Lista de obras -

A High Yield and Cost-efficient Expression System of Human Granzymes in Mammalian Cells.

artículo científico publicado en 2015

A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication

artículo científico publicado en 2008

A fragment of anthrax lethal factor delivers proteins to the cytosol without requiring protective antigen ⬇️

artículo científico publicado el 9 de mayo de 2003

A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells

scientific article published on August 2013

Alterations in RNA processing during immune-mediated programmed cell death

artículo científico publicado en 2012

An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates

scientific journal article

An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

artículo científico publicado en 2005

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

artículo científico publicado en 2005

Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3' Uridylated Intermediates Degraded by DIS3L2

artículo científico publicado en 2015

Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.

artículo científico publicado en 2013

Basal-A Triple Negative Breast Cancer Cells Selectively Rely on RNA Splicing for Survival

artículo científico publicado en 2017

Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer

artículo científico publicado en 2017

Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins

artículo científico publicado en 2012

CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy

scientific article published on 18 November 2020

Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling

artículo científico publicado en 2011

Chemoattractant-mediated leukocyte trafficking enables HIV dissemination from the genital mucosa

artículo científico publicado en 2017

Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients

artículo científico publicado en 2010

Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs

artículo científico publicado en 2011

Contributions of IFN-γ and granulysin to the clearance of Plasmodium yoelii blood stage

scientific article published on 10 September 2020

Cross-clade CD8 T-cell responses to HIV(IIIB) and Chinese B' and C/B' viruses in North American and Chinese HIV-seropositive donors

scientific article published on 01 December 2004

Cryo-EM structure of the gasdermin A3 membrane pore.

artículo científico publicado en 2018

Cytotoxic CD8 T cells recognize and kill Plasmodium vivax-infected reticulocytes

artículo científico publicado en 2018

Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes

artículo científico publicado en 2015

Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing

artículo científico publicado en 2016

Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes.

artículo científico publicado en 2014

Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts

artículo científico publicado en 2020

Desperately seeking microRNA targets

artículo científico publicado en 2010

Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras

artículo científico publicado en 2013

Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene

artículo científico publicado en 2009

Dysregulation of microRNA biogenesis and gene silencing in cancer

artículo científico

Efficient and specific gene knockdown by small interfering RNAs produced in bacteria ⬇️

artículo científico publicado el 10 de marzo de 2013

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

artículo científico publicado en 2020

FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation

artículo científico

Gasdermin D activity in inflammation and host defense

scientific article published on 01 September 2019

Gasdermin D pore structure reveals preferential release of mature interleukin-1

artículo científico publicado en 2021

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

scientific article published on 11 March 2020

Gene Knockdown by EpCAM Aptamer-siRNA Chimeras Suppresses Epithelial Breast Cancers and Their Tumor-Initiating Cells.

artículo científico publicado en 2015

Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death

artículo científico publicado en 2008

Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis

artículo científico publicado en 2005

Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70.

artículo científico publicado en 2006

Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program.

artículo científico publicado en 2017

Granzyme B binds to target cells mostly by charge and must be added at the same time as perforin to trigger apoptosis

scientific journal article

HIV DNA is heavily uracilated, which protects it from autointegration ⬇️

artículo científico publicado el 16 de mayo de 2011

Harnessing RNA interference for therapy: the silent treatment

artículo científico publicado en 2015

Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation

artículo científico publicado en 2017

Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity.

artículo científico publicado en 2008

Identification of host proteins required for HIV infection through a functional genomic screen

artículo científico publicado en 2008

Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras ⬇️

artículo científico publicado el 16 de mayo de 2011

Isolation of cytotoxic T cell and NK granules and purification of their effector proteins

artículo científico publicado en 2010

Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites.

artículo científico publicado en 2016

Knocking down disease with siRNAs

artículo científico publicado en 2006

Knocking down disease: a progress report on siRNA therapeutics

artículo científico publicado en 2015

Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV

artículo científico publicado en 2005

Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of nucleic acid binding proteins

artículo científico publicado en 2014

Lighting a Fire: Can We Harness Pyroptosis to Ignite Antitumor Immunity?

artículo científico publicado en 2021

Lighting a fire on the reef

artículo científico publicado en 2020

Listeria-infected myeloid dendritic cells produce IFN-beta, priming T cell activation

artículo científico publicado en 2005

Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes

artículo científico publicado en 2022

Micromanipulating cancer: microRNA-based therapeutics?

artículo científico publicado en 2009

Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression

artículo científico publicado en 2009

PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A) RNAs

scientific article published on 17 May 2018

Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis

scientific journal article

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells

artículo científico publicado en 2011

Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis

artículo científico publicado en 2005

Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer

artículo científico publicado en 2014

RIG-ing an antitumor response

artículo científico publicado en 2008

RNA interference and cancer: endogenous pathways and therapeutic approaches

artículo científico publicado en 2008

RNA interference targeting Fas protects mice from fulminant hepatitis

scientific article published on 10 February 2003

Resistance of HIV-infected macrophages to CD8+ T lymphocyte-mediated killing drives activation of the immune system.

artículo científico publicado en 2018

Response: Granzyme A: cell death–inducing protease, proinflammatory agent, or both?

artículo científico publicado en 2009

SAMHD1 does it again, now in resting T cells

artículo científico publicado en 2012

SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism

artículo científico publicado en 2020

Sequencing of captive target transcripts identifies the network of regulated genes and functions of primate-specific miR-522.

