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A 13-week subchronic intravaginal toxicity study of the novel broad-spectrum anti-HIV and spermicidal agent, N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (PHI-346) in mice

artículo científico publicado en 2002

A PREVIOUSLY UNKNOWN UNIQUE CHALLENGE FOR INHIBITORS OF SYK ATP-BINDING SITE: ROLE OF SYK AS A CELL CYCLE CHECKPOINT REGULATOR

artículo científico publicado en 2014

A degradation study of a series of chloromethyl and diazomethyl ketone anti-leukemic agents

artículo científico publicado en 2002

A dual function anti-leukemic agent with anti-thrombotic activity

scientific article published on 01 May 2002

A novel vaginal microbicide containing the rationally designed anti-HIV compound HI-443 (N′-[2-(2-thiophene)ethyl]-N′-[2-(5-bromopyridyl)] thiourea]) ⬇️

artículo científico publicado el 1 de febrero de 2012

A rationally designed anticancer drug targeting a unique binding cavity of tubulin

scientific article published on 01 May 2000

A rationally designed nanoparticle for RNA interference therapy in B-lineage lymphoid malignancies

artículo científico publicado en 2014

A recombinant fusion toxin targeted to the granulocyte-macrophage colony-stimulating factor receptor

artículo científico publicado en 1997

A specific inhibitor of janus kinase-3 increases survival in a transgenic mouse model of amyotrophic lateral sclerosis

scientific article published on 01 January 2000

A study of the potential of the pig as a model for the vaginal irritancy of benzalkonium chloride in comparison to the nonirritant microbicide PHI-443 and the spermicide vanadocene dithiocarbamate

artículo científico publicado en 2005

Abnormalities of chromosome bands 13q12 to 13q14 in childhood acute lymphoblastic leukemia

scientific article published on 01 November 2000

Abnormalities of chromosome bands 15q13-15 in childhood acute lymphoblastic leukemia

artículo científico publicado en 2002

Absence of Genomic Ikaros/IKZF1 Deletions in Pediatric B-Precursor Acute Lymphoblastic Leukemia

artículo científico publicado en 2013

Alpha-cyano-N-(2,5-dibromophenyl)-beta-hydroxybut-2-enamide

artículo científico publicado en 1999

An inhibitor of Janus kinase 3:4-(4-hydroxyphenylamino)-6, 7-dimethoxyquinazolin-1-ium chloride methanol solvate

scientific article published on 01 October 2000

Anti-CD2 (T, p50) intact ricin immunotoxins for GVHD-prophylaxis in allogeneic bone marrow transplantation

artículo científico publicado en 1986

Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK).

artículo científico publicado en 2006

Anti-cancer activity profile of 3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate] (Compound 003), a novel nucleoside analog.

artículo científico publicado en 2004

Anti-inflammatory activity profile of JANEX-1 in preclinical animal models

artículo científico publicado en 2007

Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds. Studies using human acute lymphoblastic leukemia cells and the zebrafish model

artículo científico publicado en 2005

Anti-retroviral activity of GMP-grade stampidine against genotypically and phenotypically nucleoside reverse transcriptase inhibitor resistant recombinant human immunodeficiency virus. An in vitro study

artículo científico publicado en 2007

Anticancer activity of synthetic analogues of the phorboxazoles

artículo científico publicado en 2001

Antileukemic activity and cellular metabolism of the aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07).

artículo científico publicado en 2005

Antiretroviral spermicide WHI-07 prevents vaginal and rectal transmission of feline immunodeficiency virus in domestic cats

artículo científico publicado en 2004

Augmentation of mast cell bactericidal activity by the anti-leukemic drug, 4-(3'bromo-4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline

artículo científico publicado en 2002

Augmentation of the antileukemia potency of total-body irradiation (TBI) by a novel P-site inhibitor of spleen tyrosine kinase (SYK).

artículo científico publicado en 2010

Biotargeted nanomedicines for cancer: six tenets before you begin

artículo científico publicado en 2013

Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases

artículo científico publicado en 1995

Bone marrow leukemic progenitor cell content in pediatric T-lineage acute lymphoblastic leukemia patients with an isolated extramedullary first relapse

scientific article published on 01 January 2001

Bruton's tyrosine kinase as a molecular target in treatment of leukemias and lymphomas as well as inflammatory disorders and autoimmunity ⬇️

artículo científico publicado el 10 de septiembre de 2010

Bruton's tyrosine kinase as a new therapeutic target

artículo científico publicado en 2007

Bruton's tyrosine kinase prevents activation of the anti-apoptotic transcription factor STAT3 and promotes apoptosis in neoplastic B-cells and B-cell precursors exposed to oxidative stress

artículo científico publicado en 2007

CD19-antigen specific nanoscale liposomal formulation of a SYK P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells

artículo científico publicado en 2014

CD22 EXON 12 deletion as a pathogenic mechanism of human B-precursor leukemia ⬇️

artículo científico publicado el 14 de septiembre de 2010

CD22 Exon 12 deletion is a characteristic genetic defect of therapy‐refractory clones in paediatric acute lymphoblastic leukaemia ⬇️

