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A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors

artículo científico publicado en 2012

A sphingosine-1-phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigration

artículo científico publicado en 2017

Actin polymerization-driven molecular movement of mDia1 in living cells

artículo científico publicado en 2004

Adhesion of platelets through thromboxane A₂ receptor signaling facilitates liver repair during acute chemical-induced hepatotoxicity

artículo científico publicado en 2015

An essential role of Cdc42-like GTPases in mitosis of HeLa cells

artículo científico publicado en 2006

Anti-inflammatory role of PGD 2 in acute lung inflammation and therapeutic application of its signal enhancement

artículo científico publicado el 11 de marzo de 2013

Aquaporin-3 potentiates allergic airway inflammation in ovalbumin-induced murine asthma

artículo científico publicado en 2016

Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern?

artículo científico publicado en 2002

Augmented cardiac hypertrophy in response to pressure overload in mice lacking the prostaglandin I2 receptor

artículo científico publicado en 2005

Bone marrow-derived EP3-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth

artículo científico publicado en 2009

CCAAT/enhancer-binding protein delta/miR135a/thrombospondin 1 axis mediates PGE2-induced angiogenesis in Alzheimer's disease

artículo científico publicado en 2014

Cdc42 and Rac family GTPases regulate mode and speed but not direction of primary fibroblast migration during platelet-derived growth factor-dependent chemotaxis

artículo científico publicado en 2009

Central PGE2exhibits anxiolytic-like activity via EP1and EP4receptors in a manner dependent on serotonin 5-HT1A, dopamine D1and GABAAreceptors

artículo científico publicado el 17 de junio de 2011

Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors

artículo científico publicado en 2003

Cigarette Smoke Extract Inhibits Platelet Aggregation by Suppressing Cyclooxygenase Activity

scientific article published on 01 July 2017

Constitutive Activation of Integrin α9 Augments Self-Directed Hyperplastic and Proinflammatory Properties of Fibroblast-like Synoviocytes of Rheumatoid Arthritis

artículo científico publicado en 2017

Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19

artículo científico publicado en 2019

Critical role of TNF-alpha-TNFR1 signaling in intracranial aneurysm formation

scientific article published on 31 March 2014

Crystal structure of the endogenous agonist-bound prostanoid receptor EP3

artículo científico publicado en 2018

Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia.

artículo científico publicado en 2011

Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth

artículo científico publicado en 2015

Disruption of Actin Dynamics Regulated by Rho Effector mDia1 Attenuates Pressure Overload-Induced Cardiac Hypertrophic Responses and Exacerbates Dysfunction

scientific article published on 09 July 2020

Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2.

artículo científico publicado en 2011

Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis

artículo científico publicado en 2010

EP2and EP4receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals

artículo científico publicado el 8 de diciembre de 2011

EP3 signaling in dendritic cells promotes liver repair by inducing IL-13-mediated macrophage differentiation in mice

scientific article published on 28 February 2020

Effects of the prostanoids on the proliferation or hypertrophy of cultured murine aortic smooth muscle cells

artículo científico publicado en 2002

Emerging roles of prostanoids in T cell‐mediated immunity

artículo científico publicado el 1 de agosto de 2010

EphA4-dependent axon retraction and midline localization of Ephrin-B3 are disrupted in the spinal cord of mice lacking mDia1 and mDia3 in combination.

artículo científico publicado en 2013

Epistatic interaction between Toll-like receptor 3 (TLR3) and prostaglandin E receptor 3 (PTGER3) genes

artículo científico publicado en 2012

Erratum: Prostaglandin E2 promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase

scientific article published in Nature Communications

Exacerbation of intracranial aneurysm and aortic dissection in hypertensive rat treated with the prostaglandin F-receptor antagonist AS604872.

artículo científico publicado en 2014

Expression of prostaglandin F receptor in scleral and subconjunctival tissue

artículo científico publicado el 11 de mayo de 2012

Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract

artículo científico publicado en 2003

Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling

artículo científico publicado en 2010

F- and G-actin homeostasis regulates mechanosensitive actin nucleation by formins

artículo científico publicado el 3 de marzo de 2013

Fever, inflammation, pain and beyond: prostanoid receptor research during these 25 years

artículo científico publicado el 1 de marzo de 2011

Functional evidence for interaction between prostaglandin EP3 and kappa-opioid receptor pathways in tactile pain induced by human immunodeficiency virus type-1 (HIV-1) glycoprotein gp120.

