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Assessment of functional recovery and axonal sprouting in oligodendrocyte-myelin glycoprotein (OMgp) null mice after spinal cord injury

scientific journal article

Blocking LINGO-1 function promotes retinal ganglion cell survival following ocular hypertension and optic nerve transection.

artículo científico publicado en 2008

Blocking LINGO-1 in vivo reduces degeneration and enhances regeneration of the optic nerve

artículo científico publicado en 2016

Characterization of trisulfide modification in antibodies

artículo científico publicado en 2010

Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination ⬇️

artículo científico publicado el 3 de julio de 2011

Disulfide structure of the leucine-rich repeat C-terminal cap and C-terminal stalk region of Nogo-66 receptor

artículo científico publicado en 2005

Exposure Levels of Anti-LINGO-1 Li81 Antibody in the Central Nervous System and Dose-Efficacy Relationships in Rat Spinal Cord Remyelination Models after Systemic Administration ⬇️

artículo científico publicado el 1 de agosto de 2011

Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site

scientific article published on 01 January 2020

Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis

artículo científico publicado en 2010

Inhibition of LINGO-1 promotes functional recovery after experimental spinal cord demyelination

artículo científico publicado en 2015

Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models

artículo científico publicado en 2007

LINGO-1 Regulates Oligodendrocyte Differentiation through the Cytoplasmic Gelsolin Signaling Pathway.

artículo científico publicado en 2017

LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury

scientific article published on 29 September 2006

LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis

artículo científico publicado en 2007

LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

artículo científico publicado en 2004

LINGO-1 negatively regulates TrkB phosphorylation after ocular hypertension.

artículo científico publicado en 2010

LINGO-1 negatively regulates myelination by oligodendrocytes

scientific journal article

LINGO-1 regulates oligodendrocyte differentiation by inhibiting ErbB2 translocation and activation in lipid rafts

artículo científico publicado en 2014

NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination

artículo científico publicado en 2007

Oligodendrocyte differentiation and myelination defects in OMgp null mice ⬇️

artículo científico publicado el 23 de febrero de 2011

Production of a PEGylated Fab′ of the anti-LINGO-1 Li33 Antibody and Assessment of Its Biochemical and Functional Properties in Vitro and in a Rat Model of Remyelination ⬇️

artículo científico publicado el 21 de enero de 2011

Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells

artículo científico publicado en 2009

Role of transmembrane semaphorin Sema6A in oligodendrocyte differentiation and myelination.

artículo científico publicado en 2012

Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo ⬇️

artículo científico publicado el 24 de junio de 2011

Structure of the LINGO-1-anti-LINGO-1 Li81 antibody complex provides insights into the biology of LINGO-1 and the mechanism of action of the antibody therapy

artículo científico publicado en 2014

TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration

artículo científico publicado en 2005

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