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A high-content screen identifies inhibitors of nuclear export of forkhead transcription factors.

artículo científico publicado en 2011

A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury

scientific article published on 21 April 2020

A phosphotyrosine switch regulates organic cation transporters

artículo científico publicado en 2016

An automated approach to efficiently reformat a large collection of compounds.

artículo científico publicado en 2011

BRAF inhibition protects against hearing loss in mice

scientific article published on 02 December 2020

Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.

artículo científico publicado en 2017

Bromodomain-selective BET inhibitors are potent antitumor agents against MYC-driven pediatric cancer

artículo científico publicado en 2020

Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5

artículo científico publicado en 2020

Development of BODIPY FL Thalidomide As a High-Affinity Fluorescent Probe for Cereblon in a Time-Resolved Fluorescence Resonance Energy Transfer Assay

artículo científico publicado en 2020

Discovery and Characterization of the Antimetabolite Action of Thioacetamide-Linked 1,2,3-Triazoles as Disruptors of Cysteine Biosynthesis in Gram-Negative Bacteria

artículo científico publicado en 2020

Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.

artículo científico publicado en 2017

Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen

artículo científico publicado en 2020

KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion

artículo científico publicado en 2020

MEKK3-MEK5-ERK5 signaling promotes mitochondrial degradation

scientific article published on 20 October 2020

Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation

artículo científico publicado en 2022

Multikinase Inhibitors Induce Cutaneous Toxicity through OAT6-Mediated Uptake and MAP3K7-Driven Cell Death

artículo científico publicado en 2015

Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning

scientific article published on 30 March 2020

Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma

artículo científico publicado en 2021

Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer

scientific article published on 28 November 2019

Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases

scientific article published on 01 October 2020

Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox

artículo científico publicado en 2017

Targeting OCT3 attenuates doxorubicin-induced cardiac injury

artículo científico publicado en 2021

The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma

artículo científico publicado en 2021

Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway

artículo científico publicado en 2017

Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway

scientific article published on 28 June 2019