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A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

scientific article published on 02 December 2019

CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells

artículo científico publicado en 2021

DT2216-a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas

scientific article published on 16 July 2020

Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity

artículo científico publicado en 2021

FoxM1 insufficiency hyperactivates Ect2-RhoA-mDia1 signaling to drive cancer

artículo científico publicado en 2020

Increased marrow adipogenesis does not contribute to age-dependent appendicular bone loss in female mice

scientific article published on 13 October 2020

Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity

scientific article published on 16 February 2020

PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics

artículo científico publicado en 2020

Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies

artículo científico publicado en 2020

Proteolysis-targeting chimera against BCL-X<sub>L</sub> destroys tumor-infiltrating regulatory T cells

artículo científico publicado en 2021

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

scientific article published on 24 April 2020

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