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A Novel Collagen Matricryptin Reduces Left Ventricular Dilation Post-Myocardial Infarction by Promoting Scar Formation and Angiogenesis

artículo científico publicado en 2015

A Novel Probe for Spliceosomal Proteins that Induces Autophagy and Death of Melanoma Cells Reveals New Targets for Melanoma Drug Discovery

artículo científico publicado en 2019

A PCNA-derived cell permeable peptide selectively inhibits neuroblastoma cell growth

artículo científico publicado en 2014

A Peptide mimicking a region in proliferating cell nuclear antigen specific to key protein interactions is cytotoxic to breast cancer

artículo científico publicado en 2014

A novel conotoxin framework with a helix-loop-helix (Cs alpha/alpha) fold

artículo científico publicado en 2005

Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates

scientific article published on 18 June 2013

AlphaLISA-based high-throughput screening assay to measure levels of soluble amyloid precursor protein α.

artículo científico publicado en 2014

Amino acid residue Val362 plays a critical role in maintaining the structure of C terminus of connexin 50 and in lens epithelial-fiber differentiation

artículo científico publicado en 2010

Analysis of flavonoid-based pharmacophores that inhibit aggrecanases (ADAMTS-4 and ADAMTS-5) and matrix metalloproteinases through the use of topologically constrained peptide substrates

artículo científico publicado en 2009

Analysis of matrix metalloproteinase triple-helical peptidase activity with substrates incorporating fluorogenic L- or D-amino acids

scientific article published on 01 October 2003

Angiogenesis in collagen I requires alpha2beta1 ligation of a GFP*GER sequence and possibly p38 MAPK activation and focal adhesion disassembly

artículo científico publicado en 2003

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage

artículo científico publicado en 2017

Application of Collagen-Model Triple-Helical Peptide-Amphiphiles for CD44-Targeted Drug Delivery Systems ⬇️

artículo científico publicado el 14 de noviembre de 2012

Application of topologically constrained mini-proteins as ligands, substrates, and inhibitors

artículo científico publicado en 2007

Bilayer Membrane Modulation of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Structure and Proteolytic Activity.

artículo científico publicado en 2016

Biophysical studies of matrix metalloproteinase/triple-helix complexes

artículo científico publicado en 2014

Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities ⬇️

artículo científico publicado el 1 de febrero de 2004

Characterization and regulation of MT1-MMP cell surface-associated activity.

artículo científico publicado en 2018

Characterization of Peptide−Amphiphiles Possessing Cellular Activation Sequences ⬇️

artículo científico publicado el 1 de mayo de 2003

Characterization of an exosite binding inhibitor of matrix metalloproteinase 13.

artículo científico publicado en 2007

Characterization of quenched fluorescent triple helical peptides for MMP-2 and MMP-9 optical imaging

Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.

artículo científico publicado en 2014

Chemical Biology for Understanding Matrix Metalloproteinase Function ⬇️

artículo científico publicado el 30 de agosto de 2012

Citrate synthase is a novel in vivo matrix metalloproteinase-9 substrate that regulates mitochondrial function in the postmyocardial infarction left ventricle.

artículo científico publicado en 2014

Clinical implications of compounds designed to inhibit ECM-modifying metalloproteinases.

artículo científico

Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis

artículo científico publicado en 2004

Collagenolytic Matrix Metalloproteinase Activities toward Peptomeric Triple-Helical Substrates

artículo científico publicado en 2015

Collagenolytic Matrix Metalloproteinase Structure-Function Relationships: Insights From Molecular Dynamics Studies

artículo científico

Comparative proteomic analysis of matched primary and metastatic melanoma cell lines

artículo científico publicado en 2008

Comparison of metalloproteinase protein and activity profiling ⬇️

artículo científico publicado el 23 de octubre de 2010

Conformational Dynamics of Matrix Metalloproteinase-1·Triple-Helical Peptide Complexes.

