Lista de obras -

"Effect of the drug transporters ABCB1, ABCC2, and ABCG2 on the disposition and brain accumulation of the taxane analog BMS-275,183".

artículo científico publicado en 2014

A Phase I Dose Escalation Study of Once-Weekly Oral Administration of Docetaxel as ModraDoc001 Capsule or ModraDoc006 Tablet in Combination with Ritonavir

scientific article published on 19 June 2019

A Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of Pictilisib in Combination with Erlotinib in Patients with Advanced Solid Tumors

artículo científico publicado en 2017

A Phase I and pharmacological study of the platinum polymer AP5280 given as an intravenous infusion once every 3 weeks in patients with solid tumors

scientific article published on 01 May 2004

A Phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent.

artículo científico publicado en 2004

A Phase Ib Dose-Escalation Study of Encorafenib and Cetuximab with or without Alpelisib in Metastatic BRAF-Mutant Colorectal Cancer

artículo científico publicado en 2017

A Population Pharmacokinetic Model of Oral Docetaxel Coadministered With Ritonavir to Support Early Clinical Development

artículo científico publicado en 2019

A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy

artículo científico publicado en 2018

A dose escalating phase I study of GLPG0187, a broad spectrum integrin receptor antagonist, in adult patients with progressive high-grade glioma and other advanced solid malignancies.

artículo científico publicado en 2016

A dose-escalation study of bi-daily once weekly oral docetaxel either as ModraDoc001 or ModraDoc006 combined with ritonavir

artículo científico publicado en 2017

A drug-drug interaction study to assess the effect of the CYP1A2 inhibitor fluvoxamine on the pharmacokinetics of dovitinib (TKI258) in patients with advanced solid tumors.

artículo científico publicado en 2017

A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours

artículo científico publicado en 2020

A model of hypertension and proteinuria in cancer patients treated with the anti-angiogenic drug E7080

artículo científico publicado en 2010

A more sensitive MS detector does not obviously lead to a more sensitive assay: experiences with ES-285.

artículo científico publicado en 2004

A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma

artículo científico publicado en 2010

A phase 0 clinical trial of novel candidate extended-release formulations of capecitabine

artículo científico publicado en 2016

A phase I followed by a randomized phase II trial of two cycles carboplatin-olaparib followed by olaparib monotherapy versus capecitabine in BRCA1- or BRCA2-mutated HER2-negative advanced breast cancer as first line treatment (REVIVAL): study protoc

artículo científico publicado en 2016

A phase I monotherapy study of RG7212, a first-in-class monoclonal antibody targeting TWEAK signaling in patients with advanced cancers

scientific article published on 11 November 2014

A phase I safety and pharmacologic study of a twice weekly dosing regimen of the oral taxane BMS-275183

artículo científico publicado en 2007

A phase I study of SAR405838, a novel human double minute 2 (HDM2) antagonist, in patients with solid tumours

artículo científico publicado en 2017

A phase I study of the HDM2 antagonist SAR405838 combined with the MEK inhibitor pimasertib in patients with advanced solid tumours

artículo científico publicado en 2018

A phase I, open-label, randomized crossover study to assess the effect of dosing of the MEK 1/2 inhibitor Selumetinib (AZD6244; ARRY-142866) in the presence and absence of food in patients with advanced solid tumors ⬇️

artículo científico publicado el 28 de septiembre de 2011

A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients

scientific article published on 01 June 2007

A phase Ib study of GSK3052230, an FGF ligand trap in combination with pemetrexed and cisplatin in patients with malignant pleural mesothelioma

scientific article published on 07 May 2019

A phosphotyrosine switch regulates organic cation transporters ⬇️

artículo científico publicado en 2016

A rapid and simple HPLC-UV method for the determination of inhibition characteristics of farnesyl transferase inhibitors

artículo científico publicado en 2006

A semi-physiological population pharmacokinetic model describing the non-linear disposition of indisulam

artículo científico publicado en 2006

A sensitive LC-MS/MS method for the quantitative analysis of the Echinacea purpurea constituent undeca-2-ene-8,10-diynoic acid isobutylamide in human plasma

artículo científico publicado en 2010

A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry

artículo científico publicado en 2008

A sensitive combined assay for the quantification of paclitaxel, docetaxel and ritonavir in human plasma using liquid chromatography coupled with tandem mass spectrometry

scientific article published on 31 August 2011

A simple and sensitive assay for the quantitative analysis of paclitaxel and metabolites in human plasma using liquid chromatography/tandem mass spectrometry

artículo científico publicado en 2006

Abcc4 Together with Abcb1 and Abcg2 Form a Robust Cooperative Drug Efflux System That Restricts the Brain Entry of Camptothecin Analogues ⬇️

artículo científico publicado el 5 de marzo de 2013

Abrogation of the G2 checkpoint by inhibition of Wee-1 kinase results in sensitization of p53-deficient tumor cells to DNA-damaging agents

artículo científico publicado en 2010

Absence of N-linked glycosylation does not affect plasma membrane localization of breast cancer resistance protein (BCRP/ABCG2).

artículo científico publicado en 2005

Absolute quantification of farnesylated Ras levels in complex samples using liquid chromatography fractionation combined with tryptic digestion and electrospray tandem mass spectrometry

artículo científico publicado en 2006

Acute poisoning after oral intake of a toluene-containing paint thinner

artículo científico publicado en 2002

Adduct-specific monoclonal antibodies for the measurement of cisplatin-induced DNA lesions in individual cell nuclei

artículo científico publicado en 2006

Age-Associated Hematological Toxicity in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Docetaxel in Clinical Practice

artículo científico publicado en 2019

An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential.

artículo científico publicado en 2018

An LC-MS/MS method for quantification of the active abiraterone metabolite Δ(4)-abiraterone (D4A) in human plasma

artículo científico publicado en 2017

An excretion balance and pharmacokinetic study of the novel anticancer agent E7070 in cancer patients

artículo científico publicado en 2002

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons

artículo científico publicado en 2003

Angiotensin II-Receptor Inhibition With Candesartan to Prevent Trastuzumab-Related Cardiotoxic Effects in Patients With Early Breast Cancer: A Randomized Clinical Trial.

artículo científico

Antidrug Antibody Formation in Oncology: Clinical Relevance and Challenges

artículo científico publicado en 2016

Application of PET/CT in the development of novel anticancer drugs

artículo científico publicado en 2008

Application of dried blood spots combined with high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry for simultaneous quantification of vincristine and actinomycin-D.

artículo científico publicado en 2009

Application of population pharmacokinetic modeling in early clinical development of the anticancer agent E7820.

artículo científico publicado en 2008

BRAF Mutations as Predictive Biomarker for Response to Anti-EGFR Monoclonal Antibodies

artículo científico publicado en 2017

BRAF-mutant Transcriptional Subtypes Predict Outcome of Combined BRAF, MEK, and EGFR Blockade with Dabrafenib, Trametinib, and Panitumumab in Patients with Colorectal Cancer

scientific article published on 11 February 2020

Baclofen overdose treated with continuous venovenous hemofiltration

artículo científico publicado en 2015

Bayesian pharmacokinetically guided dosing of paclitaxel in patients with non-small cell lung cancer.

artículo científico publicado en 2004

Bayesian pharmacokinetics of lithium after an acute self-intoxication and subsequent haemodialysis: a case report

artículo científico publicado en 2002

Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.

artículo científico publicado en 2013

Bevacizumab

artículo científico publicado en 2010

Bevacizumab combined with docetaxel, oxaliplatin, and capecitabine, followed by maintenance with capecitabine and bevacizumab, as first-line treatment of patients with advanced HER2-negative gastric cancer: A multicenter phase 2 study

artículo científico publicado en 2016

Binimetinib, Encorafenib, and Cetuximab Triplet Therapy for Patients With BRAF V600E-Mutant Metastatic Colorectal Cancer: Safety Lead-In Results From the Phase III BEACON Colorectal Cancer Study

scientific article published on 20 March 2019

Bioanalytical Aspects of Clinical Mass Balance Studies in Oncology ⬇️

artículo científico publicado el 1 de diciembre de 2011

Bioanalytical LC-MS/MS validation of therapeutic drug monitoring assays in oncology

artículo científico publicado en 2019

Bioanalytical assay for the quantification of the ALK inhibitor lorlatinib in mouse plasma using liquid chromatography-tandem mass spectrometry.

artículo científico publicado en 2018

Bioanalytical liquid chromatography-tandem mass spectrometric assay for the quantification of the ALK inhibitors alectinib, brigatinib and lorlatinib in plasma and mouse tissue homogenates

scientific article published on 19 August 2018

Bioanalytical methods for the quantification of therapeutic monoclonal antibodies and their application in clinical pharmacokinetic studies

artículo científico publicado en 2009

Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides.

artículo científico publicado en 2005

CMET-12. TUMOR CELL DETECTION BY IMMUNOFLOW CYTOMETRY AND BRAF MUTATION ANALYSIS IN CEREBROSPINAL FLUID OF MELANOMA PATIENTS WITH SUSPECTED LEPTOMENINGEAL METASTASES.

artículo científico publicado en 2017

CYP2C9 and CYP2C19 polymorphic forms are related to increased indisulam exposure and higher risk of severe hematologic toxicity

scientific article published on 01 May 2007

Cannulation of the jugular vein in mice

artículo científico publicado en 2005

Capecitabine induces severe angina-like chest pain

artículo científico publicado en 2004

Capecitabine-based treatment of a patient with a novel DPYD genotype and complete dihydropyrimidine dehydrogenase deficiency.

artículo científico publicado en 2017

Carboplatin dosing in overweight and obese patients with normal renal function, does weight matter?

