Lista de obras -

A FRET sensor for non-invasive imaging of amyloid formation in vivo

artículo científico publicado en 2011

A Nanobody Binding to Non-Amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril Formation

artículo científico publicado en 2013

A Water-Soluble Azobenzene Cross-Linker for Photocontrol of Peptide Conformation

artículo científico publicado en 2003

A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis

artículo científico publicado en 2010

A prion-like domain in ELF3 functions as a thermosensor in Arabidopsis

artículo científico publicado en 2020

ANS binding reveals common features of cytotoxic amyloid species

artículo científico publicado en 2010

Achieving photo-control of protein conformation and activity: producing a photo-controlled leucine zipper.

artículo científico publicado en 2003

Alpha-2-Macroglobulin Is Acutely Sensitive to Freezing and Lyophilization: Implications for Structural and Functional Studies

artículo científico publicado en 2015

Alpha-helix formation in a photoswitchable peptide tracked from picoseconds to microseconds by time-resolved IR spectroscopy.

artículo científico publicado en 2005

Amyloid-like Fibrils from an α-Helical Transmembrane Protein

artículo científico publicado en 2017

Analysis of the Native Structure, Stability and Aggregation of Biotinylated Human Lysozyme ⬇️

artículo científico publicado el 16 de noviembre de 2012

Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation.

artículo científico publicado en 2017

Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's β-amyloid aggregation

artículo científico publicado en 2019

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

artículo científico publicado en 2018

Clusterin protects neurons against intracellular proteotoxicity

artículo científico publicado en 2017

Disease‐related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development inDrosophila melanogaster ⬇️

artículo científico publicado el 29 de septiembre de 2011

Disulfide bonds reduce the toxicity of the amyloid fibrils formed by an extracellular protein

artículo científico

Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils

artículo científico publicado en 2008

Flow cytometric measurement of the cellular propagation of TDP-43 aggregation

artículo científico publicado en 2017

Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin

artículo científico publicado en 2014

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species

artículo científico publicado en 2017

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

artículo científico publicado en 2014

Local cooperativity in an amyloidogenic state of human lysozyme observed at atomic resolution

artículo científico publicado en 2010

Methods and models in neurodegenerative and systemic protein aggregation diseases

artículo científico publicado en 2010

Molecular determinants of the aggregation behavior of alpha- and beta-synuclein

artículo científico publicado en 2008

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

article

NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain

artículo científico publicado en 2014

Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris.

artículo científico publicado en 2011

Nature and significance of the interactions between amyloid fibrils and biological polyelectrolytes

artículo científico publicado en 2006

Normal and aberrant biological self-assembly: Insights from studies of human lysozyme and its amyloidogenic variants.

artículo científico publicado en 2006

Origins of helix-coil switching in a light-sensitive peptide.

artículo científico publicado en 2004

Photo-control of peptide helix content by an azobenzene cross-linker: steric interactions with underlying residues are not critical

artículo científico publicado en 2002

Population of nonnative states of lysozyme variants drives amyloid fibril formation

artículo científico publicado en 2011

Prevention of peptide fibril formation in an aqueous environment by mutation of a single residue to Aib.

artículo científico publicado en 2003

Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms

artículo científico publicado en 2013

Protein amyloids develop an intrinsic fluorescence signature during aggregation ⬇️

artículo científico publicado el 18 de febrero de 2013

Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution

artículo científico publicado en 2020

Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers

artículo científico publicado en 2020

Reversible photocontrol of DNA binding by a designed GCN4-bZIP protein

artículo científico publicado en 2006

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers.

artículo científico publicado en 2018

Solvent exposure of Tyr10 as a probe of structural differences between monomeric and aggregated forms of the amyloid-β peptide

artículo científico publicado en 2015

Structural Characterization of Covalently Stabilized Human Cystatin C Oligomers

scientific article published on 15 August 2020

Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms

artículo científico publicado en 2015

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease

artículo científico publicado en 2017

The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils

scientific article published on 17 March 2020

The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme

artículo científico publicado en 2016

The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures

artículo científico publicado en 2007

The influence of novel gemini surfactants containing cycloalkyl side-chains on the structural phases of DNA in solution

artículo científico publicado en 2015

The kinetics of helix unfolding of an azobenzene cross-linked peptide probed by nanosecond time-resolved optical rotatory dispersion.