artículo científico publicado en 2017

Contributions of the MMP-2 collagen binding domain to gelatin cleavage. Substrate binding via the collagen binding domain is required for hydrolysis of gelatin but not short peptides

artículo científico publicado en 2004

Correction to Synthesis of an Array of Triple-Helical Peptides from Type II Collagen for Multiplex Analysis of Autoantibodies in Rheumatoid Arthritis

artículo científico publicado en 2020

Correlated structural kinetics and retarded solvent dynamics at the metalloprotease active site

artículo científico publicado en 2011

Detection of MMP-2 and MMP-9 activity in vivo with a triple-helical peptide optical probe

artículo científico publicado en 2012

Determination of penetratin secondary structure in live cells with Raman microscopy

artículo científico publicado en 2010

Determining the Substrate Specificity of Matrix Metalloproteases using Fluorogenic Peptide Substrates

artículo científico

Development of a Förster resonance energy transfer assay for monitoring bacterial collagenase triple-helical peptidase activity

artículo científico publicado en 2014

Development of a convenient peptide-based assay for lysyl hydroxylase

artículo científico publicado en 2008

Development of a solid-phase assay for analysis of matrix metalloproteinase activity.

artículo científico publicado en 2004

Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β.

artículo científico publicado en 2014

Development of matrix metalloproteinase-13 inhibitors - A structure-activity/structure-property relationship study

artículo científico publicado en 2018

Differential modulation of human melanoma cell metalloproteinase expression by alpha2beta1 integrin and CD44 triple-helical ligands derived from type IV collagen.

artículo científico publicado en 2004

Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences

artículo científico publicado en 2007

Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate

artículo científico publicado en 2016

Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.

artículo científico publicado en 2012

Dissecting MMP P' and P' subsite sequence preferences, utilizing a positional scanning, combinatorial triple-helical peptide library

scientific article published in Journal of Biological Chemistry

Early matrix metalloproteinase-9 inhibition post-myocardial infarction worsens cardiac dysfunction by delaying inflammation resolution

artículo científico publicado en 2016

Editorial

Effects of Mutations on Structure-Function Relationships of Matrix Metalloproteinase-1.

artículo científico publicado en 2016

Effects of drug hydrophobicity on liposomal stability

artículo científico publicado en 2007

Efficient synthesis of Fmoc-protected phosphinic pseudodipeptides: Building blocks for the synthesis of matrix metalloproteinase inhibitors

artículo científico publicado en 2011

Endorepellin, the C-terminal angiostatic module of perlecan, enhances collagen-platelet responses via the alpha2beta1-integrin receptor

artículo científico publicado en 2006

Engineered sarafotoxins as tissue inhibitor of metalloproteinases-like matrix metalloproteinase inhibitors

artículo científico publicado en 2007

Enzymatic turnover of macromolecules generates long-lasting protein-water-coupled motions beyond reaction steady state

artículo científico publicado en 2014

Evaluation of a triple-helical peptide with quenched FluorSophores for optical imaging of MMP-2 and MMP-9 proteolytic activity

artículo científico publicado en 2014

Examination of matrix metalloproteinase-1 in solution: a preference for the pre-collagenolysis state.

artículo científico publicado en 2013

Exosite Interactions Impact Matrix Metalloproteinase Collagen Specificities ⬇️

artículo científico publicado el 6 de septiembre de 2011

Extracellular proteases as targets for drug development

artículo científico publicado en 2009

Glycosylation modulates melanoma cell α2β1 and α3β1 integrin interactions with type IV collagen

artículo científico publicado en 2014

Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition

artículo científico publicado en 2013

Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia

artículo científico publicado en 2020

High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate

artículo científico publicado en 2008

Identification of collagen binding domain residues that govern catalytic activities of matrix metalloproteinase-2 (MMP-2) ⬇️

artículo científico publicado el 1 de septiembre de 2012

Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds.

artículo científico

Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity.

artículo científico publicado en 2009

Imaging Matrix Metalloproteinase Activity Implicated in Breast Cancer Progression

artículo científico

Importance of the Linker Region in Matrix Metalloproteinase-1 Domain Interactions

artículo científico

Induction of endothelial cell activation by a triple helical alpha2beta integrin ligand, derived from type I collagen alpha1(I)496-507.

