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17-Allylamino-17-demethoxygeldanamycin (17-AAG) is effective in down-regulating mutated, constitutively activated KIT protein in human mast cells

artículo científico publicado en 2003

17AAG: low target binding affinity and potent cell activity--finding an explanation

artículo científico publicado en 2003

A USE1ful Biomarker and Molecular Target in Lung Cancer?

artículo científico publicado en 2016

A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

artículo científico publicado en 1987

A correlation of bombesin-responsiveness with myc-family gene expression in small cell lung carcinoma cell lines

artículo científico publicado en 1988

A growth factor required by plasmacytoma cells in vitro

artículo científico publicado en 1986

A molecular mechanism for the anti-inflammatory effect of taurine-conjugated 5-aminosalicylic acid in inflamed colon

artículo científico publicado en 2006

A network of its own: the unique interactome of the Hsp90 cochaperone, Sba1/p23

artículo científico publicado en 2011

A non-toxic Hsp90 inhibitor protects neurons from Abeta-induced toxicity

artículo científico publicado en 2007

A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib

artículo científico publicado en 2003

A phase I study of interleukin-2 in children with cancer

artículo científico publicado en 1992

A sensitive and rapid fluorimetric assay for monoamine oxidase utilizing high pressure liquid chromatography ⬇️

artículo científico publicado el 1 de junio de 1980

A small molecule cell-impermeant Hsp90 antagonist inhibits tumor cell motility and invasion

artículo científico publicado en 2007

A systematic protocol for the characterization of Hsp90 modulators.

artículo científico publicado en 2010

Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands.

artículo científico publicado en 2015

Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation.

artículo científico publicado en 2005

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

artículo científico publicado en 2011

Alternative splicing of the cell fate determinant Numb in hepatocellular carcinoma

artículo científico publicado en 2015

Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer

artículo científico publicado en 2012

An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans

artículo científico publicado en 2017

An acetylation site in the middle domain of Hsp90 regulates chaperone function

artículo científico publicado en 2007

An analysis of lymphocyte subpopulations in schizophrenic patients

artículo científico publicado en 1982

Analysis of oligonucleotide binding, internalization, and intracellular trafficking utilizing a novel radiolabeled crosslinker

artículo científico publicado el 1 de enero de 1992

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

artículo científico publicado en 1998

Antisense Efficacy: Site-Restricted In Vivo and Ex Vivo Models

artículo científico publicado el 1 de enero de 1996

Antisense inhibition of CHP100 C-myc expression results in reduced in vitro growth kinetics and loss of in vivo tumorigenesis

artículo científico publicado en 1994

Antisense inhibition of N-myc reduces cell growth but does not affect c-myc expression in the neuroepithelioma cell line CHP100.

artículo científico publicado en 1991

Antisense inhibition of gene expression: a tool for studying the role of NMYC in the growth and differentiation of neuroectoderm-derived cells

artículo científico publicado el 1 de octubre de 1992

Antisense inhibition of oncogene expression

artículo científico publicado el 1 de enero de 1992

Antisense inhibition of single copy N-myc expression results in decreased cell growth without reduction of c-myc protein in a neuroepithelioma cell line.

artículo científico publicado en 1990

Antisense suppression of N-myc expression inhibits the transdifferentiation of neuroectoderm tumor cell lines.

artículo científico publicado en 1991

Antisense technology: biological utility and practical considerations

artículo científico publicado en 1993

Application of high-performance liquid chromatography to the assay of biogenic amines and drugs--discussion

artículo científico publicado el 1 de octubre de 1979

Aptameric inhibition of p210bcr-abl tyrosine kinase autophosphorylation by oligodeoxynucleotides of defined sequence and backbone structure

artículo científico publicado en 1994

Aryl hydrocarbon nuclear translocator (ARNT) promotes oxygen-independent stabilization of hypoxia-inducible factor-1alpha by modulating an Hsp90-dependent regulatory pathway

artículo científico publicado en 2004

Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors

artículo científico publicado en 2014

Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation

artículo científico publicado en 2008

Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibition ⬇️

artículo científico publicado el 1 de abril de 1992

Bombesin-related peptides induce calcium mobilization in a subset of human small cell lung cancer cell lines.

artículo científico publicado en 1987

Bovine serum albumin is a major oligonucleotide-binding protein found on the surface of cultured cells

artículo científico

CHIP activates HSF1 and confers protection against apoptosis and cellular stress ⬇️

artículo científico publicado el 15 de octubre de 2003

Can the heat shock protein 90 inhibitor geldanamycin be designed to specifically inhibit HER-2 tyrosine kinase?

