Lista de obras -

A Blueprint for HIV Vaccine Discovery

artículo científico publicado en 2012

A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells

artículo científico publicado en 2014

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

artículo científico publicado en 2011

A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans.

artículo científico publicado en 2016

A chimeric HIV-1 envelope glycoprotein trimer with an embedded granulocyte-macrophage colony-stimulating factor (GM-CSF) domain induces enhanced antibody and T cell responses

artículo científico publicado en 2011

A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses

artículo científico publicado en 2019

Advances in structure-based vaccine design ⬇️

artículo científico publicado el 25 de junio de 2013

An HIV-1 envelope glycoprotein trimer with an embedded IL-21 domain activates human B cells

artículo científico publicado en 2013

Anti-HIV B Cell lines as candidate vaccine biosensors

artículo científico publicado en 2012

Author Correction: A Engineered immunogen binding to alum adjuvant enhances humoral immunity

artículo científico publicado en 2020

Author Correction: Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells

artículo científico publicado en 2020

Automatically Fixing Errors in Glycoprotein Structures with Rosetta

scientific article published on 18 October 2018

B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models

scientific article published on 01 September 2020

B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates

artículo científico publicado en 2013

Better together: Elements of successful scientific software development in a distributed collaborative community

scientific article published on 04 May 2020

Challenges for structure-based HIV vaccine design

artículo científico publicado en 2009

CoV3D: A database of high resolution coronavirus protein structures

scientific article published on 14 May 2020

CoV3D: a database of high resolution coronavirus protein structures

artículo científico publicado en 2020

Comprehensive sieve analysis of breakthrough HIV-1 sequences in the RV144 vaccine efficacy trial

artículo científico publicado en 2015

Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold

artículo científico publicado en 2011

Computational Protein Design Using Flexible Backbone Remodeling and Resurfacing: Case Studies in Structure-Based Antigen Design ⬇️

artículo científico publicado el 20 de octubre de 2010

Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope

artículo científico publicado en 2010

Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope

artículo científico publicado en 2012

Computational design of protein antigens that interact with the CDR H3 loop of HIV broadly neutralizing antibody 2F5.

artículo científico publicado en 2014

Correction for Ingale et al., Hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies

artículo científico publicado en 2015

Correction: Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design

artículo científico publicado en 2016

Design and Characterization of Epitope-Scaffold Immunogens That Present the Motavizumab Epitope from Respiratory Syncytial Virus

artículo científico publicado en 2011

Design and Characterization of Stabilized Derivatives of Human CD4D12 and CD4D1

article

Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer

artículo científico publicado en 2018

Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 Envelope glycoprotein trimers on neutralizing antibody induction

artículo científico publicado en 2017

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

artículo científico publicado en 2017

Elicitation of structure-specific antibodies by epitope scaffolds

artículo científico publicado en 2010

Engineered immunogen binding to alum adjuvant enhances humoral immunity

artículo científico publicado en 2020

Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

artículo científico publicado en 2013

Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes

artículo científico publicado en 2018

Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination

scientific article published on 29 July 2019

Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks

artículo científico publicado en 2021

Escape from neutralization by the respiratory syncytial virus-specific neutralizing monoclonal antibody palivizumab is driven by changes in on-rate of binding to the fusion protein

artículo científico publicado en 2014

Expression of complete SIV p27 Gag and HIV gp120 engineered outer domains targeted by broadly neutralizing antibodies in live rubella vectors

artículo científico publicado en 2017

From structure to sequence: Antibody discovery using cryoEM

scientific article published on 19 January 2022

Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies

scientific article published on 31 July 2018

Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies

artículo científico publicado en 2015

Glycan masking of Plasmodium vivax Duffy Binding Protein for probing protein binding function and vaccine development

artículo científico publicado en 2013

Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation.

artículo científico publicado en 2018

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

artículo científico publicado en 2016

HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies

scientific article published on 01 April 2020

HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

artículo científico publicado en 2015

HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.

