Lista de obras -

A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA ⬇️

artículo científico publicado el 23 de agosto de 2010

Analogs of the RSK inhibitor SL0101: optimization of in vitro biological stability

artículo científico publicado en 2012

Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival

artículo científico publicado en 2008

De novo synthesis and biological evaluation of C6″-substituted C4″-amide analogues of SL0101.

artículo científico publicado en 2014

Development of a RSK Inhibitor as a Novel Therapy for Triple-Negative Breast Cancer

artículo científico publicado en 2016

ERα-mediated nuclear sequestration of RSK2 is required for ER+ breast cancer tumorigenesis

artículo científico publicado en 2018

Estrogen receptor phosphorylation

artículo científico publicado en 2003

Extracellular signal-regulated kinase 7, a regulator of hormone-dependent estrogen receptor destruction

artículo científico publicado en 2003

Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore

scientific article published on 24 May 2006

Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation

artículo científico publicado en 2005

Identifying requirements for RSK2 specific inhibitors

artículo científico publicado en 2021

Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors

artículo científico publicado en 2011

Improving the affinity of SL0101 for RSK using structure-based design.

artículo científico publicado en 2012

Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK.

artículo científico publicado en 2006

Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor

artículo científico publicado en 2012

Novel biosensors for the detection of estrogen receptor ligands

artículo científico publicado en 2005

RNA suppression of ERK2 leads to collapse of mitochondrial membrane potential with acute oxidative stress in human lens epithelial cells

artículo científico publicado en 2008

RSK in tumorigenesis: connections to steroid signaling

artículo científico publicado en 2010

RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility

artículo científico publicado en 2009

RSK2 Binding Models Delineate Key Features for Activity ⬇️

artículo científico publicado el 1 de enero de 2010

RSK2 and ERα comrades-in-arms in homeostasis and transformation

scientific article published on 01 November 2020

Regioselective Synthesis of a C-4'' Carbamate,C-6'' n-Pr Substituted Cyclitol Analogue of SL0101

artículo científico publicado en 2020

Ribosomal S6 kinase (RSK) modulators: a patent review

artículo científico publicado en 2016

Stereoselective Synthesis and Evaluation of C6″-Substituted 5a-Carbasugar Analogues of SL0101 as Inhibitors of RSK1/2.

artículo científico publicado en 2017

Structural basis for the activity of the RSK-specific inhibitor, SL0101.

artículo científico publicado en 2007

Sustained activation of the HER1-ERK1/2-RSK signaling pathway controls myoepithelial cell fate in human mammary tissue

artículo científico publicado en 2011

Synthesis and Biological Evaluation of 4'-Substituted Kaempfer-3-ols

artículo científico publicado en 2020

Synthesis and Structure-Activity Relationship Study of 5a-Carbasugar Analogues of SL0101.

artículo científico publicado en 2014

The affinity of RSK for cylitol analogues of SL0101 is critically dependent on the B-ring C-4'-hydroxy

artículo científico publicado en 2020

Three acetylated flavonol glycosides from Forsteronia refracta that specifically inhibit p90 RSK.

artículo científico publicado en 2006

pp90rsk1 Regulates Estrogen Receptor-Mediated Transcription through Phosphorylation of Ser-167 ⬇️

artículo científico publicado el 1 de abril de 1998

Lista de obras de

A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA ⬇️

Analogs of the RSK inhibitor SL0101: optimization of in vitro biological stability

Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival

De novo synthesis and biological evaluation of C6″-substituted C4″-amide analogues of SL0101.

Development of a RSK Inhibitor as a Novel Therapy for Triple-Negative Breast Cancer

ERα-mediated nuclear sequestration of RSK2 is required for ER+ breast cancer tumorigenesis

Estrogen receptor phosphorylation

Extracellular signal-regulated kinase 7, a regulator of hormone-dependent estrogen receptor destruction

Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore

Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation

Identifying requirements for RSK2 specific inhibitors

Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors

Improving the affinity of SL0101 for RSK using structure-based design.

Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK.

Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor

Novel biosensors for the detection of estrogen receptor ligands

RNA suppression of ERK2 leads to collapse of mitochondrial membrane potential with acute oxidative stress in human lens epithelial cells

RSK in tumorigenesis: connections to steroid signaling

RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility

RSK2 Binding Models Delineate Key Features for Activity ⬇️

RSK2 and ERα comrades-in-arms in homeostasis and transformation

Regioselective Synthesis of a C-4'' Carbamate,C-6'' n-Pr Substituted Cyclitol Analogue of SL0101

Ribosomal S6 kinase (RSK) modulators: a patent review

Stereoselective Synthesis and Evaluation of C6″-Substituted 5a-Carbasugar Analogues of SL0101 as Inhibitors of RSK1/2.

Structural basis for the activity of the RSK-specific inhibitor, SL0101.

Sustained activation of the HER1-ERK1/2-RSK signaling pathway controls myoepithelial cell fate in human mammary tissue

Synthesis and Biological Evaluation of 4'-Substituted Kaempfer-3-ols

Synthesis and Structure-Activity Relationship Study of 5a-Carbasugar Analogues of SL0101.

The affinity of RSK for cylitol analogues of SL0101 is critically dependent on the B-ring C-4'-hydroxy

Three acetylated flavonol glycosides from Forsteronia refracta that specifically inhibit p90 RSK.

pp90rsk1 Regulates Estrogen Receptor-Mediated Transcription through Phosphorylation of Ser-167 ⬇️