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(-)-Epigallocatechin-3-gallate induces apoptosis and differentiation in leukaemia by targeting reactive oxygen species and PIN1

artículo científico publicado en 2021

3D Scaffolds to Model the Hematopoietic Stem Cell Niche: Applications and Perspectives

scientific article published on 26 January 2021

51Cr-EDTA measurements of the glomerular filtration rate in patients with sickle cell anaemia and minor renal damage.

artículo científico publicado en 2006

A novel beta-globin variant: Hb Poços de Caldas [beta 61(E5)Lys-->Gln].

artículo científico publicado en 2002

ANKHD1 silencing inhibits Stathmin 1 activity, cell proliferation and migration of leukemia cells

artículo científico publicado en 2014

ANKHD1, a novel component of the Hippo signaling pathway, promotes YAP1 activation and cell cycle progression in prostate cancer cells

artículo científico publicado en 2014

ANKHD1, ankyrin repeat and KH domain containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells

artículo científico publicado en 2006

ARHGAP10, a novel human gene coding for a potentially cytoskeletal Rho-GTPase activating protein

artículo científico publicado en 2002

ARHGAP21 associates with FAK and PKCzeta and is redistributed after cardiac pressure overload

artículo científico publicado en 2008

ARHGAP21 protein, a new partner of α-tubulin involved in cell-cell adhesion formation and essential for epithelial-mesenchymal transition

artículo científico publicado en 2012

Abnormal Hedgehog pathway in myelodysplastic syndrome and its impact on patients' outcome.

artículo científico publicado en 2015

Altered red cell and platelet adhesion in hemolytic diseases: Hereditary spherocytosis, paroxysmal nocturnal hemoglobinuria and sickle cell disease.

artículo científico publicado en 2013

An efficient protocol for the generation of monocyte derived dendritic cells using serum-free media for clinical applications in post remission AML patients.

artículo científico publicado en 2014

An inherited mutation leading to production of only the short isoform of GATA-1 is associated with impaired erythropoiesis

article

An update on arginine in sickle cell disease

artículo científico publicado en 2019

Apoptosis-regulating proteins and prognosis in diffuse large B cell non-Hodgkin's lymphomas

artículo científico publicado en 2002

Artemisinin-type drugs for the treatment of hematological malignancies

artículo científico publicado en 2020

Association of the G-463A myeloperoxidase polymorphism with infection in sickle cell anemia

artículo científico publicado en 2005

BCR-ABL binds to IRS-1 and IRS-1 phosphorylation is inhibited by imatinib in K562 cells

artículo científico publicado en 2003

BNIP3L in myelodysplastic syndromes and acute myeloid leukemia: impact on disease outcome and cellular response to decitabine

artículo científico publicado en 2016

BRD4 Inhibition Enhances Azacitidine Efficacy in Acute Myeloid Leukemia and Myelodysplastic Syndromes

artículo científico publicado en 2019

Band 3Tambaú: a de novo mutation in the AE1 gene associated with hereditary spherocytosis. Implications for anion exchange and insertion into the red blood cell membrane

artículo científico publicado en 2005

Bone marrow progenitor cells from chemically exposed workers display an intrinsic ability for autonomous proliferation

scientific article published on 01 January 2005

Both interleukin-3 and interleukin-6 are necessary for better ex vivo expansion of CD133+ cells from umbilical cord blood

artículo científico publicado en 2010

CATS (FAM64A) abnormal expression reduces clonogenicity of hematopoietic cells

artículo científico publicado en 2016

CXCR4hi effector neutrophils in sickle cell anemia: potential role for elevated circulating serotonin (5-HT) in CXCR4hi neutrophil polarization

artículo científico publicado en 2020

CXCR7 is highly expressed in acute lymphoblastic leukemia and potentiates CXCR4 response to CXCL12.

artículo científico publicado en 2014

CXCR7 participates in CXCL12-mediated migration and homing of leukemic and normal hematopoietic cells

artículo científico publicado en 2018

Causes of incidental neutropenia in adulthood.