artículo científico publicado el 21 de octubre de 2011

CD22ΔE12 as a molecular target for RNAi therapy

artículo científico publicado en 2015

CD22ΔE12 as a molecular target for corrective repair using RNA trans-splicing: anti-leukemic activity of a rationally designed RNA trans-splicing molecule

artículo científico publicado en 2015

CD95 (APO-1/FAS) deficiency in infant acute lymphoblastic leukemia: detection of novel soluble Fas splice variants

artículo científico publicado en 2003

CNS activity of Pokeweed anti-viral protein (PAP) in mice infected with lymphocytic choriomeningitis virus (LCMV)

artículo científico publicado en 2005

COBRA-1, a rationally-designed epoxy-THF containing compound with potent tubulin depolymerizing activity as a novel anticancer agent

scientific article published on 01 June 2000

CYP1A-Mediated Metabolism of the Janus Kinase-3 Inhibitor 4-(4′-Hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: Structural Basis for Inactivation by Regioselective O-Demethylation ⬇️

artículo científico publicado el 1 de enero de 2002

Calphostin C triggers calcium-dependent apoptosis in human acute lymphoblastic leukemia cells.

artículo científico publicado en 1998

Cathepsin inhibition induces apoptotic death in human leukemia and lymphoma cells

scientific article published on 01 October 2000

Chemoprevention of colorectal cancer by targeting Janus kinase 3 with a rationally designed small molecule inhibitor

artículo científico publicado en 2010

Chemosensitizing anti-cancer activity of LFM-A13, a leflunomide metabolite analog targeting polo-like kinases

artículo científico publicado en 2007

Clinical activity of folinic acid in patients with chronic fatigue syndrome

artículo científico publicado en 2006

Clinical development of microbicides for the prevention of HIV infection

artículo científico publicado en 2004

Clinical features and treatment outcome of childhood T-lineage acute lymphoblastic leukemia according to the apparent maturational stage of T-lineage leukemic blasts: a Children's Cancer Group study

artículo científico publicado en 1997

Clinical potential of targeting Bruton's tyrosine kinase

artículo científico publicado en 2008

Clinical significance of deletions of chromosome arm 6q in childhood acute lymphoblastic leukemia: a report from the Children's Cancer Group

artículo científico publicado en 2000

Clinical significance of translocation t(1;19) in childhood acute lymphoblastic leukemia in the context of contemporary therapies: a report from the Children's Cancer Group ⬇️

artículo científico publicado el 1 de febrero de 1998

Conceival, a novel noncontraceptive vaginal vehicle for lipophilic microbicides

artículo científico publicado en 2005

Constitutive function of the Ikaros transcription factor in primary leukemia cells from pediatric newly diagnosed high-risk and relapsed B-precursor ALL patients

artículo científico publicado en 2013

Contraceptive activity of a spermicidal aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-05) in rabbits

artículo científico publicado en 2003

Contraceptive activity of a spermicidal aryl phosphate derivative of bromo-methoxy-zidovudine (compound WHI-07) in rabbits ⬇️

artículo científico publicado el 1 de abril de 2003

Correction: Stampidine prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virus

artículo científico publicado en 2004

Cysteine chloromethyl and diazomethyl ketone derivatives with potent anti-leukemic activity

artículo científico publicado en 2000

Dawn of non-nucleoside inhibitor-based anti-HIV microbicides

artículo científico publicado en 2006

Defective expression of Bruton's tyrosine kinase in acute lymphoblastic leukemia

artículo científico publicado en 2003

Deletion of 7p or monosomy 7 in pediatric acute lymphoblastic leukemia is an adverse prognostic factor: a report from the Children's Cancer Group

artículo científico publicado en 2004

Development and evaluation of a thermoreversible ovule formulation of stampidine, a novel nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide

artículo científico publicado en 2003

Development of Polypeptide-based Nanoparticles for Non-viral Delivery of CD22 RNA Trans-splicing Molecule as a New Precision Medicine Candidate Against B-lineage ALL.

artículo científico publicado en 2015

Developmental Toxicology Studies of WHI-07, a Novel Nucleoside Analogue-Based Dual-Function Microbicide, Administered Intravaginally to Rabbits ⬇️

artículo científico publicado el 1 de noviembre de 2003

Developmental safety profile of the anti-HIV agent stampidine in rabbits

artículo científico publicado en 2006

Differential effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on the radiation sensitivity of normal versus leukemic bone marrow progenitor cell populations

artículo científico publicado en 1997

Dimeric drug polymeric nanoparticles with exceptionally high drug loading and quantitative loading efficiency

artículo científico publicado en 2015

Discovery of 2,5-dimethoxy-substituted 5-bromopyridyl thiourea (PHI-236) as a potent broad-spectrum anti-human immunodeficiency virus microbicide

artículo científico publicado en 2005

Donor-specific unmodified bone marrow transfusion does not facilitate intestinal engraftment after bowel transplantation in a porcine model

scientific article published on 01 January 1997

Dual targeting of Bruton's tyrosine kinase and Janus kinase 3 with rationally designed inhibitors prevents graft-versus-host disease (GVHD) in a murine allogeneic bone marrow transplantation model