artículo científico publicado en 2008

Cellular and clinical pharmacology of the taxanes docetaxel and paclitaxel--a review

artículo científico

Characterization of the in vitro activity of AZD3409, a novel prenyl transferase inhibitor

artículo científico publicado en 2010

Chronic hepatotoxicity after long-term antiretroviral treatment including nevirapine

artículo científico publicado en 2005

Circulating epithelial tumor cell analysis in CSF in patients with leptomeningeal metastases

scientific article published on 06 January 2020

Circulating tumor cells as pharmacodynamic biomarker in early clinical oncological trials ⬇️

artículo científico publicado el 17 de mayo de 2011

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update.

artículo científico publicado en 2017

Clinical Pharmacokinetics and Pharmacodynamics of Pazopanib: Towards Optimized Dosing

artículo científico publicado en 2017

Clinical Pharmacokinetics of Systemically Administered Antileishmanial Drugs.

artículo científico publicado en 2017

Clinical and pharmacologic study of the farnesyltransferase inhibitor tipifarnib in cancer patients with normal or mildly or moderately impaired hepatic function

artículo científico publicado en 2006

Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors

artículo científico publicado en 2008

Clinical experience with aurora kinase inhibitors: a review

scientific article published on 14 August 2009

Clinical pharmacokinetics of an amorphous solid dispersion tablet of elacridar

artículo científico publicado en 2016

Clinical pharmacokinetics of therapeutic monoclonal antibodies

artículo científico publicado en 2010

Clinical pharmacokinetics, pharmacodynamics and metabolism of the novel matrix metalloproteinase inhibitor ABT-518

artículo científico publicado en 2002

Clinical pharmacology of the novel marine-derived anticancer agent Ecteinascidin 743 administered as a 1- and 3-h infusion in a phase I study

artículo científico publicado en 2002

Clinical proteomics in breast cancer: a review

artículo científico publicado en 2008

Clinical proteomics: searching for better tumour markers with SELDI-TOF mass spectrometry

artículo científico publicado en 2006

Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data

artículo científico publicado en 2015

Clinical trial simulations in paediatric oncology: A feasibility study from the Innovative Therapies for Children with Cancer Consortium.

artículo científico publicado en 2017

Coadministration of ritonavir strongly enhances the apparent oral bioavailability of docetaxel in patients with solid tumors.

artículo científico publicado en 2009

Combined BRAF, EGFR, and MEK Inhibition in Patients with BRAFV600E-Mutant Colorectal Cancer

artículo científico publicado en 2018

Combined action and regulation of phase II enzymes and multidrug resistance proteins in multidrug resistance in cancer

artículo científico publicado en 2008

Combined quantification of paclitaxel, docetaxel and ritonavir in human feces and urine using LC-MS/MS.

artículo científico publicado en 2013

Comparison of toxicity and effectiveness between fixed-dose and body surface area-based dose capecitabine

article

Concise Drug Review: Azacitidine and Decitabine ⬇️

artículo científico publicado el 13 de mayo de 2013

Concise Drug Review: Pazopanib and Axitinib ⬇️

artículo científico publicado el 25 de junio de 2012

Concise review: Clinical relevance of drug drug and herb drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein).

artículo científico publicado en 2007

Concomitant use of proton pump inhibitors and systemic corticosteroids

artículo científico publicado el 1 de enero de 2013

Correction of peripheral blood mononuclear cell cytosolic protein for hemoglobin contamination ⬇️

artículo científico publicado el 15 de enero de 2013

Corrigendum to "Semiphysiological versus Empirical Modelling of the Population Pharmacokinetics of Free and Total Cefazolin during Pregnancy".

artículo científico publicado en 2015

Covariate-based dose individualization of the cytotoxic drug indisulam to reduce the risk of severe myelosuppression

artículo científico publicado en 2009

Crizotinib-induced fatal fulminant liver failure

artículo científico publicado en 2015

Current knowledge and future directions of the selective epidermal growth factor receptor inhibitors erlotinib (Tarceva) and gefitinib (Iressa).

artículo científico publicado en 2005

Cytotoxicity of the organic ruthenium anticancer drug Nami-A is correlated with DNA binding in four different human tumor cell lines

artículo científico publicado en 2004

DNA repair mechanisms involved in gemcitabine cytotoxicity and in the interaction between gemcitabine and cisplatin

artículo científico publicado en 2003

DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis

artículo científico publicado en 2018

DPYD genotype-guided dose individualisation of fluoropyrimidine therapy: who and how? - Authors' reply

artículo científico publicado en 2019

Decitabine triphosphate levels in peripheral blood mononuclear cells from patients receiving prolonged low-dose decitabine administration: a pilot study ⬇️

artículo científico publicado el 1 de marzo de 2012

Deoxyuridine analog nucleotides in deoxycytidine analog treatment: secondary active metabolites?

artículo científico publicado en 2011

Design of a drug-drug interaction study of vincristine with azole antifungals in pediatric cancer patients using clinical trial simulation.

artículo científico publicado en 2014

Design of informative renal impairment studies: evaluation of the impact of design stratification on bias, precision and dose adjustment error

artículo científico publicado en 2014

Detection of Colorectal Cancer by Serum and Tissue Protein Profiling: A Prospective Study in a Population at Risk

artículo científico publicado en 2008

Detection of single nucleotide polymorphisms in the ABCG2 gene in a Dutch population

artículo científico publicado en 2005

Determination of 9-nitrocamptothecin and its metabolite 9-aminocamptothecin in human plasma using high-performance liquid chromatography with ultraviolet and fluorescence detection

artículo científico publicado en 2002

Determination of Platinum Originating from Carboplatin in Human Urine and Canine Excretion Products by Inductively Coupled Plasma Mass Spectrometry ⬇️

artículo científico publicado el 1 de abril de 2011

Determination of Sunitinib and Its Active Metabolite N-Desethylsunitinib in Sweat of a Patient ⬇️

artículo científico publicado el 1 de octubre de 2011

Determination of imatinib mesylate and its main metabolite (CGP74588) in human plasma and murine specimens by ion-pairing reversed-phase high-performance liquid chromatography

artículo científico publicado en 2007

Determination of platinum originating from carboplatin in canine sebum and cerumen by inductively coupled plasma mass spectrometry ⬇️

artículo científico publicado el 17 de septiembre de 2010

Determination of ruthenium originating from the investigational anti-cancer drug NAMI-A in human plasma ultrafiltrate, plasma, and urine by inductively coupled plasma mass spectrometry

artículo científico publicado en 2007

Development and clinical validation of an LC-MS/MS method for the quantification of pazopanib in DBS

artículo científico publicado en 2015

Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine

scientific article published on 22 January 2019

Development and validation of a method to determine the unbound paclitaxel fraction in human plasma

artículo científico publicado en 2004

Development and validation of a quantitative method for thymidine phosphorylase activity in peripheral blood mononuclear cells

article

Development and validation of a rapid and sensitive UPLC-MS/MS method for determination of uracil and dihydrouracil in human plasma

artículo científico publicado en 2016

Development and validation of an enzyme-linked immunosorbent assay for the quantification of trastuzumab in human serum and plasma.

artículo científico publicado en 2009

Development of a Pharmacokinetic Model to Describe the Complex Pharmacokinetics of Pazopanib in Cancer Patients

artículo científico publicado en 2016

Development of a Tumour Growth Inhibition Model to Elucidate the Effects of Ritonavir on Intratumoural Metabolism and Anti-tumour Effect of Docetaxel in a Mouse Model for Hereditary Breast Cancer

artículo científico publicado en 2015

Development of a framework for cohort simulation in cost-effectiveness analyses using a multistep ordinary differential equation solver algorithm in R.

artículo científico publicado en 2013

Development of an LC-MS/MS assay for the quantitative determination of the intracellular 5-fluorouracil nucleotides responsible for the anticancer effect of 5-fluorouracil.

artículo científico publicado en 2015

Development of an extended-release formulation of capecitabine making use of in vitro-in vivo correlation modelling.

artículo científico publicado en 2013

Development of an optimal pharmacokinetic sampling schedule for rubitecan administered orally in a daily times five schedule

artículo científico publicado en 2002

Development of an oral solid dispersion formulation for use in low-dose metronomic chemotherapy of paclitaxel

artículo científico publicado en 2012

Development of farnesyl transferase inhibitors: a review

artículo científico publicado en 2005

Development, validation, and clinical application of a high-performance liquid chromatography-tandem mass spectrometry assay for the quantification of total intracellular β-decitabine nucleotides and genomic DNA incorporated β-decitabine and 5-meth

article

Dexrazoxane in anthracycline induced cardiotoxicity and extravasation

artículo científico publicado en 2010

Diagnostic and Therapeutic Strategies for Fluoropyrimidine Treatment of Patients Carrying Multiple DPYD Variants

article

Dihydrofolate Reductase/Thymidylate Synthase Fine-Tunes the Folate Status and Controls Redox Homeostasis in Plants.

artículo científico publicado en 2017

Disposition and metabolism of 14C-dovitinib (TKI258), an inhibitor of FGFR and VEGFR, after oral administration in patients with advanced solid tumors ⬇️

artículo científico publicado el 22 de agosto de 2012

Dose-Response Relationship in Phase I Clinical Trials: A European Drug Development Network (EDDN) Collaboration Study

article

Dose-finding phase I clinical and pharmacokinetic study of orally administered irinotecan in patients with advanced solid tumors

artículo científico publicado en 2006

Dosing algorithm to target a predefined AUC in patients with primary central nervous system lymphoma receiving high dose methotrexate.

artículo científico publicado en 2012

Dried Blood Spot Self-Sampling at Home for the Individualization of Tamoxifen Treatment: A Feasibility Study

artículo científico publicado en 2015

Drug interactions in oncology

artículo científico publicado en 2004

Drug-drug interaction between itraconazole and the antiretroviral drug lopinavir/ritonavir in an HIV-1-infected patient with disseminated histoplasmosis

artículo científico publicado en 2004

E7070: a novel synthetic sulfonamide targeting the cell cycle progression for the treatment of cancer

artículo científico publicado en 2002

Effect of inhibition of the FGFR–MAPK signaling pathway on the development of ocular toxicities ⬇️

artículo científico publicado el 19 de febrero de 2013

Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type mice

artículo científico publicado en 2008

Effect of the drug transporters ABCG2, Abcg2, ABCB1 and ABCC2 on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy-QPA.