scientific article published on 01 August 2000

Cancer cells harboring MET gene amplification activate alternative signaling pathways to escape MET inhibition but remain sensitive to Hsp90 inhibitors

artículo científico publicado en 2009

Cancer: the rules of attraction

artículo científico publicado en 2003

Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity

artículo científico publicado en 2011

Caspase-dependent deubiquitination of monoubiquitinated nucleosomal histone H2A induced by diverse apoptogenic stimuli

artículo científico publicado en 2001

Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

artículo científico publicado en 2002

Chaperoning parasitism: the importance of molecular chaperones in pathogen virulence

artículo científico publicado en 2014

Characterization of an interleukin-6-mediated autocrine growth loop in the human multiple myeloma cell line, U266.

artículo científico publicado en 1991

Characterization of oligonucleotide transport into living cells

artículo científico publicado en 1989

Characterization of three monoclonal antibodies that recognize the interferon alpha 2 receptor

artículo científico publicado en 1990

Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity

artículo científico publicado en 2012

Cholera toxin action in the central nervous system: effects on serotonin metabolism

artículo científico publicado el 1 de enero de 1979

Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

artículo científico publicado en 2015

Clients Place Unique Functional Constraints on Hsp90.

artículo científico publicado en 2016

Colony stimulating factor-induced differentiation of murine M1 myeloid leukemia cells is permissive in early G1 phase

artículo científico publicado en 1986

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

artículo científico publicado en 2009

Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas.

artículo científico publicado en 2015

Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells

artículo científico publicado en 2012

Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides

artículo científico publicado en 1989

Computational polypharmacology analysis of the heat shock protein 90 interactome.

artículo científico publicado en 2015

Concise modular asymmetric synthesis of deguelin, tephrosin and investigation into their mode of action

artículo científico publicado en 2010

Contribution of sequence and phosphorothioate content to inhibition of cell growth and adhesion caused by c-myc antisense oligomers

artículo científico publicado en 1995

Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity

artículo científico

Coordinated regulation of serum- and glucocorticoid-inducible kinase 3 by a C-terminal hydrophobic motif and Hsp90-Cdc37 chaperone complex

artículo científico publicado en 2013

Curcumin is an inhibitor of p300 histone acetylatransferase

artículo científico publicado en 2006

Curcumin-induced degradation of ErbB2: A role for the E3 ubiquitin ligase CHIP and the Michael reaction acceptor activity of curcumin

artículo científico publicado en 2006

Cytostatic and cytotoxic activity of sex steroids against human leukemia cell lines

artículo científico publicado en 1994

Delivery of c-myc antisense phosphorothioate oligodeoxynucleotides to hematopoietic cells in culture by liposome fusion: specific reduction in c-myc protein expression correlates with inhibition of cell growth and DNA synthesis

artículo científico publicado en 1988

Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity

artículo científico publicado en 1997

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

artículo científico publicado en 1996

Detecting HSP90 phosphorylation

artículo científico publicado en 2011

Detecting Posttranslational Modifications of Hsp90.

artículo científico publicado en 2018

Detection of (11;22)(q24;q12) translocation-bearing cells in peripheral blood progenitor cells of patients with Ewing's sarcoma family of tumors

artículo científico publicado en 1995

Detection of functional interferon alpha receptors in human neuroendocrine tumor cell lines using a new monoclonal antibody

artículo científico publicado el 1 de marzo de 1992

Development of small molecule Hsp90 inhibitors: utilizing both forward and reverse chemical genomics for drug identification

artículo científico publicado en 2003

Differential expression of c-myc and the transferrin receptor in G1 synchronized M1 myeloid leukemia cells

scientific article published on 01 May 1988

Diltiazem inhibits transferrin receptor expression and causes G1 arrest in normal and neoplastic T cells

artículo científico publicado en 1986

Direct identification of ubiquitination sites on ubiquitin-conjugated CHIP using MALDI mass spectrometry

artículo científico publicado en 2005

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).

artículo científico publicado en 2017

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association ⬇️

artículo científico publicado el 13 de octubre de 1995

Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor

artículo científico publicado en 2008

Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy

artículo científico publicado en 2002

Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress

artículo científico publicado en 2007

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

scientific article published on 01 February 2020

Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine

artículo científico publicado en 2012

Dynamics-Based Discovery of Allosteric Inhibitors: Selection of New Ligands for the C-terminal Domain of Hsp90.

artículo científico publicado en 2010

Effect of over-expression of bacterial ribonuclease H on the utility of antisense MYC oligodeoxynucleotides in the monocytic leukemia cell line U937.

artículo científico publicado en 1993

Effect of the proteasome inhibitor ALLnL on cisplatin sensitivity in human ovarian tumor cells.