artículo científico publicado en 2004

EGF-genistein inhibits neointimal hyperplasia after vascular injury in an experimental restenosis model

scientific article published on 01 April 2000

Effect of pretreatment of semen with pokeweed antiviral protein on pregnancy outcome in the rabbit model

artículo científico publicado en 2001

Effect of stereo and regiochemistry towards wild and multidrug resistant HIV-1 virus: viral potency of chiral PETT derivatives

artículo científico publicado en 2004

Effect of stereochemistry on the anti-HIV activity of chiral thiourea compounds

artículo científico publicado en 2004

Effect of targeted disruption of signal transducer and activator of transcription (Stat)4 and Stat6 genes on the autoimmune diabetes development induced by multiple low doses of streptozotocin

artículo científico publicado en 2005

Effect of targeting janus kinase 3 on the development of intestinal tumors in the adenomatous polyposis coli(min) mouse model of familial adenomatous polyposis

scientific article published on 01 January 2007

Effects of aryl substituents on the anti-HIV activity of the arylphosphoramidate derivatives of stavudine

artículo científico publicado en 2002

Effects of recombinant growth factors on radiation survival of human bone marrow progenitor cells

artículo científico publicado en 1989

Effects of the intermolecular toxin-monoclonal antibody linkage on the in vivo stability, immunogenicity and anti-leukemic activity of B43 (anti-CD19) pokeweed antiviral protein immunotoxin

artículo científico publicado en 1993

Enhanced transmembrane signalling activity of monoclonal antibody heteroconjugates suggests molecular interactions between receptors on the T cell surface

artículo científico publicado en 1989

Evaluating dissolution profiles of an anti-HIV agent using ANOVA and non-linear regression models in JMP software

artículo científico publicado en 2003

Evaluation of local tolerance of the antiretroviral spermicide (WHI-07)-loaded gel-microemulsion in the porcine female reproductive tract

artículo científico publicado en 2008

Evaluation of temozolomide in a SCID mouse model of human B-cell precursor leukemia

artículo científico publicado en 1999

Evaluation of the pharmacokinetic features and tissue distribution of the potent nonnucleoside inhibitor of HIV-1 reverse transcriptase, N-[2-(2-fluorophenethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-240) with an analytical HPLC method

artículo científico publicado en 1999

Ex vivo elimination of neoplastic T-cells from human marrow using an anti-Mr 41,000 protein immunotoxin: potentiation by ASTA Z 7557

scientific article published on 01 January 1985

Exposure of B-lineage lymphoid cells to low energy electromagnetic fields stimulates Lyn kinase

artículo científico publicado en 1995

Expression of BCR-ABL, E2A-PBX1, and MLL-AF4 Fusion Transcripts in Newly Diagnosed Children with Acute Lymphoblastic Leukemia: A Children's Cancer Group Initiative ⬇️

artículo científico publicado el 1 de junio de 1997

Expression of TEL-AML1 Fusion Transcripts and Response to Induction Therapy in Standard Risk Acute Lymphoblastic Leukemia

scientific article published on 01 June 2001

Expression of a unique helios isoform in human leukemia cells

artículo científico publicado en 2002

Favorable pharmacodynamic features and superior anti-leukemic activity of B43 (anti-CD19) immunotoxins containing two pokeweed antiviral protein molecules covalently linked to each monoclonal antibody molecule

scientific article published on 01 June 1995

Frequency and clinical significance of cytogenetic abnormalities in pediatric T-lineage acute lymphoblastic leukemia: a report from the Children's Cancer Group ⬇️

artículo científico publicado el 1 de abril de 1998

Gene expression profiles of infant acute lymphoblastic leukaemia and its prognostically distinct subsets

artículo científico publicado en 2010

Genomic studies of the spleen protein tyrosine kinase locus reveal a complex promoter structure and several genetic variants

artículo científico publicado en 2002

Granulocyte-macrophage colony-stimulating factor receptor-targeted therapy of chemotherapy- and radiation-resistant human myeloid leukemias

artículo científico publicado en 1997

High resolution X-ray structure and potent anti-HIV activity of recombinant dianthin antiviral protein

artículo científico publicado en 2004

High resolution X-ray structure of potent anti-HIV pokeweed antiviral protein-III ⬇️

artículo científico publicado el 15 de mayo de 2003

Highly sensitive liquid chromatography-electrospray mass spectrometry (LC-MS) method for the determination of etoposide levels in human serum and plasma

scientific article published on 01 July 2000

Human sperm immobilizing activity of aminophenyl arsenic acid and its N-substituted quinazoline, pyrimidine, and purine derivatives: protective effect of glutathione

artículo científico publicado en 2002

IGF-1 receptor targeted nanoparticles for image-guided therapy of stroma-rich and drug resistant human cancer

artículo científico publicado en 2016

IGF1 Receptor Targeted Theranostic Nanoparticles for Targeted and Image-Guided Therapy of Pancreatic Cancer

