Lista de obras -

Agonism for the bile acid receptor GPBAR1 reverses liver and vascular damage in a mouse model of steatohepatitis

article

Anti-inflammatory cyclopeptides from the marine sponge Theonella swinhoei

article published in 2012

BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis

artículo científico publicado en 2017

Biomolecular Fishing for Calixarene Partners by a Chemoproteomic Approach

artículo científico publicado en 2015

Biomolecular proteomics discloses ATP synthase as the main target of the natural glycoside deglucoruscin

artículo científico publicado en 2016

Callipeltins F–I: new antifungal peptides from the marine sponge Latrunculia sp

Carbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite

artículo científico publicado en 2020

Characterization of a New Mixture of Mono-Rhamnolipids Produced by Pseudomonas gessardii Isolated from Edmonson Point (Antarctica)

artículo científico publicado en 2020

Chemical Proteomics Reveals Heat Shock Protein 60 To Be the Main Cellular Target of the Marine Bioactive Sesterterpene Suvanine

artículo científico publicado en 2012

Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol

Chemical proteomics discloses petrosapongiolide M, an antiinflammatory marine sesterterpene, as a proteasome inhibitor.

artículo científico publicado en 2010

Chemical proteomics reveals bolinaquinone as a clathrin-mediated endocytosis inhibitor.

artículo científico publicado en 2010

Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor.

artículo científico publicado en 2013

Chemistry and biology of anti-inflammatory marine natural products: molecules interfering with cyclooxygenase, NF-kappaB and other unidentified targets

artículo científico publicado en 2006

Chemoproteomic fishing identifies arzanol as a positive modulator of brain glycogen phosphorylase

artículo científico publicado en 2018

Concise Synthesis of All Stereoisomers of β-Methoxytyrosine and Determination of the Absolute Configuration of the Residue in Callipeltin A

artículo científico publicado en 2005

Crellastatin A, a PARP-1 Inhibitor Discovered by Complementary Proteomic Approaches

scientific article published on 08 January 2020

Cystathionine γ-lyase, a H2S-generating enzyme, is a GPBAR1-regulated gene and contributes to vasodilation caused by secondary bile acids

article

Determination of Gymnemic Acid I as a Protein Biosynthesis Inhibitor Using Chemical Proteomics.

artículo científico publicado en 2017

Determining the Effect of Pterostilbene on Insulin Secretion Using Chemoproteomics

artículo científico publicado en 2020

Differential in gel electrophoresis (DIGE) comparative proteomic analysis of macrophages cell cultures in response to perthamide C treatment

artículo científico publicado en 2013

Discovering the Biological Target of 5-epi-Sinuleptolide Using a Combination of Proteomic Approaches.

artículo científico publicado en 2017

Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1

scientific article published on 21 February 2019

Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis

artículo científico publicado en 2012

Dissociation of intestinal and hepatic activities of FXR and LXRα supports metabolic effects of terminal ileum interposition in rodents.

artículo científico publicado en 2013

Drug Repositioning for Fabry Disease: Acetylsalicylic Acid Potentiates the Stabilization of Lysosomal Alpha-Galactosidase by Pharmacological Chaperones

artículo científico publicado en 2022

Effects of petrosaspongiolide R on the surface topology of bee venom PLA(2): a limited proteolysis and mass spectrometry analysis

artículo científico publicado en 2008

Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands.

artículo científico publicado en 2014

Further insights on the structural aspects of PLA(2) inhibition by gamma-hydroxybutenolide-containing natural products: a comparative study on petrosaspongiolides M-R.

artículo científico publicado en 2004

Genomics-Metabolomics Profiling Disclosed Marine Vibrio spartinae 3.6 as a Producer of a New Branched Side Chain Prodigiosin ⬇️

scientific article published on 10 April 2020

Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice.

artículo científico publicado en 2017

Heat shock proteins as key biological targets of the marine natural cyclopeptide perthamide C.

artículo científico publicado en 2012

Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders

artículo científico publicado en 2014

Homophymine A, an anti-HIV cyclodepsipeptide from the sponge Homophymia sp.

artículo científico publicado en 2008

Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling

artículo científico publicado en 2015

In Cell Interactome of Oleocanthal, an Extra Virgin Olive Oil Bioactive Component

artículo científico publicado en 2015

Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists.

artículo científico publicado en 2016

Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties

artículo científico publicado en 2019

Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists

artículo científico publicado en 2019

Involvement of 3',5'-cyclic inosine monophosphate in cystathionine γ-lyase-dependent regulation of the vascular tone

scientific article published on 11 June 2021

Mechanistic insights on petrosaspongiolide M inhibitory effects on immunoproteasome and autophagy.

artículo científico publicado en 2014

Mesoglycan exerts its fibrinolytic effect through the activation of annexin A2

artículo científico publicado en 2020

Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1)

artículo científico publicado en 2014

Modulation of proteasome machinery by natural and synthetic analogues of the marine bioactive compound petrosaspongiolide M.

artículo científico publicado en 2012

Modulation of tau protein fibrillization by oleocanthal.

