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A Bounty of New Challenging Targets in Oncology for Chemical Discovery

scientific article published on 25 July 2019

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

artículo científico publicado en 2016

A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments

artículo científico publicado en 2022

A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses

artículo científico publicado en 2016

An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer

artículo científico publicado en 2021

Bcl-2 Family Genetic Profiling Reveals Microenvironment-Specific Determinants of Chemotherapeutic Response ⬇️

artículo científico publicado el 22 de julio de 2011

CRISPR interference (CRISPRi) for sequence-specific control of gene expression

artículo científico publicado en 2013

Cellular response to small molecules that selectively stall protein synthesis by the ribosome

artículo científico publicado en 2019

Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70)

artículo científico publicado en 2018

Exploring genetic interaction manifolds constructed from rich single-cell phenotypes

scientific article published on 08 August 2019

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer

KRASG12C inhibition produces a driver-limited state revealing collateral dependencies

scientific article published on 28 May 2019

Mapping cancer genetics at single-cell resolution

scientific article published on 01 August 2020

Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

artículo científico publicado en 2016

The DNA methylation landscape of advanced prostate cancer

scientific article published on 13 July 2020

The Promise and Challenge of In Vivo Delivery for Genome Therapeutics.

artículo científico publicado en 2017

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