artículo científico publicado en 2015

Immunophenotype predicts radiation resistance in T-lineage acute lymphoblastic leukemia and T-lineage non-Hodgkin's lymphoma

artículo científico publicado el 1 de enero de 1992

Immunotoxins for ex vivo marrow purging in autologous bone marrow transplantation for acute nonlymphocytic leukemia

artículo científico publicado en 1988

Improved clinical outcome for children with T-lineage acute lymphoblastic leukemia after contemporary chemotherapy: a Children's Cancer Group Study

scientific article published on 01 December 1996

Improved oral bioavailability of anti-HIV agent N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (HI-443) in a novel lipophilic formulation

artículo científico publicado en 2007

In Vivo., Toxicity and Pharmacokinetic Features of B43(Anti-CD19)-Genistein Immunoconjugate ⬇️

artículo científico publicado el 1 de julio de 1998

In vitro activity of stampidine against primary clinical human immunodeficiency virus isolates

artículo científico publicado en 2004

In vitro and in vivo anti-leukemic efficacy of cyclic AMP modulating agents against human leukemic B-cell precursors

artículo científico publicado en 1996

In vitro and in vivo chemosensitizing activity of LFM-A13, a dual-function inhibitor of Bruton's tyrosine kinase and polo-like kinases, against human leukemic B-cell precursors

artículo científico publicado en 2011

In vitro and in vivo pharmacokinetic features and metabolism of the novel cytotoxic nucleoside analog 3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate] (Compound 003).

artículo científico publicado en 2004

In vitro anti-HIV potency of stampidine alone and in combination with standard anti-HIV drugs

artículo científico publicado en 2005

In vivo antiretroviral activity of stampidine in chronically feline immunodeficiency virus-infected cats

artículo científico publicado en 2003

In vivo pharmacokinetic features, toxicity profile, and chemosensitizing activity of alpha-cyano-beta-hydroxy-beta- methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13), a novel antileukemic agent targeting Bruton's tyrosine kinase.

artículo científico publicado en 2002

In vivo pharmacokinetics and toxicity of a novel hydrophilic oral formulation of the potent non-nucleoside reverse transcriptase inhibitor compound N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (HI-443)

scientific article published on 01 January 2007

In vivo pharmacokinetics and toxicity profile of the anti-HIV agent stampidine in dogs and feline immunodeficiency virus-infected cats

artículo científico publicado en 2006

In vivo pharmacokinetics, metabolism, toxicity, and anti-HIV activity of N'-[2-(2-Thiophene)ethyl]-N'-[2-(5-bromopyridyl)]thiourea (HI-443), a potent non-nucleoside inhibitor of HIV reverse transcriptase

artículo científico publicado en 2007

In vivo toxicity and antithrombotic profile of the oral formulation of the antileukemic agent, LFM-A13-F.

artículo científico publicado en 2004

In vivo toxicity and pharmacokinetic features of the janus kinase 3 inhibitor WHI-P131 [4-(4'hydroxyphenyl)-amino-6,7- dimethoxyquinazoline

artículo científico publicado en 1999

In vivo toxicity, pharmacokinetic features, and immunogenicity of B43(Anti-CD19)-genistein immunoconjugate in mice and non-human primates

artículo científico publicado en 1999

In vivo toxicity, pharmacokinetics, and anti-human immunodeficiency virus activity of stavudine-5'-(p-bromophenyl methoxyalaninyl phosphate) (stampidine) in mice

artículo científico publicado en 2002

Incidence and biological significance of IKZF1/Ikaros gene deletions in pediatric Philadelphia chromosome negative and Philadelphia chromosome positive B-cell precursor acute lymphoblastic leukemia

artículo científico publicado en 2013

Increased efficacy in selective elimination of leukemic cell line clonogenic cells by a combination of monoclonal antibodies BA-1, BA-2, BA-3 + complement and mafosfamid (ASTA Z 7557)

artículo científico publicado en 1986

Increased hydroxyl radical production and apoptosis in PC12 neuron cells expressing the gain-of-function mutant G93A SOD1 gene

artículo científico publicado en 1999

Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network

artículo científico publicado en 2011

Influence of long-term stability conditions on microbicidal nucleoside prodrug (WHI-07)-loaded gel-microemulsion

artículo científico publicado en 2006

Inhibition of mast cell leukotriene release by thiourea derivatives

artículo científico publicado en 2003

Inhibitor of HIV-1 reverse transcriptase: N'-(5-bromo-2-pyridyl)-N-[2-(2,5-dimethoxyphenyl)ethyl]thiourea

scientific article published on 01 December 1999

Innovative treatment programs against cancer. I. Ras oncoprotein as a molecular target

artículo científico publicado en 1998

Innovative treatment programs against cancer: II. Nuclear factor-kappaB (NF-kappaB) as a molecular target

artículo científico publicado en 1999

Interleukin 7 receptor engagement stimulates tyrosine phosphorylation, inositol phospholipid turnover, proliferation, and selective differentiation to the CD4 lineage by human fetal thymocytes

artículo científico publicado en 1991

Interleukin 7 receptor ligation stimulates tyrosine phosphorylation, inositol phospholipid turnover, and clonal proliferation of human B-cell precursors ⬇️

artículo científico publicado el 1 de mayo de 1991

JAK3 pathway is constitutively active in B-lineage acute lymphoblastic leukemia ⬇️

artículo científico publicado el 11 de noviembre de 2010

Janus kinase 3 inhibitor WHI-P131/JANEX-1 prevents graft-versus-host disease but spares the graft-versus-leukemia function of the bone marrow allografts in a murine bone marrow transplantation model

scientific article published on 01 June 2002

KU HAPLOINSUFFIENCY CAUSES A LYMPHOPROLIFERATIVE DISORDER OF IMMATURE T-CELL PRECURSORS DUE TO IKAROS MALFUNCTION.

