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A GATA-2-GPR65 Regulatory Module Controls Hematopoietic Stem Cell Generation

artículo científico publicado en 2015

A Hierarchical Framework for State-Space Matrix Inference and Clustering.

artículo científico publicado en 2016

A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis

artículo científico publicado en 2015

A Systems Approach Identifies Essential FOXO3 Functions in Erythroblast Enucleation Process

scholarly article

A WW domain-binding motif within the activation domain of the hematopoietic transcription factor NF-E2 is essential for establishment of a tissue-specific histone modification pattern

artículo científico publicado en 2003

A splicing factor switch controls hematopoietic lineage specification of pluripotent stem cells

artículo científico publicado en 2020

Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes

artículo científico publicado en 2022

Author Correction: Perspectives on ENCODE

artículo científico publicado en 2022

Autophagy driven by a master regulator of hematopoiesis

artículo científico publicado en 2012

BRG1 directly regulates nucleosome structure and chromatin looping of the alpha globin locus to activate transcription

artículo científico publicado en 2009

Breaking the spatial constraint between neighboring zinc fingers: a new germline mutation in GATA2 deficiency syndrome

scientific article published on 14 April 2020

Building multifunctionality into a complex containing master regulators of hematopoiesis

artículo científico publicado en 2010

Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal region

artículo científico publicado en 2005

Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity

artículo científico publicado en 2012

Cis-regulatory mechanisms governing stem and progenitor cell transitions

artículo científico publicado en 2015

Cistrome Control of Hematopoieitic Stem/Progenitor Cell Function

artículo científico publicado en 2015

Context-dependent GATA factor function: combinatorial requirements for transcriptional control in hematopoietic and endothelial cells

artículo científico publicado en 2007

Cooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain

artículo científico publicado en 2002

Coregulator-dependent facilitation of chromatin occupancy by GATA-1.

artículo científico publicado en 2004

Developmental control via GATA factor interplay at chromatin domains

artículo científico publicado en 2005

Differential GATA factor stabilities: implications for chromatin occupancy by structurally similar transcription factors

artículo científico publicado en 2007

Differential coregulator requirements for function of the hematopoietic transcription factor GATA-1 at endogenous loci

artículo científico publicado en 2010

Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy

artículo científico publicado en 2009

Discovering transcription factor binding sites in highly repetitive regions of genomes with multi-read analysis of ChIP-Seq data

artículo científico publicado en 2011

Dissecting Regulatory Mechanisms Using Mouse Fetal Liver-Derived Erythroid Cells

artículo científico publicado en 2018

Distinct functions of dispersed GATA factor complexes at an endogenous gene locus

artículo científico

Dynamic GATA factor interplay at a multicomponent regulatory region of the GATA-2 locus

artículo científico publicado en 2004

Dynamic regulation of histone H3 methylated at lysine 79 within a tissue-specific chromatin domain.

artículo científico publicado en 2003

Endothelial Jarid2/Jumonji Is Required for Normal Cardiac Development and Proper Notch1 Expression

artículo científico publicado el 14 de marzo de 2011

Epigenetic Determinants of Erythropoiesis: Role of the Histone Methyltransferase SetD8 in Promoting Erythroid Cell Maturation and Survival

artículo científico publicado en 2015

Epigenetic and genetic mechanisms in red cell biology

artículo científico

Establishing a hematopoietic genetic network through locus-specific integration of chromatin regulators.

artículo científico publicado en 2013

Establishment of a cell-type-specific genetic network by the mediator complex component Med1.

artículo científico publicado en 2013

Evidence that C promoter-binding factor 1 binding is required for Notch-1-mediated repression of activator protein-1.

artículo científico publicado en 2003

Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis

artículo científico publicado en 2016

Friend of GATA-1-independent transcriptional repression: a novel mode of GATA-1 function

artículo científico publicado en 2007

GATA Factor-Dependent Positive-Feedback Circuit Controls Acute Myeloid Leukemia Cell Proliferation: Mechanisms and Targets for Therapeutic Intervention

artículo científico publicado en 2016

GATA Factor-Dependent Positive-Feedback Circuit in Acute Myeloid Leukemia Cells

artículo científico publicado en 2016

GATA Factor-G-Protein-Coupled Receptor Circuit Suppresses Hematopoiesis.