artículo científico publicado en 2001

Effects of chronic haloperidol on caudate 3H-spiroperidol binding in lesioned rats ⬇️

artículo científico publicado el 20 de diciembre de 1979

Electroporation enhances c-myc antisense oligodeoxynucleotide efficacy

artículo científico publicado en 1993

Electroporation of synthetic oligodeoxynucleotides: a novel technique for ex vivo bone marrow purging

scientific article published on 01 July 1996

Emetine Promotes von Hippel-Lindau-Independent Degradation of Hypoxia-Inducible Factor-2α in Clear Cell Renal Carcinoma ⬇️

artículo científico publicado el 2 de septiembre de 2010

Endoplasmic reticulum vacuolization and valosin-containing protein relocalization result from simultaneous hsp90 inhibition by geldanamycin and proteasome inhibition by velcade

scientific article published on 01 September 2006

Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality

artículo científico publicado en 2013

Enhanced c-fos expression in differentiated monomyelocytic cells is associated with differentiation and not with the position of the differentiated cells in the cell cycle

artículo científico publicado en 1987

Episome generated C-myc antisense RNA inhibits growth and tumorigenicity of a human neuroendocrine tumor-cell line

artículo científico publicado en 1995

Episome-generated N-myc antisense RNA restricts the differentiation potential of primitive neuroectodermal cell lines

artículo científico publicado en 1991

Epithelial-directed drug delivery: influence of formulation and delivery devices

artículo científico publicado en 2004

ErbB2 and NFκB overexpression as predictors of chemoradiation resistance and putative targets to overcome resistance in muscle-invasive bladder cancer

artículo científico publicado en 2011

Evidence for Neuronal Feedback Regulation of Serotonin Formation in Brain ⬇️

artículo científico publicado el 1 de enero de 1981

Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70)

artículo científico publicado en 2018

Expression of PAX3 in Ewing's sarcoma family of tumors

artículo científico

Expression of the insulin-like growth factor I receptor and urokinase plasminogen activator in breast cancer is associated with poor survival: potential for intervention with 17-allylamino geldanamycin

artículo científico publicado en 2004

Extracellular heat shock protein 90: a role for a molecular chaperone in cell motility and cancer metastasis

artículo científico publicado en 2007

FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells

artículo científico publicado en 2007

Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

artículo científico publicado en 2009

Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness

artículo científico publicado en 2004

Gambogic acid identifies an isoform-specific druggable pocket in the middle domain of Hsp90β

artículo científico publicado en 2016

Gamma/delta lineage relationship within a consecutive series of human precursor T-cell neoplasms

artículo científico publicado en 1989

Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription

artículo científico publicado en 2001

Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.

artículo científico publicado en 2003

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

artículo científico publicado en 1999

Geldanamycin selectively destabilizes and conformationally alters mutated p53

artículo científico publicado el 7 de septiembre de 1995

Geldanamycin-Induced Destabilization of Raf-1 Involves the Proteasome ⬇️

artículo científico publicado el 29 de octubre de 1997

Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

artículo científico publicado en 1997

Genetic basis of cancer of the kidney: disease-specific approaches to therapy.

artículo científico publicado en 2004

Genistein-induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity

artículo científico publicado en 1997

Genistein-stimulated adherence of prostate cancer cells is associated with the binding of focal adhesion kinase to beta-1-integrin

artículo científico publicado en 1996

Gr(i)p the ER to Stress Out Melanoma

artículo científico publicado en 2016

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

artículo científico publicado en 2005

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation.

artículo científico publicado en 2018

HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study

artículo científico publicado en 2021

Habenular modulation of raphe indoleamine metabolism

artículo científico publicado en 1980

Hamster scrapie: evidence for alterations in serotonin metabolism

artículo científico publicado en 1981

Heat shock factor 1 (HSF1)-targeted anticancer therapeutics: overview of current preclinical progress

scientific article published on 07 April 2019

Heat shock protein 90 as a molecular target for cancer therapeutics

artículo científico publicado en 2003

Heat shock protein 90 inhibition by 17-allylamino-17- demethoxygeldanamycin: a novel therapeutic approach for treating hormone-refractory prostate cancer.

artículo científico publicado en 2002

Heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin enhances EphA2+ tumor cell recognition by specific CD8+ T cells.

artículo científico publicado en 2009

Heat shock protein 90 is a rational molecular target in breast cancer

artículo científico publicado en 2002

Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha

artículo científico publicado en 2002

Heat shock protein 90.

artículo científico publicado en 2003

Heat shock protein 90: its inhibition and function

artículo científico publicado en 2018

Heat shock protein 90: the cancer chaperone

artículo científico publicado en 2007

Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response

artículo científico publicado en 2012

Heat-shock protein 90 inhibitors as novel cancer chemotherapeutic agents

scientific article published on 01 October 2002

Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an update

artículo científico publicado en 2005

Hereditary kidney cancer: unique opportunity for disease-based therapy.

artículo científico publicado en 2009

How do antisense oligodeoxynucleotides inhibit the growth of chronic myelogenous leukemia cells?

scientific article published on 01 May 1996

Hsp90 as an anti-cancer target

scientific article published on 01 June 1999

Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain

artículo científico publicado en 2009

Hsp90 in Cancer: Transcriptional Roles in the Nucleus.