artículo científico publicado en 2013

Effective strategies for management of hypertension after vascular endothelial growth factor signaling inhibition therapy: results from a phase II randomized, factorial, double-blind study of Cediranib in patients with advanced solid tumors

artículo científico publicado en 2009

Effectiveness and safety of reduced-dose fluoropyrimidine therapy in patients carrying the DPYD*2A variant: A matched pair analysis

artículo científico publicado en 2019

Effects of low-fat and high-fat meals on steady-state pharmacokinetics of lapatinib in patients with advanced solid tumours.

artículo científico publicado en 2013

Efficacy of BGJ398, a Fibroblast Growth Factor Receptor 1–3 Inhibitor, in Patients with Previously Treated Advanced Urothelial Carcinoma with FGFR3 Alterations

artículo científico publicado en 2018

Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice

artículo científico publicado en 2004

Electrospray ionization quadrupole ion-mobility time-of-flight mass spectrometry as a tool to distinguish the lot-to-lot heterogeneity in N-glycosylation profile of the therapeutic monoclonal antibody trastuzumab.

artículo científico publicado en 2009

Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer

artículo científico publicado en 2019

Enhanced resolution triple-quadrupole mass spectrometry for ultra-sensitive and quantitative analysis of the investigational anticancer agent EO9 (apaziquone) and its metabolite EO5a in human and dog plasma to support (pre)-clinical studies of EOqui

artículo científico publicado en 2008

Enrichment of Circulating Endothelial Cells by CD34 Microbeads Followed by Enumeration Using Flow Cytometry

artículo científico publicado en 2017

Enzymatic digestion as a tool for the LC-MS/MS quantification of large peptides in biological matrices: measurement of chymotryptic fragments from the HIV-1 fusion inhibitor enfuvirtide and its metabolite M-20 in human plasma

artículo científico publicado en 2007

Enzyme linked immunosorbent assay for the quantification of nivolumab and pembrolizumab in human serum and cerebrospinal fluid

artículo científico publicado en 2018

EpCAM-based assays for epithelial tumor cell detection in cerebrospinal fluid

artículo científico publicado en 2017

EpCAM-based flow cytometry in cerebrospinal fluid greatly improves diagnostic accuracy of leptomeningeal metastases from epithelial tumors

artículo científico publicado en 2015

Evaluating the role of ENOSF1 and TYMS variants as predictors in fluoropyrimidine-related toxicities: An IPD meta-analysis

artículo científico publicado en 2019

Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansi

artículo científico publicado en 2016

Evaluation of a pharmacology-driven dosing algorithm of 3-weekly paclitaxel using therapeutic drug monitoring: a pharmacokinetic-pharmacodynamic simulation study

artículo científico publicado en 2012

Evaluation of human neutrophil peptide-1, -2 and -3 as serum markers for colorectal cancer

artículo científico publicado en 2010

Evaluation of human plasma protein binding of trabectedin (Yondelis, ET-743).

artículo científico publicado en 2009

Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2).

artículo científico publicado en 2003

Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment.

artículo científico publicado en 2015

Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors

artículo científico publicado en 2015

Expression of the breast cancer resistance protein in breast cancer.

artículo científico publicado en 2002

Extensive metabolism and hepatic accumulation of gemcitabine after multiple oral and intravenous administration in mice

artículo científico publicado en 2008

Facile small scale synthesis of nucleoside 5'-phosphate mixtures

artículo científico publicado en 2010

Fast and Adequate Liquid Chromatography-Tandem Mass Spectrometric Determination of Z-endoxifen Serum Levels for Therapeutic Drug Monitoring

artículo científico publicado en 2017

Fast and straightforward method for the quantification of pazopanib in human plasma using LC-MS/MS.

artículo científico publicado en 2017

First-in-Human Phase I Study of GSK2126458, an Oral Pan-Class I Phosphatidylinositol-3-Kinase Inhibitor, in Patients with Advanced Solid Tumor Malignancies

artículo científico publicado en 2015

First-in-Human Phase I Study of Lumretuzumab, a Glycoengineered Humanized Anti-HER3 Monoclonal Antibody, in Patients with Metastatic or Advanced HER3-Positive Solid Tumors.

artículo científico publicado en 2015

Fixed Dosing of Monoclonal Antibodies in Oncology

artículo científico publicado en 2017

Flat dosing of carboplatin is justified in adult patients with normal renal function

artículo científico publicado en 2006

Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers

artículo científico publicado en 2018

Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material

artículo científico publicado en 2002

Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer

artículo científico publicado en 2006

Germline polymorphisms in patients with advanced nonsmall cell lung cancer receiving first‐line platinum‐gemcitabine chemotherapy ⬇️

artículo científico publicado el 28 de septiembre de 2011

Haptoglobin phenotype is not a predictor of recurrence free survival in high-risk primary breast cancer patients.

artículo científico publicado en 2008

Herb-drug interactions in oncology: focus on mechanisms of induction

artículo científico publicado en 2006

High-Tech Drugs in Creaky Formulations

artículo científico publicado en 2017

High-performance liquid chromatographic analysis of the anticancer drug irinotecan (CPT-11) and its active metabolite SN-38 in human plasma

artículo científico publicado en 2003

High-performance liquid chromatography coupled with mass spectrometry for the quantitative analysis of vinca-alkaloids in biological matrices: a concise survey from the literature

artículo científico publicado en 2010

Homologous recombination is a highly conserved determinant of the synergistic cytotoxicity between cisplatin and DNA topoisomerase I poisons

artículo científico publicado en 2004

Hot flashes are not predictive for serum concentrations of tamoxifen and its metabolites

artículo científico publicado en 2013

How Much Longer Will We Put Up With $100,000 Cancer Drugs?

artículo científico publicado en 2017

Human metabolism of [(14)C]indisulam following i.v. infusion in cancer patients.

artículo científico publicado en 2005

Identification of serum proteins as prognostic and predictive markers of colorectal cancer using surface enhanced laser desorption ionization-time of flight mass spectrometry

artículo científico publicado en 2010

Identification of serum proteins discriminating colorectal cancer patients and healthy controls using surface-enhanced laser desorption ionisation-time of flight mass spectrometry

artículo científico publicado en 2006

Identification of two new serum protein profiles for renal cell carcinoma.

artículo científico publicado en 2009

Impact of Older Age on the Exposure of Paclitaxel: a Population Pharmacokinetic Study

scientific article published on 07 January 2019

Impact of age on exposure to oral antiandrogen therapies in clinical practice

artículo científico publicado en 2018

Implementation of a Multicenter Biobanking Collaboration for Next-Generation Sequencing-Based Biomarker Discovery Based on Fresh Frozen Pretreatment Tumor Tissue Biopsies.

artículo científico publicado en 2016

Improved pharmacodynamic (PD) assessment of low dose PARP inhibitor PD activity for radiotherapy and chemotherapy combination trials

artículo científico publicado en 2017

Improved pharmacodynamic assay for dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells

artículo científico publicado en 2015

Improving safety of fluoropyrimidine chemotherapy by individualizing treatment based on dihydropyrimidine dehydrogenase activity - Ready for clinical practice?

artículo científico publicado en 2016

Improving the solubility of nilotinib through novel spray-dried solid dispersions.

artículo científico publicado en 2017

In vitro characterization of the biotransformation of thiocoraline, a novel marine anti-cancer drug

artículo científico publicado en 2004

In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug

artículo científico publicado en 2006

In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug

artículo científico publicado en 2007

In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction

artículo científico publicado en 2005

Incidence of hematologic toxicity in older adults treated with gemcitabine or a gemcitabine-containing regimen in routine clinical practice: a multicenter retrospective cohort study

artículo científico publicado en 2014

Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses

artículo científico publicado en 2015

Increased risk of severe fluoropyrimidine-associated toxicity in patients carrying a G to C substitution in the first 28-bp tandem repeat of the thymidylate synthase 2R allele.

artículo científico publicado en 2015

Individualised cancer chemotherapy: strategies and performance of prospective studies on therapeutic drug monitoring with dose adaptation: a review

artículo científico publicado en 2005

Individualized Pazopanib Dosing: A Prospective Feasibility Study in Cancer Patients

artículo científico publicado en 2016

Inducing synthetic lethality using PARP inhibitors

artículo científico publicado en 2010

Influence of sample storage duration on serum protein profiles assessed by surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry (SELDI-TOF MS).

artículo científico publicado en 2009

Influence of variations in sample handling on SELDI-TOF MS serum protein profiles for colorectal cancer

artículo científico publicado en 2008

Inhibitors of mTOR.

artículo científico publicado en 2010

Integrated semi-physiological pharmacokinetic model for both sunitinib and its active metabolite SU12662.

artículo científico publicado en 2015

Inter- and intratumoral disposition of platinum in solid tumors after administration of cisplatin

artículo científico publicado en 2002

Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides

artículo científico publicado en 2018

Is fluorouracil-induced severe toxicity in DPYD*2A individuals related to sex or to treatment regimen?

artículo científico publicado en 2008

Is rectal administration an alternative route for imatinib?

scientific article published on 08 February 2007

Isocratic ion-exchange chromatographic assay for the nucleotide gemcitabine triphosphate in human white blood cells

artículo científico publicado en 2002

Lapatinib for advanced or metastatic breast cancer

artículo científico publicado en 2012

Letter to the editor regarding "A prospective, controlled study of the botanical compound mixture LCS101 for chemotherapy-induced hematological complications in breast cancer" by Yaal-Hahoshen et al. (The Oncologist 2011;16:1197-1202).