artículo científico publicado en 2003

G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2.

artículo científico publicado en 2016

G-actin regulates rapid induction of actin nucleation by mDia1 to restore cellular actin polymers

artículo científico publicado en 2008

Genetic and pharmacological inhibition of Rho-associated kinase II enhances adipogenesis.

artículo científico publicado en 2007

Hepatic stellate cells relay inflammation signaling from sinusoids to parenchyma in mouse models of immune-mediated hepatitis

artículo científico publicado en 2015

Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth

artículo científico publicado en 2003

Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis

artículo científico publicado en 2009

Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft model

artículo científico publicado en 2010

Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes

artículo científico publicado en 2003

Impaired vascular remodeling in the yolk sac of embryos deficient in ROCK-I and ROCK-II

artículo científico publicado el 5 de septiembre de 2011

Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP(4) receptor

artículo científico publicado en 2012

Inactivation of Rho GTPases with Clostridium difficile toxin B impairs centrosomal activation of Aurora-A in G2/M transition of HeLa cells

artículo científico publicado en 2007

Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice

artículo científico publicado en 2018

Involvement of cyclooxygenase-2 and EP3 prostaglandin receptor in acute herpetic but not postherpetic pain in mice

artículo científico publicado en 2005

Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.

artículo científico publicado en 2002

Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo

artículo científico publicado en 2007

LPA Induces Keratinocyte Differentiation and Promotes Skin Barrier Function through the LPAR1/LPAR5-RHO-ROCK-SRF Axis

scientific article published on 14 November 2018

Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface

artículo científico publicado en 2018

Lipocalin-type prostaglandin D synthase regulates light-induced phase advance of the central circadian rhythm in mice

artículo científico publicado en 2020

Loss of a Rho-Regulated Actin Nucleator, mDia2, Impairs Cytokinesis during Mouse Fetal Erythropoiesis

artículo científico publicado el 14 de noviembre de 2013

Macrophage Imaging of Cerebral Aneurysms with Ferumoxytol: an Exploratory Study in an Animal Model and in Patients.

artículo científico publicado en 2017

Migration without a clutch

scientific article published on 01 December 2009

Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV

scientific journal article

Multiple spatiotemporal modes of actin reorganization by NMDA receptors and voltage-gated Ca2+ channels

artículo científico publicado en 2002

Opposing immunomodulatory roles of prostaglandin D2 during the progression of skin inflammation

artículo científico publicado en 2013

Orally administered rubiscolin-6, a δ opioid peptide derived from Rubisco, stimulates food intake via leptomeningeal lipocallin-type prostaglandin D synthase in mice

artículo científico publicado en 2012

PS144. Dopamine D1 receptor in the medial prefrontal cortex mediates behavioral resilience under stress in mice.

artículo científico publicado en 2016

PS205. Innate immune molecules activate microglia in mPFC to induce neuronal and emotional changes in mice.

artículo científico publicado en 2016

Pathophysiological roles of the prostanoids in the cardiovascular system: studies using mice deficient in prostanoid receptors

artículo científico publicado en 2003

Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis

artículo científico publicado en 2006

Prostaglandin D 2 -DP Signaling Promotes Endothelial Barrier Function via the cAMP/PKA/Tiam1/Rac1 Pathway

artículo científico publicado el 10 de enero de 2013

Prostaglandin D2 protects neonatal mouse brain from hypoxic ischemic injury.

artículo científico publicado en 2007

Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher.

artículo científico publicado en 2006

Prostaglandin E receptor EP1 controls impulsive behavior under stress.

artículo científico publicado en 2005

Prostaglandin E receptor EP1 enhances GABA-mediated inhibition of dopaminergic neurons in the substantia nigra pars compacta and regulates dopamine level in the dorsal striatum

artículo científico publicado en 2009

Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells.