artículo científico publicado en 2015

Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation

artículo científico publicado en 2006

Hsp90 inhibitors as novel cancer chemotherapeutic agents

artículo científico publicado en 2002

Hsp90 inhibitors disrupt mitochondrial homeostasis in cancer cells

scientific article published on 01 November 2007

Hsp90 inhibitors identified from a library of novobiocin analogues

artículo científico publicado en 2005

Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1.

artículo científico publicado en 2019

Hsp90 molecular chaperone inhibitors: are we there yet? ⬇️

artículo científico publicado en 2012

Hsp90 phosphorylation, Wee1 and the cell cycle

artículo científico publicado en 2010

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

artículo científico publicado en 2002

Hsp90, not Grp94, regulates the intracellular trafficking and stability of nascent ErbB2

artículo científico publicado en 2002

Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.

artículo científico publicado en 2008

Human T lymphotropic virus I infection deregulates surface expression of the transferrin receptor

artículo científico publicado en 1988

Human leukocyte antigen A2 and psychopathology in chronic schizophrenia

artículo científico publicado en 1980

Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappa B activation

artículo científico publicado en 2003

Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis.

artículo científico publicado en 2000

IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis

artículo científico publicado en 2003

Identification of the genes for kidney cancer: opportunity for disease-specific targeted therapeutics

artículo científico publicado en 2007

Immunity in migraine: the effect of heparin

scientific article published on 01 November 1981

Immunoblotting methods for the study of protein ubiquitination

artículo científico publicado en 2002

Impact of Posttranslational Modifications on the Anticancer Activity of Hsp90 Inhibitors.

artículo científico publicado en 2015

Impact of heat-shock protein 90 on cancer metastasis

artículo científico publicado en 2009

In Vivo Modulation of N-myc Expression by Continuous Perfusion with an Antisense Oligonucleotide ⬇️

artículo científico publicado el 1 de enero de 1991

In vitro enhancement of immunoglobulin gene expression in chronic lymphocytic leukemia

artículo científico publicado en 1984

In vivo degradation of N-myc in neuroblastoma cells is mediated by the 26S proteasome

artículo científico publicado en 1998

Incorporation of radiophosphorus from labeled oligodeoxynucleotides into RNA of mycoplasma in cell cultures

artículo científico publicado en 1992

Increased adenylate cyclase activity and rapid weight loss following intraseptal injection of cholera toxin

artículo científico publicado el 15 de septiembre de 1978

Increased serotonin turnover in corpus striatum following an injection of kainic acid: Evidence for neuronal feedback regulation of synthesis ⬇️

artículo científico publicado el 1 de marzo de 1979

Increased whole blood serotonin concentrations in chronic schizophrenic patients

artículo científico publicado en 1981

Increasing reactive oxygen species as a therapeutic approach to treat hereditary leiomyomatosis and renal cell carcinoma ⬇️

artículo científico publicado el 27 de octubre de 2010

Induction of Thioredoxin-Interacting Protein by a Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and Apoptosis in Esophageal Adenocarcinoma

scientific article published on 22 June 2018

Induction of differentiation in a case of common acute lymphoblastic leukemia

scientific article published on 01 November 1982

Induction of immunoglobulin secretion in follicular non-Hodgkin's lymphomas: role of immunoregulatory T cells

artículo científico publicado en 1985

Induction of megakaryocytic differentiation and modulation of protein kinase gene expression by site-selective cAMP analogs in K-562 human leukemic cells

artículo científico publicado en 1989

Influence of olfactory bulbectomy and the serotonergic system upon intermale aggression and maternal behavior in the mouse ⬇️

artículo científico publicado el 1 de julio de 1975

Inhibition of DNA synthesis by a small-cell lung carcinoma-derived protein

artículo científico publicado en 1986

Inhibition of EWS-FLI-1 fusion protein with antisense oligodeoxynucleotides

artículo científico publicado en 1997

Inhibition of HSP90 with pochoximes: SAR and structure-based insights

artículo científico publicado en 2009

Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone

artículo científico publicado en 2008

Inhibition of cancer invasion and metastasis by targeting the molecular chaperone heat-shock protein 90.

scientific article published on March 2009

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

artículo científico publicado en 1994

Inhibition of interferon-gamma-induced intercellular adhesion molecule-1 expression on human keratinocytes by phosphorothioate antisense oligodeoxynucleotides is the consequence of antisense-specific and antisense-non-specific effects

artículo científico publicado en 1995

Inhibition of protein-tyrosine kinase activity in intact cells by the aptameric action of oligodeoxynucleotides

artículo científico publicado en 1995

Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target

artículo científico publicado en 2008

Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones

artículo científico publicado en 1999

Intratumor injection of the Hsp90 inhibitor 17AAG decreases tumor growth and induces apoptosis in a prostate cancer xenograft model

artículo científico publicado en 2007

Just say NO: nitric oxide regulation of Hsp90.