artículo científico publicado en 2012

Liquid chromatographic assay for the antiviral nucleotide analogue tenofovir in plasma using derivatization with chloroacetaldehyde

artículo científico publicado en 2003

Liquid chromatographic assay for the cyclic depsipeptide aplidine, a new marine antitumor drug, in whole blood using derivatization with trans-4'-hydrazino-2-stilbazole.

artículo científico publicado en 2004

Liquid chromatographic assay for the non-peptidic protease inhibitor tipranavir in plasma

artículo científico publicado en 2006

Liquid chromatographic assay for the protease inhibitor atazanavir in plasma

artículo científico publicado en 2006

Liquid chromatography-tandem mass spectrometric assay for clobetasol propionate in human serum from patients with atopic dermatitis

artículo científico publicado en 2010

Liquid chromatography-tandem mass spectrometric assay for diclofenac and three primary metabolites in mouse plasma

artículo científico publicado en 2008

Liquid chromatography-tandem mass spectrometric assay for ponatinib and N-desmethyl ponatinib in mouse plasma

artículo científico publicado en 2016

Liquid chromatography-tandem mass spectrometric assay for pravastatin and two isomeric metabolites in mouse plasma and tissue homogenates ⬇️

artículo científico publicado el 21 de agosto de 2010

Liquid chromatography-tandem mass spectrometric assay for sorafenib and sorafenib-glucuronide in mouse plasma and liver homogenate and identification of the glucuronide metabolite

artículo científico publicado en 2008

Liquid chromatography-tandem mass spectrometric assay for the JAK2 inhibitor CYT387 in plasma

artículo científico publicado en 2012

Liquid chromatography-tandem mass spectrometric assay for the PARP inhibitor rucaparib in plasma

artículo científico publicado en 2013

Liquid chromatography-tandem mass spectrometric assay for the PI3K/mTOR inhibitor GSK2126458 in mouse plasma and tumor homogenate.

artículo científico publicado en 2015

Liquid chromatography-tandem mass spectrometric assay for the T790M mutant EGFR inhibitor osimertinib (AZD9291) in human plasma

artículo científico publicado en 2016

Liquid chromatography-tandem mass spectrometric assay for the VEGFR inhibitor cediranib and its primary human metabolite cediranib-N⁺-glucuronide in plasma

artículo científico publicado en 2012

Liquid chromatography-tandem mass spectrometric assay for the analysis of uracil, 5,6-dihydrouracil and beta-ureidopropionic acid in urine for the measurement of the activities of the pyrimidine catabolic enzymes

artículo científico publicado en 2006

Liquid chromatography-tandem mass spectrometric assay for the cyclin-dependent kinase inhibitor AT7519 in mouse plasma

artículo científico publicado en 2013

Liquid chromatography-tandem mass spectrometric assay for the light sensitive survivin suppressant sepantronium bromide (YM155) in mouse plasma

artículo científico publicado en 2014

Liquid chromatography-tandem mass spectrometric assay for the light sensitive tyrosine kinase inhibitor axitinib in human plasma

artículo científico publicado en 2009

Liquid chromatography-tandem mass spectrometric assay for the multikinase inhibitor regorafenib in plasma

artículo científico publicado en 2014

Liquid chromatography-tandem mass spectrometric assay for the mutated BRAF inhibitor dabrafenib in mouse plasma.

artículo científico publicado en 2013

Liquid chromatography-tandem mass spectrometric assay for the mutated BRAF inhibitor vemurafenib in human and mouse plasma.

artículo científico publicado en 2012

Liquid chromatography-tandem mass spectrometric assay for the nucleoside reverse transcriptase inhibitor emtricitabine in human plasma

artículo científico publicado en 2007

Liquid chromatography-tandem mass spectrometric assay for the quantitative determination of the tyrosine kinase inhibitor quizartinib in mouse plasma using salting-out liquid-liquid extraction

artículo científico publicado en 2017

Liquid chromatography-tandem mass spectrometric assay for the simultaneous determination of the irreversible BTK inhibitor ibrutinib and its dihydrodiol-metabolite in plasma and its application in mouse pharmacokinetic studies.

artículo científico publicado en 2015

Liquid chromatography-tandem mass spectrometric assay for the tyrosine kinase inhibitor afatinib in mouse plasma using salting-out liquid-liquid extraction

artículo científico publicado en 2016

Liquid chromatography-tandem mass spectrometric assay for therapeutic drug monitoring of the B-Raf inhibitor encorafenib, the EGFR inhibitors afatinib, erlotinib and gefitinib and the O-desmethyl metabolites of erlotinib and gefitinib in human plasm

artículo científico publicado en 2016

Liquid chromatography-tandem mass spectrometric assays for salinomycin in mouse plasma, liver, brain and small intestinal contents and in OptiMEM cell culture medium

artículo científico publicado en 2007

Liquid chromatography-tandem mass spectrometry assay for the EGFR inhibitor pelitinib in plasma.

artículo científico publicado en 2013

Liquid chromatography/tandem mass spectrometric method for the quantification of eight proteolytic fragments of ITIH4 with biomarker potential in human plasma and serum

artículo científico publicado en 2008

Liquid chromatography–tandem mass spectrometric assay for the ALK inhibitor crizotinib in mouse plasma ⬇️

artículo científico publicado el 21 de agosto de 2012

Liquid chromatography–tandem mass spectrometric assay for the PARP-1 inhibitor olaparib in combination with the nitrogen mustard melphalan in human plasma ⬇️

artículo científico publicado el 7 de mayo de 2011

Liquid chromatography–tandem mass spectrometric assay for therapeutic drug monitoring of the tyrosine kinase inhibitor pazopanib in human plasma ⬇️

artículo científico publicado el 10 de agosto de 2012

Long-term platinum retention after treatment with cisplatin and oxaliplatin

artículo científico publicado en 2008

Long-term safety and anti-tumour activity of olaparib monotherapy after combination with carboplatin and paclitaxel in patients with advanced breast, ovarian or fallopian tube cancer.

artículo científico publicado en 2015

Low systemic exposure of oral docetaxel in mice resulting from extensive first-pass metabolism is boosted by ritonavir

artículo científico publicado en 2002

Macrophage Activation Marker Neopterin: A Candidate Biomarker for Treatment Response and Relapse in Visceral Leishmaniasis.

artículo científico publicado en 2018

Management of Hot Flashes in Patients Who Have Breast Cancer With Venlafaxine and Clonidine: A Randomized, Double-Blind, Placebo-Controlled Trial ⬇️

artículo científico publicado el 12 de septiembre de 2011

Mass Balance Study of [14C]Eribulin in Patients with Advanced Solid Tumors ⬇️

artículo científico publicado el 31 de octubre de 2011

Mass balance studies, with a focus on anticancer drugs.

artículo científico publicado en 2006

Mass spectrometry in the quantitative analysis of therapeutic intracellular nucleotide analogs

artículo científico publicado en 2010

Measurement of NLG207 (formerly CRLX101) nanoparticle-bound and released camptothecin in human plasma

scientific article published on 27 December 2019

Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions

artículo científico publicado en 2004

Metabolism of docetaxel in mice

artículo científico publicado en 2005

Metabolism of paclitaxel in mice

artículo científico publicado en 2003

Metabolism of trabectedin (ET-743, Yondelis) in patients with advanced cancer

artículo científico publicado en 2006

Metabolite Profiling of Bendamustine in Urine of Cancer Patients after Administration of [14C]Bendamustine ⬇️

artículo científico publicado el 4 de abril de 2012

Metabolite profiling of 14C-omacetaxine mepesuccinate in plasma and excreta of cancer patients.

artículo científico publicado en 2016

Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison

artículo científico publicado en 2016

Methylnaltrexone

artículo científico publicado en 2009

Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4.

artículo científico publicado en 2005

Milk Thistle’s Active Components Silybin and Isosilybin: Novel Inhibitors of PXR-Mediated CYP3A4 Induction ⬇️

artículo científico publicado el 14 de mayo de 2013

Model-based evaluation and optimization of cardiac monitoring protocols for adjuvant treatment of breast cancer with trastuzumab

artículo científico publicado en 2012

Model‐based treatment optimization of a novel VEGFR inhibitor ⬇️

artículo científico publicado el 1 de agosto de 2012

Molecular Imaging of ABCB1/ABCG2 Inhibition at the Human Blood Brain Barrier using Elacridar and 11C-Erlotinib PET.

artículo científico publicado en 2017

Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer

artículo científico publicado en 2016

Molecular Pathways: Targeting the Protein Kinase Wee1 in Cancer

artículo científico publicado en 2017

Moving towards dose individualization of tyrosine kinase inhibitors ⬇️

artículo científico publicado el 15 de septiembre de 2010

Multiparameter Flow Cytometry Assay for Quantification of Immune Cell Subsets, PD-1 Expression Levels and PD-1 Receptor Occupancy by Nivolumab and Pembrolizumab

artículo científico publicado en 2019

NT-23PHASE 1/2A STUDY OF GLUTATHIONE PEGYLATED LIPOSOMAL DOXORUBICIN (2B3-101) IN BREAST CANCER PATIENTS WITH BRAIN METASTASES (BCBM) OR RECURRENT HIGH GRADE GLIOMAS (HGG)

artículo científico publicado en 2014

Neutropenia and docetaxel exposure in metastatic castration-resistant prostate cancer patients: A meta-analysis and evaluation of a clinical cohort

artículo científico publicado en 2019

New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine

artículo científico publicado en 2008

No pharmacokinetic drug-drug interaction between nevirapine and paclitaxel

artículo científico publicado en 2005

No relation between docetaxel administration route and high-grade diarrhea incidence

artículo científico publicado en 2020

Optimizing drug development of anti‐cancer drugs in children using modelling and simulation ⬇️

artículo científico publicado el 1 de julio de 2013

Oral administration of gemcitabine in patients with refractory tumors: a clinical and pharmacologic study

artículo científico publicado en 2008

Oral anticancer drugs: mechanisms of low bioavailability and strategies for improvement.

