Lista de obras -

A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast

artículo científico publicado en 2007

A mixture of fortunes: the curious determination of the structure of Escherichia coli BL21 Gab protein

artículo científico publicado en 2008

A recruited protease is involved in catabolism of pyrimidines

artículo científico publicado en 2008

Altered Pre-mRNA Splicing Caused by a Novel Intronic Mutation c.1443+5G>A in the Dihydropyrimidinase (DPYS) Gene

artículo científico publicado en 2016

Amidohydrolases of the reductive pyrimidine catabolic pathway purification, characterization, structure, reaction mechanisms and enzyme deficiency

artículo científico publicado en 2008

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage

artículo científico publicado en 2017

Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency.

artículo científico publicado en 2007

Clinical, biochemical and molecular analysis of 13 Japanese patients with β-ureidopropionase deficiency demonstrates high prevalence of the c.977G > A (p.R326Q) mutation [corrected].

artículo científico publicado en 2014

Corrigendum to “Dihydropyrimidine dehydrogenase: a flavoprotein with four iron–sulfur clusters” [Biochim. Biophys. Acta 1701 (2004) 61–74]

scholarly article published in BBA - Proteins and Proteomics

Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism

artículo científico publicado en 2018

Crystal structure of an arthritogenic anticollagen immune complex

artículo científico publicado en 2011

Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater ⬇️

artículo científico publicado en 2012

Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer

artículo científico publicado en 2002

Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis

artículo científico publicado en 2007

Crystal structures of yeast beta-alanine synthase complexes reveal the mode of substrate binding and large scale domain closure movements

artículo científico publicado en 2007

Crystallization and X-ray diffraction analysis of dihydropyrimidinase from Saccharomyces kluyveri.

artículo científico publicado en 2005

Crystallization and preliminary X-ray analysis of beta-alanine synthase from the yeast Saccharomyces kluyveri

artículo científico publicado en 2003

Crystallization and preliminary X-ray data analysis of beta-alanine synthase from Drosophila melanogaster.

artículo científico publicado en 2007

Dihydropyrimidinase deficiency in four East Asian patients due to novel and rare DPYS mutations affecting protein structural integrity and catalytic activity

artículo científico publicado en 2017

Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients.

artículo científico publicado en 2010

Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters

artículo científico publicado en 2004

Directed Evolution of Alcohol Dehydrogenase for Improved Stereoselective Redox Transformations of 1-Phenylethane-1,2-diol and Its Corresponding Acyloin

artículo científico publicado en 2018

Epitope-specific antibody response is controlled by immunoglobulin V H polymorphisms

artículo científico publicado en 2014

Epoxide hydrolysis as a model system for understanding flux through a branched reaction scheme

artículo científico publicado en 2018

Erratum to: Clinical, biochemical and molecular analysis of 13 Japanese patients with β-ureidopropionase deficiency demonstrates high prevalence of the c.977G > A (p.R326Q) mutation.

artículo científico publicado en 2014

Genome sequencing reveals a novel genetic mechanism underlying dihydropyrimidine dehydrogenase deficiency: A novel missense variant c.1700G > A and a large intragenic inversion in DPYD spanning intron 8 to intron 12.

artículo científico publicado en 2018

Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in

scientific article published on 01 April 2019

How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets.

artículo científico

Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes.

artículo científico publicado en 2015

Identification of three novel mutations in the dihydropyrimidine dehydrogenase gene associated with altered pre-mRNA splicing or protein function

artículo científico publicado en 2005

Insights into the mechanism of dihydropyrimidine dehydrogenase from site-directed mutagenesis targeting the active site loop and redox cofactor coordination

artículo científico publicado en 2010

Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity ⬇️

artículo científico publicado el 29 de agosto de 2010

Laboratory-Evolved Enzymes Provide Snapshots of the Development of Enantioconvergence in Enzyme-Catalyzed Epoxide Hydrolysis

artículo científico publicado en 2016

Novel PRPS1 gain-of-function mutation in a patient with congenital hyperuricemia and facial anomalies.

artículo científico publicado en 2017

Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure

artículo científico publicado en 2002

Phenotypic and clinical implications of variants in the dihydropyrimidine dehydrogenase gene

artículo científico publicado en 2016

Positional identification of RT1-B (HLA-DQ) as susceptibility locus for autoimmune arthritis.

artículo científico publicado en 2015

Purification, crystallization and X-ray diffraction analysis of dihydropyrimidinase from Dictyostelium discoideum

artículo científico publicado en 2005

Relaxation of nonproductive binding and increased rate of coenzyme release in an alcohol dehydrogenase increases turnover with a nonpreferred alcohol enantiomer

artículo científico publicado en 2017

Saccharomyces kluyveri as a model organism to study pyrimidine degradation

scientific article published on 19 September 2008

Severe fluoropyrimidine toxicity due to novel and rare DPYD missense mutations, deletion and genomic amplification affecting DPD activity and mRNA splicing

artículo científico publicado en 2016

Stereo- and Regioselectivity in Catalyzed Transformation of a 1,2-Disubstituted Vicinal Diol and the Corresponding Diketone by Wild Type and Laboratory Evolved Alcohol Dehydrogenases