artículo científico publicado en 2006

Characterisation of a new splice variant of MASK-BP3(ARF) and MASK human genes, and their expression patterns during haematopoietic cell differentiation

artículo científico publicado en 2005

Characterization of a novel decellularized bone marrow scaffold as an inductive environment for hematopoietic stem cells

scientific article published on 01 March 2019

Chronic liver abnormalities in sickle cell disease: a clinicopathological study in 70 living patients

scientific article published on 03 September 2007

Coinheritance of Hb Bristol-Alesha [β67(E11)Val→Met; HBB: c.202G>A] and the α212 Patchwork Allele in a Brazilian Child with Severe Congenital Hemolytic Anemia

artículo científico publicado en 2017

Consensus statement for diagnosis and treatment of paroxysmal nocturnal haemoglobinuria

scientific article published on 06 July 2020

Cytokine polymorphisms in sickle cell disease and the relationship with cytokine expression

artículo científico publicado en 2016

DNA-based typing of blood groups for the management of multiply-transfused sickle cell disease patients

artículo científico publicado en 2002

DNAase I hypersensitive site 3' to the beta-globin gene cluster containing two TAA insertions and a G-->A polymorphism is predominantly associated with the beta+-thalassemia IVS-I-6 (T-->C) mutation

scientific article published on 01 January 2005

DNAase I hypersensitive site 3' to the beta-globin gene cluster contains a TAA insertion specific for beta(S)-Benin haplotype

artículo científico publicado en 2002

Deferasirox associated with liver failure and death in a sickle cell anemia patient homozygous for the -1774delG polymorphism in the Abcc2 gene

artículo científico publicado en 2017

Detection and possible prognostic relevance of p53 gene mutations in diffuse large B-cell lymphoma. An analysis of 51 cases and review of the literature.

artículo científico publicado en 2004

Determinants of change in paternal smoking trends during pregnancy in Lebanon

artículo científico publicado en 2010

Differences in heme and hemopexin content in lipoproteins from patients with sickle cell disease

artículo científico publicado en 2018

Differential profile of CDKN1A and TP53 expressions in bone marrow mesenchymal stromal cells from myeloid neoplasms.

artículo científico publicado en 2016

Differential profile of PIP4K2A expression in hematological malignancies.

artículo científico publicado en 2015

Differentiation of C2C12 myoblasts is critically regulated by FAK signaling.

artículo científico publicado en 2005

Diskitis in toddlers revisited

artículo científico publicado en 2010

Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients.

artículo científico publicado en 2012

Downregulation of IRS2 in myelodysplastic syndrome: a possible role in impaired hematopoietic cell differentiation

artículo científico publicado en 2012

Echocardiografic abnormalities in patients with sickle cell/β-thalassemia do not depend on the β-thalassemia phenotype

artículo científico publicado en 2018

Effect of cytokines and chemokines on sickle neutrophil adhesion to fibronectin.

artículo científico publicado en 2005

Effectiveness of a home-based therapeutic exercise program on lower back pain and functionality in Sickle Cell Disease (SCD) patients

artículo científico publicado en 2020

Effects of RhoA and RhoC upon the sensitivity of prostate cancer cells to glutamine deprivation

scientific article published on 18 November 2018

Effects of home-based inspiratory muscle training on sickle cell disease (SCD) patients

scientific article published on 14 September 2020

Elevated plasma levels and platelet-associated expression of the pro-thrombotic and pro-inflammatory protein, TNFSF14 (LIGHT), in sickle cell disease.

artículo científico publicado en 2012

Enalapril therapy and cardiac remodelling in sickle cell disease patients

artículo científico publicado en 2008

Exosomes in the serum of Acute Myeloid Leukemia patients induce dendritic cell tolerance: Implications for immunotherapy

artículo científico publicado en 2019

Expression of alpha-hemoglobin stabilizing protein gene during human erythropoiesis

artículo científico publicado en 2004

Expression of new red cell-related genes in erythroid differentiation

artículo científico publicado en 2009

FMNL1 promotes proliferation and migration of leukemia cells

artículo científico publicado en 2013

Follow-up of sickle cell disease patients with priapism treated by hydroxyurea

artículo científico publicado en 2004

Gene expression analysis of the Brazilian type of hereditary persistence of fetal hemoglobin: identification of genes that could be related to γ-globin activation.

artículo científico publicado en 2013

Granulocytic adhesive interactions and their role in sickle cell vaso-occlusion

artículo científico publicado en 2005

Guidelines on neonatal screening and painful vaso-occlusive crisis in sickle cell disease: Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular: Project guidelines: Associação Médica Brasileira - 2016.

artículo científico publicado en 2016

Guidelines on the treatment of anemia of chronic renal failure using recombinant human erythropoietin: Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Guidelines Project: Associação Médica Brasileira - 2014.

artículo científico publicado en 2014

Hematopoietic cell kinase (HCK) is a potential therapeutic target for dysplastic and leukemic cells due to integration of erythropoietin/PI3K pathway and regulation of erythropoiesis: HCK in erythropoietin/PI3K pathway.