artículo científico

Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors

artículo científico publicado en 2009

PARP Inhibitors in the Treatment of Triple-Negative Breast Cancer

artículo científico publicado en 2017

Part 1: background, methodology, and clinical adoption of pharmacogenetics

artículo científico publicado en 2011

Part 2: Pharmacogenetic Variability in Drug Transport and Phase I Anticancer Drug Metabolism ⬇️

artículo científico publicado el 31 de mayo de 2011

Part 3: Pharmacogenetic Variability in Phase II Anticancer Drug Metabolism ⬇️

artículo científico publicado el 9 de junio de 2011

Part 4: Pharmacogenetic Variability in Anticancer Pharmacodynamic Drug Effects ⬇️

artículo científico publicado el 9 de junio de 2011

Patients homozygous for DPYD c.1129-5923C>G/haplotype B3 have partial DPD deficiency and require a dose reduction when treated with fluoropyrimidines

artículo científico publicado en 2016

Pembrolizumab After Two or More Lines of Previous Therapy in Patients With Recurrent or Metastatic SCLC: Results From the KEYNOTE-028 and KEYNOTE-158 Studies

scientific article published on 20 December 2019

Pembrolizumab for the treatment of programmed death-ligand 1-positive advanced carcinoid or pancreatic neuroendocrine tumors: Results from the KEYNOTE-028 study

artículo científico publicado en 2020

Pemetrexed pathway-associated germline polymorphisms: a useful tool for treatment individualization?

artículo científico publicado en 2010

Performance of Methods for Handling Missing Categorical Covariate Data in Population Pharmacokinetic Analyses ⬇️

artículo científico publicado el 31 de mayo de 2012

Persistent neuropathy after treatment with cisplatin and oxaliplatin

artículo científico publicado en 2009

Personalized medicine in oncology: a personal view with myths and facts

scientific article published on August 2010

Pharmaceutical development of an oral tablet formulation containing a spray dried amorphous solid dispersion of docetaxel or paclitaxel

artículo científico publicado en 2016

Pharmacodynamic assay of thymidylate synthase activity in peripheral blood mononuclear cells ⬇️

artículo científico publicado el 12 de enero de 2013

Pharmacodynamic biomarkers in model-based drug development in oncology

scientific article published on February 2011

Pharmacodynamic modeling of cardiac biomarkers in breast cancer patients treated with anthracycline and trastuzumab regimens

artículo científico publicado en 2018

Pharmacodynamics and pharmacokinetics of oral topotecan in patients with advanced solid tumours and impaired renal function

artículo científico publicado en 2015

Pharmacogenetic analysis of irreversible severe cisplatin-induced nephropathy: a case report of a 27-year-old woman

artículo científico publicado en 2017

Pharmacogenetic screening of CYP3A and ABCB1 in relation to population pharmacokinetics of docetaxel

scientific article published on 01 October 2006

Pharmacogenetic screening of the gene deletion and duplications of CYP2D6.

artículo científico publicado en 2007

Pharmacokinetic Optimization of Everolimus Dosing in Oncology: A Randomized Crossover Trial

artículo científico publicado en 2017

Pharmacokinetic drug-drug interaction of the novel anticancer agent E7070 and acenocoumarol

artículo científico publicado en 2004

Pharmacokinetic evaluation of three oral formulations of docetaxel boosted with ritonavir: two single-drug formulations vs. a fixed-dose combination tablet

artículo científico publicado en 2013

Pharmacokinetics and Excretion of 14C-Bendamustine in Patients with Relapsed or Refractory Malignancy ⬇️

artículo científico publicado el 1 de marzo de 2013

Pharmacokinetics and Safety of Olaparib in Patients with Advanced Solid Tumours and Renal Impairment

artículo científico publicado en 2019

Pharmacokinetics and excretion of (14)C-lenvatinib in patients with advanced solid tumors or lymphomas.

artículo científico publicado en 2014

Pharmacokinetics and excretion of (14)C-omacetaxine in patients with advanced solid tumors

artículo científico publicado en 2016

Pharmacokinetics and safety of olaparib in patients with advanced solid tumours and mild or moderate hepatic impairment

scientific article published on 29 March 2020

Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis

scientific article published on 20 November 2019

Pharmacokinetics of Selected Anticancer Drugs in Elderly Cancer Patients: Focus on Breast Cancer

artículo científico publicado en 2016

Pharmacokinetics of eribulin mesylate in patients with solid tumours receiving repeated oral rifampicin ⬇️

artículo científico publicado el 1 de febrero de 2013

Pharmacokinetics of gemcitabine and metabolites in a patient with double-sided nephrectomy: a case report and review of the literature

artículo científico publicado en 2009

Phase 1 and pharmacological study of olaparib in combination with high-dose radiotherapy with and without concurrent cisplatin for non-small cell lung cancer

artículo científico publicado en 2020

Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer

scientific article published on 09 March 2020

Phase 1a/1b and pharmacogenetic study of docetaxel, oxaliplatin and capecitabine in patients with advanced cancer of the stomach or the gastroesophageal junction

artículo científico publicado en 2015

Phase I Study Evaluating WEE1 Inhibitor AZD1775 As Monotherapy and in Combination With Gemcitabine, Cisplatin, or Carboplatin in Patients With Advanced Solid Tumors

artículo científico

Phase I Study of Afatinib and Selumetinib in Patients with KRAS-Mutated Colorectal, Non-Small Cell Lung, and Pancreatic Cancer

artículo científico publicado en 2020

Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors

artículo científico publicado en 2018

Phase I and pharmacokinetic study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced solid malignancies ⬇️

artículo científico publicado el 2 de agosto de 2011

Phase I and pharmacokinetic study of combined treatment with perifosine and radiation in patients with advanced solid tumours

artículo científico publicado en 2006

Phase I and pharmacokinetic trial of AP5346, a DACH-platinum-polymer conjugate, administered weekly for three out of every 4 weeks to advanced solid tumor patients

artículo científico publicado en 2007

Phase I clinical and pharmacokinetic study of kahalalide F in patients with advanced androgen refractory prostate cancer.

artículo científico publicado en 2005

Phase I clinical and pharmacologic study of a 2-weekly administration of cisplatin and gemcitabine in patients with advanced non-small cell lung cancer

artículo científico publicado en 2005

Phase I dose-escalation study and population pharmacokinetic analysis of fixed dose rate gemcitabine plus carboplatin as second-line therapy in patients with ovarian cancer.

artículo científico publicado en 2013

Phase I dose-escalation study of the pan-HER inhibitor, PF299804, in patients with advanced malignant solid tumors

artículo científico publicado en 2011

Phase I evaluation of telatinib, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in combination with irinotecan and capecitabine in patients with advanced solid tumors

artículo científico publicado en 2010

Phase I pharmacokinetic and pharmacodynamic study of Carboplatin and topotecan administered intravenously every 28 days to patients with malignant solid tumors

artículo científico publicado en 2009

Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer

artículo científico publicado en 2007

Phase I pharmacokinetic study of the safety and tolerability of lapatinib (GW572016) in combination with oxaliplatin/fluorouracil/leucovorin (FOLFOX4) in patients with solid tumors

artículo científico publicado en 2007

Phase I pharmacological study of continuous chronomodulated capecitabine treatment

scientific article published on 07 May 2020

Phase I study of Oral gemcitabine prodrug (LY2334737) alone and in combination with erlotinib in patients with advanced solid tumors

artículo científico publicado en 2011

Phase I study of an oral formulation of irinotecan administered daily for 14 days every 3 weeks in patients with advanced solid tumours

artículo científico publicado en 2004

Phase I study of continuous olaparib capsule dosing in combination with carboplatin and/or paclitaxel (Part 1)

scientific article published on 30 October 2019

Phase I study of docetaxel in combination with the P-glycoprotein inhibitor, zosuquidar, in resistant malignancies

artículo científico publicado en 2004

Phase I study of intermittent olaparib capsule or tablet dosing in combination with carboplatin and paclitaxel (part 2)

scientific article published on 21 October 2019

Phase I study of lapatinib plus trametinib in patients with KRAS-mutant colorectal, non-small cell lung, and pancreatic cancer

scientific article published on 09 April 2020

Phase I study of lonafarnib (SCH66336) in combination with trastuzumab plus paclitaxel in Her2/neu overexpressing breast cancer: EORTC study 16023 ⬇️

artículo científico publicado el 29 de septiembre de 2012

Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy

artículo científico publicado en 2014

Phase II Study of WEE1 Inhibitor AZD1775 Plus Carboplatin in Patients With TP53-Mutated Ovarian Cancer Refractory or Resistant to First-Line Therapy Within 3 Months

artículo científico publicado en 2016

Phase II and pharmacological study of oral docetaxel plus cyclosporin A in anthracycline pre-treated metastatic breast cancer

artículo científico publicado en 2014

Phase Ib Study of Lumretuzumab Plus Cetuximab or Erlotinib in Solid Tumor Patients and Evaluation of HER3 and Heregulin as Potential Biomarkers of Clinical Activity

artículo científico publicado en 2017

Phase Ib study of BGJ398 in combination with BYL719 in patients (pts) with select advanced solid tumors

Phosphatidylinositol 3-Kinase α-Selective Inhibition With Alpelisib (BYL719) in PIK3CA-Altered Solid Tumors: Results From the First-in-Human Study

artículo científico publicado en 2018

Photodynamic therapy in oncology

scientific article published on 01 October 2006

Piraña and PCluster: a modeling environment and cluster infrastructure for NONMEM.