artículo científico publicado en 2013

Large-scale synthesis and formulation of GMP-grade stampidine, a new anti-HIV agent

scientific article published on 01 February 2006

Large-scale synthesis of GMP grade N'- [2-(2-thiophene) ethyl]-N'- [2- (5-bromopyridyl)] -thiourea (HI-443), a new anti-HIV drug candidate

scientific article published on 01 January 2007

Large-scale synthesis of GMP grade alpha-cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl) propenamide (LFM-A13), a new anti-cancer drug candidate

artículo científico publicado en 2007

Limitations of the human-PBL-SCID mouse model for vaginal transmission of HIV-1

artículo científico publicado en 2007

Liposomal Nanoparticles of a Spleen Tyrosine Kinase P-Site Inhibitor Amplify the Potency of Low Dose Total Body Irradiation Against Aggressive B-Precursor Leukemia and Yield Superior Survival Outcomes in Mice

artículo científico publicado en 2015

Low Dose Total Body Irradiation Combined With Recombinant CD19-Ligand × Soluble TRAIL Fusion Protein is Highly Effective Against Radiation-Resistant B-Precursor Acute Lymphoblastic Leukemia in Mice

artículo científico publicado en 2015

Metabolism of stavudine-5'-[p-bromophenyl methoxyalaninyl phosphate], stampidine, in mice, dogs, and cats

artículo científico publicado en 2002

Metvan: a novel oxovanadium(IV) complex with broad spectrum anticancer activity

artículo científico publicado en 2002

Modeling and alanine scanning mutagenesis studies of recombinant pokeweed antiviral protein

artículo científico publicado en 2000

Mucosal safety of PHI-443 and stampidine as a combination microbicide to prevent genital transmission of HIV-1

artículo científico publicado en 2007

Mucosal toxicity studies of a gel formulation of native pokeweed antiviral protein

artículo científico publicado en 2004

N'-[2-(2-thiophene) ethyl]-N'-[2-(5-bromopyridyl)]thiourea (HI-443), a rationally designed non-nucleoside reverse transcriptase inhibitor compound with potent anti-HIV activity

artículo científico publicado en 2007

N-[2-(4-methylphenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea as a potent inhibitor of NNRTI-resistant and multidrug-resistant human immunodeficiency virus type 1.

artículo científico publicado en 2000

Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia ⬇️

artículo científico publicado el 8 de abril de 2013

Non-receptor tyrosine kinases as molecular targets for patient tailored cancer therapy

scientific article published on 01 November 2007

Novel Bruton's tyrosine kinase inhibitors currently in development ⬇️

artículo científico publicado el 6 de marzo de 2013

Novel broad-spectrum thiourea non-nucleoside inhibitors for the prevention of mucosal HIV transmission

artículo científico publicado en 2006

Novel tight binding PETT, HEPT and DABO-based non-nucleoside inhibitors of HIV-1 reverse transcriptase

artículo científico publicado en 2006

Organic phenyl arsonic acid compounds with potent antileukemic activity

artículo científico publicado en 2003

PHI-443: a novel noncontraceptive broad-spectrum anti-human immunodeficiency virus microbicide

artículo científico publicado en 2004

Pharmacokinetic features and metabolism of calphostin C, a naturally occurring perylenequinone with antileukemic activity

artículo científico publicado en 1999

Pharmacokinetics and biodistribution of radioimmunoconjugates of anti-CD19 antibody and single-chain Fv for treatment of human B-cell malignancy

artículo científico publicado en 1998

Pharmacokinetics and biologic activity of the novel mast cell inhibitor, 4-(3-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline in mice

artículo científico publicado en 1999

Phenyl phosphoramidate derivatives of stavudine as anti-HIV agents with potent and selective in-vitro antiviral activity against adenovirus

artículo científico publicado en 2004

Phenylarsonic acid compounds with broad-spectrum and potent cytotoxic activity against human cancer cells

artículo científico publicado en 2003

Piperidinylethyl, phenoxyethyl and fluoroethyl bromopyridyl thiourea compounds with potent anti-HIV activity

artículo científico publicado en 2000

Plant resistance to fungal infection induced by nontoxic pokeweed antiviral protein mutants

artículo científico publicado en 1997

Polo-like-kinase 1 (PLK1) as a molecular target to overcome SYK-mediated resistance of B-lineage acute lymphoblastic leukaemia cells to oxidative stress

artículo científico publicado en 2009

Poor treatment outcome of Philadelphia chromosome-positive pediatric acute lymphoblastic leukemia despite intensive chemotherapy

artículo científico publicado en 1999

Potency of stampidine against multi-nucleoside reverse transcriptase inhibitor resistant human immunodeficiency viruses

scientific article published on 01 February 2006

Potent dual anti-HIV and spermicidal activities of novel oxovanadium(V) complexes with thiourea non-nucleoside inhibitors of HIV-1 reverse transcriptase

artículo científico publicado en 2003

Pre-clinical safety evaluation of novel nucleoside analogue-based dual-function microbicides (WHI-05 and WHI-07).

