significant Attenuation of Doxorubicin‐Induced Mutagenicity via Suppression of Oxidative Stress ⬇️

artículo científico publicado el 1 de noviembre de 2010

Protease activated receptor-2 mediated upregulation of IL-17 receptor signaling on airway epithelial cells is responsible for neutrophilic infiltration during acute exposure of house dust mite allergens in mice

artículo científico publicado en 2019

Protection by tyrosine kinase inhibitor, tyrphostin AG126, through the suppression of IL-17A, RORγt, and T-bet signaling, in the BTBR mouse model of autism

scientific article published on 30 August 2018

Protection of mouse bone marrow from etoposide-induced genomic damage by dexrazoxane

artículo científico publicado en 2009

Protective effect of captopril against cisplatin-induced nephrotoxicity in rats

artículo científico publicado en 2008

Psoriatic inflammation enhances allergic airway inflammation through IL-23/STAT3 signaling in a murine model.

artículo científico publicado en 2016

Regulation of TNF-α and NF-κB activation through the JAK/STAT signaling pathway downstream of histamine 4 receptor in a rat model of LPS-induced joint inflammation.

artículo científico publicado en 2015

Resveratrol Ameliorates Dysregulation of Th1, Th2, Th17, and T Regulatory Cell-Related Transcription Factor Signaling in a BTBR T + tf/J Mouse Model of Autism

artículo científico publicado en 2016

Resveratrol Improves Neuroimmune Dysregulation Through the Inhibition of Neuronal Toll-Like Receptors and COX-2 Signaling in BTBR T+ Itpr3tf/J Mice

artículo científico publicado en 2018

Resveratrol attenuates pro-inflammatory cytokines and activation of JAK1-STAT3 in BTBR T+ Itpr3tf/J autistic mice.

artículo científico publicado en 2018

Resveratrol treatment attenuates chemokine receptor expression in the BTBR T+tf/J mouse model of autism

artículo científico publicado en 2016

Role of a histamine 4 receptor as an anti-inflammatory target in carrageenan-induced pleurisy in mice

scientific article published on 01 July 2014

S3I-201, a selective Stat3 inhibitor, restores neuroimmune function through upregulation of Treg signaling in autistic BTBR T+ Itpr3tf/J mice

artículo científico publicado en 2018

STA-21, a STAT-3 inhibitor, attenuates the development and progression of inflammation in collagen antibody-induced arthritis.

artículo científico publicado en 2016

Sample stacking microemulsion electrokinetic capillary chromatography induced by reverse migrating pseudostationary phase for the quantification of phenobarbital and its p-hydroxyphenobarbital metabolite in rat urine.

artículo científico publicado en 2011

Selective microemulsion liquid chromatography analysis of dopamine receptor antagonist LE300 and its N-methyl metabolite in mouse sera by using a monolithic silica column

artículo científico publicado en 2015

Sinapic acid ameliorate cadmium-induced nephrotoxicity: In vivo possible involvement of oxidative stress, apoptosis, and inflammation via NF-κB downregulation

artículo científico publicado en 2017

Stimulation of the histamine 4 receptor with 4-methylhistamine modulates the effects of chronic stress on the Th1/Th2 cytokine balance.

artículo científico publicado en 2014

Synthesis and biological evaluation of some novel cyclic-imides as hypoglycaemic, anti-hyperlipidemic agents.

artículo científico publicado en 2011

Systemic inflammation in asocial BTBR T+ tf/J mice predisposes them to increased psoriatic inflammation.