artículo científico publicado en 2013

Prostaglandin E receptor EP3 deficiency modifies tumor outcome in mouse two-stage skin carcinogenesis

artículo científico publicado en 2005

Prostaglandin E receptor EP4 stimulates lymphangiogenesis to promote mucosal healing during DSS-induced colitis

scientific article published on 21 May 2020

Prostaglandin E receptor subtype EP(1) deficiency inhibits colon cancer development

artículo científico publicado en 2004

Prostaglandin E receptor subtype EP3 in conjunctival epithelium regulates late-phase reaction of experimental allergic conjunctivitis

artículo científico publicado en 2008

Prostaglandin E receptors

artículo científico publicado en 2007

Prostaglandin E(2) regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells.

artículo científico publicado en 2013

Prostaglandin E2 (PGE2)-EP2 signaling negatively regulates murine atopic dermatitis-like skin inflammation by suppressing thymic stromal lymphopoietin expression

artículo científico publicado en 2019

Prostaglandin E2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum.

artículo científico publicado en 2007

Prostaglandin E2 promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase

artículo científico publicado el 1 de enero de 2013

Prostaglandin E2 protects the heart from ischemia-reperfusion injury via its receptor subtype EP4.

artículo científico publicado en 2004

Prostaglandin E2 stimulates adaptive IL-22 production and promotes allergic contact dermatitis

artículo científico publicado en 2017

Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor.

artículo científico publicado en 2009

Prostaglandin E2, an immunoactivator.

artículo científico publicado en 2010

Prostaglandin E2-EP2-NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms.

artículo científico publicado en 2017

Prostaglandin E2-EP4 signaling persistently amplifies CD40-mediated induction of IL-23 p19 expression through canonical and non-canonical NF-κB pathways.

artículo científico publicado en 2015

Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion

scientific journal article

Prostaglandin E2-Mediated Attenuation of Mesocortical Dopaminergic Pathway Is Critical for Susceptibility to Repeated Social Defeat Stress in Mice

artículo científico publicado el 21 de marzo de 2012

Prostaglandin E2-prostaglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression

artículo científico publicado en 2011

Prostaglandin E₂ constrains systemic inflammation through an innate lymphoid cell-IL-22 axis

artículo científico publicado en 2016

Prostaglandin F(2alpha) receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-beta

artículo científico publicado en 2009

Prostaglandin F2α Facilitates Platelet Activation by Acting on Prostaglandin E2 Receptor Subtype EP3 and Thromboxane A2 Receptor TP in Mice

artículo científico publicado en 2019

Prostaglandin I2 plays a key role in zymosan-induced mouse pleurisy

artículo científico publicado en 2008

Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling.

artículo científico publicado en 2009

Prostaglandin I2 suppresses the development of diet-induced nonalcoholic steatohepatitis in mice.

artículo científico publicado en 2017

Prostaglandin receptors EP2, EP3, and IP mediate exudate formation in carrageenin-induced mouse pleurisy

artículo científico publicado en 2004

Prostaglandin-cytokine crosstalk in chronic inflammation

artículo científico publicado en 2019

Prostanoid receptors: structures, properties, and functions

artículo científico publicado en 1999

Protection of atherogenesis in thromboxane A2 receptor-deficient mice is not associated with thromboxane A2 receptor in bone marrow-derived cells

artículo científico publicado en 2006

RNA sequencing analysis revealed the induction of CCL3 expression in human intracranial aneurysms

scientific article published on 17 July 2019

ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts

artículo científico publicado en 2002

ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo

artículo científico publicado en 2005

ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles

artículo científico publicado en 2005

Real-time Imaging of an Experimental Intracranial Aneurysm in Rats

scientific article published on 15 December 2018

Repeated social defeat stress impairs attentional set shifting irrespective of social avoidance and increases female preference associated with heightened anxiety.

artículo científico publicado en 2018

Rho and anillin-dependent control of mDia2 localization and function in cytokinesis

artículo científico publicado en 2010

Rho signaling research: history, current status and future directions

artículo científico publicado en 2018

Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion

artículo científico publicado en 2009

RhoA/Rho kinase signaling in the cumulus mediates extracellular matrix assembly

artículo científico publicado en 2009

Role of PGE-type receptor 4 in auditory function and noise-induced hearing loss in mice

artículo científico publicado el 16 de diciembre de 2011

Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E2 synthesis in the brain and their behavioral relevance

scientific article published on 26 November 2019

Roles of prostaglandin E receptors in stress responses

artículo científico publicado en 2009

Roles of prostaglandin E2-EP1 receptor signaling in regulation of gastric motor activity and emptying