artículo científico

Plasma concentrations of tyrosine kinase inhibitors imatinib, erlotinib, and sunitinib in routine clinical outpatient cancer care

artículo científico publicado en 2014

Platinated DNA adducts enhance poisoning of DNA topoisomerase I by camptothecin

artículo científico publicado en 2004

Population Pharmacokinetics of MCLA-128, a HER2/HER3 Bispecific Monoclonal Antibody, in Patients with Solid Tumors

artículo científico publicado en 2020

Population pharmacokinetic and adverse event analysis of topotecan in patients with solid tumors.

artículo científico publicado en 2002

Population pharmacokinetic and pharmacodynamic analysis to support treatment optimization of combination chemotherapy with indisulam and carboplatin

artículo científico publicado en 2008

Population pharmacokinetics and pharmacodynamics for treatment optimization in clinical oncology

artículo científico publicado en 2008

Population pharmacokinetics and pharmacodynamics of doxorubicin and cyclophosphamide in breast cancer patients: a study by the EORTC-PAMM-NDDG.

artículo científico publicado en 2007

Population pharmacokinetics and pharmacodynamics of paclitaxel and carboplatin in ovarian cancer patients: a study by the European organization for research and treatment of cancer-pharmacology and molecular mechanisms group and new drug development

artículo científico publicado en 2007

Population pharmacokinetics of doxorubicin: establishment of a NONMEM model for adults and children older than 3 years

artículo científico publicado en 2013

Population pharmacokinetics of intravenously and orally administered docetaxel with or without co-administration of ritonavir in patients with advanced cancer

artículo científico publicado en 2010

Population pharmacokinetic–pharmacodynamic analysis for eribulin mesilate‐associated neutropenia ⬇️

artículo científico publicado el 1 de septiembre de 2013

Postoperative serum proteomic profiles may predict recurrence-free survival in high-risk primary breast cancer

artículo científico publicado en 2011

Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.

artículo científico publicado en 2002

Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology

artículo científico publicado en 2017

Practical guidelines for therapeutic drug monitoring of anticancer tyrosine kinase inhibitors: focus on the pharmacokinetic targets

artículo científico

Prediction of treatment outcome by cisplatin-DNA adduct formation in patients with stage III/IV head and neck squamous cell carcinoma, treated by concurrent cisplatin-radiation (RADPLAT)

scientific article published on 01 August 2006

Predictive ability of a semi-mechanistic model for neutropenia in the development of novel anti-cancer agents: two case studies.

artículo científico publicado en 2010

Predictive value of CYP3A and ABCB1 phenotyping probes for the pharmacokinetics of sunitinib: the ClearSun study

artículo científico publicado en 2014

Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity

artículo científico publicado en 2017

Prevention of severe toxicity from capecitabine, 5-fluorouracil and tegafur by screening for DPD-deficiency

artículo científico publicado el 1 de enero de 2012

Procedures and practices for the validation of bioanalytical methods using dried blood spots: a review

artículo científico publicado en 2014

Prolonged versus standard gemcitabine infusion: translation of molecular pharmacology to new treatment strategy

artículo científico publicado en 2008

Pronounced between-subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers

artículo científico publicado en 2016

Prospective DPYD genotyping to reduce the risk of fluoropyrimidine-induced severe toxicity: Ready for prime time.

artículo científico

Protein versus DNA as a marker for peripheral blood mononuclear cell counting

artículo científico publicado en 2009

P‐glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel ⬇️

artículo científico publicado el 14 de noviembre de 2012

Quantification of 11 Therapeutic Kinase Inhibitors in Human Plasma for Therapeutic Drug Monitoring Using Liquid Chromatography Coupled With Tandem Mass Spectrometry

artículo científico publicado en 2016

Quantification of farnesylmethylcysteine in lysates of peripheral blood mononuclear cells using liquid chromatography coupled with electrospray tandem mass spectrometry: pharmacodynamic assay for farnesyl transferase inhibitors

scientific article published on 01 April 2006

Quantification of the pharmacokinetic-toxicodynamic relationship of oral docetaxel co-administered with ritonavir

artículo científico publicado en 2020

Quantifying vemurafenib in dried blood spots using high-performance LC-MS/MS

artículo científico publicado en 2014

Quantitative analysis of D-24851, a novel anticancer agent, in human plasma and urine by liquid chromatography coupled with tandem mass spectrometry

artículo científico publicado en 2004

Quantitative analysis of EO9 (apaziquone) and its metabolite EO5a in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray tandem mass spectrometry

artículo científico publicado en 2006

Quantitative analysis of the P-glycoprotein inhibitor Elacridar (GF120918) in human and dog plasma using liquid chromatography with tandem mass spectrometric detection

artículo científico publicado en 2004

Quantitative analysis of the farnesyl transferase inhibitor lonafarnib (Sarasartrade mark, SCH66336) in human plasma using high-performance liquid chromatography coupled with tandem mass spectrometry

artículo científico publicado en 2005

Quantitative and selective assay of 5-methylindirubine, an inhibitor of cyclin-dependent kinases, in murine plasma using coupled liquid chromatography and electrospray tandem mass spectrometry

artículo científico publicado en 2007

Quantitative aspects of the analysis of the monoclonal antibody trastuzumab using high-performance liquid chromatography coupled with electrospray mass spectrometry

artículo científico publicado en 2007

Quantitative assay for six potential breast cancer biomarker peptides in human serum by liquid chromatography coupled to tandem mass spectrometry

scientific article published on 18 January 2010

Quantitative bioanalysis of peptides by liquid chromatography coupled to (tandem) mass spectrometry

artículo científico publicado en 2008

Quantitative bioanalytical assay for the tropomyosin receptor kinase inhibitor larotrectinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry

artículo científico publicado en 2018

Quantitative determination of azacitidine triphosphate in peripheral blood mononuclear cells using liquid chromatography coupled with high-resolution mass spectrometry.

artículo científico publicado en 2013

Quantitative determination of capecitabine and its six metabolites in human plasma using liquid chromatography coupled to electrospray tandem mass spectrometry ⬇️

artículo científico publicado el 7 de diciembre de 2012

Quantitative determination of the novel anticancer drug E7070 (indisulam) and its metabolite (1,4-benzenedisulphonamide) in human plasma, urine and faeces by high-performance liquid chromatography coupled with electrospray ionization tandem mass spe

artículo científico publicado en 2004

Quantitative effect of gender, age, liver function, and body size on the population pharmacokinetics of Paclitaxel in patients with solid tumors

artículo científico publicado en 2006

Radiosensitization of squamous cell carcinoma by the alkylphospholipid perifosine in cell culture and xenografts

artículo científico publicado en 2006

Randomized phase I clinical and pharmacologic study of weekly versus twice-weekly dose-intensive cisplatin and gemcitabine in patients with advanced non-small cell lung cancer ⬇️

artículo científico publicado el 1 de septiembre de 2003

Rapid detection of the DPYD IVS14+1G>A mutation for screening patients to prevent fluorouracil-related toxicity

artículo científico publicado en 2007

Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy

artículo científico publicado en 2007

Recent developments in the chromatographic bioanalysis of approved kinase inhibitor drugs in oncology.

artículo científico publicado en 2016

Relationship between cisplatin administration and the development of ototoxicity

artículo científico publicado en 2006

Relationship between single nucleotide polymorphisms and haplotypes in DPYD and toxicity and efficacy of capecitabine in advanced colorectal cancer

artículo científico publicado en 2011

Relevance of in vitro and clinical data for predicting CYP3A4-mediated herb-drug interactions in cancer patients.

artículo científico publicado en 2013

Renal function, body surface area, and age are associated with risk of early-onset fluoropyrimidine-associated toxicity in patients treated with capecitabine-based anticancer regimens in daily clinical care

artículo científico publicado en 2016

Reply to T. Magnes et al.

artículo científico publicado en 2016

Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP.

artículo científico publicado en 2010

Retention studies of 2'-2'-difluorodeoxycytidine and 2'-2'-difluorodeoxyuridine nucleosides and nucleotides on porous graphitic carbon: development of a liquid chromatography-tandem mass spectrometry method

artículo científico publicado en 2009

Reviewing the cost-effectiveness of endocrine early breast cancer therapies: influence of differences in modeling methods on outcomes

artículo científico

Ritonavir inhibits intratumoral docetaxel metabolism and enhances docetaxel antitumor activity in an immunocompetent mouse breast cancer model

artículo científico publicado en 2015

Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001.

artículo científico publicado en 2002

Rs895819 in MIR27A improves the predictive value of DPYD variants to identify patients at risk of severe fluoropyrimidine-associated toxicity

artículo científico publicado en 2016

Saturable binding of indisulam to plasma proteins and distribution to human erythrocytes

artículo científico publicado en 2006

Screening for polymorphisms in the PXR gene in a Dutch population

artículo científico publicado en 2006

Selected new developments in oncology

artículo científico publicado en 2010

Selective Oral MEK1/2 Inhibitor Pimasertib in Metastatic Melanoma: Antitumor Activity in a Phase I, Dose-Escalation Trial

artículo científico publicado en 2020

Selective Oral MEK1/2 Inhibitor Pimasertib: A Phase I Trial in Patients with Advanced Solid Tumors

artículo científico publicado en 2020

Semi-physiological model describing the hematological toxicity of the anti-cancer agent indisulam

artículo científico publicado en 2005

Semiphysiological versus empirical modelling of the population pharmacokinetics of free and total cefazolin during pregnancy

artículo científico publicado en 2014

Sensitive liquid chromatography/tandem mass spectrometry assay for absolute quantification of ITIH4-derived putative biomarker peptides in clinical serum samples

artículo científico publicado en 2010

Serum degradome markers for the detection of breast cancer

artículo científico publicado en 2010

Serum protein profiling for diagnosis of breast cancer using SELDI-TOF MS.