artículo científico publicado en 2016

GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia

artículo científico publicado en 2017

GATA Switches as Developmental Drivers

artículo científico publicado el 29 de julio de 2010

GATA factor-regulated solute carrier ensemble reveals a nucleoside transporter-dependent differentiation mechanism

artículo científico publicado en 2020

GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling

artículo científico publicado en 2003

GATA-1-mediated transcriptional repression yields persistent transcription factor IIB-chromatin complexes

artículo científico

GATA-2 Dependent Hematologic Disease Mechanism

scholarly article

GATA/Heme Multi-omics Reveals a Trace Metal-Dependent Cellular Differentiation Mechanism

scientific article published on 16 August 2018

GATA2 +9.5 enhancer: from principles of hematopoiesis to genetic diagnosis in precision medicine

artículo científico publicado en 2020

GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm

scientific article published on 08 August 2019

GATA2 functions at multiple steps in hemangioblast development and differentiation

artículo científico publicado en 2006

GATA2 haploinsufficiency caused by mutations in a conserved intronic element leads to MonoMAC syndrome

artículo científico publicado en 2013

Gata2 -77 enhancer regulates adult hematopoietic stem cell survival

artículo científico publicado en 2020

Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo

artículo científico publicado en 2013

Genetic Basis For Hematopoietic Stem Cell Generation In The Mammalian Embryo

artículo científico publicado en 2013

Genetic Determinants of the Definitive Hematopoietic Stem/Progenitor Cell Compartment

artículo científico publicado en 2012

Genetic framework for GATA factor function in vascular biology

artículo científico publicado en 2011

H3 K79 dimethylation marks developmental activation of the beta-globin gene but is reduced upon LCR-mediated high-level transcription

artículo científico publicado en 2008

Hematopoietic Signaling Mechanism Revealed from a Stem/Progenitor Cell Cistrome

artículo científico publicado en 2015

Hematopoietic transcriptional mechanisms: from locus-specific to genome-wide vantage points.

artículo científico

Hematopoietic-specific activators establish an overlapping pattern of histone acetylation and methylation within a mammalian chromatin domain

artículo científico publicado en 2002

Highly restricted localization of RNA polymerase II within a locus control region of a tissue-specific chromatin domain

artículo científico publicado en 2003

Histone deacetylase-dependent establishment and maintenance of broad low-level histone acetylation within a tissue-specific chromatin domain

artículo científico publicado en 2002

Human leukemia mutations corrupt but do not abrogate GATA-2 function

article published in the Proceedings of the National Academy of Sciences of the United States of America

Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype

scientific article published on 27 July 2018

Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program

artículo científico publicado en 2017

Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program

artículo científico publicado en 2017

Integration of Hi-C and ChIP-seq data reveals distinct types of chromatin linkages

artículo científico publicado en 2012

Integrative analysis with ChIP-seq advances the limits of transcript quantification from RNA-seq

artículo científico publicado en 2016

Loss-of-Function and Gain-of-Function Consequences of GATA2 Disease Mutations

scholarly article

Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies

artículo científico publicado el 5 de abril de 2012

Measurement of protein-DNA interactions in vivo by chromatin immunoprecipitation

artículo científico publicado en 2004

Mechanism governing a stem cell-generating cis-regulatory element

artículo científico publicado en 2014

Mechanism governing heme synthesis reveals a GATA factor/heme circuit that controls differentiation

artículo científico publicado en 2015

Mechanisms of erythrocyte development and regeneration: implications for regenerative medicine and beyond.

artículo científico publicado en 2018

Metabolic Pathways Control Normal and Beta-Thalassemic Erythroid Cell Maturation

scholarly article

Molecular basis of crosstalk between oncogenic Ras and the master regulator of hematopoiesis GATA-2

artículo científico publicado en 2014

Molecular hallmarks of endogenous chromatin complexes containing master regulators of hematopoiesis

scientific journal article

Mouse Modeling of GATA2 Related MDS/AML

artículo científico publicado en 2015

Orchestrating Developmental Signaling to Balance Erythroblast Proliferation and Differentiation

scholarly article

PRAM: a novel pooling approach for discovering intergenic transcripts from large-scale RNA sequencing experiments

scientific article published on 21 September 2020

Polycomb Group Protein YY1 Is an Essential Regulator of Hematopoietic Stem Cell Quiescence.

artículo científico publicado en 2018

Post-transcriptional control of cellular differentiation by the RNA exosome complex

artículo científico publicado en 2020

RNA-regulatory exosome complex confers cellular survival to promote erythropoiesis

artículo científico publicado en 2021

Relocalizing Genetic Loci into Specific Subnuclear Neighborhoods

artículo científico publicado el 11 de marzo de 2011

Repression of activator protein-1-mediated transcriptional activation by the Notch-1 intracellular domain

artículo científico publicado en 2001

Requirements for utilization of CREB binding protein by hypersensitive site two of the beta-globin locus control region

artículo científico publicado en 2002

Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia

publication published on 12 May 2021

Single-molecule analysis reveals widespread structural variation in multiple myeloma.

artículo científico publicado en 2015

Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer

scientific article published on 11 February 2019

Sterile alpha motif domain requirement for cellular signaling and survival

scientific article published on 02 April 2020

The GATA factor revolution in hematology

artículo científico

The exosome complex establishes a barricade to erythroid maturation

artículo científico publicado en 2014

Transcriptional mechanisms underlying hemoglobin synthesis

artículo científico publicado en 2013

jMOSAiCS: joint analysis of multiple ChIP-seq datasets

artículo científico publicado en 2013

p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia

artículo científico publicado en 2016