Structural and Mutagenesis Studies of the Thiamine-Dependent, Ketone-Accepting YerE from Pseudomonas protegens

artículo científico publicado en 2018

Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme

artículo científico publicado en 2014

The crystal structure of beta-alanine synthase from Drosophila melanogaster reveals a homooctameric helical turn-like assembly

artículo científico publicado en 2008

The crystal structures of dihydropyrimidinases reaffirm the close relationship between cyclic amidohydrolases and explain their substrate specificity.

artículo científico publicado en 2006

Yeast β-Alanine Synthase Shares a Structural Scaffold and Origin with Dizinc-dependent Exopeptidases ⬇️

artículo científico publicado el 8 de octubre de 2003

ß-ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patients.

artículo científico publicado en 2012

Lista de obras de

A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast

A mixture of fortunes: the curious determination of the structure of Escherichia coli BL21 Gab protein

A recruited protease is involved in catabolism of pyrimidines

Altered Pre-mRNA Splicing Caused by a Novel Intronic Mutation c.1443+5G>A in the Dihydropyrimidinase (DPYS) Gene

Amidohydrolases of the reductive pyrimidine catabolic pathway purification, characterization, structure, reaction mechanisms and enzyme deficiency

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage

Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency.

Clinical, biochemical and molecular analysis of 13 Japanese patients with β-ureidopropionase deficiency demonstrates high prevalence of the c.977G > A (p.R326Q) mutation [corrected].

Corrigendum to “Dihydropyrimidine dehydrogenase: a flavoprotein with four iron–sulfur clusters” [Biochim. Biophys. Acta 1701 (2004) 61–74]

Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism

Crystal structure of an arthritogenic anticollagen immune complex

Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater ⬇️

Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer

Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis

Crystal structures of yeast beta-alanine synthase complexes reveal the mode of substrate binding and large scale domain closure movements

Crystallization and X-ray diffraction analysis of dihydropyrimidinase from Saccharomyces kluyveri.

Crystallization and preliminary X-ray analysis of beta-alanine synthase from the yeast Saccharomyces kluyveri

Crystallization and preliminary X-ray data analysis of beta-alanine synthase from Drosophila melanogaster.

Dihydropyrimidinase deficiency in four East Asian patients due to novel and rare DPYS mutations affecting protein structural integrity and catalytic activity

Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients.

Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters

Directed Evolution of Alcohol Dehydrogenase for Improved Stereoselective Redox Transformations of 1-Phenylethane-1,2-diol and Its Corresponding Acyloin

Epitope-specific antibody response is controlled by immunoglobulin V H polymorphisms

Epoxide hydrolysis as a model system for understanding flux through a branched reaction scheme

Erratum to: Clinical, biochemical and molecular analysis of 13 Japanese patients with β-ureidopropionase deficiency demonstrates high prevalence of the c.977G > A (p.R326Q) mutation.

Genome sequencing reveals a novel genetic mechanism underlying dihydropyrimidine dehydrogenase deficiency: A novel missense variant c.1700G > A and a large intragenic inversion in DPYD spanning intron 8 to intron 12.

Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in

How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets.

Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes.

Identification of three novel mutations in the dihydropyrimidine dehydrogenase gene associated with altered pre-mRNA splicing or protein function

Insights into the mechanism of dihydropyrimidine dehydrogenase from site-directed mutagenesis targeting the active site loop and redox cofactor coordination

Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity ⬇️

Laboratory-Evolved Enzymes Provide Snapshots of the Development of Enantioconvergence in Enzyme-Catalyzed Epoxide Hydrolysis

Novel PRPS1 gain-of-function mutation in a patient with congenital hyperuricemia and facial anomalies.

Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure

Phenotypic and clinical implications of variants in the dihydropyrimidine dehydrogenase gene

Positional identification of RT1-B (HLA-DQ) as susceptibility locus for autoimmune arthritis.

Purification, crystallization and X-ray diffraction analysis of dihydropyrimidinase from Dictyostelium discoideum

Relaxation of nonproductive binding and increased rate of coenzyme release in an alcohol dehydrogenase increases turnover with a nonpreferred alcohol enantiomer

Saccharomyces kluyveri as a model organism to study pyrimidine degradation

Severe fluoropyrimidine toxicity due to novel and rare DPYD missense mutations, deletion and genomic amplification affecting DPD activity and mRNA splicing

Stereo- and Regioselectivity in Catalyzed Transformation of a 1,2-Disubstituted Vicinal Diol and the Corresponding Diketone by Wild Type and Laboratory Evolved Alcohol Dehydrogenases

Structural and Mutagenesis Studies of the Thiamine-Dependent, Ketone-Accepting YerE from Pseudomonas protegens

Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme

The crystal structure of beta-alanine synthase from Drosophila melanogaster reveals a homooctameric helical turn-like assembly

The crystal structures of dihydropyrimidinases reaffirm the close relationship between cyclic amidohydrolases and explain their substrate specificity.

Yeast β-Alanine Synthase Shares a Structural Scaffold and Origin with Dizinc-dependent Exopeptidases ⬇️

ß-ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patients.