artículo científico publicado en 2009

Serum proteomics and disease-specific biomarkers of patients with advanced gastric cancer

artículo científico publicado en 2010

Serum β-HCG and CA-125 as Tumor Markers in a Patient with Osteosarcoma: Case Report ⬇️

artículo científico publicado el 1 de enero de 2011

Severe cannabinoid intoxication in a patient with non-small-cell lung cancer

scientific article published on 01 January 2012

Severe lactic acidosis in a diabetic patient after ethanol abuse and floor cleaner intake.

artículo científico publicado en 2014

Severe pulmonary toxicity in patients with leiomyosarcoma after treatment with gemcitabine and docetaxel

artículo científico publicado en 2007

Severe skin toxicity in pediatric oncology patients treated with voriconazole and concomitant methotrexate.

artículo científico publicado en 2013

Simple high‐performance liquid chromatographic assay for melphalan in perfusate, rat liver and tumour tissue ⬇️

artículo científico publicado el 1 de octubre de 2003

Simultaneous Integrated Boost–Intensity Modulated Radiation Therapy With Concomitant Capecitabine and Mitomycin C for Locally Advanced Anal Carcinoma: A Phase 1 Study ⬇️

artículo científico publicado el 1 de abril de 2013

Simultaneous determination of AZD1152 (prodrug) and AZD1152-hydroxyquinazoline pyrazol anilide by reversed phase liquid chromatography

artículo científico publicado en 2009

Simultaneous population pharmacokinetic modelling of plasma and intracellular PBMC miltefosine concentrations in New World cutaneous leishmaniasis and exploration of exposure-response relationships

artículo científico publicado en 2018

Simultaneous quantification of 2',2'-difluorodeoxycytidine and 2',2'-difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry

artículo científico publicado en 2009

Slow dissolution behaviour of amorphous capecitabine ⬇️

artículo científico publicado el 5 de diciembre de 2012

Solubility and bioavailability improvement of pazopanib hydrochloride

scientific article published on 19 April 2018

Specific Investigation of Sample Handling Effects on Protease Activities and Absolute Serum Concentrations of Various Putative Peptidome Cancer Biomarkers ⬇️

artículo científico publicado el 30 de septiembre de 2010

Stability experiments in human urine with EO9 (apaziquone): a novel anticancer agent for the intravesical treatment of bladder cancer

scientific article published on 22 August 2006

Standard fluoropyrimidine dosages in chemoradiation therapy result in an increased risk of severe toxicity in DPYD variant allele carriers

article

Standard-Dose Tegafur Combined With Uracil Is Not Safe Treatment After Severe Toxicity From 5-Fluorouracil or Capecitabine ⬇️

artículo científico publicado el 7 de diciembre de 2010

Standard-dose tegafur-uracil (UFT) is not a safe alternative in partial dihydropyrimidine dehydrogenase-deficient patients ⬇️

artículo científico publicado el 1 de enero de 2013

Structure elucidation of aplidine metabolites formed in vitro by human liver microsomes using triple quadrupole mass spectrometry

artículo científico publicado en 2005

Symptoms and treatment in cancer therapy-induced early menopause

artículo científico publicado en 2006

Systematic review of biomarkers to monitor therapeutic response in leishmaniasis

artículo científico publicado en 2015

Systemic and tumor disposition of platinum after administration of cisplatin or STEALTH liposomal-cisplatin formulations (SPI-077 and SPI-077 B103) in a preclinical tumor model of melanoma

scientific article published on 12 December 2003

Tailored Tamoxifen Treatment for Breast Cancer Patients: A Perspective

artículo científico

Taxanes: Old drugs, new oral formulations ⬇️

artículo científico publicado el 7 de mayo de 2013

The Dutch model for clinical pharmacology: collaboration between physician- and pharmacist--clinical pharmacologists

artículo científico publicado en 2008

The European Medicines Agency review of vemurafenib (Zelboraf®) for the treatment of adult patients with BRAF V600 mutation-positive unresectable or metastatic melanoma: summary of the scientific assessment of the Committee for Medicinal Products fo

artículo científico

The Use of Dried Blood Spots for Pharmacokinetic Monitoring of Vemurafenib Treatment in Melanoma Patients

artículo científico publicado en 2016

The absolute quantification of eight inter‐α‐trypsin inhibitor heavy chain 4 (ITIH4)‐derived peptides in serum from breast cancer patients ⬇️

artículo científico publicado el 1 de diciembre de 2010

The application of inductively coupled plasma mass spectrometry in clinical pharmacological oncology research

artículo científico publicado en 2008

The bioanalysis of the major Echinacea purpurea constituents dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides in human plasma using LC-MS/MS

artículo científico publicado en 2012

The bioanalysis of the monoclonal antibody trastuzumab by high-performance liquid chromatography with fluorescence detection after immuno-affinity purification from human serum.

artículo científico publicado en 2009

The bioanalysis of trastuzumab in human serum using precipitate-enhanced ellipsometry.

artículo científico publicado en 2009

The bioanalysis of vinorelbine and 4-O-deacetylvinorelbine in human and mouse plasma using high-performance liquid chromatography coupled with heated electrospray ionization tandem mass-spectrometry

artículo científico publicado en 2009

The biological and clinical role of drug transporters at the intestinal barrier

artículo científico publicado en 2008

The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

artículo científico publicado en 2003

The cloudy crystal ball of cost-effectiveness studies

artículo científico publicado en 2013

The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib

artículo científico publicado en 2005

The effect of Echinacea purpurea on the pharmacokinetics of docetaxel ⬇️

artículo científico publicado el 1 de septiembre de 2013

The effect of P-gp (Mdr1a/1b), BCRP (Bcrp1) and P-gp/BCRP inhibitors on the in vivo absorption, distribution, metabolism and excretion of imatinib

artículo científico publicado en 2008

The effect of St John's wort on the pharmacokinetics of docetaxel

artículo científico publicado en 2014

The effect of complementary and alternative medicines on CYP3A4-mediated metabolism of three different substrates: 7-benzyloxy-4-trifluoromethyl-coumarin, midazolam and docetaxel

artículo científico publicado en 2014

The effect of food on the pharmacokinetics of S-1 after single oral administration to patients with solid tumors

artículo científico publicado en 2004

The effect of grape seed extract on the pharmacokinetics of dextromethorphan in healthy volunteers.

artículo científico publicado en 2013

The effect of hydroxyurea on P-glycoprotein/BCRP-mediated transport and CYP3A metabolism of imatinib mesylate

artículo científico publicado en 2006

The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models

artículo científico publicado en 2006

The effect of seasonal variation and secretion of sunitinib in sweat on the development of hand-foot syndrome

scientific article published on 31 August 2013

The effects of sulfur-containing compounds and gemcitabine on the binding of cisplatin to plasma proteins and DNA determined by inductively coupled plasma mass spectrometry and high performance liquid chromatography-inductively coupled plasma mass s

artículo científico publicado en 2008

The impact of liver resection on the dihydrouracil:uracil plasma ratio in patients with colorectal liver metastases

artículo científico publicado en 2018

The impact of structural uncertainty on cost-effectiveness models for adjuvant endocrine breast cancer treatments: the need for disease-specific model standardization and improved guidance

artículo científico

The in-vitro effect of complementary and alternative medicines on cytochrome P450 2C9 activity.

artículo científico publicado en 2014

The pharmacokinetic behavior of the photosensitizer meso-tetra-hydroxyphenyl-chlorin in mice and men.

artículo científico publicado en 2006

The use of combinations of monoclonal antibodies in clinical oncology

artículo científico

Therapeutic Drug Monitoring of Oral Anti-Hormonal Drugs in Oncology

artículo científico publicado en 2019

Therapeutic drug monitoring of small molecule kinase inhibitors in oncology in a real-world cohort study: does age matter?

artículo científico publicado en 2018

Thermal stability study of crystalline and novel spray-dried amorphous nilotinib hydrochloride

artículo científico publicado en 2017

Topoisomerase I inhibitors in the treatment of gastrointestinal cancer: from intravenous to oral administration

artículo científico publicado en 2004

Topoisomerase I levels in white blood cells of patients with ovarian cancer treated with paclitaxel-cisplatin-topotecan in a phase I study

artículo científico publicado en 2002

Trabectedin (ET-743, Yondelis) is a substrate for P-glycoprotein, but only high expression of P-glycoprotein confers the multidrug resistance phenotype

artículo científico publicado en 2007

Translating DPYD genotype into DPD phenotype: using the DPYD gene activity score

artículo científico

Translational PK-PD modeling analysis of MCLA-128, a HER2/HER3 bispecific monoclonal antibody, to predict clinical efficacious exposure and dose

artículo científico publicado en 2018

Trastuzumab

scientific article published on 31 May 2011

Trastuzumab and bevacizumab combined with docetaxel, oxaliplatin and capecitabine as first-line treatment of advanced HER2-positive gastric cancer: a multicenter phase II study

artículo científico publicado en 2015

Treatment Individualization in Colorectal Cancer

artículo científico publicado en 2015

Treatment of Peritoneal Dissemination in Stomach Cancer Patients With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC): Rationale and Design of the PERISCOPE Study

artículo científico publicado en 2017

Tumor and normal tissue pharmacokinetics of perifosine, an oral anti-cancer alkylphospholipid

artículo científico publicado en 2005

Two-stage model-based clinical trial design to optimize phase I development of novel anticancer agents

artículo científico publicado en 2009

Two-stage model-based design of cancer phase I dose escalation trials: evaluation using the phase I program of barasertib (AZD1152) ⬇️

artículo científico publicado el 28 de mayo de 2011

Upfront Genotyping of DPYD*2A to Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis.