artículo científico publicado en 2003

The non-core regions of human lysozyme amyloid fibrils influence cytotoxicity

artículo científico publicado en 2010

The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis

artículo científico publicado en 2017

Towards multiparametric fluorescent imaging of amyloid formation: studies of a YFP model of alpha-synuclein aggregation

artículo científico publicado en 2009

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

scientific article published on 13 August 2020

Trodusquemine enhances Aβ aggregation but suppresses its toxicity by displacing oligomers from cell membranes

scientific article published in Nature Communications

Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis

scientific article published on 18 September 2019

Using an azobenzene cross-linker to either increase or decrease peptide helix content upon trans-to-cis photoisomerization.

artículo científico publicado en 2002

Lista de obras de

A FRET sensor for non-invasive imaging of amyloid formation in vivo

A Nanobody Binding to Non-Amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril Formation

A Water-Soluble Azobenzene Cross-Linker for Photocontrol of Peptide Conformation

A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis

A prion-like domain in ELF3 functions as a thermosensor in Arabidopsis

ANS binding reveals common features of cytotoxic amyloid species

Achieving photo-control of protein conformation and activity: producing a photo-controlled leucine zipper.

Alpha-2-Macroglobulin Is Acutely Sensitive to Freezing and Lyophilization: Implications for Structural and Functional Studies

Alpha-helix formation in a photoswitchable peptide tracked from picoseconds to microseconds by time-resolved IR spectroscopy.

Amyloid-like Fibrils from an α-Helical Transmembrane Protein

Analysis of the Native Structure, Stability and Aggregation of Biotinylated Human Lysozyme ⬇️

Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation.

Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's β-amyloid aggregation

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

Clusterin protects neurons against intracellular proteotoxicity

Disease‐related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development inDrosophila melanogaster ⬇️

Disulfide bonds reduce the toxicity of the amyloid fibrils formed by an extracellular protein

Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils

Flow cytometric measurement of the cellular propagation of TDP-43 aggregation

Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

Local cooperativity in an amyloidogenic state of human lysozyme observed at atomic resolution

Methods and models in neurodegenerative and systemic protein aggregation diseases

Molecular determinants of the aggregation behavior of alpha- and beta-synuclein

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain

Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris.

Nature and significance of the interactions between amyloid fibrils and biological polyelectrolytes

Normal and aberrant biological self-assembly: Insights from studies of human lysozyme and its amyloidogenic variants.

Origins of helix-coil switching in a light-sensitive peptide.

Photo-control of peptide helix content by an azobenzene cross-linker: steric interactions with underlying residues are not critical

Population of nonnative states of lysozyme variants drives amyloid fibril formation

Prevention of peptide fibril formation in an aqueous environment by mutation of a single residue to Aib.

Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms

Protein amyloids develop an intrinsic fluorescence signature during aggregation ⬇️

Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution

Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers

Reversible photocontrol of DNA binding by a designed GCN4-bZIP protein

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers.

Solvent exposure of Tyr10 as a probe of structural differences between monomeric and aggregated forms of the amyloid-β peptide

Structural Characterization of Covalently Stabilized Human Cystatin C Oligomers

Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease

The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils

The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme

The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures

The influence of novel gemini surfactants containing cycloalkyl side-chains on the structural phases of DNA in solution

The kinetics of helix unfolding of an azobenzene cross-linked peptide probed by nanosecond time-resolved optical rotatory dispersion.

The non-core regions of human lysozyme amyloid fibrils influence cytotoxicity

The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis

Towards multiparametric fluorescent imaging of amyloid formation: studies of a YFP model of alpha-synuclein aggregation

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

Trodusquemine enhances Aβ aggregation but suppresses its toxicity by displacing oligomers from cell membranes

Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis

Using an azobenzene cross-linker to either increase or decrease peptide helix content upon trans-to-cis photoisomerization.