artículo científico publicado el 26 de agosto de 2010

Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation

artículo científico publicado en 2011

Roles of prostanoids in the pathogenesis of cardiovascular diseases: Novel insights from knockout mouse studies

artículo científico publicado el 1 de febrero de 2011

Roles of thromboxane A(2) and prostacyclin in the development of atherosclerosis in apoE-deficient mice

artículo científico publicado en 2004

Rotational Movement of the Formin mDia1 Along the Double Helical Strand of an Actin Filament

artículo científico publicado el 9 de diciembre de 2010

Selective activation of the prostaglandin E2 receptor subtype EP2 or EP4 leads to inhibition of platelet aggregation

artículo científico publicado en 2010

Single-cell RNA sequencing identifies a migratory keratinocyte subpopulation expressing THBS1 in epidermal wound healing

artículo científico publicado en 2022

Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation

artículo científico publicado en 2002

Stress responses: the contribution of prostaglandin E2 and its receptors

artículo científico publicado el 30 de noviembre de 2010

Suppression of polyI:C-inducible gene expression by EP3 in murine conjunctival epithelium

artículo científico publicado el 12 de septiembre de 2013

Suppression of polyi:c-inducible gene expression by EP3 in murine conjunctival epithelium

artículo científico publicado en 2014

Sustained expression of MCP-1 by low wall shear stress loading concomitant with turbulent flow on endothelial cells of intracranial aneurysm

artículo científico publicado en 2016

T cell function is dispensable for intracranial aneurysm formation and progression

artículo científico publicado en 2017

T cell-intrinsic prostaglandin E-EP2/EP4 signaling is critical in pathogenic T17 cell-driven inflammation

artículo científico publicado en 2018

TNF-alpha induces thromboxane receptor signaling-dependent microcirculatory dysfunction in mouse liver

artículo científico publicado en 2008

The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation

artículo científico publicado en 2018

The PGE2-EP4 receptor is necessary for stimulation of the renin-angiotensin-aldosterone system in response to low dietary salt intake in vivo

artículo científico publicado el 19 de septiembre de 2012

The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src

artículo científico publicado en 2006

The intrinsic prostaglandin E2–EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice

artículo científico publicado el 18 de abril de 2012

The novel prostaglandin I2 mimetic ONO-1301 escapes desensitization in an antiplatelet effect due to its inhibitory action on thromboxane A2 synthesis in mice

artículo científico publicado en 2015

The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut

artículo científico publicado en 2002

Thromboxane A 2 Regulates Vascular Tone via Its Inhibitory Effect on the Expression of Inducible Nitric Oxide Synthase

artículo científico publicado el 13 de octubre de 2003

Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia

scientific journal article

Thromboxane A2 facilitates IL-17A production from Vγ4+ γδ T cells and promotes psoriatic dermatitis in mice.

artículo científico publicado en 2018

Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity

artículo científico publicado en 2003

Thromboxane A2 receptor signaling in endothelial cells attenuates monocrotaline-induced liver injury

scientific article published on 27 August 2019

Thromboxane A2 receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment

artículo científico publicado el 21 de diciembre de 2011

Thromboxane receptor activation enhances striatal dopamine release, leading to suppression of GABAergic transmission and enhanced sugar intake

artículo científico publicado en 2011

Timely interaction between prostaglandin and chemokine signaling is a prerequisite for successful fertilization

artículo científico publicado en 2008

Two Diverse Hemodynamic Forces, a Mechanical Stretch and a High Wall Shear Stress, Determine Intracranial Aneurysm Formation

artículo científico publicado en 2019

Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons

artículo científico publicado en 2018

Vasa vasorum formation is associated with rupture of intracranial aneurysms

artículo científico publicado en 2019

mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety.

artículo científico publicado en 2016

mDia1 targets v-Src to the cell periphery and facilitates cell transformation, tumorigenesis, and invasion

artículo científico publicado en 2010

mDia1/3 generate cortical F-actin meshwork in Sertoli cells that is continuous with contractile F-actin bundles and indispensable for spermatogenesis and male fertility

scientific article published on 26 September 2018

mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse

scientific article published on 01 January 2020