artículo científico publicado en 2009

KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules

artículo científico publicado en 1999

KIT regulates tyrosine phosphorylation and nuclear localization of beta-catenin in mast cell leukemia

artículo científico publicado en 2007

Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration

artículo científico publicado en 2015

Lactacystin enhances cisplatin sensitivity in resistant human ovarian cancer cell lines via inhibition of DNA repair and ERCC-1 expression.

artículo científico publicado en 2001

Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity

artículo científico publicado en 2020

Liquid-chromatographic quantification of plasma phenylalanine, tyrosine, and tryptophan

artículo científico publicado en 1981

Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity

artículo científico publicado en 2006

Low dose geldanamycin inhibits hepatocyte growth factor and hypoxia-stimulated invasion of cancer cells

artículo científico publicado en 2007

Low-dose Hsp90 inhibitors tumor-selectively sensitize bladder cancer cells to chemoradiotherapy

artículo científico publicado en 2011

Low-grade lymphomas. Expression of developmentally regulated B-cell antigens ⬇️

artículo científico publicado el 1 de abril de 1984

Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras

artículo científico publicado en 2008

Lymphocyte monoamine oxidase activity and chronic schizophrenia

artículo científico publicado en 1980

Lymphocyte monoamine oxidase and plasma prolactin and growth hormone in tardive dyskinesia

artículo científico publicado en 1981

Lymphokine-activated killer cell phenomenon. III. Evidence that IL-2 is sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer cells

artículo científico publicado en 1983

Measurement of 5HT turnover rate in discrete nuclei of rat brain

artículo científico publicado en 1976

Measurement of tryptophan hydroxylase in single brain nuclei by high pressure liquid chromatography

artículo científico publicado en 1975

Measuring ubiquitin conjugation in cells

artículo científico publicado en 2005

Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer

artículo científico publicado en 2007

Mechanisms of disease: the role of heat-shock protein 90 in genitourinary malignancy

artículo científico publicado en 2006

Megakaryocyte differentiation: studies at the molecular level using the K-562 cell line

artículo científico publicado en 1986

Melanoma cell lines contain a proteasome-sensitive, nuclear cytoskeleton-associated pool of beta-catenin

artículo científico publicado en 1999

Metabolic and pharmacological properties of rutin, a dietary quercetin glycoside, for treatment of inflammatory bowel disease

artículo científico publicado en 2005

Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development

artículo científico publicado en 2018

Methoxychalcone inhibitors of androgen receptor translocation and function

artículo científico publicado en 2012

Microtubule disruption utilizes an NFkappa B-dependent pathway to stabilize HIF-1alpha protein

artículo científico publicado en 2002

Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells

artículo científico

Mitochondrial topoisomerase I (top1mt) is a novel limiting factor of doxorubicin cardiotoxicity

artículo científico publicado en 2014

Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism

artículo científico publicado en 2012

Mitoribosome sensitivity to HSP70 inhibition uncovers metabolic liabilities of castration-resistant prostate cancer

Modulation of brain tryptophan hydroxylase activity by brain tryptophan content ⬇️

artículo científico publicado el 1 de abril de 1977

Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228

artículo científico publicado en 2002

Modulation of prion protein structural integrity by geldanamycin

artículo científico publicado en 2003

Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

artículo científico publicado en 2013

Molecular chaperones in pathogen virulence: emerging new targets for therapy.

artículo científico publicado en 2008

Molecular diagnosis and therapy of kidney cancer

artículo científico publicado en 2010

Monitoring of the Heat Shock Response with a Real-Time Luciferase Reporter

artículo científico publicado en 2018

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors

artículo científico publicado en 2016

Muscarinic cholinergic binding sites on intact human lymphocytes ⬇️

artículo científico publicado el 6 de julio de 1981

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

artículo científico publicado en 1996

NAD glycohydrolase: enzyme characterization using intact mammalian erythrocytes ⬇️

artículo científico publicado el 1 de enero de 1982

New insights into von Hippel-Lindau function highlighted by investigation of the trichloroethylene-induced p.P81S hotspot mutation

artículo científico publicado en 2013

Non-antisense oligonucleotide approaches for experimental treatment of glioblastoma

artículo científico publicado en 1998

Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex

scientific article published on 01 September 2000

Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

artículo científico publicado en 2000

Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90.

artículo científico publicado en 2006

Nuclear beta-catenin displays GSK-3beta- and APC-independent proteasome sensitivity in melanoma cells

artículo científico publicado en 2000

Oligodeoxynucleotide inhibitors of function: mRNA and protein interactions

artículo científico publicado en 1998

Oligonucleotides protect cells from the cytotoxicity of several anti-cancer chemotherapeutic drugs

artículo científico publicado en 1994

Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells.