artículo científico publicado en 2016

Hematopoietic defects in response to reduced Arhgap21.

artículo científico publicado en 2017

High expression of FMNL1 protein in T non-Hodgkin's lymphomas

artículo científico publicado en 2006

High expression of apoptosis-regulating proteins in Burkitt's lymphomas

artículo científico publicado en 2002

High levels of human gamma-globin are expressed in adult mice carrying a transgene of the Brazilian type of hereditary persistence of fetal hemoglobin ((A)gamma -195)

artículo científico publicado en 2009

Highlight article: Whole-exome sequencing indicates FLG2 variant associated with leg ulcers in Brazilian sickle cell anemia patients

scientific article published on 12 May 2019

Human leukocyte formin: a novel protein expressed in lymphoid malignancies and associated with Akt.

artículo científico publicado en 2003

Hypocholesterolemia and dysregulated production of angiopoietin-like proteins in sickle cell anemia patients

artículo científico publicado en 2019

IL10 inversely correlates with the percentage of CD8⁺ cells in MDS patients

artículo científico publicado en 2013

IL32 expression in peripheral blood CD3+ cells from myelodysplastic syndromes patients

IL4 and IFNalpha generation of dendritic cells reveals great migratory potential and NFkB and cJun expression in IL4DCs

artículo científico publicado en 2013

IRAK1 expression in bone marrow cells does not impact patient outcomes in myelodysplastic syndromes.

artículo científico publicado en 2017

Identification of novel candidate genes for globin regulation in erythroid cells containing large deletions of the human beta-globin gene cluster

artículo científico publicado en 2006

Immunophenotyping in myelodysplastic syndromes can add prognostic information to well-established and new clinical scores

artículo científico publicado en 2013

Impaired red cell deformability in iron deficient subjects

artículo científico publicado en 2009

In vitro microfluidic model for the study of vaso-occlusive processes

artículo científico publicado en 2014

Increased adhesive properties of eosinophils in sickle cell disease

artículo científico publicado en 2004

Increased adhesive properties of neutrophils in sickle cell disease may be reversed by pharmacological nitric oxide donation

artículo científico publicado en 2008

Increased adhesive properties of platelets in sickle cell disease: roles for alphaIIb beta3-mediated ligand binding, diminished cAMP signalling and increased phosphodiesterase 3A activity

artículo científico publicado en 2010

Increased levels of soluble ICAM-1 in the plasma of sickle cell patients are reversed by hydroxyurea

artículo científico publicado en 2004

Increased soluble guanylate cyclase activity in the red blood cells of sickle cell patients

artículo científico publicado en 2004

Inhibition of caspase-dependent spontaneous apoptosis via a cAMP-protein kinase A dependent pathway in neutrophils from sickle cell disease patients

artículo científico publicado en 2007

Inhibition of phosphodiesterase 9A reduces cytokine-stimulated in vitro adhesion of neutrophils from sickle cell anemia individuals.

artículo científico publicado en 2011

LEF1-AS1, long non-coding RNA, inhibits proliferation in myeloid malignancy

artículo científico publicado en 2019

Lack of Arg972 polymorphism in the IRS1 gene in Parakanã Brazilian Indians

artículo científico publicado en 2004

Lithium, a classic drug in psychiatry, improves nilotinib-mediated antileukemic effects.

artículo científico publicado en 2018

Liver transplantation in a patient with S(beta)o-thalassemia

artículo científico publicado en 2002

Low Ten-eleven-translocation 2 (TET2) transcript level is independent of TET2 mutation in patients with myeloid neoplasms.

artículo científico publicado en 2016

Low expression of tissue inhibitor of metalloproteinase-2 may be associated with high-risk myelodysplastic syndrome

scientific article published on 28 September 2012

MDR-1 and GST polymorphisms are involved in myelodysplasia progression.

artículo científico publicado en 2013

Maturation-associated immunophenotypic abnormalities in bone marrow B-lymphocytes in myelodysplastic syndromes

artículo científico publicado en 2005

Mesenchymal stromal cells from adipose tissue attached to suture material enhance the closure of enterocutaneous fistulas in a rat model

artículo científico publicado en 2014

Mild hemolysis in a girl with G6PD Sumaré (class I variant) associated with G6PD A− ⬇️

artículo científico publicado el 1 de mayo de 2003

Molecular characterization of hemoglobin alpha-D chains from Geochelone carbonaria and Geochelone denticulata land turtles

artículo científico publicado en 2003

Molecular effects of the phosphatidylinositol-3-kinase inhibitor NVP-BKM120 on T and B-cell acute lymphoblastic leukaemia.