artículo científico publicado en 2014

Small RNAs guide hematopoietic cell differentiation and function

scientific article published on June 2010

Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury.

scholarly article

Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages

artículo científico publicado en 2003

Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis

artículo científico publicado en 2012

The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation

artículo científico publicado en 2015

The SET complex acts as a barrier to autointegration of HIV-1

artículo científico publicado en 2009

The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1.

artículo científico publicado en 2009

The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death

artículo científico publicado en 2006

The gp49B1 inhibitory receptor regulates the IFN-gamma responses of T cells and NK cells

artículo científico publicado en 2003

The prospect of silencing disease using RNA interference

artículo científico publicado en 2005

Tombusvirus p19 Captures RNase III-Cleaved Double-Stranded RNAs Formed by Overlapping Sense and Antisense Transcripts in Escherichia coli

artículo científico publicado en 2020

Tombusvirus p19 captures RNase III-cleaved double-stranded RNAs formed by overlapping sense and antisense transcripts in E. coli

Tumor-secreted extracellular vesicles promote the activation of cancer-associated fibroblasts via the transfer of microRNA-125b

artículo científico publicado en 2019

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

artículo científico publicado en 2015

gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair

artículo científico publicado en 2005

let-7 regulates self renewal and tumorigenicity of breast cancer cells

artículo científico publicado en 2007

miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential

scientific article published on 11 July 2018

miR-200 enhances mouse breast cancer cell colonization to form distant metastases

artículo científico publicado en 2009

miR-200-containing extracellular vesicles promote breast cancer cell metastasis

artículo científico publicado en 2014

miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements

artículo científico publicado en 2009

miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells

artículo científico publicado en 2009

miR-34 and p53: New Insights into a Complex Functional Relationship

artículo científico publicado en 2015

p16(INK4a) translation suppressed by miR-24

artículo científico publicado en 2008

siRNA-directed inhibition of HIV-1 infection

artículo científico publicado en 2002

γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis

artículo científico publicado en 2021

Lista de obras de

A High Yield and Cost-efficient Expression System of Human Granzymes in Mammalian Cells.

A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication

A fragment of anthrax lethal factor delivers proteins to the cytosol without requiring protective antigen ⬇️

A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells

Alterations in RNA processing during immune-mediated programmed cell death

An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates

An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3' Uridylated Intermediates Degraded by DIS3L2

Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.

Basal-A Triple Negative Breast Cancer Cells Selectively Rely on RNA Splicing for Survival

Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer

Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins

CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy

Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling

Chemoattractant-mediated leukocyte trafficking enables HIV dissemination from the genital mucosa

Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients

Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs

Contributions of IFN-γ and granulysin to the clearance of Plasmodium yoelii blood stage

Cross-clade CD8 T-cell responses to HIV(IIIB) and Chinese B' and C/B' viruses in North American and Chinese HIV-seropositive donors

Cryo-EM structure of the gasdermin A3 membrane pore.

Cytotoxic CD8 T cells recognize and kill Plasmodium vivax-infected reticulocytes

Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes

Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing

Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes.

Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts

Desperately seeking microRNA targets

Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras

Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene

Dysregulation of microRNA biogenesis and gene silencing in cancer

Efficient and specific gene knockdown by small interfering RNAs produced in bacteria ⬇️

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation

Gasdermin D activity in inflammation and host defense

Gasdermin D pore structure reveals preferential release of mature interleukin-1

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

Gene Knockdown by EpCAM Aptamer-siRNA Chimeras Suppresses Epithelial Breast Cancers and Their Tumor-Initiating Cells.

Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death

Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis

Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70.

Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program.

Granzyme B binds to target cells mostly by charge and must be added at the same time as perforin to trigger apoptosis

HIV DNA is heavily uracilated, which protects it from autointegration ⬇️

Harnessing RNA interference for therapy: the silent treatment

Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation

Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity.

Identification of host proteins required for HIV infection through a functional genomic screen

Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras ⬇️

Isolation of cytotoxic T cell and NK granules and purification of their effector proteins

Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites.

Knocking down disease with siRNAs

Knocking down disease: a progress report on siRNA therapeutics

Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV

Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of nucleic acid binding proteins

Lighting a Fire: Can We Harness Pyroptosis to Ignite Antitumor Immunity?

Lighting a fire on the reef

Listeria-infected myeloid dendritic cells produce IFN-beta, priming T cell activation

Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes

Micromanipulating cancer: microRNA-based therapeutics?

Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression

PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A) RNAs

Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells

Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis

Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer

RIG-ing an antitumor response

RNA interference and cancer: endogenous pathways and therapeutic approaches

RNA interference targeting Fas protects mice from fulminant hepatitis

Resistance of HIV-infected macrophages to CD8+ T lymphocyte-mediated killing drives activation of the immune system.

Response: Granzyme A: cell death–inducing protease, proinflammatory agent, or both?

SAMHD1 does it again, now in resting T cells

SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism

Sequencing of captive target transcripts identifies the network of regulated genes and functions of primate-specific miR-522.

Small RNAs guide hematopoietic cell differentiation and function

Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury.

Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages

Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis

The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation

The SET complex acts as a barrier to autointegration of HIV-1