artículo científico publicado en 2013

Out with the old: Hsp90 finds amino acid residue more useful than co-chaperone protein

artículo científico publicado en 2017

Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function

artículo científico publicado en 2020

Phase 1 study of the HSP90 inhibitor onalespib in combination with AT7519, a pan-CDK inhibitor, in patients with advanced solid tumors

scientific article published on 23 October 2020

Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors.

artículo científico publicado en 2005

Phase I study of the heat shock protein 90 (Hsp90) inhibitor onalespib (AT13387) administered on a daily for 2 consecutive days per week dosing schedule in patients with advanced solid tumors

artículo científico publicado en 2015

Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies

artículo científico publicado en 2010

Phorbol ester enhances deoxynucleoside incorporation while inhibiting proliferation of K-562 cells

artículo científico publicado en 1985

Phorbol ester induces c-sis gene transcription in stem cell line K-562.

artículo científico publicado en 1986

Phorbol ester-induced surface transferrin receptor modulation. No correlation with decreased cell proliferation

artículo científico publicado en 1986

Phosphorothioate and normal oligodeoxyribonucleotides with 5'-linked acridine: characterization and preliminary kinetics of cellular uptake

artículo científico publicado en 1988

Phosphorothioate oligodeoxycytidine interferes with binding of HIV-1 gp120 to CD4

artículo científico publicado el 1 de enero de 1991

Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation

artículo científico publicado en 2018

Plasma levels of chlorimipramine and its demethyl metabolite during treatment of depression ⬇️

artículo científico publicado el 1 de noviembre de 1979

Plasma phenylalanine, tyrosine, and tryptophan in schizophrenia

artículo científico publicado en 1983

Polymorphonuclear neutrophils express the common acute lymphoblastic leukemia antigen ⬇️

artículo científico publicado el 1 de marzo de 1983

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

artículo científico publicado en 1996

Possible role for serine/threonine phosphorylation in the regulation of the heteroprotein complex between the hsp90 stress protein and the pp60v-src tyrosine kinase

artículo científico publicado en 1995

Post-translational modification of heat-shock protein 90: impact on chaperone function

artículo científico publicado en 2007

Post-translational modifications of Hsp90 and their contributions to chaperone regulation

artículo científico publicado en 2011

Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors

artículo científico publicado en 2013

Potential role of Hsp90 inhibitors in overcoming cisplatin resistance of bladder cancer-initiating cells

artículo científico publicado en 2011

Prevention of cisplatin-DNA adduct repair and potentiation of cisplatin-induced apoptosis in ovarian carcinoma cells by proteasome inhibitors

scientific article published on 01 November 2000

Proceedings of the Oxygen Homeostasis/Hypoxia Meeting

artículo científico publicado en 2004

Proteasome inhibition disrupts the metabolism of fumarate hydratase- deficient tumors by downregulating p62 and c-Myc

scientific article published on 05 December 2019

Protein synthesis but not DNA synthesis is required for tumor cell invasion in vitro.

artículo científico publicado en 1984

Proteomic analysis of proteome and histone post-translational modifications in heat shock protein 90 inhibition-mediated bladder cancer therapeutics

artículo científico publicado en 2017

Pseudohypoxic pathways in renal cell carcinoma

artículo científico publicado en 2007

Putative gamma-subunit of the IL-2 receptor is detected in low, intermediate, and high affinity IL-2 receptor-bearing cells

artículo científico publicado en 1990

Pyrazole-Based Lactate Dehydrogenase (LDH) Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties

artículo científico publicado en 2020

Quantification of a New Anti-Cancer Molecule MJC13 Using a Rapid, Sensitive, and Reliable Liquid Chromatography-Tandem Mass Spectrometry Method

artículo científico publicado en 2014

Quantitative determination of immunoglobulins in CSF and plasma of chronic schizophrenic patients

artículo científico publicado en 1981

Quantum chemical calculations and mutational analysis suggest heat shock protein 90 catalyzes trans-cis isomerization of geldanamycin

artículo científico publicado en 2004

Quinacrine: New anti-tumor application for an old anti-malaria drug.

artículo científico publicado en 2010

Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death.