artículo científico publicado en 2003

Interstitial collagen catabolism

artículo científico publicado en 2013

Introduction to Peptide Synthesis

artículo científico publicado en 2002

Introduction to peptide synthesis

artículo científico publicado en 2002

Introduction to peptide synthesis

artículo científico publicado en 2012

Introduction to peptide synthesis

artículo científico publicado en 2002

LETTER FROM THE EDITOR

article published in 2004

Lips symposia in print and other issues

Local conformation and dynamics of isoleucine in the collagenase cleavage site provide a recognition signal for matrix metalloproteinases.

artículo científico publicado en 2010

Lysyl Hydroxylase 2 Is Secreted by Tumor Cells and Can Modify Collagen in the Extracellular Space.

artículo científico publicado en 2016

MMP-12 catalytic domain recognizes triple helical peptide models of collagen V with exosites and high activity

artículo científico publicado en 2008

MT1-MMP Binds Membranes by Opposite Tips of Its β Propeller to Position It for Pericellular Proteolysis

artículo científico publicado en 2018

Matrix Metalloproteinase 13 Inhibitors for Modulation of Osteoclastogenesis: Enhancement of Solubility and Stability

artículo científico publicado en 2020

Matrix Metalloproteinase Triple-Helical Peptide Inhibitors: Potential Cross-Reactivity with Caspase-11

scientific article published on 28 November 2019

Matrix metalloproteinase collagenolysis in health and disease

artículo científico

Matrix metalloproteinase inhibition by heterotrimeric triple-helical Peptide transition state analogues

artículo científico publicado en 2015

Matrix metalloproteinase triple-helical peptidase activities are differentially regulated by substrate stability

scientific article published on 01 September 2004

Matrix metalloproteinases and collagen catabolism

artículo científico publicado en 2002

Matrix metalloproteinases as reagents for cell isolation.

artículo científico

Mechanisms of Action of Novel Drugs Targeting Angiogenesis-Promoting Matrix Metalloproteinases.

artículo científico publicado en 2019

Melanoma cell CD44 interaction with the alpha 1(IV)1263-1277 region from basement membrane collagen is modulated by ligand glycosylation

artículo científico publicado en 2003

Methods for the Construction of Collagen-Based Triple-Helical Peptides Designed as Matrix Metalloproteinase Inhibitors

artículo científico publicado en 2019

Modulation of receptor binding to collagen by glycosylated 5-hydroxylysine: Chemical biology approaches made feasible by Carpino's Fmoc group

artículo científico publicado en 2020

Modulation of triple-helical stability and subsequent melanoma cellular responses by single-site substitution of fluoroproline derivatives

artículo científico publicado en 2002

Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression

artículo científico publicado en 2014

NMR and Bioinformatics Discovery of Exosites That Tune Metalloelastase Specificity for Solubilized Elastin and Collagen Triple Helices ⬇️

artículo científico publicado el 27 de julio de 2010

Near-infrared triple-helical peptide with quenched fluorophores for optical imaging of MMP-2 and MMP-9 proteolytic activity in vivo

artículo científico publicado en 2014

New strategies for targeting matrix metalloproteinases

artículo científico publicado en 2015

Novel pyrrolidine diketopiperazines selectively inhibit melanoma cells via induction of late-onset apoptosis

artículo científico publicado en 2014

Parallel problems: Applying institutional corruption analysis of Congress to big pharma

artículo científico publicado en 2013

Path to Collagenolysis: COLLAGEN V TRIPLE-HELIX MODEL BOUND PRODUCTIVELY AND IN ENCOUNTERS BY MATRIX METALLOPROTEINASE-12.

artículo científico publicado en 2016

Peptide-based selective inhibitors of matrix metalloproteinase-mediated activities

artículo científico publicado en 2012

Peptide-mediated targeting of liposomes to tumor cells

artículo científico publicado en 2007

Polypeptide chains containing D-gamma-hydroxyvaline

artículo científico publicado en 2005

Potential clinical implications of recent matrix metalloproteinase inhibitor design strategies

artículo científico publicado en 2015

Proteolytic profiling of the extracellular matrix degradome

artículo científico publicado en 2007

Rapid lead discovery through iterative screening of one bead one compound libraries

artículo científico publicado en 2014

Regenerative Medicine in the State of Florida: Letter Outlining the Florida Organization for Regenerative Medicine

artículo científico publicado en 2018

Regulation of collagenase activities of human cathepsins by glycosaminoglycans

artículo científico publicado en 2003

SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.