artículo científico publicado en 2015

Molecular heterogeneity of G6PD deficiency in an Amazonian population and description of four new variants

artículo científico publicado en 2002

Molecular matching for Rh and K reduces red blood cell alloimmunisation in patients with myelodysplastic syndrome.

artículo científico publicado en 2014

Motivating medical students to learn basic science concepts using chronic myeloid leukemia as an integration theme

artículo científico publicado en 2014

Multitarget effects of quercetin in leukemia.

artículo científico publicado en 2014

Myelodysplastic syndrome with synchronous gastric cancer: when the symptoms suggest something else

artículo científico publicado en 2014

Natural Type II Collagen Hydrogel, Fibrin Sealant, and Adipose-Derived Stem Cells as a Promising Combination for Articular Cartilage Repair

artículo científico publicado en 2016

Neuroprotection and immunomodulation by xenografted human mesenchymal stem cells following spinal cord ventral root avulsion

artículo científico publicado en 2015

Novel mutations associated with pyruvate kinase deficiency in Brazil.

artículo científico publicado en 2017

Obesity and inflammation and the effect on the hematopoietic system

artículo científico publicado en 2014

Overexpression and Characterization of The C-Terminal Domain of Human Siva1, A Proapoptotic Factor and Cytoskeleton Binding Protein.

artículo científico publicado en 2015

PIP4KIIA and beta-globin: transcripts differentially expressed in reticulocytes and associated with high levels of Hb H in two siblings with Hb H disease

artículo científico publicado en 2009

PIPKIIα is widely expressed in hematopoietic-derived cells and may play a role in the expression of alpha- and gamma-globins in K562 cells.

artículo científico publicado en 2014

PTK2 and PTPN11 expression in myelodysplastic syndromes.

scientific article published on October 2013

Pancytopenia in untreated patients with Graves' disease

artículo científico publicado en 2006

Phylogenetic analysis of RhoGAP domain-containing proteins

artículo científico publicado en 2006

Pilot randomized controlled trial to evaluate the effect of aquatic and land physical therapy on musculoskeletal dysfunction of sickle cell disease patients.

artículo científico publicado en 2014

Platelet associated IgG may be related with thrombocytopenia in patients with myelodysplastic syndromes

artículo científico publicado en 2011

Polymorphisms of interleukin-1 gene complex, IL6 and tumour necrosis factor genes in chronic idiopathic neutropenia of adults.

artículo científico publicado en 2005

Practical approach to the child presenting with back pain

scientific article published on 22 May 2010

Prevalence of Bartonella spp. Infection in Patients with Sickle Cell Disease

scientific article published on 03 February 2020

Probiotics modulate gut microbiota and improve insulin sensitivity in DIO mice.

artículo científico publicado en 2017

Progesterone upregulates GATA-1 on erythroid progenitors cells in liquid culture

artículo científico publicado en 2002

Quelação oral de ferro na Beta-Talassemia

Rabbit antithymocyte globulin dose does not affect response or survival as first-line therapy for acquired aplastic anemia: a multicenter retrospective study

artículo científico publicado en 2018

Reactive oxygen species production triggers green tea-induced anti-leukaemic effects on acute promyelocytic leukaemia model

artículo científico publicado en 2017

Recombinant erythropoietin as alternative to red cell transfusion in sickle cell disease

artículo científico publicado en 2019

Red blood cells microparticles are associated with hemolysis markers and may contribute to clinical events among sickle cell disease patients

artículo científico publicado en 2019

Reduced expression of FLIP SHORT in bone marrow of low risk myelodysplastic syndrome.

artículo científico publicado en 2007

Reduced expression of NR4A1 activates glycolytic pathway in acute promyelocytic leukemia cells.

artículo científico publicado en 2017

Reduced rate of sickle-related complications in Brazilian patients carrying HbF-promoting alleles at the BCL11A and HMIP-2 loci.