artículo científico publicado en 2002

Preclinical evaluation of a dual-acting microbicidal prodrug WHI-07 in combination with vanadocene dithiocarbamate in the female reproductive tract of rabbit, pig, and cat.

artículo científico publicado en 2007

Preclinical toxicity and pharmacokinetics of the Bruton's tyrosine kinase-targeting anti-leukemic drug candidate, alpha-cyano-beta-hydroxy-beta-methyl-N- (2,5-dibromophenyl) propenamide (LFM-A13).

artículo científico publicado en 2007

Prevention of UVB-induced skin inflammation, genotoxicity, and photocarcinogenesis in mice by WHI-P131, a dual-function inhibitor of Janus kinase 3 and EGF receptor kinase

artículo científico publicado en 2010

Prevention of islet allograft rejection in diabetic mice by targeting Janus Kinase 3 with 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (JANEX-1).

artículo científico publicado en 2003

Production of a pokeweed antiviral protein (PAP)-containing immunotoxin, B43-PAP, directed against the CD19 human B lineage lymphoid differentiation antigen in highly purified form for human clinical trials

scientific article published on 01 February 1991

Prognostic Significance of B-Lineage Leukemic Cell Growth in SCID Mice: A Children's Cancer Group Study ⬇️

artículo científico publicado el 1 de agosto de 1998

Prognostic impact of trisomies of chromosomes 10, 17, and 5 among children with acute lymphoblastic leukemia and high hyperdiploidy (> 50 chromosomes)

artículo científico publicado en 2000

Protein kinase inhibitors against malignant lymphoma ⬇️

artículo científico publicado el 1 de abril de 2013

Quantitation of hydroxyl radicals produced by radiation and copper-linked oxidation of ascorbate by 2-deoxy-D-ribose method

scientific article published on 01 January 1997

Quantitative high-performance liquid chromatographic method for pharmacokinetic studies of the potent mast cell inhibitor 4-(4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P131).

artículo científico publicado en 1999

Quantitative high-performance liquid chromatography-based detection method for calphostin C, a naturally occurring perylenequinone with potent antileukemic activity

scientific article published on 01 March 1999

Radiation and heat sensitivity of human T-lineage acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML) clones displaying multiple drug resistance (MDR).

artículo científico publicado en 1992

Radiation resistance of primary clonogenic blasts from children with acute lymphoblastic leukemia

artículo científico publicado en 1993

Radiobiological features of human pluripotent bone marrow progenitor cells (CFU-GEMM)

artículo científico publicado en 1989

Radiobiological heterogeneity of leukemic lymphocyte precursors from acute lymphoblastic leukemia patients

scientific article published on 01 November 1989

Rational design and synthesis of phenethyl-5-bromopyridyl thiourea derivatives as potent non-nucleoside inhibitors of HIV reserve transcriptase

artículo científico publicado en 1998

Rational design of an immunoconjugate for selective knock-down of leukemia-specific E2A-PBX1 fusion gene expression in human Pre-B leukemia

artículo científico publicado en 2013

Recipient preconditioning and donor-specific bone marrow infusion in a pig model of total bowel transplantation

artículo científico publicado en 1997

Recombinant human CD19L-sTRAIL effectively targets B cell precursor acute lymphoblastic leukemia

artículo científico publicado en 2015

Recombinant human CD19‐ligand protein as a potent anti‐leukaemic agent ⬇️

artículo científico publicado el 17 de febrero de 2011

Redox-responsive, reversibly-crosslinked thiolated cationic helical polypeptides for efficient siRNA encapsulation and delivery

artículo científico publicado en 2015

Reduced folate carrier and dihydrofolate reductase expression in acute lymphocytic leukemia may predict outcome: a Children's Cancer Group Study

artículo científico publicado en 2003

Regulatory phosphorylation of Ikaros by Bruton's tyrosine kinase

artículo científico publicado en 2013

Role of Janus kinase 3 in mast cell-mediated innate immunity against gram-negative bacteria

scientific article published on 01 August 2001

Role of PRKCM (PKCmu) in radiation-induced increase of JUN proto-oncogene mRNA levels in B-lineage lymphoid cells

artículo científico publicado en 2000

Role of STAT6 in IgE Receptor/FcεRI-Mediated Late Phase Allergic Responses of Mast Cells ⬇️

artículo científico publicado el 1 de enero de 2002

Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation

artículo científico publicado en 2001

Role of the leukemia-associated transcription factor STAT3 in platelet physiology