artículo científico publicado en 2017

TNF-α inhibitory effect of Euphorbia hirta in rats

artículo científico publicado en 2013

The PPARδ agonist GW0742 restores neuroimmune function by regulating Tim-3 and Th17/Treg-related signaling in the BTBR autistic mouse model

scientific article published on 15 September 2018

The Stat3 inhibitor, S3I-201, downregulates lymphocyte activation markers, chemokine receptors, and inflammatory cytokines in the BTBR T+ Itpr3tf/J mouse model of autism

scientific article published on 09 July 2019

The chemotherapeutic agents nocodazole and amsacrine cause meiotic delay and non-disjunction in spermatocytes of mice

artículo científico publicado en 2007

The genotoxic and cytotoxic effects of nicotine in the mouse bone marrow

artículo científico publicado en 2007

The histamine-4 receptor antagonist JNJ7777120 prevents immune abnormalities by inhibiting RORγt/T-bet transcription factor signaling pathways in BTBR T+ Itpr3tf/J mice exposed to gamma rays

artículo científico publicado en 2019

The impact of quercetin on cisplatin-induced clastogenesis and apoptosis in murine marrow cells

artículo científico publicado en 2010

The influence of lentinan on the capacity of repair of DNA damage and apoptosis induced by paclitaxel in mouse bone marrow cells

artículo científico publicado en 2013

The potent immunomodulatory compound VGX-1027 regulates inflammatory mediators in CD4+ T cells, which are concomitant with the prevention of neuroimmune dysregulation in BTBR T+ Itpr3tf/J mice

artículo científico publicado en 2019

The role of poly(ADP-ribose) polymerase-1 inhibitor in carrageenan-induced lung inflammation in mice.

artículo científico publicado en 2014

The tyrosine kinase inhibitor tyrphostin AG126 reduces activation of inflammatory cells and increases Foxp3+ regulatory T cells during pathogenesis of rheumatoid arthritis.

artículo científico publicado en 2016

Therapeutic treatment with Ibrutinib attenuates imiquimod-induced psoriasis-like inflammation in mice through downregulation of oxidative and inflammatory mediators in neutrophils and dendritic cells

scientific article published on 28 March 2020

Thymoquinone inhibits growth of human medulloblastoma cells by inducing oxidative stress and caspase-dependent apoptosis while suppressing NF-κB signaling and IL-8 expression.

artículo científico publicado en 2016

Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis.

artículo científico publicado en 2014

Toll-like receptor 4 signaling is associated with upregulated NADPH oxidase expression in peripheral T cells of children with autism.

artículo científico publicado en 2016

Toll-like receptors, NF-κB, and IL-27 mediate adenosine A2A receptor signaling in BTBR T+ Itpr3tf/J mice

artículo científico publicado en 2017

Ubiquitous plasticizer, Di-(2-ethylhexyl) phthalate enhances existing inflammatory profile in monocytes of children with autism

artículo científico publicado en 2020

Upregulation of IL-9 and JAK-STAT signaling pathway in children with autism.

artículo científico publicado en 2017

Upregulation of enzymatic antioxidants in CD4+ T cells of autistic children

artículo científico publicado en 2020

Upregulation of interleukin (IL)-31, a cytokine producing CXCR1 peripheral immune cells, contributes to the immune abnormalities of autism spectrum disorder

artículo científico publicado en 2020

Upregulation of peripheral CXC and CC chemokine receptor expression on CD4+ T cells is associated with immune dysregulation in children with autism

artículo científico publicado en 2017

Use of centromeric and telomeric DNA probes in in situ hybridization for differentiation of micronuclei induced by lomefloxacin

artículo científico publicado en 2009

Utility of Dexrazoxane for the Attenuation of Epirubicin-Induced Genetic Alterations in Mouse Germ Cells

artículo científico publicado en 2016

Validated liquid chromatographic-fluorescence method for the quantitation of darifenacin in mice plasma and its application to a pharmacokinetic study.

artículo científico publicado en 2013

Vorinostat is genotoxic and epigenotoxic in the mouse bone marrow cells at the human equivalent doses

artículo científico publicado en 2020

Wogonin attenuates etoposide-induced oxidative DNA damage and apoptosis via suppression of oxidative DNA stress and modulation of OGG1 expression

artículo científico publicado en 2013

p53, MAPKAPK-2 and caspases regulate nickel oxide nanoparticles induce cell death and cytogenetic anomalies in rats

artículo científico publicado en 2017

β-1,3-Glucan reverses aflatoxin B1-mediated suppression of immune responses in mice

artículo científico publicado en 2016

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