artículo científico publicado en 2012

N-Formyl-7-amino-11-cycloamphilectene, a marine sponge metabolite, binds to tubulin and modulates microtubule depolymerization

artículo científico publicado en 2014

Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands

artículo científico publicado en 2016

New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component

artículo científico publicado en 2011

Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury

artículo científico publicado en 2018

Oligosaccharidic fractions derived from Triticum vulgare extract accelerate tissutal repairing processes in in vitro and in vivo models of skin lesions

artículo científico publicado en 2014

Opposite effects of the FXR agonist obeticholic acid on Mafg and Nrf2 mediate the development of acute liver injury in rodent models of cholestasis

artículo científico publicado en 2020

Perthamides C and D, two new potent anti-inflammatory cyclopeptides from a Solomon Lithistid sponge Theonella swinhoei

Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ.

artículo científico publicado en 2012

Proteasome as a New Target for Bio-Inspired Benzo[k,l]xanthene Lignans.

artículo científico publicado en 2017

Proteomic Analysis of Zn Depletion/Repletion in the Hormone-Secreting Thyroid Follicular Cell Line FRTL-5

scientific article published on 14 December 2018

Quantitative proteomics discloses monacolin K-induced alterations in triple-negative breast cancer cell proteomes and phosphoproteomes

scientific article published on 01 February 2020

Quantum Mechanical Calculation of Coupling Constants in the Configurational Analysis of Flexible Systems: Determination of the Configuration of Callipeltin A

Retracted: Perthamide C Inhibits eNOS and iNOS Expression and Has Immunomodulating Activity In Vivo

artículo científico publicado en 2013

Scalaradial, a Dialdehyde-Containing Marine Metabolite That Causes an Unexpected Noncovalent PLA2 Inactivation

scientific article published on 01 September 2007

Scalarane sesterterpenes from Thorectidae sponges as inhibitors of TDP-43 nuclear factor

artículo científico publicado en 2014

Serum Bile Acid Levels Before and After Sleeve Gastrectomy and Their Correlation with Obesity-Related Comorbidities

scientific article published on 01 August 2019

Structure-based design, synthesis and preliminary anti-inflammatory activity of bolinaquinone analogues ⬇️

artículo científico publicado el 24 de noviembre de 2010

Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases

artículo científico publicado en 2017

The HIV matrix protein p17 induces hepatic lipid accumulation via modulation of nuclear receptor transcriptoma.

artículo científico publicado en 2015

The antimicrobial potential of algicolous marine fungi for counteracting multidrug-resistant bacteria: phylogenetic diversity and chemical profiling.

artículo científico publicado en 2016

The bile acid activated receptors GPBAR1 and FXR exert antagonistic effects on autophagy

artículo científico publicado en 2021

The binding mode of cladocoran A to the human group IIA phospholipase A(2).

artículo científico publicado en 2011

The binding mode of petrosaspongiolide M to the human group IIA phospholipase A(2): exploring the role of covalent and noncovalent interactions in the inhibition process

artículo científico publicado en 2009

The inactivation mechanism of human group IIA phospholipase A(2) by Scalaradial

artículo científico publicado en 2012

The inactivation of phospholipase A2 by scalaradial: a biomimetic study by electrospray mass spectrometry

artículo científico publicado en 2005

The molecular mechanism of bee venom phospholipase A2 inactivation by bolinaquinone

artículo científico publicado en 2006

The molecular mechanism of human group IIA phospholipase A2 inactivation by bolinaquinone.

artículo científico publicado en 2009

The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate

artículo científico publicado en 2011

Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation.

artículo científico publicado en 2019

Ursodeoxycholic acid is a GPBAR1 agonist and resets liver/intestinal FXR signaling in a model of diet-induced dysbiosis and NASH

scientific article published on 17 July 2019

Lista de obras de

Agonism for the bile acid receptor GPBAR1 reverses liver and vascular damage in a mouse model of steatohepatitis

Anti-inflammatory cyclopeptides from the marine sponge Theonella swinhoei

BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis

Biomolecular Fishing for Calixarene Partners by a Chemoproteomic Approach

Biomolecular proteomics discloses ATP synthase as the main target of the natural glycoside deglucoruscin

Callipeltins F–I: new antifungal peptides from the marine sponge Latrunculia sp

Carbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite

Characterization of a New Mixture of Mono-Rhamnolipids Produced by Pseudomonas gessardii Isolated from Edmonson Point (Antarctica)

Chemical Proteomics Reveals Heat Shock Protein 60 To Be the Main Cellular Target of the Marine Bioactive Sesterterpene Suvanine

Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol

Chemical proteomics discloses petrosapongiolide M, an antiinflammatory marine sesterterpene, as a proteasome inhibitor.

Chemical proteomics reveals bolinaquinone as a clathrin-mediated endocytosis inhibitor.

Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor.