artículo científico publicado en 2015

Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate

artículo científico publicado en 2007

Second Generation Triple-Helical Peptide Inhibitors of Matrix Metalloproteinases.

artículo científico

Selective hydrolysis of triple-helical substrates by matrix metalloproteinase-2 and -9

artículo científico publicado en 2003

Selective modulation of matrix metalloproteinase 9 (MMP-9) functions via exosite inhibition

artículo científico publicado en 2008

Shedding of Discoidin Domain Receptor 1 by Membrane-type Matrix Metalloproteinases ⬇️

artículo científico publicado el 21 de marzo de 2013

Solid-phase synthesis, characterization, and cellular activities of collagen-model nanodiamond-peptide conjugates

artículo científico publicado en 2015

Stabilization of collagen-model, triple-helical peptides for in vitro and in vivo applications

artículo científico publicado en 2013

Structural basis for matrix metalloproteinase 1-catalyzed collagenolysis

artículo científico publicado en 2012

Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors.

artículo científico

Substrate conformation modulates aggrecanase (ADAMTS-4) affinity and sequence specificity. Suggestion of a common topological specificity for functionally diverse proteases.

artículo científico publicado en 2006

Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide

artículo científico publicado en 2017

Synthesis and biological applications of collagen-model triple-helical peptides

artículo científico publicado en 2010

Synthesis and solid-phase application of suitably protected gamma-hydroxyvaline building blocks

artículo científico publicado en 2007

Synthesis and solid-phase application of suitably protected gamma-hydroxyvaline building blocks.

artículo científico publicado en 2009

Synthesis of Fmoc-Gly-Ile Phosphinic Pseudodipeptide: Residue Specific Conditions for Construction of Matrix Metalloproteinase Inhibitor Building Blocks

artículo científico publicado en 2012

TF-containing MUC1 glycopeptides fail to entice Galectin-1 recognition of tumor-associated Thomsen-Freidenreich (TF) antigen (CD176) in solution

artículo científico publicado en 2020

Targeted drug delivery utilizing protein-like molecular architecture

artículo científico publicado en 2007

The Expanding Role of MT1-MMP in Cancer Progression

artículo científico publicado en 2019

The Mechanism by Which MYCN Amplification Confers an Enhanced Sensitivity to a PCNA-Derived Cell Permeable Peptide in Neuroblastoma Cells

artículo científico publicado en 2015

The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma

scientific article published on 26 July 2018

The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma

scientific article published on 27 August 2019

The Roles of Matrix Metalloproteinases in Pancreatic Cancer

artículo científico

The history of matrix metalloproteinases: milestones, myths, and misperceptions ⬇️

artículo científico publicado el 17 de agosto de 2012

The interface between catalytic and hemopexin domains in matrix metalloproteinase-1 conceals a collagen binding exosite.

artículo científico publicado en 2011

The normalization of gene expression data in melanoma: investigating the use of glyceraldehyde 3-phosphate dehydrogenase and 18S ribosomal RNA as internal reference genes for quantitative real-time PCR.

artículo científico publicado en 2008

The role of collagen charge clusters in the modulation of matrix metalloproteinase activity.

artículo científico publicado en 2013

The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity

artículo científico publicado en 2006

The synthesis and application of Fmoc‐Lys(5‐Fam) building blocks ⬇️

artículo científico publicado el 1 de julio de 2013

Transient collagen triple helix binding to a key metalloproteinase in invasion and development.

artículo científico publicado en 2015

Tricine as a convenient scaffold for the synthesis of C-terminally branched collagen-model peptides

artículo científico publicado en 2017

Triple-helical peptide analysis of collagenolytic protease activity

artículo científico publicado en 2002

Triple-helical transition state analogues: a new class of selective matrix metalloproteinase inhibitors

artículo científico publicado en 2007

Using fluorogenic peptide substrates to assay matrix metalloproteinases

Variability in melanoma metalloproteinase expression profiling

artículo científico publicado en 2010

δ/ω-Plectoxin-Pt1a: An Excitatory Spider Toxin with Actions on both Ca2+ and Na+ Channels ⬇️

artículo científico publicado el 14 de mayo de 2013

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