artículo científico publicado en 1997

Rapid Deubiquitination of Nucleosomal Histones in Human Tumor Cells Caused by Proteasome Inhibitors and Stress Response Inducers: Effects on Replication, Transcription, Translation, and the Cellular Stress Response ⬇️

artículo científico publicado el 25 de noviembre de 1997

Ras, ROS and proteotoxic stress: a delicate balance

artículo científico publicado en 2011

Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia ⬇️

artículo científico publicado el 1 de julio de 1983

Reduction of tryptophan hydroxylase activity and 5-hydroxytryptamine concentration in certain rat brain nuclei after p-chloroamphetamine ⬇️

artículo científico publicado el 1 de febrero de 1976

Regulation and function of the human HSP90AA1 gene

artículo científico publicado en 2015

Regulation of BRCA1 by protein degradation

artículo científico publicado en 1999

Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase

artículo científico publicado en 2009

Regulation of Transferrin Receptor Expression and Control of Cell Growth ⬇️

artículo científico publicado el 1 de enero de 1991

Regulation of murine plasmacytoma transferrin receptor expression and G1 traversal by plasmacytoma cell growth factor

artículo científico publicado en 1988

Requirement for HDM2 activity in the rapid degradation of p53 in neuroblastoma

artículo científico publicado en 2001

Reverse transformation of Harvey murine sarcoma virus-transformed NIH/3T3 cells by site-selective cyclic AMP analogs.

artículo científico publicado en 1988

STA-8666, a novel HSP90 inhibitor/SN-38 drug conjugate, causes complete tumor regression in preclinical mouse models of pediatric sarcoma

artículo científico publicado en 2016

STA-9090, a small-molecule Hsp90 inhibitor for the potential treatment of cancer

artículo científico publicado el 1 de diciembre de 2010

Screening for inducers of kinase degradation

artículo científico publicado en 2003

Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir

artículo científico publicado en 2012

Sensitive and simple bioassay for human tumour necrosis factor-alpha

artículo científico publicado en 1993

Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition

artículo científico publicado en 2007

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

artículo científico publicado en 2001

Serotonin concentrations in brain and blood of scrapie-infected and normal hamsters and mice

artículo científico publicado en 1981

Significant non-S-phase DNA synthesis visualized by flow cytometry in activated and in malignant human lymphoid cells

artículo científico publicado en 1985

Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity.

artículo científico publicado en 2004

Site-selective cAMP analogs at micromolar concentrations induce growth arrest and differentiation of acute promyelocytic, chronic myelocytic, and acute lymphocytic human leukemia cell lines

Site-selective cyclic AMP analogs as new biological tools in growth control, differentiation, and proto-oncogene regulation

artículo científico publicado en 1989

Site-selective cyclic AMP analogs provide a new approach in the control of cancer cell growth

artículo científico publicado en 1987

Solution formulation development and efficacy of MJC13 in a preclinical model of castration-resistant prostate cancer

artículo científico publicado en 2014

Some kinetic parameters of platelet monoamine oxidase in chronic schizophrenia

artículo científico publicado en 1979

Specific inhibition of oncogene expression in vitro and in vivo by antisense oligonucleotides

artículo científico publicado en 1992

Spontaneous alteration of idiotype in a monoclonal B-cell lymphoma. Escape from detection by anti-idiotype

artículo científico publicado en 1985

Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: implications for therapeutic application within the central nervous system

artículo científico publicado en 1993

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

artículo científico publicado en 1998

Stereospecific antitumor activity of radicicol oxime derivatives

artículo científico publicado en 2001

Stimulation of the beta-subunit of the IL-2 receptor induces MHC-unrestricted cytotoxicity in T acute lymphoblastic leukemia cells and normal thymocytes

scientific article published on 01 August 1988

Stressing the development of small molecules targeting HSP90

artículo científico publicado en 2014

Studies on transferrin receptor expression in mouse plasmacytoma cells

scientific article published on 01 January 1986

Substance P afferents from the habenula innervate the dorsal raphe nucleus ⬇️

artículo científico publicado el 1 de enero de 1979

Suppression of immunoglobulin synthesis by lymphocyte subpopulations in patients with Crohn's disease

artículo científico publicado el 1 de junio de 1984

Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex.

artículo científico publicado en 2005

Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function

artículo científico publicado en 2010

Synergistic inhibition of growth of breast and colon human cancer cell lines by site-selective cyclic AMP analogues

artículo científico publicado en 1988

Synthesis and structure-activity relationship studies of novel dihydropyridones as androgen receptor modulators

artículo científico publicado en 2013

Synthesis of a stable and orally bioavailable englerin analogue

artículo científico publicado en 2016

T-lymphocytes in migraine

scientific article published on 01 November 1981

TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells

artículo científico publicado en 2013

Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer

artículo científico publicado en 2014

Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

artículo científico publicado en 2019

Targeting Hsp90 in Non-Cancerous Maladies.

artículo científico publicado en 2016

Targeting Hsp90 prevents escape of breast cancer cells from tyrosine kinase inhibition

scientific article published on 30 September 2008

Targeting heat shock protein 90 for the treatment of malignant pheochromocytoma

artículo científico publicado en 2013

Targeting loss of the Hippo signaling pathway in NF2-deficient papillary kidney cancers.

artículo científico publicado en 2018

Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer

artículo científico publicado en 2018

Targeting the dynamic HSP90 complex in cancer

artículo científico publicado en 2010

Targeting the molecular chaperone heat shock protein 90 provides a multifaceted effect on diverse cell signaling pathways of cancer cells

artículo científico publicado en 2007

Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells

artículo científico publicado en 2011

Taxol induction of p21WAF1 and p53 requires c-raf-1.