artículo científico publicado en 2016

Reduction of AHSP synthesis in hemin-induced K562 cells and EPO-induced CD34(+) cells leads to alpha-globin precipitation, impairment of normal hemoglobin production, and increased cell death

artículo científico publicado en 2008

Regulation of chondrogenesis by transforming growth factor-beta 3 and insulin-like growth factor-1 from human mesenchymal umbilical cord blood cells

artículo científico publicado en 2010

Regulation of the GATA3 promoter by human T-cell lymphotropic virus type I Tax protein

artículo científico publicado en 2004

Risk factors for conjunctival and retinal vessel alterations in sickle cell disease

artículo científico publicado en 2006

Role for cAMP-protein kinase A signalling in augmented neutrophil adhesion and chemotaxis in sickle cell disease

artículo científico publicado en 2007

S100A8 acts as an autocrine priming signal for heme-induced human Mϕ pro-inflammatory responses in hemolytic inflammation

scientific article published on 15 May 2019

SEMA3A partially reverses VEGF effects through binding to neuropilin-1.

artículo científico publicado en 2017

Serine peptidase inhibitor Kunitz type 2 (SPINT2) in cancer development and progression.

artículo científico publicado en 2018

Serine protease inhibitor kunitz-type 2 is downregulated in myelodysplastic syndromes and modulates cell-cell adhesion

artículo científico publicado en 2014

Sickle cell disease serum induces NADPH enzyme subunit expression and oxidant production in leukocytes

artículo científico publicado en 2010

Sickle cell/β-thalassemia: Comparison of Sβ0 and Sβ+ Brazilian patients followed at a single institution

artículo científico publicado en 2016

Simple fluorescent PCR method for detection of large deletions in the beta-globin gene cluster

artículo científico publicado en 2003

Small Particles, Big Effects: The Interplay Between Exosomes and Dendritic Cells in Antitumor Immunity and Immunotherapy

scientific article published on 16 December 2019

Stathmin 1 expression in plasma cell neoplasms

artículo científico publicado en 2017

Stathmin 1 in normal and malignant hematopoiesis.

artículo científico

Stathmin 1 inhibition amplifies ruxolitinib-induced apoptosis in JAK2V617F cells

artículo científico publicado en 2015

Stathmin 1 is involved in the highly proliferative phenotype of high-risk myelodysplastic syndromes and acute leukemia cells.

artículo científico publicado en 2013

TET2 is upregulated during erythroid differentiation of CD34+ cells from healthy donors and myelodysplastic syndrome patients

Technetium-99m-dimercaptosuccinic acid renal scintigraphy and single photon emission computed tomography/computed tomography in patients with sickle cell disease

scientific article published on 01 November 2019

Ten-eleven-translocation 2 (TET2) is downregulated in myelodysplastic syndromes

scientific article published on 01 October 2014

The CALM and CALM/AF10 interactor CATS is a marker for proliferation

artículo científico publicado en 2008

The CATS (FAM64A) protein is a substrate of the Kinase Interacting Stathmin (KIS).

artículo científico publicado en 2013

The Cratylia mollis seed lectin induces membrane permeability transition in isolated rat liver mitochondria and a cyclosporine a-insensitive permeability transition in Trypanosoma cruzi mitochondria

artículo científico publicado en 2014

The Gly972Arg polymorphism in insulin receptor substrate-1 is associated with decreased birth weight in a population-based sample of Brazilian newborns

artículo científico publicado en 2002

The U2AF homology motif kinase 1 (UHMK1) is upregulated upon hematopoietic cell differentiation

artículo científico publicado en 2018

The challenges of handling deferasirox in sickle cell disease patients older than 40 years

scientific article published on 01 December 2019

The effects of exchange transfusion for prevention of complications during pregnancy of sickle hemoglobin C disease patients.

artículo científico publicado en 2015

The polyphenol quercetin induces cell death in leukemia by targeting epigenetic regulators of pro-apoptotic genes

article

Therapy with hydroxyurea is associated with reduced adhesion molecule gene and protein expression in sickle red cells with a concomitant reduction in adhesive properties.

artículo científico publicado en 2007

Transfusion service management of sickle-cell disease patients

artículo científico publicado en 2015

Up-regulation of NADPH oxidase components and increased production of interferon-gamma by leukocytes from sickle cell disease patients

article

Up-regulation of SPINT2/HAI-2 by Azacytidine in bone marrow mesenchymal stromal cells affects leukemic stem cell survival and adhesion

artículo científico publicado en 2018

Useful properties of undifferentiated mesenchymal stromal cells and adipose tissue as the source in liver-regenerative therapy studied in an animal model of severe acute fulminant hepatitis

artículo científico publicado en 2015

Viability of umbilical cord blood mononuclear cell subsets until 96 hours after collection

scientific article published on 16 January 2013

YAP1 expression in myelodysplastic syndromes and acute leukemias.

artículo científico publicado en 2014

alpha-cardiac actin (ACTC) binds to the band 3 (AE1) cardiac isoform

scientific journal article

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