artículo científico publicado en 2002

Role of tyrosine phosphorylation in radiation-induced cell cycle-arrest of leukemic B-cell precursors at the G2-M transition checkpoint

artículo científico publicado en 1996

STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress

artículo científico publicado en 2010

SYK and LYN mediate B-cell receptor-independent calcium-induced apoptosis in DT-40 lymphoma B-cells

artículo científico publicado en 2002

SYK as a New Therapeutic Target in B-Cell Precursor Acute Lymphoblastic Leukemia

artículo científico publicado en 2014

Selective homing of human leukemic B-cell precursors to specific lymphohematopoietic microenvironments in SCID mice: a role for the beta 1 integrin family surface adhesion molecules VLA-4 and VLA-5

scientific article published on 01 September 1996

Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros ⬇️

artículo científico publicado el 15 de octubre de 2012

Signal transduction through the CD19 receptor during discrete developmental stages of human B-cell ontogeny ⬇️

artículo científico publicado el 5 de octubre de 1993

Signal transduction through the beta1 integrin family surface adhesion molecules VLA-4 and VLA-5 of human B-cell precursors activates CD19 receptor-associated protein-tyrosine kinases

artículo científico publicado en 1996

Site-specific enzymatic activation of the anti-HIV agent stampidine

scientific article published on 01 February 2006

Size-Dependent Tumor Penetration and in Vivo Efficacy of Monodisperse Drug–Silica Nanoconjugates ⬇️

artículo científico publicado el 12 de febrero de 2013

Spermicidal activity of oxovanadium(IV) complexes of 1, 10-phenanthroline, 2,2'-bipyridyl, 5'-bromo-2'-hydroxyacetophenone and derivatives in humans

artículo científico publicado en 1999

Spleen tyrosine kinase (Syk) deficiency in childhood pro-B cell acute lymphoblastic leukemia

artículo científico publicado en 2001

Spleen tyrosine kinase as a molecular target for treatment of leukemias and lymphomas ⬇️

artículo científico publicado el 1 de septiembre de 2010

Stampidine as a novel nucleoside reverse transcriptase inhibit with potent anti-HIV activity

artículo científico publicado en 2006

Stampidine as a promising antiretroviral drug candidate for pre-exposure prophylaxis against sexually transmitted HIV/AIDS ⬇️

artículo científico publicado el 24 de febrero de 2012

Stampidine is a potent inhibitor of Zidovudine- and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations

artículo científico publicado en 2002

Stampidine is a potential nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide

artículo científico publicado en 2004

Stampidine prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virus

artículo científico publicado en 2004

Stampidine: a selective oculo-genital microbicide

artículo científico publicado en 2005

Stereochemistry as a Major Determinant of the Anti-HIV Activity of Chiral Naphthyl Thiourea Compounds ⬇️

artículo científico publicado el 1 de julio de 2001

Stimulation of Bruton's tyrosine kinase (BTK) and inositol 1,4,5-trisphosphate production in leukemia and lymphoma cells exposed to low energy electromagnetic fields

scientific article published on 01 December 2000

Structural and biological characterization of a novel spermicidal vanadium(IV) complex: bis(pi-cyclopentadienyl)-N,N-diethyl dithiocarbamato vanadium(IV) tetrafluoro borate, [VCp2(DeDtc)](BF4).

artículo científico publicado en 1998

Structural requirements for potent anti-human immunodeficiency virus (HIV) and sperm-immobilizing activities of cyclohexenyl thiourea and urea non-nucleoside inhibitors of HIV-1 reverse transcriptase.

artículo científico publicado en 2002

Structure-based design and engineering of a nontoxic recombinant pokeweed antiviral protein with potent anti-human immunodeficiency virus activity

artículo científico publicado en 2003

Structure-based design of a novel synthetic spiroketal pyran as a pharmacophore for the marine natural product spongistatin 1

scientific article published on 01 March 2000

Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents

artículo científico publicado en 1999

Studies in humans on the mechanism of potent spermicidal and apoptosis-inducing activities of vanadocene complexes

artículo científico publicado en 2000

Subchronic (13-week) toxicity studies of intravaginal administration of spermicidal vanadocene acetylacetonato monotriflate in mice ⬇️

artículo científico publicado el 15 de enero de 2002

Subchronic (13-week) toxicity studies of intravaginal administration of spermicidal vanadocene dithiocarbamate in mice ⬇️

artículo científico publicado el 1 de septiembre de 2001

Substituted heterocyclic thiourea compounds as a new class of anti-allergic agents inhibiting IgE/Fc epsilon RI receptor mediated mast cell leukotriene release

artículo científico publicado en 2003

Suppression of Hepatic Inflammation via Systemic siRNA Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide Hybrid Nanoparticles

artículo científico publicado en 2016

Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation

artículo científico publicado en 2013

Synthesis and Structure of Bis(π-cyclopentadienyl)vanadium(IV) 1,10-Phenanthroline and 2,2‘-Bipyridine Compounds and Their Interactions with Artificial Membranes ⬇️

artículo científico publicado el 9 de agosto de 1999

Synthesis and anti-HIV activity of carbamates of antiviral agent stavudine

artículo científico publicado en 2002

Synthesis, X-ray structure, and anti-leukemic activity of oxovanadium(IV) complexes

artículo científico publicado en 2000

Synthesis, separation and anti-HIV activity of distereoisomers of N-[p-(4-bromophenyl) -2',3'-didehydro-3'-deoxy-5'-thymidylyl]-L-alanine methyl ester (stampidine).