artículo científico publicado en 2015

Urinary and fecal excretion of topotecan in patients with malignant solid tumours

artículo científico publicado en 2002

Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs

artículo científico publicado en 2005

Utility and Work Productivity Data for Economic Evaluation of Breast Cancer Therapies in the Netherlands and Sweden ⬇️

artículo científico publicado el 28 de marzo de 2013

Validated assay for the simultaneous determination of the anti-cancer agent gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma by high-performance liquid chromatography with tandem mass spectrometry

artículo científico publicado en 2007

Validated assay for the simultaneous quantification of total vincristine and actinomycin-D concentrations in human EDTA plasma and of vincristine concentrations in human plasma ultrafiltrate by high-performance liquid chromatography coupled with tan

artículo científico publicado en 2009

Validation of SELDI-TOF MS serum protein profiles for renal cell carcinoma in new populations

artículo científico publicado en 2007

Validation of a liquid chromatographic method for the pharmaceutical quality control of products containing elacridar

artículo científico publicado en 2016

Validation of a multiparameter flow cytometry method for the determination of phosphorylated extracellular‐signal‐regulated kinase and DNA in circulating tumor cells ⬇️

artículo científico publicado el 12 de abril de 2012

Validation of a quantitative assay for human neutrophil peptide-1, -2, and -3 in human plasma and serum by liquid chromatography coupled to tandem mass spectrometry

artículo científico publicado en 2010

Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo

artículo científico publicado en 2005

Variability in bioavailability of small molecular tyrosine kinase inhibitors

artículo científico

Vorinostat in patients with resistant BRAFV600E mutated advanced melanoma: a proof of concept study

artículo científico publicado en 2020

[Demethylating medication in myelodysplastic syndrome]

scientific article published on 01 January 2012

[Drug research in oncology; advances in the genome era]

artículo científico publicado en 2014

[Hyperglycaemia during treatment with everolimus].

artículo científico publicado en 2014

[Threshold value for reimbursement of costs of new drugs: cost-effectiveness research and modelling are essential links]

artículo científico publicado en 2015

Lista de obras de

"Effect of the drug transporters ABCB1, ABCC2, and ABCG2 on the disposition and brain accumulation of the taxane analog BMS-275,183".

A Phase I Dose Escalation Study of Once-Weekly Oral Administration of Docetaxel as ModraDoc001 Capsule or ModraDoc006 Tablet in Combination with Ritonavir

A Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of Pictilisib in Combination with Erlotinib in Patients with Advanced Solid Tumors

A Phase I and pharmacological study of the platinum polymer AP5280 given as an intravenous infusion once every 3 weeks in patients with solid tumors

A Phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent.

A Phase Ib Dose-Escalation Study of Encorafenib and Cetuximab with or without Alpelisib in Metastatic BRAF-Mutant Colorectal Cancer

A Population Pharmacokinetic Model of Oral Docetaxel Coadministered With Ritonavir to Support Early Clinical Development

A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy

A dose escalating phase I study of GLPG0187, a broad spectrum integrin receptor antagonist, in adult patients with progressive high-grade glioma and other advanced solid malignancies.

A dose-escalation study of bi-daily once weekly oral docetaxel either as ModraDoc001 or ModraDoc006 combined with ritonavir

A drug-drug interaction study to assess the effect of the CYP1A2 inhibitor fluvoxamine on the pharmacokinetics of dovitinib (TKI258) in patients with advanced solid tumors.

A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours

A model of hypertension and proteinuria in cancer patients treated with the anti-angiogenic drug E7080

A more sensitive MS detector does not obviously lead to a more sensitive assay: experiences with ES-285.

A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma

A phase 0 clinical trial of novel candidate extended-release formulations of capecitabine

A phase I followed by a randomized phase II trial of two cycles carboplatin-olaparib followed by olaparib monotherapy versus capecitabine in BRCA1- or BRCA2-mutated HER2-negative advanced breast cancer as first line treatment (REVIVAL): study protoc

A phase I monotherapy study of RG7212, a first-in-class monoclonal antibody targeting TWEAK signaling in patients with advanced cancers

A phase I safety and pharmacologic study of a twice weekly dosing regimen of the oral taxane BMS-275183

A phase I study of SAR405838, a novel human double minute 2 (HDM2) antagonist, in patients with solid tumours

A phase I study of the HDM2 antagonist SAR405838 combined with the MEK inhibitor pimasertib in patients with advanced solid tumours

A phase I, open-label, randomized crossover study to assess the effect of dosing of the MEK 1/2 inhibitor Selumetinib (AZD6244; ARRY-142866) in the presence and absence of food in patients with advanced solid tumors ⬇️

A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients

A phase Ib study of GSK3052230, an FGF ligand trap in combination with pemetrexed and cisplatin in patients with malignant pleural mesothelioma

A phosphotyrosine switch regulates organic cation transporters ⬇️

A rapid and simple HPLC-UV method for the determination of inhibition characteristics of farnesyl transferase inhibitors

A semi-physiological population pharmacokinetic model describing the non-linear disposition of indisulam

A sensitive LC-MS/MS method for the quantitative analysis of the Echinacea purpurea constituent undeca-2-ene-8,10-diynoic acid isobutylamide in human plasma

A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry

A sensitive combined assay for the quantification of paclitaxel, docetaxel and ritonavir in human plasma using liquid chromatography coupled with tandem mass spectrometry

A simple and sensitive assay for the quantitative analysis of paclitaxel and metabolites in human plasma using liquid chromatography/tandem mass spectrometry

Abcc4 Together with Abcb1 and Abcg2 Form a Robust Cooperative Drug Efflux System That Restricts the Brain Entry of Camptothecin Analogues ⬇️

Abrogation of the G2 checkpoint by inhibition of Wee-1 kinase results in sensitization of p53-deficient tumor cells to DNA-damaging agents

Absence of N-linked glycosylation does not affect plasma membrane localization of breast cancer resistance protein (BCRP/ABCG2).

Absolute quantification of farnesylated Ras levels in complex samples using liquid chromatography fractionation combined with tryptic digestion and electrospray tandem mass spectrometry

Acute poisoning after oral intake of a toluene-containing paint thinner

Adduct-specific monoclonal antibodies for the measurement of cisplatin-induced DNA lesions in individual cell nuclei

Age-Associated Hematological Toxicity in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Docetaxel in Clinical Practice

An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential.

An LC-MS/MS method for quantification of the active abiraterone metabolite Δ(4)-abiraterone (D4A) in human plasma

An excretion balance and pharmacokinetic study of the novel anticancer agent E7070 in cancer patients

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons

Angiotensin II-Receptor Inhibition With Candesartan to Prevent Trastuzumab-Related Cardiotoxic Effects in Patients With Early Breast Cancer: A Randomized Clinical Trial.

Antidrug Antibody Formation in Oncology: Clinical Relevance and Challenges

Application of PET/CT in the development of novel anticancer drugs

Application of dried blood spots combined with high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry for simultaneous quantification of vincristine and actinomycin-D.

Application of population pharmacokinetic modeling in early clinical development of the anticancer agent E7820.

BRAF Mutations as Predictive Biomarker for Response to Anti-EGFR Monoclonal Antibodies

BRAF-mutant Transcriptional Subtypes Predict Outcome of Combined BRAF, MEK, and EGFR Blockade with Dabrafenib, Trametinib, and Panitumumab in Patients with Colorectal Cancer

Baclofen overdose treated with continuous venovenous hemofiltration

Bayesian pharmacokinetically guided dosing of paclitaxel in patients with non-small cell lung cancer.

Bayesian pharmacokinetics of lithium after an acute self-intoxication and subsequent haemodialysis: a case report

Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.

Bevacizumab

Bevacizumab combined with docetaxel, oxaliplatin, and capecitabine, followed by maintenance with capecitabine and bevacizumab, as first-line treatment of patients with advanced HER2-negative gastric cancer: A multicenter phase 2 study

Binimetinib, Encorafenib, and Cetuximab Triplet Therapy for Patients With BRAF V600E-Mutant Metastatic Colorectal Cancer: Safety Lead-In Results From the Phase III BEACON Colorectal Cancer Study

Bioanalytical Aspects of Clinical Mass Balance Studies in Oncology ⬇️

Bioanalytical LC-MS/MS validation of therapeutic drug monitoring assays in oncology

Bioanalytical assay for the quantification of the ALK inhibitor lorlatinib in mouse plasma using liquid chromatography-tandem mass spectrometry.

Bioanalytical liquid chromatography-tandem mass spectrometric assay for the quantification of the ALK inhibitors alectinib, brigatinib and lorlatinib in plasma and mouse tissue homogenates

Bioanalytical methods for the quantification of therapeutic monoclonal antibodies and their application in clinical pharmacokinetic studies

Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides.

CMET-12. TUMOR CELL DETECTION BY IMMUNOFLOW CYTOMETRY AND BRAF MUTATION ANALYSIS IN CEREBROSPINAL FLUID OF MELANOMA PATIENTS WITH SUSPECTED LEPTOMENINGEAL METASTASES.

CYP2C9 and CYP2C19 polymorphic forms are related to increased indisulam exposure and higher risk of severe hematologic toxicity

Cannulation of the jugular vein in mice

Capecitabine induces severe angina-like chest pain

Capecitabine-based treatment of a patient with a novel DPYD genotype and complete dihydropyrimidine dehydrogenase deficiency.

Carboplatin dosing in overweight and obese patients with normal renal function, does weight matter?

Cellular and clinical pharmacology of the taxanes docetaxel and paclitaxel--a review

Characterization of the in vitro activity of AZD3409, a novel prenyl transferase inhibitor

Chronic hepatotoxicity after long-term antiretroviral treatment including nevirapine

Circulating epithelial tumor cell analysis in CSF in patients with leptomeningeal metastases

Circulating tumor cells as pharmacodynamic biomarker in early clinical oncological trials ⬇️

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update.

Clinical Pharmacokinetics and Pharmacodynamics of Pazopanib: Towards Optimized Dosing

Clinical Pharmacokinetics of Systemically Administered Antileishmanial Drugs.

Clinical and pharmacologic study of the farnesyltransferase inhibitor tipifarnib in cancer patients with normal or mildly or moderately impaired hepatic function

Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors

Clinical experience with aurora kinase inhibitors: a review