Chemistry and biology of anti-inflammatory marine natural products: molecules interfering with cyclooxygenase, NF-kappaB and other unidentified targets

Chemoproteomic fishing identifies arzanol as a positive modulator of brain glycogen phosphorylase

Concise Synthesis of All Stereoisomers of β-Methoxytyrosine and Determination of the Absolute Configuration of the Residue in Callipeltin A

Crellastatin A, a PARP-1 Inhibitor Discovered by Complementary Proteomic Approaches

Cystathionine γ-lyase, a H2S-generating enzyme, is a GPBAR1-regulated gene and contributes to vasodilation caused by secondary bile acids

Determination of Gymnemic Acid I as a Protein Biosynthesis Inhibitor Using Chemical Proteomics.

Determining the Effect of Pterostilbene on Insulin Secretion Using Chemoproteomics

Differential in gel electrophoresis (DIGE) comparative proteomic analysis of macrophages cell cultures in response to perthamide C treatment

Discovering the Biological Target of 5-epi-Sinuleptolide Using a Combination of Proteomic Approaches.

Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1

Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis

Dissociation of intestinal and hepatic activities of FXR and LXRα supports metabolic effects of terminal ileum interposition in rodents.

Drug Repositioning for Fabry Disease: Acetylsalicylic Acid Potentiates the Stabilization of Lysosomal Alpha-Galactosidase by Pharmacological Chaperones

Effects of petrosaspongiolide R on the surface topology of bee venom PLA(2): a limited proteolysis and mass spectrometry analysis

Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands.

Further insights on the structural aspects of PLA(2) inhibition by gamma-hydroxybutenolide-containing natural products: a comparative study on petrosaspongiolides M-R.

Genomics-Metabolomics Profiling Disclosed Marine Vibrio spartinae 3.6 as a Producer of a New Branched Side Chain Prodigiosin ⬇️

Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice.

Heat shock proteins as key biological targets of the marine natural cyclopeptide perthamide C.

Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders

Homophymine A, an anti-HIV cyclodepsipeptide from the sponge Homophymia sp.

Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling

In Cell Interactome of Oleocanthal, an Extra Virgin Olive Oil Bioactive Component

Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists.

Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties

Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists

Involvement of 3',5'-cyclic inosine monophosphate in cystathionine γ-lyase-dependent regulation of the vascular tone

Mechanistic insights on petrosaspongiolide M inhibitory effects on immunoproteasome and autophagy.

Mesoglycan exerts its fibrinolytic effect through the activation of annexin A2

Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1)

Modulation of proteasome machinery by natural and synthetic analogues of the marine bioactive compound petrosaspongiolide M.

Modulation of tau protein fibrillization by oleocanthal.

N-Formyl-7-amino-11-cycloamphilectene, a marine sponge metabolite, binds to tubulin and modulates microtubule depolymerization

Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands

New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component

Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury

Oligosaccharidic fractions derived from Triticum vulgare extract accelerate tissutal repairing processes in in vitro and in vivo models of skin lesions

Opposite effects of the FXR agonist obeticholic acid on Mafg and Nrf2 mediate the development of acute liver injury in rodent models of cholestasis

Perthamides C and D, two new potent anti-inflammatory cyclopeptides from a Solomon Lithistid sponge Theonella swinhoei

Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ.

Proteasome as a New Target for Bio-Inspired Benzo[k,l]xanthene Lignans.

Proteomic Analysis of Zn Depletion/Repletion in the Hormone-Secreting Thyroid Follicular Cell Line FRTL-5

Quantitative proteomics discloses monacolin K-induced alterations in triple-negative breast cancer cell proteomes and phosphoproteomes

Quantum Mechanical Calculation of Coupling Constants in the Configurational Analysis of Flexible Systems: Determination of the Configuration of Callipeltin A

Retracted: Perthamide C Inhibits eNOS and iNOS Expression and Has Immunomodulating Activity In Vivo

Scalaradial, a Dialdehyde-Containing Marine Metabolite That Causes an Unexpected Noncovalent PLA2 Inactivation

Scalarane sesterterpenes from Thorectidae sponges as inhibitors of TDP-43 nuclear factor

Serum Bile Acid Levels Before and After Sleeve Gastrectomy and Their Correlation with Obesity-Related Comorbidities

Structure-based design, synthesis and preliminary anti-inflammatory activity of bolinaquinone analogues ⬇️

Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases

The HIV matrix protein p17 induces hepatic lipid accumulation via modulation of nuclear receptor transcriptoma.

The antimicrobial potential of algicolous marine fungi for counteracting multidrug-resistant bacteria: phylogenetic diversity and chemical profiling.

The bile acid activated receptors GPBAR1 and FXR exert antagonistic effects on autophagy

The binding mode of cladocoran A to the human group IIA phospholipase A(2).

The binding mode of petrosaspongiolide M to the human group IIA phospholipase A(2): exploring the role of covalent and noncovalent interactions in the inhibition process

The inactivation mechanism of human group IIA phospholipase A(2) by Scalaradial

The inactivation of phospholipase A2 by scalaradial: a biomimetic study by electrospray mass spectrometry

The molecular mechanism of bee venom phospholipase A2 inactivation by bolinaquinone

The molecular mechanism of human group IIA phospholipase A2 inactivation by bolinaquinone.

The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate

Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation.

Ursodeoxycholic acid is a GPBAR1 agonist and resets liver/intestinal FXR signaling in a model of diet-induced dysbiosis and NASH