artículo científico publicado en 2006

Targeting JAK3 and BTK tyrosine kinases with rationally-designed inhibitors

artículo científico publicado en 2006

Targeting JAK3 tyrosine kinase-linked signal transduction pathways with rationally-designed inhibitors

artículo científico publicado en 2007

Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice

artículo científico publicado en 2003

Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis

artículo científico publicado en 1999

Targeting Janus kinase 3 in the treatment of leukemia and inflammatory diseases

artículo científico publicado en 2004

Targeting Janus kinase 3 to attenuate the severity of acute graft-versus-host disease across the major histocompatibility barrier in mice

scientific article published on 01 September 2001

Targeting Mantle Cell Lymphoma with Anti-SYK Nanoparticles.

artículo científico publicado en 2012

Targeting SYK kinase-dependent anti-apoptotic resistance pathway in B-lineage acute lymphoblastic leukaemia (ALL) cells with a potent SYK inhibitory pentapeptide mimic

artículo científico publicado en 2010

Targeting leukemic stem cells with multifunctional bioactive polypeptide nanoparticles

artículo científico publicado en 2015

Targeting mast cells in endometriosis with janus kinase 3 inhibitor, JANEX-1.

artículo científico publicado en 2007

Ten-year survival of children with acute lymphoblastic leukemia: a report from the Children's Oncology Group

artículo científico publicado en 2008

The Anti-leukemic Bruto n's Tyrosine Kinase Inhibitor α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl) Propenamide (LFM-A13) Prevents Fatal Thromboembolism ⬇️

artículo científico publicado el 1 de septiembre de 2003

The S-alkyl chain length as a determinant of the anti-leukemic activity of cysteine chloromethyl ketone compounds

artículo científico publicado en 2000

Therapeutic nanoparticle constructs of a JAK3 tyrosine kinase inhibitor against human B-lineage ALL cells

artículo científico publicado en 2010

Thermal sensitivity and thermal tolerance of human B-lineage acute lymphoblastic leukemia (ALL) cells.

artículo científico publicado en 1990

Three leflunomide metabolite analogs

artículo científico publicado en 2000

Thrombopoietin induces p-selectin expression on platelets and subsequent platelet/leukocyte interactions

artículo científico publicado en 2002

Toxicity and pharmacokinetics of stampidine in mice and rats

artículo científico publicado en 2003

Toxicity profile of the investigational new biotherapeutic agent, B43 (anti-CD19)-pokeweed antiviral protein immunotoxin

scientific article published on 01 June 1996

Treatment of BCL-1 murine B-cell leukemia with recombinant cytokines. Comparative analysis of the anti-leukemic potential of interleukin 1 beta (IL-1 beta), interleukin 2 (IL-2), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF alpha), granulo

scientific article published on 01 May 1992

Treatment of Human B-Cell Precursor Leukemia in SCID Mice by Using a Combination of the Anti-CD19 Immunotoxin B43-PAP with the Standard Chemotherapeutic Drugs Vincristine, Methylprednisolone, and L-Asparaginase ⬇️

artículo científico publicado el 1 de septiembre de 1998

Treatment of atherosclerosis in apolipoprotein E-deficient mice with 4-(3-Bromobenzoyl)-6,7-dimethoxyquinazoline (WHI-P164), a potent inhibitor of triglyceride synthesis

scientific article published on 01 February 2000

Treatment of post-bone marrow transplant acute graft-versus-host disease with a rationally designed JAK3 inhibitor

artículo científico publicado en 2002

Treatment outcome and prognostic factors for infants with acute lymphoblastic leukemia treated on two consecutive trials of the Children's Cancer Group

artículo científico publicado en 1999

Two-year toxicity and carcinogenicity studies in B(6)C(3)F(1) mice with 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate (WHI-07), a novel anti-HIV and contraceptive agent

artículo científico publicado en 2002

Tyrosine kinases as new molecular targets in treatment of inflammatory disorders and leukemia

artículo científico publicado en 2004

Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia

artículo científico publicado en 1996

Unmet challenges in HIV therapy and potential of stampidine.

artículo científico publicado en 2006

Use of Lymphoid Progenitor Cell Assays for a More Detailed Analysis of the Cytogenetic Changes Occurring During Clonal Evolution in Acute Lymphoblastic Leukemia

artículo científico publicado en 1990

Vaginal contraceptive activity of a chelated vanadocene

artículo científico publicado en 2005

Vaginal microbicides and their delivery platforms

artículo científico publicado en 2014

Vinorelbine-based salvage chemotherapy for therapy-refractory aggressive leukaemias

artículo científico publicado en 2006

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