artículo científico publicado en 2015

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

artículo científico publicado en 2016

Heterologous epitope-scaffold prime:boosting immuno-focuses B cell responses to the HIV-1 gp41 2F5 neutralization determinant

artículo científico publicado en 2011

High-resolution structure prediction of a circular permutation loop

artículo científico publicado en 2011

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

artículo científico publicado en 2016

Hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies

artículo científico publicado en 2014

Immune Tolerance Negatively Regulates B Cells in Knock-In Mice Expressing Broadly Neutralizing HIV Antibody 4E10 ⬇️

artículo científico publicado el 12 de agosto de 2013

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice

artículo científico publicado en 2015

Immunogenicity of HIV-1 envelope glycoprotein oligomers

artículo científico publicado en 2009

Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles

scientific article published on 19 August 2019

Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2

artículo científico publicado en 2012

Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires

artículo científico publicado en 2016

Inhibition of kinesin motility by ADP and phosphate supports a hand-over-hand mechanism.

artículo científico publicado en 2004

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

artículo científico publicado en 2018

Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.

artículo científico publicado en 2017

Liquid-crystalline collapse of pulmonary surfactant monolayers

artículo científico publicado en 2003

Macromolecular modeling and design in Rosetta: recent methods and frameworks

artículo científico publicado en 2020

Mapping a common interaction site used by Plasmodium falciparum Duffy binding-like domains to bind diverse host receptors

artículo científico publicado en 2007

Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.

artículo científico publicado en 2016

Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers

artículo científico publicado en 2021

Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.

artículo científico publicado en 2017

Molecular motors: single-molecule recordings made easy.

artículo científico publicado en 2002

Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

artículo científico publicado en 2020

Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors

artículo científico publicado en 2020

Nitric oxide synthase domain interfaces regulate electron transfer and calmodulin activation

artículo científico publicado en 2013

Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25

scientific article published on 24 September 2019

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

artículo científico publicado en 2017

Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice

artículo científico publicado en 2016

Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV.

artículo científico publicado en 2014

Proof of principle for epitope-focused vaccine design

artículo científico publicado en 2014

PyRosetta Jupyter Notebooks Teach Biomolecular Structure Prediction and Design

artículo científico

Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization ⬇️

artículo científico publicado en 2019

Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan

artículo científico publicado en 2019

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

artículo científico publicado en 2013

Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

artículo científico publicado en 2010

Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections

artículo científico publicado en 2011

Refocussing Antibody Responses by Chemical Modification of Vaccine Antigens

article

Residue-centric modeling and design of saccharide and glycoconjugate structures

artículo científico publicado en 2016

Reversion of somatic mutations of the respiratory syncytial virus-specific human monoclonal antibody Fab19 reveal a direct relationship between association rate and neutralizing potency

artículo científico publicado en 2013

Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralization

artículo científico publicado en 2010

Role of nanoscale antigen organization on B-cell activation probed using DNA origami

artículo científico publicado en 2020

Rosetta predictions in CASP5: successes, failures, and prospects for complete automation.

artículo científico publicado en 2003

RosettaAntibodyDesign (RAbD): A General Framework for Computational Antibody Design

RosettaAntibodyDesign (RAbD): A general framework for computational antibody design

artículo científico publicado en 2018

RosettaRemodel: a generalized framework for flexible backbone protein design.

artículo científico publicado en 2011

Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice

artículo científico publicado en 2016

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

scientific article published on 09 May 2019

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

artículo científico publicado en 2020

Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice.

artículo científico publicado en 2016

Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein

artículo científico publicado en 2016

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

artículo científico publicado en 2011

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

artículo científico publicado en 2010

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies

artículo científico publicado en 2016

Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations

scientific article published on 05 August 2020

The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen

article

Vaccination induces HIV broadly neutralizing antibody precursors in humans ⬇️

artículo científico publicado en 2022

Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells

scientific article published on 17 November 2020

Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cells

artículo científico publicado en 2021

Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates

artículo científico publicado en 2024

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

artículo científico publicado en 2015

Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers

scholarly article by Matthias G Pauthner et al published 15 January 2019 in Immunity

When designing vaccines, consider the starting material: the human B cell repertoire

scholarly article by Colin Havenar-Daughton et al published 1 August 2018 in Current Opinion in Immunology

Lista de obras de

A Blueprint for HIV Vaccine Discovery

A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans.

