Lista de obras -

A Highly Durable RNAi Therapeutic Inhibitor of PCSK9.

artículo científico publicado en 2016

A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice

artículo científico publicado en 2014

AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue.

artículo científico publicado en 2016

Acetate dependence of tumors

artículo científico publicado en 2014

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation

artículo científico publicado en 2017

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.

artículo científico publicado en 2017

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2 ⬇️

artículo científico publicado el 1 de junio de 1998

Adipocyte Xbp1s overexpression drives uridine production and reduces obesity

artículo científico publicado en 2018

An acetate switch regulates stress erythropoiesis

artículo científico publicado en 2014

An adipo-biliary-uridine axis that regulates energy homeostasis

artículo científico publicado en 2017

Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells

artículo científico publicado en 2009

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

artículo científico publicado en 2007

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice

artículo científico publicado en 2008

Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).

artículo científico publicado en 1998

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

scientific journal article

Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells

artículo científico publicado en 2007

Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver ⬇️

artículo científico publicado el 11 de noviembre de 1997

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

artículo científico publicado en 2003

Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver

scientific journal article

Crystal structure of Spot 14, a modulator of fatty acid synthesis ⬇️

artículo científico publicado el 15 de octubre de 2010

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

scientific journal article

Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis

scientific journal article

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

artículo científico publicado en 2008

Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance

artículo científico publicado en 2014

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

artículo científico publicado en 1997

Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

artículo científico publicado en 2002

Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL

artículo científico publicado en 1999

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial

artículo científico publicado en 2013

Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

artículo científico

Enhanced fatty acid flux triggered by adiponectin overexpression

artículo científico publicado en 2011

Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice.

artículo científico publicado en 2017

Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans

artículo científico publicado en 2010

Genetic and metabolic determinants of plasma PCSK9 levels

artículo científico publicado en 2009

Hepatic gluconeogenesis is enhanced by phosphatidic acid which remains uninhibited by insulin in lipodystrophic Agpat2-/- mice

artículo científico publicado en 2014

Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease.

artículo científico publicado en 2018

Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice.

artículo científico publicado en 2011

Human fatty liver disease: old questions and new insights

artículo científico publicado en 2011

Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade

artículo científico publicado en 2003

Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis

scientific journal article

Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes

artículo científico publicado en 2001

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

artículo científico publicado en 1999

Interplay between ChREBP and SREBP-1c Coordinates Postprandial Glycolysis and Lipogenesis in Livers of Mice

artículo científico publicado en 2018

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

scientific article published on March 1997

Lack of a relationship between plasma PCSK9 concentrations and hepatic lipoprotein kinetics in obese people

artículo científico publicado en 2011

Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors

artículo científico publicado en 2013

Metabolic response to high-carbohydrate and low-carbohydrate meals in a nonhuman primate model.

artículo científico publicado en 2012

MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels

artículo científico publicado en 2015

Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice

artículo científico publicado en 2016

Molecular basis for LDL receptor recognition by PCSK9

artículo científico publicado en 2008

Molecular biology of PCSK9: its role in LDL metabolism

artículo científico publicado en 2007

Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote

artículo científico publicado en 2006

Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy

artículo científico publicado en 2009

Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver

artículo científico publicado en 1998

Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

artículo científico publicado en 2002

Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis

artículo científico publicado en 2004

Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.

artículo científico publicado en 2003

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

artículo científico publicado en 1996

PCSK9: a convertase that coordinates LDL catabolism

artículo científico publicado en 2008

Plasma PCSK9 preferentially reduces liver LDL receptors in mice

artículo científico publicado en 2008

Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

artículo científico publicado en 2004

Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity

artículo científico publicado en 2004

Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice

artículo científico publicado en 2012

Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice ⬇️

artículo científico publicado el 26 de mayo de 1998

SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation

artículo científico publicado en 2001

SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1

scientific article published on 16 July 2019

SREBPs: transcriptional mediators of lipid homeostasis

artículo científico publicado en 2002

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins

scientific journal article

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

artículo científico publicado en 2006

Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.

artículo científico publicado en 2010

The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals ⬇️

artículo científico publicado el 8 de febrero de 2012

The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism

artículo científico publicado en 2012

The impact of endotrophin on the progression of chronic liver disease

artículo científico publicado en 2020

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

artículo científico publicado en 2008

Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice.

artículo científico publicado en 2002

WholePathwayScope: a comprehensive pathway-based analysis tool for high-throughput data

artículo científico publicado en 2006

Lista de obras de

A Highly Durable RNAi Therapeutic Inhibitor of PCSK9.

A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice

AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue.

Acetate dependence of tumors

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2 ⬇️

Adipocyte Xbp1s overexpression drives uridine production and reduces obesity

An acetate switch regulates stress erythropoiesis

An adipo-biliary-uridine axis that regulates energy homeostasis

Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice

Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells

Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver ⬇️

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver

Crystal structure of Spot 14, a modulator of fatty acid synthesis ⬇️

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial

Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

Enhanced fatty acid flux triggered by adiponectin overexpression

Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice.

Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans

Genetic and metabolic determinants of plasma PCSK9 levels

Hepatic gluconeogenesis is enhanced by phosphatidic acid which remains uninhibited by insulin in lipodystrophic Agpat2-/- mice

Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease.

Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice.

Human fatty liver disease: old questions and new insights

Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade

Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis

Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

Interplay between ChREBP and SREBP-1c Coordinates Postprandial Glycolysis and Lipogenesis in Livers of Mice

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

Lack of a relationship between plasma PCSK9 concentrations and hepatic lipoprotein kinetics in obese people

Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors

Metabolic response to high-carbohydrate and low-carbohydrate meals in a nonhuman primate model.

MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels

Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice

Molecular basis for LDL receptor recognition by PCSK9

Molecular biology of PCSK9: its role in LDL metabolism

Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote

Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy

Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver

Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis

Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

PCSK9: a convertase that coordinates LDL catabolism

Plasma PCSK9 preferentially reduces liver LDL receptors in mice

Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity

Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice

Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice ⬇️

SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation

SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1

SREBPs: transcriptional mediators of lipid homeostasis

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.

The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals ⬇️

The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism

The impact of endotrophin on the progression of chronic liver disease

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice.

WholePathwayScope: a comprehensive pathway-based analysis tool for high-throughput data