artículo científico publicado en 1995

Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway

artículo científico publicado en 1996

The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation ⬇️

artículo científico publicado el 19 de septiembre de 1997

The C-terminal half of heat shock protein 90 represents a second site for pharmacologic intervention in chaperone function

artículo científico publicado en 2003

The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with <i>pan</i>-Hsp90 Inhibition

artículo científico publicado en 2021

The GLU that holds cancer together: targeting GLUtamine transporters in breast cancer

artículo científico publicado en 2015

The HSP90 inhibitor ganetespib synergizes with the MET kinase inhibitor crizotinib in both crizotinib-sensitive and -resistant MET-driven tumor models

artículo científico publicado en 2013

The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

artículo científico publicado en 2001

The IXth CSSI international symposium on heat shock proteins in biology and medicine: stress responses in health and disease : Alexandria Old Town, Alexandria, Virginia, November 10-13, 2018

scientific article published on 01 January 2019

The action of fenfluramine andp-chloramphetamine on serotonergic mechanisms: A comparative study in rat brain nuclei

artículo científico publicado en 1976

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

artículo científico publicado en 1998

The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase

artículo científico publicado en 1999

The complex dance of the molecular chaperone Hsp90.

artículo científico publicado en 2009

The double edge of the HSP90-CDC37 chaperone machinery: opposing determinants of kinase stability and activity

artículo científico publicado en 2012

The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation

artículo científico publicado en 2008

The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome

artículo científico publicado en 2000

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

artículo científico publicado en 2000

The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells.

artículo científico publicado en 2003

The measurement of ubiquitin and ubiquitinated proteins

artículo científico publicado en 1999

The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis

artículo científico publicado en 2020

The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis

scientific article published in Nature Communications

The role of Bcl-2 protein and autocrine growth factors in a human follicular lymphoma-derived B cell line.

artículo científico publicado en 1995

The role of plasmacytoma growth factor in the in vitro responses of murine plasmacytoma cells

scientific article published on 01 January 1989

The role of the transferrin receptor in human B lymphocyte activation ⬇️

artículo científico publicado el 1 de noviembre de 1984

The therapeutic target Hsp90 and cancer hallmarks

artículo científico

Theophylline induced differentiation provides direct evidence for the deregulation of c-myc in Burkitt's lymphoma and suggests participation of immunoglobulin enhancer sequences.

artículo científico publicado en 1993

Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity

artículo científico publicado en 2011

Tonantzitlolone cytotoxicity toward renal cancer cells is PKCθ- and HSF1-dependent

artículo científico publicado en 2015

Transcriptional inactivation of c-myc and the transferrin receptor in dibutyryl cyclic AMP-treated HL-60 cells

artículo científico publicado en 1987

Transferrin Receptors Regulate Proliferation of Normal and Malignant B Cells ⬇️

artículo científico publicado el 1 de enero de 1984

Transferrin receptor expression and the control of cell growth

scientific article published on 01 January 1986

Transferrin receptor induction in mitogen-stimulated human T lymphocytes is required for DNA synthesis and cell division and is regulated by interleukin 2 ⬇️

artículo científico publicado el 1 de junio de 1983

Transferrin receptor induction is required for human B-lymphocyte activation but not for immunoglobulin secretion

scientific article published on 01 January 1985

Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive

artículo científico publicado en 2006

Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy

artículo científico publicado en 2012

Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress-induced activation of the MAP kinase JNK

scientific journal article

Tumour-specific inhibition of lymphoma growth by an antisense oligodeoxynucleotide

artículo científico publicado en 1990

UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer

artículo científico publicado en 2010

Uncoupling tumor-stroma interactions in breast cancer patients

artículo científico publicado en 2017

Understanding of the Hsp90 molecular chaperone reaches new heights ⬇️

artículo científico publicado el 1 de diciembre de 2010

Update on Hsp90 inhibitors in clinical trial.

artículo científico publicado en 2009

Using natural product inhibitors to validate Hsp90 as a molecular target in cancer

artículo científico publicado en 2006

Visualizing the twists and turns of a molecular chaperone.

artículo científico publicado en 2009

aHIF: the missing link between HIF-1 and VHL?

artículo científico publicado en 1999

bcl-2 protein downregulation is not required for differentiation of multidrug resistant HL60 leukemia cells

artículo científico publicado en 1996

c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells

artículo científico publicado en 2015

c-myc protein in normal tissue. Effects of fixation on its apparent subcellular distribution

artículo científico publicado en 1988

p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

artículo científico publicado en 1996

p53 inhibits hypoxia-inducible factor-stimulated transcription

scientific article published on 01 May 1998

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