A chimeric HIV-1 envelope glycoprotein trimer with an embedded granulocyte-macrophage colony-stimulating factor (GM-CSF) domain induces enhanced antibody and T cell responses

A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses

Advances in structure-based vaccine design ⬇️

An HIV-1 envelope glycoprotein trimer with an embedded IL-21 domain activates human B cells

Anti-HIV B Cell lines as candidate vaccine biosensors

Author Correction: A Engineered immunogen binding to alum adjuvant enhances humoral immunity

Author Correction: Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells

Automatically Fixing Errors in Glycoprotein Structures with Rosetta

B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models

B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates

Better together: Elements of successful scientific software development in a distributed collaborative community

Challenges for structure-based HIV vaccine design

CoV3D: A database of high resolution coronavirus protein structures

CoV3D: a database of high resolution coronavirus protein structures

Comprehensive sieve analysis of breakthrough HIV-1 sequences in the RV144 vaccine efficacy trial

Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold

Computational Protein Design Using Flexible Backbone Remodeling and Resurfacing: Case Studies in Structure-Based Antigen Design ⬇️

Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope

Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope

Computational design of protein antigens that interact with the CDR H3 loop of HIV broadly neutralizing antibody 2F5.

Correction for Ingale et al., Hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies

Correction: Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design

Design and Characterization of Epitope-Scaffold Immunogens That Present the Motavizumab Epitope from Respiratory Syncytial Virus

Design and Characterization of Stabilized Derivatives of Human CD4D12 and CD4D1

Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer

Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 Envelope glycoprotein trimers on neutralizing antibody induction

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

Elicitation of structure-specific antibodies by epitope scaffolds

Engineered immunogen binding to alum adjuvant enhances humoral immunity

Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes

Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination

Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks

Escape from neutralization by the respiratory syncytial virus-specific neutralizing monoclonal antibody palivizumab is driven by changes in on-rate of binding to the fusion protein

Expression of complete SIV p27 Gag and HIV gp120 engineered outer domains targeted by broadly neutralizing antibodies in live rubella vectors

From structure to sequence: Antibody discovery using cryoEM

Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies

Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies

Glycan masking of Plasmodium vivax Duffy Binding Protein for probing protein binding function and vaccine development

Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation.

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies

HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

Heterologous epitope-scaffold prime:boosting immuno-focuses B cell responses to the HIV-1 gp41 2F5 neutralization determinant

High-resolution structure prediction of a circular permutation loop

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

Hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies

Immune Tolerance Negatively Regulates B Cells in Knock-In Mice Expressing Broadly Neutralizing HIV Antibody 4E10 ⬇️

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice

Immunogenicity of HIV-1 envelope glycoprotein oligomers

Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles

Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2

Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires

Inhibition of kinesin motility by ADP and phosphate supports a hand-over-hand mechanism.

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.

Liquid-crystalline collapse of pulmonary surfactant monolayers

Macromolecular modeling and design in Rosetta: recent methods and frameworks

Mapping a common interaction site used by Plasmodium falciparum Duffy binding-like domains to bind diverse host receptors

Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.

Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers

Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.

Molecular motors: single-molecule recordings made easy.

Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors

Nitric oxide synthase domain interfaces regulate electron transfer and calmodulin activation

Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice

Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV.

Proof of principle for epitope-focused vaccine design

PyRosetta Jupyter Notebooks Teach Biomolecular Structure Prediction and Design

Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization ⬇️